Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Chondromalacia Patellae:A Review


Affiliations
1 School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-117, Tamilnadu, India
2 Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India
     

   Subscribe/Renew Journal


Chondromalacia patella (knee pain) is the softening and breakdown of the tissue (cartilage) on the underside of the kneecap (patella) and is often referred to as chondromalacia of the patella, patellofemoral syndrome, or runner's knee. Pain Results when the knee and the thigh bone (femur) rub together. Abnormal knee cap positioning, tightness or weakness of the muscles associated with the knee, too much activity involving the knee, and flat feet may increase the likelihood of chondromalacia patella. The undersurface of the patella is covered with hyaline cartilage that articulates with the hyaline cartilage covered femoral groove (trochlear groove). Post-traumatic injuries, microtrauma wear and tear, and iatrogenic injections of medication can lead to the development of chondromalacia. Chondromalacia occurs in any joint and is especially common in joints that have had trauma and deformities. Cartilage is the soft tissue padding which is present between all joint and bones and acts like a shock absorber. The cartilage experiences a lot of wear, tear and damage over time. The cartilage is essentially avascular (has no blood or nerve supply) and is therefore quite a difficult area to heal. Long term therapy is essential in ensuring healthy repair so that further complications are not experienced in the future.

Keywords

Chondromalacia, Chondromalacia Patella, Knee Pain, Cartilage.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Duran S, Cavusoglu M, Kocadal O, Sakman B. Association between trochlear morphology and chondromalacia patella: an MRI study. Clin Imaging. 2017;41:7-10.

  • Brody LT and Thein JM. Nonoperative treatment for patellofemoral pain. J Orthop Sports Phys Ther. 1998; 28: 336–344.

  • Wittstein JR, O’Brien SD, Vinson EN, Garrett WE Jr. MRI evaluation of anterior knee pain: predicting response to nonoperative treatment. Skeletal Radiol. 2009; 38: 895–901.

  • Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, et al. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008; 11: 343–353.

  • Pak J. Autologous adipose tissue-derived stem cells induce persistent bone- like tissue in osteonecrotic femoral heads. Pain Physician. 2012; 15:75–85.

  • Fisher TF, Waterman BR, Orr JD, Holland CA, Bader J, Belmont PJ. Tibial Tubercle Osteotomy for Patellar Chondral Pathology in an Active United States Military Population. Arthroscopy. 2016; 32(11): 2342-2349.

  • Wang Y, Sun JY, Zha GC. Results of Lateral Retinacular Release PlusCircumpatellarElectrocautery in Total Knee Arthroplasty without Patellar Resurfacing. J Knee Surg. 2017; 30(3):212-217.

  • Reider B. A Pain in the Knee. Am J Sports Med. 2016; 44(5):1103-5.

  • Petersen W, Ellermann A, Rembitzki IV, Scheffler S, Herbort M, Brüggemann GP, Best R, Zantop T, Liebau C. Evaluating the potential synergistic benefit of a realignment brace on patients receiving exercise therapy for patellofemoral pain syndrome: a randomized clinical trial. Arch Orthop Trauma Surg. 2016; 136(7):975-82.

  • Crossley KM, Callaghan MJ, Van Linschoten R. Patellofemoral pain. Br J Sports Med. 2016; 50(4): 247-50.

  • Glaviano NR, Kew M, Hart JM, Saliba S. Demographic and Epidemiological Trends In Patellofemoral Pain. Int J Sports PhysTher. 2015; 10(3):281-90.

  • Antholz CR, Cherian JJ, Elmallah RK, Jauregui JJ, Pierce TP, Mont MA. Selective Patellar Resurfacing: A Literature Review. SurgTechnol Int. 2015; 26:355-60.

  • Korean Food and Drug Administration (KFDA). Cell therapy: Rules and Regulations, Chapter 2, Section 14. Seoul, Korea, 2009; 4.

  • Walsh CJ, Goodman D, Caplan AI, Goldberg VM. Meniscus regeneration in a rabbit partial meniscectomy model. Tissue Eng. 1999; 5: 327–337.

  • Hong E, Kraft MC. Evaluating anterior knee pain. Med. Clin. North Am. 2014; 98(4):697-717.


Abstract Views: 386

PDF Views: 0




  • Chondromalacia Patellae:A Review

Abstract Views: 386  |  PDF Views: 0

Authors

A. Vijayalakshmi
School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-117, Tamilnadu, India
S. Sangeetha
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India
N. Ranjith
Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu, India

Abstract


Chondromalacia patella (knee pain) is the softening and breakdown of the tissue (cartilage) on the underside of the kneecap (patella) and is often referred to as chondromalacia of the patella, patellofemoral syndrome, or runner's knee. Pain Results when the knee and the thigh bone (femur) rub together. Abnormal knee cap positioning, tightness or weakness of the muscles associated with the knee, too much activity involving the knee, and flat feet may increase the likelihood of chondromalacia patella. The undersurface of the patella is covered with hyaline cartilage that articulates with the hyaline cartilage covered femoral groove (trochlear groove). Post-traumatic injuries, microtrauma wear and tear, and iatrogenic injections of medication can lead to the development of chondromalacia. Chondromalacia occurs in any joint and is especially common in joints that have had trauma and deformities. Cartilage is the soft tissue padding which is present between all joint and bones and acts like a shock absorber. The cartilage experiences a lot of wear, tear and damage over time. The cartilage is essentially avascular (has no blood or nerve supply) and is therefore quite a difficult area to heal. Long term therapy is essential in ensuring healthy repair so that further complications are not experienced in the future.

Keywords


Chondromalacia, Chondromalacia Patella, Knee Pain, Cartilage.

References