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The GC MS Studies of One Ayurvedic Medicine, Amritarishtam


Affiliations
1 Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600092, India
2 Department of Anatomy, Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600 092, India
3 Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
4 Central Research Facility, Sri Ramachandra Medical College and Research Institute, Purur, Chennai - 600116, India
     

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The knowledge of the types of biomolecules present in Ayurvedic medicines can help in understanding the underlying mechanism of action of such medicines. This type of study is very pertinent and being sought after in the present day medical scenario, which needs newer and better approaches of treatment. The present study deals with the GC MS analysis of one such Ayurvedic medicine, Amritarishtam, which is used for the treatment of all types of fevers. The medicines was procured from standard Ayurvedic vendor at Chennai and subjected to GC MS analysis after following proper procedures. The GC MS profile indicated the presence of 12 biomolecules, such as, Phenylethyl Alcohol, Ethyl Hydrogen Succinate, 5-Hydroxymethylfurfural, Thymol, Ethanone,1-(2-hydroxy-4-methoxyphenyl)-, Hexadecanoic acid,2-hydroxy-1-(hydroxymethyl)ethyl ester and Ocatadecanoic acid,2,3-dihyroxypropyl ester which have medicinal values relating to that of Amritarishtam. Further work to isolate the molecules and understand their role is in process.

Keywords

Ayurveda, Amritarishtam, GC MS, Phenylethyl Alcohol, 6-Hydroxymethylfurfural, Thymol.
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  • Upadhyay AK, Kumar K, Kumar A, Mishra HS. Tinosporacordifolia(Willd.) Hook.f. and Thomas. (Guduchi) - validation of the Ayurvedic pharmacology through experimental and clinical studies. Int J Ayurveda Res, 2010; 1: 112–121.

  • ShahedurRahman, RashidaParvin. Therapeutic potential of Aeglemarmelos(L.)An overview. Asian Pac J Trop Dis, 2014; 4(1): 71–77.

  • Ahad A, Ganai AA, Sareer O, Najm MZ, Kausar MA, Mohd M, Siddiqu WAI. Therapeutic potential of Oroxylumindicum: A Review. Journal of Pharmaceutical Research and Opinion, 2012; 2(10): 163-172.

  • Ashalatha M, KuberSankh. Toxicity Study of GambhariPhalaChurna. International Ayurvedic Medical Journal, 2014; 2(6): 959-963.

  • Rohith K, Patel V, Chakraborty M, Kamath JV. Phytochemical and Pharmacological profile of Gmelinaarborea: An overview. International Research Journal of Pharmacy, 2012; 3(2): 61-64.

  • Meena AK, Yadav AK, Panda P, Preet K, Rao MM. Review on Stereospermumsuaveolens(Roxb.) DC: a potential herb. Drug Invention Today,2010; 2(5): 238-239.

  • Balasubramanian T, Senthilkumar GP, Karthikeyan M, Chatterjee TK. Antihyperglycemic and antioxidant activities of medicinal plant Stereospermumsuaveolensin streptozotocin-induced diabetic rats. ClinExpPharmacol, 2014; 4:162.

  • Khatun H, Majumder R, Mamun AL, Alam EK, Jami SI, Alam B. Preliminary pharmacological activity of the methanolic extract of Premnaintegrifoliabarks in rats. Avicenna J Phytomed, 4(3), 2014, 215-224.

  • Bhattacharjee A, Shastry C, S Saha S. Phytochemical and ethno-pharmacological profile of Desmodiumgangeticum(L.) DC: A review. IJBR, 2013; 4(10): 508-515.

  • Yasmeen N, Ellandala R, Sujatha K, Veenavamshee R. Evaluation of renal protective effects of DesmodiumGangeticumL. in streptozotocin– induced diabetic rats. Int J Res Pharm Chem, 2011; 1(2): 121-128.

  • Mutalik S, Paridhavi K, Rao CM, Udupa N. Antipyretic and analgesic effect of leaves of Solanummelongenalinn. in rodents. Indian Journal of Pharmacology, 2003; 35: 312-315.

  • Deb PK, Ghosh R, Chakraverty R, Debnath R, Das L, Bhakta T. Phytochemical and Pharmacological Evaluation of Fruits of SolanumindicumLinn. Int J Pharm Sci Rev Res, 2014; 25(2): 28-32.

  • Fatima MSL, Sultana A, Ahmed S, Sultana S. Pharmacological activities of Tribulusterrestris Linn.: A Systemic review. World J of Pharmacy and Pharmaceutical Sciences, 2015;4(2): 136-150.

  • Sahoo HB, Sahoo SK, Sarangi SP, Sagar R, Kori ML. Antidiarrhoealinvestigation from aqueous extract of Cuminumcyminum Linn. Seed in Albino rats.Pharmacognosy Res, 2014; 6(3): 204-209.

  • Gupta PC, Sharma N, RaoCh V. A review on ethnobotany, phytochemistry and pharmacology of Fumariaindica (Fumitory).Asian Pac J Trop Biomed, 2012; 2(8): 665–669.

  • Kalaria Pankti, Gheewala Payal, Chakraborty Manodeep, Kamath Jagadish A. Phytopharmacological review of Alstoniascholaris: A panoramic herbal Medicine. IJRAP, 2012; 3(3): 367-371

  • Zadeh JL, Ko NM. Physiological and pharmaceutical effects of Ginger (Zingiberofficinale Roscoe) as a valuable medicinal plant. European Journal of Experimental Biology, 2014; 4(1): 87-90.

  • Adel PRS, Prakash J. Chemical composition and antioxidant properties of ginger ischolar_main (Zingiberofficinale). Journal of Medicinal Plants Research, 2010; 4(24): 2674-2679.

  • Smith C, Crowther C, Wilson K., Hotham N, McMilian V. A randomized controlled trial of Ginger to treat nausea and vomiting in Pregnancy. Obstetrics and Gynecology, 2004; 103(4): 639-645.

  • Ghayur NM, Gilani AH. Ginger lowers blood pressure through blockade of voltage dependent calcium channels. Journal of Cardiovascular Pharmacology, 2005; 45(1): 74- 80.

  • Shamkuwar PB, Shahi SR, Jadhav ST. Evaluation of antidiarrheal effect of Black pepper (Piper nigrumL.). Asian Journal of Plant Science and Research, 2012; 2(1), 2012, 48-53.

  • Meghwal M, Goswami TK. Chemical Composition, Nutritional, Medicinal And Functional Properties of Black Pepper: A Review. 2012; 1, 172.doi:10.4172/scientificreports.

  • Kumar S, Kamboj J, Suman, Sharma S. Overview for various aspects of the health benefits of Piper longumLinn. fruit. J of Acupuncture and Meridian studies. 4(2), 2011, 134-140.

  • Ali AM, Alam NM, Yeasmin MS, Khan Am, Sayeed A. Antimicrobial screening of different extracts of Piper longumLinn. Res J Agr Bio Sci., 3, 2007, 852-857.

  • Iwashita M, Saito M, Yamaguchi Y, Takagaki T, Nakahata N. Inhibitory effect of ethanol extract of Piper longumLinn. on rabbit platelet aggregation through antagonizing thromoxane A2 receptor. Phytomedicine, 14, 2007, 853-855.

  • Wakade AS, Shah AS, Kulkarni MP, Juvekar AR. Protective effect of Piper longumL. on oxidative stress induced injury and cellular abnormality in adriamycin induced cardiotoxicity in rats. Ind J Exp Biol., 46, 2008, 528-533.

  • Chahar K, Kumar SDS, Geetha L, Lokesh T, Manohara KP. Mesuaferrea L.: A review of the medical evidence for its phytochemistry and pharmacological actions. African Journal of Pharmacy and Pharmacology, 2013; 7(6): 211-219.

  • Jayanthi G, Kamalraj S, KannanKarthikeyan, Muthumary J. Antimicrobial and antioxidant activity of the endophytic fungus Phomopsis sp. GJJM07 isolated from Mesuaferrea. Int J CurrSci, 1, 2011, 85-90.

  • Tiwari PK, Irchhaiya R, Jain SK. Evaluation of anticonvulsant activity of Mesuaferrea Linn. ethanolic flower extract. Int J Pharm Life Sci, 2012; 23: 1507-1509.

  • Jalalpure SS, Yuvaraj D, Mandavkar, Pallavi R, Khalure, Gulab S, Shinde, Pournima A, Shelar, Amol S, Shah. Antiarthritic activity of various extracts of Mesuaferrea Linn. seed. J. Ethnopharmacol, 2011; 138: 700-704.

  • Sivapalan SR. Medicinal uses and Pharmacological activities of Cyperusrotundus Linn - A Review. International Journal of Scientific and Research Publications. 2013; 3(5):1-8.

  • Upadhyay D, Dash RP, Anandjiwala S, Nivsarkar M. Comparative pharmacokinetics profiles of Picrosides I and II from Kutkin, P. kurroa extract and its formulation in rats. Fitoterapia, 2013; 85:76–78.

  • Girish C,Pradhan SC. Hepatoprotective activities of picroliv, curcumin, and ellagic acid compared to silymarin on carbon-tetrachloride-induced liver toxicity in mice. J PharmacolPharmacoTher, 2012, 3(2): 149-155.

  • Tiwari SS, Pandey MM, Srivastava S, Rawat AKS.TLC densitometric quantification of picrosides (picroside-I and picroside-II) in Picrorhizakurrooa and its substitute Picrorhizascrophulariifloraand their antioxidant studies. Biomed Chromatogr, 2012; 26:61–68

  • Kant K; Walia M, Agnihotri VK; Pathania V, Singh B. Evaluation of Antioxidant Activity of Picrorhizakurroa (Leaves) Extracts. Indian J Pharm Sci, 2013: 75(3):324-329.

  • 36.Luis JC, Valdes F, Martin R, Carmona AJ, Diaz JG. DPPH radical scavenging activity of two flavonol glycosides from Aconitum napellus sp. Lusitanicum.Fitoterapia,2006, 77(6), 469-471.

  • Khan S, Khan H, Shah MAR, Khan FU; Shahnaz, Khan RU. Phytotoxic, antioxidant and Cytotoxic effect of Holarrhenaantidysenterica Seeds extracts. International Journal of Advanced Research, 2013, 1(8), 28-33.

  • HaiGu, Zequn Jiang, Mingyan Wang MD, Haiying Jiang, Fengming Zhao, Xia Ding, BaochangCai, Zhen Zhan MD. 5-Hydroxymethylfurfural from wine-processed Fructuscorni inhibits hippocampal neuron apoptosis. Neural Regen Res.2013; 8(28): 2605-2614.

  • Mastelic J, Jerkovic I, Blazevic I, Poljab-BlaziM.et al..Comparative study on the antioxidant and biologicalactivities of carvacrol, thymol and Eugenol derivatives. J of Agriculture and Food Chemistry, 2008; 56(11):3989-3996.

  • Mathela CS, Singh KK, Gupta.VK.. Synthesis and in vitro antibacterial activity of thymol and carvacrolderivatives .ActaPoloniaePharmaceutica and Drug Research, 2010; 67 (4):375-380.

  • Riella R, MrinhoRR, Santos JS, R. N. Pereira-Filho RN, Cardoso JC, Albuquerque-Junior RLC, Thomazzi SM. J of Ethnopharmacology, 2012, 143(2):656-663.

  • Akmachi, KG, Padmawar PA, Thatte UM, Rege, NN, Dahnukar, SA. Synthesis and In‐vitro Evaluation of Platelet Aggregation Inhibitory Activity of Paeonol and its Analogues.February 2010; https://doi.org/10.1211/146080899128734910


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  • The GC MS Studies of One Ayurvedic Medicine, Amritarishtam

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Authors

Hassan Mohammad
Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600092, India
K. Prabhu
Department of Anatomy, Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600 092, India
Mudiganti Ram Krishna Rao
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
R. Lakshmi Sundaram
Central Research Facility, Sri Ramachandra Medical College and Research Institute, Purur, Chennai - 600116, India
Sampad Shil
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
N. Vijayalakshmi
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India

Abstract


The knowledge of the types of biomolecules present in Ayurvedic medicines can help in understanding the underlying mechanism of action of such medicines. This type of study is very pertinent and being sought after in the present day medical scenario, which needs newer and better approaches of treatment. The present study deals with the GC MS analysis of one such Ayurvedic medicine, Amritarishtam, which is used for the treatment of all types of fevers. The medicines was procured from standard Ayurvedic vendor at Chennai and subjected to GC MS analysis after following proper procedures. The GC MS profile indicated the presence of 12 biomolecules, such as, Phenylethyl Alcohol, Ethyl Hydrogen Succinate, 5-Hydroxymethylfurfural, Thymol, Ethanone,1-(2-hydroxy-4-methoxyphenyl)-, Hexadecanoic acid,2-hydroxy-1-(hydroxymethyl)ethyl ester and Ocatadecanoic acid,2,3-dihyroxypropyl ester which have medicinal values relating to that of Amritarishtam. Further work to isolate the molecules and understand their role is in process.

Keywords


Ayurveda, Amritarishtam, GC MS, Phenylethyl Alcohol, 6-Hydroxymethylfurfural, Thymol.

References