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A Survey on the Most Common Side Effects of Isotretinoin among a Group of Syrian Patients


Affiliations
1 Department of Biochemistry, Alsham Private University, Latakia, Syrian Arab Republic
2 Department of Staistics, Tishreen University. Latakia, Syrian Arab Republic
     

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Acne vulgaris is considered one of the most important cutaneous conditions affecting people in the society at the ages of adolescence and youth. There are many topical treatments along with systemic treatments that can be used to treat it. Isotretinoin is one of the most popular medications that can be used to treat acne vulgaris. Its use can be accompanied by serious side effects; especially teratogenicity. We aimed of this study to evaluate the most common side effects associated to oral isotretinoin intake among the Syrian society to increase the awareness among young adults. We designed an electronic questionnaire containing 20 questions and directed to patients who are treated with oral isotretinoin; taking in consideration the privacy of the questionnaire. 320 individuals (292 females – 28 males from all Syrian communities answered the questionnaire. Among all participants, 8.4% had taken oral isotretinoin without a medical prescription and 55% (176 of 320) had not done liver function tests before starting the course. We noticed that the most frequent side effect was chapped and dry lips 96.3%, and secondly dermatoxerasia 81.6%. It was surprising that 55.6% of all participants suffered from mood disorders and depression. These results confirm the importance of the survey in shedding light on isotretinoin side effects and increasing the awareness of its possible complications, in addition to educate the patients about the effects of this medication on the mental state along with mood disorders that may be associated to long-term use.

Keywords

Survey, Isotretinoin, Oral Administration, Side Effects.
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  • Gollnick HP, Zouboulis CC, Akamatsu H, Kurokawa I, Schulte A. Pathogenesis and pathognesis-related treatment of acne. J Dermatol. 1991;18:489–99.
  • Sanjay K Rathi. ACNE VULGARIS TREATMENT: THE CURRENT SCENARIO. Indian J Dermatol. 2011 Jan-Feb; 56(1): 7–13.
  • Diane K. Wysowski, Marilyn Pitts, Julie Beitz. An analysis of reports of depression and suicide in patients treated with isotretinoin. JAAD October 2001Volume 45, Issue 4, Pages 515– 519.
  • Piotr Brzezinski, Katarzyna Borowska, Anca Chiriac, Janusz Smigielski. Adverse effects of isotretinoin: A large, retrospective review. Dermatologic Therapy. 2017;30: e12483.
  • Borovaya, A., Dombrowski, Y., Zwicker, S., Olisova, O., Ruzicka, T., Wolf, R., et al. (2014). Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris. Archives of Dermatological Research ,306, 689–700.
  • Parinitha Rao K, Ramesh Bhat M, Nandakishore B, Dandakeri S, Martis J, et al. (2014) Safety and efficacy of low-dose isotretinoin in the treatment of moderate to severe Acne vulgaris. Indian Journal Dermatology 59: 316
  • Al-Harbi M. Concerns and Awareness of Acne Patients About Isotretinoin in Qassim Region of Saudi Arabia. Int J Health Sci (Qassim). 2010 Jan; 4(1): 47–51.
  • Al-Suhaibani S. (2016) The Impact of Oral Isotretinoin Dryness and Depression on Saudi Women in Qassim Region: A Survey. J Depress Anxiety 5: 245. doi: 10.4172/2167-1044.1000245.

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  • A Survey on the Most Common Side Effects of Isotretinoin among a Group of Syrian Patients

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Authors

Rim M. Harfouch
Department of Biochemistry, Alsham Private University, Latakia, Syrian Arab Republic
Jawa Bitar
Department of Biochemistry, Alsham Private University, Latakia, Syrian Arab Republic
Rawan Badawi
Department of Biochemistry, Alsham Private University, Latakia, Syrian Arab Republic
Ali Salloum
Department of Biochemistry, Alsham Private University, Latakia, Syrian Arab Republic
Ali Spih
Department of Biochemistry, Alsham Private University, Latakia, Syrian Arab Republic
Nihal Marashli
Department of Biochemistry, Alsham Private University, Latakia, Syrian Arab Republic
Mounzer Boubou
Department of Staistics, Tishreen University. Latakia, Syrian Arab Republic
Faten Chouman
Department of Biochemistry, Alsham Private University, Latakia, Syrian Arab Republic

Abstract


Acne vulgaris is considered one of the most important cutaneous conditions affecting people in the society at the ages of adolescence and youth. There are many topical treatments along with systemic treatments that can be used to treat it. Isotretinoin is one of the most popular medications that can be used to treat acne vulgaris. Its use can be accompanied by serious side effects; especially teratogenicity. We aimed of this study to evaluate the most common side effects associated to oral isotretinoin intake among the Syrian society to increase the awareness among young adults. We designed an electronic questionnaire containing 20 questions and directed to patients who are treated with oral isotretinoin; taking in consideration the privacy of the questionnaire. 320 individuals (292 females – 28 males from all Syrian communities answered the questionnaire. Among all participants, 8.4% had taken oral isotretinoin without a medical prescription and 55% (176 of 320) had not done liver function tests before starting the course. We noticed that the most frequent side effect was chapped and dry lips 96.3%, and secondly dermatoxerasia 81.6%. It was surprising that 55.6% of all participants suffered from mood disorders and depression. These results confirm the importance of the survey in shedding light on isotretinoin side effects and increasing the awareness of its possible complications, in addition to educate the patients about the effects of this medication on the mental state along with mood disorders that may be associated to long-term use.

Keywords


Survey, Isotretinoin, Oral Administration, Side Effects.

References