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Antiarthritic Medicinal Plants:A Review


Affiliations
1 Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, Karnataka, India
2 R&D center, The Himalaya Drug Company, Makali, Bangalore- 562162, Karnataka, India
     

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Arthritis is a chronic inflammatory condition which is a major disability throughout the world. The exact pathophysiology of the disease is still unknown but many factors may be responsible for this. Several conventional therapies are used for the treatment but they have certain disadvantages such as side effects, poor bioavailability, high cost etc. So, researches are going on for the development of alternative effective therapy for arthritis. Medicinal plants are very useful for the development of the complimentary therapy. Varieties of medicinal plants are available throughout the world which are having good antiarthritic potential. In India, medicinal plants are widely used in different indigenous systems of medicine for the prevention and cure of arthritis. This review article covers the description of the medicinal plants which are reported to have significant antiarthritic property. Here the possible mechanism of action of the herbs reported for the treatment is also discussed.

Keywords

Arthritis, Alternative Therapy, Medicinal Plants, Mechanism of Action, Poor Bioavailability.
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  • Cotran r, kumar v, collins t. Robbins Pathologic Basis of Disease. W.B. Saunders Company, Philadelphia. 1999.

  • Lineker s et al. Defining morning stiffness in rheumatoid arthritis. Journal of Rheumatology. 1999; 26: 1052-1057.

  • Kasper DL et al. Harrison’s Principle of Internal Medicine. Mc-Graw Hill Companies, New York, United States of America. Edition 16 Vol. II 2005.

  • Chunxia C, Peng Z, Huifang P, Hanli R, Zehua H, Jizhou W. Extracts of Arisaema rhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice. Journal of Ethnopharmacology. 2011; 133: 573-582.

  • Centers for Disease control and Prevention Rheumatoid arthritis. Available from: URL: http://www.cdc.gov/arthritis/basics/rheumatoid.htm, last accessed on 22nd May 2013.

  • Sunita Y. Ranade and Ram S. Gaud. Current strategies in herbal drug delivery for arthritis an overview. International Journal Of Pharmaceutical Sciences And Research. 2013; 4(10): 3782-3794.

  • Helmick CG et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis and Rheumatism. 2008; 58: 15–25.

  • Ngoc DD et al. Inhibition by Artocarpus tonkinensis of the development of collagen-induced arthritis in rats. Scandinavian Journal of Immunology. 2005; 61: 234-241.

  • Kasper DL et al. Harrison’s Principle of Internal Medicine. Mc-Graw Hill Companies, New York, United States of America. Edition 16 Vol. II 2005.

  • Finckh A et al. Treatment of very early rheumatoid arthritis with symptomatic therapy, disease-modifying antirheumatic drugs, or biologic agents: a cost-effectiveness analysis. Annals of Internal Medicine. 2009; 151: 612– 621.

  • Muller RB et al. Effectiveness, tolerability, and safety of subcutaneous methotrexate in early rheumatoid arthritis: a retrospective analysis of realworld data from the St. Gallen cohort. Seminars in Arthritis and Rheumatism. 2015; 45: 28–34.

  • Shivaprasad H. et al. Control of autoimmune arthritis by herbal extracts and their bioactive components. Asian journal of pharmaceutical sciences. 2016; 11: 301–307.

  • Manjusha Choudhary. Medicinal plants with potential antiarthritic activity. Journal of Intercultural Ethnopharmacology. 2015; 4: 147-179.

  • C.K.Kokate, A.P.Purohit, S.B.Gokhale. Pharmacognosy 49 th Edition. Nirali Prakashan, Pune, India. 2014.

  • Ezzat abdel-lateef, Faten mahmoud, Olfat hammam, Eman el-ahwany, Eman el-wakil, Sherihan kandil: Bioactive chemical constituents of Curcuma longa L. rhizomes extract inhibit the growth of human hepatoma cell line (HepG2). Acta Pharmaceutica Sinica B. 2016; 66:387–398.

  • Zheng Z et al. The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug Design, Development and Therapy. 2015; 9: 4931-4942. Doi:10.2147/DDDT.S90147.

  • R Arora et al. Curcumin loaded solid lipid nanoparticles ameliorate adjuvant‐induced arthritis in rats. European Journal of Pain. 2014; DOI: 10.1002/ejp.620.

  • Nonose Nilson et al. Oral administration of curcumin (Curcuma longa) can attenuate the neutrophil inflammatory response in zymosan-induced arthritis in rats. Acta Cirurgica Brasileira. 2014; 29(11): 727-734.

  • Huang G. et al. Curcumin Protects Against Collagen-Induced Arthritis via Suppression of BAFF Production. Journal of Clinical Immunology. 2013; 33: 550 DOI- https://doi.org/10.1007/s10875-012-9839-0.

  • Davinder Kumar, Virender Kumar and Pawan Jalwal. Boswellic Acid- Potential tumors suppressant terpenoid -Photochemistry, Extraction and Isolation Methods -A comprehensive review study. Journal of Pharmacognosy and Phytochemistry 2016; 5(3): 231-239.

  • Suva et al. Aflapin® for arthritis management. Indian Journal of Pain. 2018; 32(1): 16-23.

  • N.K. Mishra et al. Anti-arthritic activity of Glycyrrhiza glabra, Boswellia serrata and their synergistic activity in combined formulation studied in freund’s adjuvant induced arthritic rats. Journal of Pharmaceutical Education and Research. 2011; 2(2): 92-98.

  • SadiqUmar et al. Boswellia serrata extract attenuates inflammatory mediators and oxidative stress collagen induced arthritis. Phytomedicine. 2014; 21 (6): 847-856.

  • Pooja Saini, Rekha Mithal and Ekta Menghani. A parasitic Medicinal plant Cuscuta reflexa: An Overview. International Journal of Scientific & Engineering Research. 2015; 6(12): 951-959.

  • Lalchand et al: Cuscuta reflexa (dodder plant): a critical review on the medicinal plant used in Ayurveda. International Journal Of Research in Ayurveda and Pharmacy. 2017; 8 (6): 38-42.

  • Damerakonda Kumaraswamy, Goverdhan Puchchakayala, Prashanth Yatla. Evaluation of anti-rheumatoid activity of cuscuta reflexa in Freund’s adjuvant induced arthritic rats. International Journal Of Pharmacy & Technology. 2016; 8(2): 13515-13530.

  • Vennila V and Anitha R. In vitro evaluation of anti-arthritic activity in different solvent extracts from cuscuta reflexa. World journal of pharmacy and pharmaceutical sciences. 2015; 4(4): 1340-1350.

  • Subhash R. Yende et al. Antirheumatoid activity of aqueous extract of Piper longum on freund’s adjuvant induced arthritis in rats. International Journal of Pharmaceutical Sciences and Research. 2010; 1: 129-33.

  • Pathak Nimish L et al. Phytopharmacological Properties of Coriander Sativum as a Potential Medicinal Tree: An Overview. Journal of Applied Pharmaceutical Science 2011; 01 (04): 20-25.

  • Nair V, Singh S, Gupta YK. Evaluation of disease modifying activity of Coriandrum sativum in experimental models. The Indian Journal of Medical Research. 2012;135(2): 240-245.

  • Vetal S. Anti-inflammatory and anti-arthritic activity of type-A procyanidine polyphenols from bark of Cinnamomum zeylanicum in rats. Food Science and Human Wellness. 2013; 2:59-67.

  • Nainwal Pankaj, Nanda Deepak, Batsa Ranveer. A review on phytochemical and pharmacological aspects of caesalpinia pulcherrim. International Journal of Research in Ayurveda and Pharmacy. 2011; 2 (2): 416-421.

  • Cuddapah Rajaram, Kandula Ravindra Reddy, Kothapalli Bonnth Chandra Sekhar. Evaluation of anti-arthritic activity of Caesalpinia pulcherrima. Journal of Young Pharmacists. 2015; 7(2): 128-132.

  • Negi JS et al. Chemical constituents of Asparagus. Pharmacognosy Reviews. 2010; 4(8): 215-220. doi:10.4103/0973-7847.70921.

  • Suchita Mittal, Praveen K. Dixit. In-vivo anti-inflammatory and anti-arthritic activity of Asparagus racemosus ischolar_mains. International Journal of Pharmaceutical Sciences and Research. 2013; 4(7): 2652-2658.

  • Archna Sharma, R.A. Sharma, Hemlata Singh. Phytochemical and Pharmacological Profile of Abutilon indicum L. Sweet : A Review. International Journal of Pharmaceutical Sciences Review and Research. 2013; 20: 120-127.

  • Dr. Nitin S. Bhajipale. Anti-Arthritic Activity of Abutilon hirtum. International Journal of Pharmaceutical & Biological Archives. 2014; 5(4): 99 – 101.

  • Said Muhammad. The morphology, extractions, chemical constituents and uses of Terminalia chebula: A review. Journal of Medicinal Plants Research. 2012; 6(33): 4772-4775.

  • Hamed Ali Shaik. Study of In vitro Anti-Arthritic Activity of Ethanolic Extract of Terminalia pallida on Bovine Serum Albumin. International Journal Of Chemistry and Life Sciences. 2013; 02(04): 1153-1155.

  • Gupta A, Singh S. Evaluation of anti-inflammatory effect of Withania somnifera ischolar_main on collagen-induced arthritis in rats. Pharmaceutical Biology. 2014; 52: 308-320.

  • Khedgikar V et al. Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone. Cell Death & Disease. 2013; 4(8): e 778. doi:10.1038/cddis.2013.294.

  • Kiran R Giri. Comparative study of anti-inflammatory activity of Withania somnifera (Ashwagandha) with hydrocortisone in experimental animals (Albino rats). Journal of Medicinal Plants Studies. 2016; 4(1): 78-83.

  • Tillán Capó et al. Antiarthritic activity of Allium sativum L syrup. Revista Cubana de Plantas Medicinales 2007; 12(2).

  • Sindhu G et al. Antiinflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (Fenugreek) on adjuvant induced arthritic rats International Immunopharmacology 2012; 12: 205-11.

  • Nair V, Singh S, Gupta YK. Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models. Journal of Pharmacy and Pharmacology. 2010; 62:1801-1806.

  • Kore K.J., Shete R.V., Desai N.V. Anti-Arthritic activity of Hydroalcoholic extract of Lawsonia inermis. International Journal of Drug Development & Research. 2011; 3 (4): 217-224.

  • Jurenka JS. Therapeutic applications of pomegranate (Punica granatum L.): A review. Alternative Medicine Review. 2008; 13: 128-144.

  • Shukla M et al. Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition. 2008; 24: 733-743.

  • Asgarpanah J, Khoshkam R. Phytochemistry and pharmacological properties of Ruta graveolens L. Journal of Medicinal Plants Research. 2012; 6: 3942-3949.

  • Ratheesh M et al. Protective effects of isolated polyphenolic and alkaloid fractions of Ruta graveolens L. on acute and chronic models of inflammation. Inflammation. 2010; 33:18-24.

  • Rastogi RP, Mehrotra BN: Compendium of Indian Medicinal Plants. Vol. III. Lucknow: CDRI; 1993.

  • Gupta SR et al. Anti-arthritic activity of various extracts of Sida rhombifolia aerial parts. Natural Product Research. 2009; 23:689-695.

  • Anjoo Kamboj, Ajay Kumar Saluja. Phytopharmacological review of Xanthium strumarium L. (Cocklebur). International Journal of Green Pharmacy. 2010; 4(3):129-139.

  • Patil MV, Kandhare AD, Bhise SD. Anti-arthritic and anti-inflammatory activity of Xanthium srtumarium L. ethanolic extract in freund’s complete adjuvant induced arthritis. Biomedicine and Aging Pathology. 2012; 2: 6-15.

  • Nadkarni KM. Indian Materia Medica Vol. I. Popular Prakashan Pvt. Ltd. Bombay, India. 2009.

  • Tandon VR. Medical uses and biological activities of Vitex negundo. Natural Product Radiance. 2005; 4: 162-5.

  • Pandey A et al. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. Inflammation Research. 2012; 61: 293-304.

  • Deepak Ganjewala, Silviya Sam, Kishwar Hayat Khan. Biochemical compositions and antibacterial activities of Lantana camara plants with yellow, lavender, red and white flowers. EurAsian Journal of BioSciences. 2009; 3:69-77.

  • Gundamaraju R, Sheeba DS, Ramesh C. Evaluation of anti-arthritic effects of Lantana camara var Linn. using acute model on albino rats. International Journal of Advances in Pharmaceutical Sciences. 2012; 3: 272-277.

  • Shelendra Singh Kachhawah et al. Standardization protocol development of hydroalcoholic extract of fruits of Citrullus Colocynthis against anti-arthritic activity. International Journal of Green Pharmacy. 2016; 10(1): 59-62.


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  • Antiarthritic Medicinal Plants:A Review

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Authors

Nabarun Mukhopadhyay
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, Karnataka, India
V. Sampath
R&D center, The Himalaya Drug Company, Makali, Bangalore- 562162, Karnataka, India
Sameer Pai
R&D center, The Himalaya Drug Company, Makali, Bangalore- 562162, Karnataka, India
U. V. Babu
R&D center, The Himalaya Drug Company, Makali, Bangalore- 562162, Karnataka, India
Richard Lobo
Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal- 576104, Karnataka, India

Abstract


Arthritis is a chronic inflammatory condition which is a major disability throughout the world. The exact pathophysiology of the disease is still unknown but many factors may be responsible for this. Several conventional therapies are used for the treatment but they have certain disadvantages such as side effects, poor bioavailability, high cost etc. So, researches are going on for the development of alternative effective therapy for arthritis. Medicinal plants are very useful for the development of the complimentary therapy. Varieties of medicinal plants are available throughout the world which are having good antiarthritic potential. In India, medicinal plants are widely used in different indigenous systems of medicine for the prevention and cure of arthritis. This review article covers the description of the medicinal plants which are reported to have significant antiarthritic property. Here the possible mechanism of action of the herbs reported for the treatment is also discussed.

Keywords


Arthritis, Alternative Therapy, Medicinal Plants, Mechanism of Action, Poor Bioavailability.

References