Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Design, Development and Evaluation of Fast Dissolving Tablet of Antiasthmatic Drug


Affiliations
1 Ashokrao Mane College of Pharmacy, Dept. of Pharmaceutics, Peth Vadgaon, 416112, Kolhapur, Maharashtra, India
     

   Subscribe/Renew Journal


The aim of the work is an attempt to design, development and evaluation of fast dissolving tablets of Levosalbutamol sulphate by direct compression method with the aid of superdisintegrant addition. Levosalbutamol (LS) is the R – enantiomer of short acting beta2 adrenergic receptor agonist of salbutamol used to treat asthma and Chronic obstructive pulmonary disease. Nine formulations were prepared by using three different superdisintegrants in varying concentration in such way that total weight of the tablet remains same. The drug-polymer incompatibility was analysed by FTIR studies. All the formulated tablets were subjected for pre and post-compression evaluation parameters. From the FTIR studies the drug-polymer compatibility were confirmed. The pre-compression parameters like bulk density, tapped density, Carr’s index and angle of repose was determined. The optimized formulation showed acceptable flow properties. The post-compression parameters like the thickness, hardness, friability and in vitro dispersion time, wetting time, water absorption ratio and in- vitro drug release were carried out and the values were found to be within IP limits. Among the nine formulations, the formulation containing Kyron T 314 (F9) showed highest drug release of 97.71 % than other formulations.

Keywords

Levosalbutamol Sulphate, Fast Dissolving Tablet, Direct Compression, Superdisintegrants.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Bhandari S, Mittapalli RK.. Orodisprsible tablet: An overview. Asian Journal of Pharmaceutics. 2008: 2-11.

  • Velmuragan S, Vinushitha S. Oral Disintegreating Tablets: An Overview. International Journal of Chemical and Pharmaceutical Science. 1(2);2010:1-6.

  • Jagani H, Patel R. Fast Dissolving Tablets. Journal of Advances in Pharmacy and Health Research. 2011; 2(1): 57-70.

  • Saroha K, Mathur P. Mouth Dissolving Tablets: An Overview on Future Compaction Oral Formulation Technologies. Pelagia Research Library. 1(1);2010: 179-187.

  • Siddiqui A, Garg G. Fast Dissolving Tablets: Preparation, Characterization and Evaluation: An Overview. International Journal of Pharmaceutical Sciences Review and research. 4(2); 2010: 87-96.

  • Shelake S, Patil S, Patil S, Sangave S. Formulation and evaluation of fenofibrate-loaded nanoparticles by precipitation method. Indian J Pharm Sci. 80(3); 2018: 420-427.

  • Bandgar S. A , Shelake S. S., Patil S. S. Solubility enhancement of poorly soluble drug by Various techniques. World Journal of Pharmacy and Pharmaceutical sciences. 6(9); 2017: 1405-1416.

  • Shelake S, Mhetre R, Patil S, Patil S, Khade V. Formulation and evaluation of Microspheres for nasal delivery of antihypertensive drug. Indian J Pharm Sci. 80(3);2018:420-427.

  • Prajapati BJ, Patel B. Formulation, Evaluation and Optimization of Oraly Disintigrating Tablet Piroxicam. International Journal of Pharma Tech Reseach. 2(3); 2010:1893-1899.

  • Bangale GS, Yadhav GJ. New Generation of Orodispersible Tablets: Resent Advances and Future Prospect. International Journal Of Pharmacy And Pharmaceutical Science Research. 1(2);2011:52-62.

  • Agrawal VA, Rajurkar RM. Fast disintegrating Tablet as a New Drug Delivery: A Review. Pharmacophore. 2(1); 2011:1-8.

  • Raut Indrayani D., Bandgar Sandip A., Shah R. R., Chougule D.D. Formulation and Evaluation of Gastric Floating Tablet of Domperidone. Asian J. Res. Pharm. Sci. 4(1); 2014: 22-25.

  • Bandgar S. A. , Yadav A. V., Patil S. S. Formulation and Evaluation of Cefetamet Pivoxil Hydrochloride Dispersible Tablet by Using Taste Masking (Particle Coating) Approach. Journal of Pharmacy Research. 2(11); 2009:1789-1793.

  • Raut Indrayani D, Gharge Manisha, Dandwde Sonli, Mohite S.K., Magdum C.S. Formulation and Characterization of fast Dissolving tablets of Perindopril. Asian Journal of Pharmacy and Technology. 7(1); 2017: 51-55.

  • Shelake S., Khade V., Sangave P, Patil S. Development and Evaluation of Colon Specific Drug Delivery System via pH and Microbial Triggered Mechanism for Colon Cancer. American Journal of Pharmaceutical Research. 7(5); 2017: 218-228.

  • Bhati S, Sethi V. Formulation and evaluation of fast dissolving tablets of metoclopramide hydrochloride using natural sweetening agent of stevia leaf powder. Int. J. Res. Dev. Pharm. L. Sci. 3(1);2013:833-838.

  • Dekivadia M, Gudigennavar A, Patil C, Umarji B. Development and optimization of fast Dissolving tablet of levocetirizine HCL. International Journal of Drug Development and Research.4(2);2012:237-246.


Abstract Views: 224

PDF Views: 0




  • Design, Development and Evaluation of Fast Dissolving Tablet of Antiasthmatic Drug

Abstract Views: 224  |  PDF Views: 0

Authors

Nikhil A. Patil
Ashokrao Mane College of Pharmacy, Dept. of Pharmaceutics, Peth Vadgaon, 416112, Kolhapur, Maharashtra, India
Sandip A. Bandgar
Ashokrao Mane College of Pharmacy, Dept. of Pharmaceutics, Peth Vadgaon, 416112, Kolhapur, Maharashtra, India
Sardar S. Shelake
Ashokrao Mane College of Pharmacy, Dept. of Pharmaceutics, Peth Vadgaon, 416112, Kolhapur, Maharashtra, India
Pravin S. Patil
Ashokrao Mane College of Pharmacy, Dept. of Pharmaceutics, Peth Vadgaon, 416112, Kolhapur, Maharashtra, India
Shitalkumar S. Patil
Ashokrao Mane College of Pharmacy, Dept. of Pharmaceutics, Peth Vadgaon, 416112, Kolhapur, Maharashtra, India

Abstract


The aim of the work is an attempt to design, development and evaluation of fast dissolving tablets of Levosalbutamol sulphate by direct compression method with the aid of superdisintegrant addition. Levosalbutamol (LS) is the R – enantiomer of short acting beta2 adrenergic receptor agonist of salbutamol used to treat asthma and Chronic obstructive pulmonary disease. Nine formulations were prepared by using three different superdisintegrants in varying concentration in such way that total weight of the tablet remains same. The drug-polymer incompatibility was analysed by FTIR studies. All the formulated tablets were subjected for pre and post-compression evaluation parameters. From the FTIR studies the drug-polymer compatibility were confirmed. The pre-compression parameters like bulk density, tapped density, Carr’s index and angle of repose was determined. The optimized formulation showed acceptable flow properties. The post-compression parameters like the thickness, hardness, friability and in vitro dispersion time, wetting time, water absorption ratio and in- vitro drug release were carried out and the values were found to be within IP limits. Among the nine formulations, the formulation containing Kyron T 314 (F9) showed highest drug release of 97.71 % than other formulations.

Keywords


Levosalbutamol Sulphate, Fast Dissolving Tablet, Direct Compression, Superdisintegrants.

References