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Ameliorative Potential of Eclipta albaon Gentamycin Induced Renal Toxicity in Rats


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1 NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India
     

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Nephrotoxicity is a common event, which can cause significant morbidity and can be easily overlooked. Gentamycin is an antimicrobial agent which can cause nephrotoxicity on prolonged use. A large number of herbs have traditionally been used to treat drug or toxin-induced renal diseases. The present study was a similar attempt in that direction to evaluate the nephroprotective activity of ethanolic extract of whole plant of Eclipta alba against gentamycin induced nephrotoxicity. The animals were divided into five groups (n=6) consisting of normal control, toxic control and three test groups which received different doses of the extract (100,200 & 400mg/kg, p.o). Nephroprotective effect of ethanolic extract of Eclipta alba was evaluated by assessing the blood parameters and histopathological studies of kidney. Elevated levels of serum urea, serum creatinine, total protein and uric acid have been significantly reduced in dose depending manner by oral administration of ethanolic extract of whole plant of Eclipta alba. These observations were supported by histopathological studies.

Keywords

Eclipta alba, Gentamycin, Nephrotoxicity, Nephroprotection.
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  • Ameliorative Potential of Eclipta albaon Gentamycin Induced Renal Toxicity in Rats

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Authors

Prince Thomas
NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India
M. P. Gururaja
NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India
Himanshu Joshi
NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India
K. Prasannashama
NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India
Ullas D’Souza
NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India
Nimmy Chacko
NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India
K. C. Bharath Raj
NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India
K. S. Rajesh
NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangalore, India

Abstract


Nephrotoxicity is a common event, which can cause significant morbidity and can be easily overlooked. Gentamycin is an antimicrobial agent which can cause nephrotoxicity on prolonged use. A large number of herbs have traditionally been used to treat drug or toxin-induced renal diseases. The present study was a similar attempt in that direction to evaluate the nephroprotective activity of ethanolic extract of whole plant of Eclipta alba against gentamycin induced nephrotoxicity. The animals were divided into five groups (n=6) consisting of normal control, toxic control and three test groups which received different doses of the extract (100,200 & 400mg/kg, p.o). Nephroprotective effect of ethanolic extract of Eclipta alba was evaluated by assessing the blood parameters and histopathological studies of kidney. Elevated levels of serum urea, serum creatinine, total protein and uric acid have been significantly reduced in dose depending manner by oral administration of ethanolic extract of whole plant of Eclipta alba. These observations were supported by histopathological studies.

Keywords


Eclipta alba, Gentamycin, Nephrotoxicity, Nephroprotection.

References