Open Access
Subscription Access
Open Access
Subscription Access
Neermulli Kudineer–A Classical Polyherbal Decoction in Siddha System of Medicin
Subscribe/Renew Journal
Siddha system of medicine enunciates the usage of herbs and herbal formulations since time immemorial. The advancement in the application of ethno-medicine has been increased globally. The treatment approach in Siddha methodology primarily commences with the administration of “Kudineer” i.e. decoction as a first line of treatment for many diseases. Neermulli Kudineer (NMK) is one such polyherbal decoction enumerated in Siddha medical literatures for various ailments. The usage of Neermulli Kudineer is prevalent among the traditional Siddha clinicians in the treatment of diseases such as oedema, urolithiasis, anuria, dysuria, urinary tract infections, oliguria, ascites, inflammation, obesity, renal hypertension and even in the management of certain infertility cases. Thus Neermulli Kudineer has gained its iconic significance as a potent diuretic in Siddha system of medicine. Diuretics in general, play a pivotal role in renal diseases, cardiovascular diseases and liver diseases. As NMK is a natural herbal diuretic in Siddha medicine, it may overcome the adverse effects of conventional diuretics. The current review is aimed to substantiate the traditional efficacy of ingredients of NMK through Siddha literatures and various scientific literatures. The pharmacological review of the ingredients of this decoction revealed their excellency in antiurolithiatic, diuretic, hepatoprotective, nephroprotective, hematinic, anti-inflammatory, lithotriptic, analgesic, antioxidant, antimicrobial, immunomodulatory, antihyperglycemic and lipid lowering activities. Hence the traditional use of Neermulli Kudineer is validated with available literatures.
Keywords
Neermulli kudineer, Polyherbal, Decoction, Diuretic, Siddha Medicine, Literatures, Pharmacological Activity.
Subscription
Login to verify subscription
User
Font Size
Information
- Dr. Thiagarajan R, Gunapadam Thathu- Jeeva vaguppu, Part II and III, Eighth edition, Dept. of Indian Medicine and Homeopathy, Chennai, 2013.
- Utthamarayan K S, Thottra kirama Araichiyum Siddha Maruthuva Varalarum, Dept. of Indian Medicine and Homeopathy, Chennai, 1992.
- Thirunarayanan T, Introduction to Siddha Medicine, Centre for Traditional Medicine and Research, Chennai, 2012.
- Dr. Deva Aasirvadham Samuel, Marundhu Sei Iyalum Kalaiyum, Dept. of Indian Medicine and Homeopathy, Chennai.
- Kannusamy Pillai C, Sikitcha Rathna Deepam Ennum Vaithiya Nool, B. Rathna Nayakar and Sons, Chennai, 2007.
- Sambasivam Pillai T V, Tamil- English Dictionary of Medicine, Chemistry, Botany and Allied Sciences (Based on Indian Medical Science), Vol II, III and IV, Dept. of Indian Medicine and Homeopathy, Chennai,1991.
- Kuppusami Mudaliar KN, Utthamarayan KS, Siddha Vaithiya Thirattu, Dept. of Indian Medicine and Homeopathy, Chennai, First edition, 1998.
- Siddha Formulary of India, Part I, Govt.of India, Ministry of Health and Family Welfare, Dept. of Health, First edition, 1991.
- Kuppusamy Mudaliar K N, Siddha Maruthuvam (Podhu), Dept. of Indian Medicine and Homeopathy, Chennai, New Edition, 2012.
- Murugesa mudaliar K S, Gunapadam Mooligai Vaguppu, Part I, Dept. of Indian Medicine and Homeopathy, Chennai, Second Edition, 2002.
- Dr. Nadkarni KM, Indian Materia Medica with Ayurvedic, Unani-Tibbi, Siddha, Allopathic, Homeopathic, Naturopathic and Home Remedies, Vol I, 1982.
- Siddha Pharmacoepia of India, Part I, Vol I, Govt. of India, Ministry of Health and Family Welfare, Dept. of AYUSH, New Delhi, 2008.
- Siddha Pharmacoepia of India, Part I, Vol II, Govt. of India, Ministry of Health and Family Welfare, Dept. of AYUSH, New Delhi, 2011.
- Niemat Ahmed El-Amin Eljabri, Ahmed Khalil. Ahmed, Awatif Ahmed, Antihypertensive and hematological effects of Tribulus terrestris Aqueous Extract, International Journal for Innovation Education and Research, Vol 3(8), 2015.
- Ali M Sharifi, Radbod Darabi, Nasrin Akbarloo, Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: Role of tissue ACE activity, Article in Life Sciences, 73 (23), 2003..
- Saravanasingh K, Ramamurthy M, Bioactivity studies of extracts from Tribulus terrestris, International journal of current research in chemistry and pharmaceutical sciences, 3(1), 2016.
- Chitra Devi V, Mothil S, Tamizharasi S, Calcium oxalate crystallization inhibition by Pedalium murex and Tribulus terrestris fruit extracts, International journal of ChemTech Research, 10(3), 2017.
- Muneer Al-Ali, Salman Wahbi, Husni Twaij, Ahmad Al-Badr, Tribulus terrestris: Preliminary study of its diuretic and contractile effects and comparison with Zea mays, Journal of Ethnopharmacology, 85(2-3), 2003.
- Hariprasath K, Triveni T, Spandana A, Rama Tejaswi K, Pavan Kumar V S, and Raj Kumar E, Antiurolithiatic activity of Tribulus terrestris fruits and Punica granatum seeds in ethylene glycol induced rat models, Indo American Journal of Pharmaceutical Research, 3(6), 2013.
- Mallaiah GK, Kranthi Raju P, Thirupathi K, Krishna Mohan G, Evaluation of immunomodulatory activity of Tribulus terrestris in animal model, International Journal of Pharmacy and Biological Sciences, Vol 6 (2), 2016.
- Yogita R. Indalkar, Nayana V. Pimpodkar, Anita S Godase, Puja S. Gaikwad, A Compressive Review on the Study of Nanotechnology for Herbal Drugs, Asian Journal of Pharmaceutical Research, 5(4), 2015.
- Maged S. Abdel-Kader, Abdullah Al-Qutaym, Abdulaziz S. Bin Saeedan, Abubaker M. Hamad, Khalid M. Alkharfy, Nephroprotective and hepatoprotective effects of Tribulus terrestris L. growing in Saudi Arabia, Journal of Pharmacy and Pharmacognosy Research, 4 (4), 2016.
- Sally I. Ismaiel, Sameh M. Farouk, Raafat A. El-Ramady Waleed F. Khalil, Ameliorative impacts of Tribulus terrestris against Ivermectin-induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological Study, American Journal of Animal and Veterinary Sciences, 12(1), 2017.
- Sudhanshu Kumar Meher, P K Mukherjee, S K Banarjee Chaudhury, Bani Marjit, B PShaw. Experimental studies on the Renal Protective effect of Gokshura (Tribulus terrestris Linn) and Varuna (Crataeva nurvala Buch-Ham). Research Journal of Pharmacology and Pharmacodynamics, 8(2), 2016.
- Kamboj P, Aggarwal M, Puri S, Singla SK, Effect of aqueous extract of Tribulus terrestris on oxalate-induced oxidative stress in rats, Indian Journal of Nephrology, 21 (3), 2011.
- Karimi Jashni H, Malekzadeh Shiravani S, Hoshmand F, The effect of the Tribulus terrestris extract on spermatogenesis in the rat, Journal of Jahrom University of Medical Sciences, 9(4), 2012.
- Kundan G. Ingale, Prasad A. Thakurdesai, Neeraj S. Vyawahare, Effect of Hygrophila spinosa in ethylene glycol induced nephrolithiasis in rats, Indian Journal of Pharmacology, 44(5), 2012.
- Sathish R, Natarajan K, Mukesh Madhavrao Nikhad, Effect of Hygrophila spinosa T.Anders on Ethylene Glycol induced Urolithiasis in rats, Asian Journal of Pharmaceutical and Clinical Research, Vol 3, Issue 4, 2010.
- Preethi GP, Gopalakrishna HN, Rathnakar UP, Durga P, Vishnu, Jnaneshwara Shenoy, Acute Diuretic activity of Alcoholic Extracts of Hygrophila auriculata seeds in normal wistar albino rats, International Journal of Pharma and Bio Sciences, Vol 3(1), 2012.
- Md. Hassan Kawsar, Md. Akbar Hossain, Aninda Kumar Nath, Md. Zia Uddin, Mycal Dutta, Md. Masud Morshed, Antimicrobial and Cytotoxic activity of Asteracantha longifolia Nees, International journal of Pharmaceutical sciences and Research, 3(12), 2012.
- Ashwini U. Hegde, Madhuri S, Srilakshmi NS, Prashith Kekuda T.R, Rudrappa D, Antimicrobial and radical scavenging activity of Asteracantha longifolia (L.) Nees, An International Journal of Advances in Pharmaceutical Sciences, Vol 5(4), 2014.
- Raj VP, Chandrasekhar RH, Vijayan P, Dhanaraj SA, Mallikarjuna C Rao, Venkata J Rao, Nitesh K, In vitro and in vivo hepatoprotective effects of the total alkaloid fraction of Hygrophila auriculata leaves, Indian journal of Pharmacology,Vol 42(2), 2010.
- Dhanaraj TS, Gowthami R, Rajlakshmi S, Murugaiah K, Antihepatotoxicity of Hygrophila auriculata on CCl4 Induced Hepatotoxicity in Rats, Asian Journal of Research in Pharmaceutical Sciences, 2(4), 2012.
- Bibu KJ, Joy AD, Mercey KA, Therapeutic effect of ethanolic extract of Hygrophila spinosa on gentamycin induced nephrotoxicity in rats, Indian journal of experimental biology, Vol 48(9), 2010.
- Pawar RS, Jain AP, Kashaw KS, Singhai AK, Haematopoietic activity of Asteracantha longifolia on cyclophosphamide-induced bone marrow suppression, Indian journal of Pharamceutical sciences, Vol 68(3), 2006.
- Sanju M, Dutta GK, Thakur KK, Nath S, Effect of Hygrophila spinosa extract on induced anemic Wistar rats and its comparison with conventional hematinics, Environment and Ecology Journal article, Vol 33 (2), 2015.
- Nirjala Laxmi Madhikarmi, Kora Rudraiah Siddalinga Murthy, Study of oxidative stress and antioxidants status in iron deficient anemic patients, Research Journal of Science and Technology, 4(4), 2012.
- Md. Al Amin, Ishtiaque A Chowdhury, K. M.M. Mahbub, Mafruhi Sattar, Masum Shahriar, Md. Ruhul Kuddus, Mohammad A. Rashid, Anti-inflammatory and Analgesic Activities of Asteracantha longifolia Nees, Bangladesh Pharmaceutical Journal, Vol 15 (2), 2012.
- Sudeshna Saha and Santanu Paul, Potential of Hygrophila auriculata (Schumach.) Heine as a source of future anti-cancer drugs: A comprehensive review, Journal of Pharmacognosy and Phytochemistry, Vol 6(4), 2017.
- Nagendra S. Chauhan, Vikas Sharma, Dixit VK, Effect of Asteracantha longifolia seeds on the sexual behaviour of male rats, Natural Product Research: Formerly Natural Product Letters, 25:15, 2011.
- Cheng Zhong, Deng Hu, Lian-Bing Hou, Lu-Yao Song, Ying-Jun Zhang, Yang Xie, Li-Wen Tian, Phenolic Compounds from the Rhizomes of Smilax china L. and their Anti-Inflammatory activity, Molecules, 22, 515, 2017.
- Lvyi Chen, Huafeng Yin, Zhou Lan, Shuwei Ma, Chunfeng Zhang and Zhonglin Yang. Antihyperuricemic and nephroprotective effects of Smilax china L. Journal of Ethnopharmacology, 135(2), 2011.
- Jung Ae Park, Kyong-Suk Jin, Hyun Ju Kwon, Byung Woo Kim, The Anti-Obesity effect of Smilax china extract, Korean Journal of Microbiology and Biotechnology, 42(4), 2014.
- Solomon Raju BG, Ganga Rao B, Manju Latha YB, Antidiabetic activity of Smilax china ischolar_mains in alloxan-induced diabetic rats, International Journal of PharmTech Research, Vol 4(1), 2012.
- Agrawal K, Shivani Ghildiyal, Gautam MK, Joshi VK, Goel RK, Studies on laxative effect of extract of dried fruit pulp of Cassia fistula, Journal of Natural Remedies, Vol. 12(2), 2012.
- Seyyed Ali Mozaffarpur, Mohsen Naseri, Mohammad Reza Esmaeilidooki, Mohammad Kamalinejad, Ali Bijani, The effect of Cassia fistula emulsion on pediatric functional constipation in comparison with mineral oil: A Randomized clinical trial, DARU Journal of Pharmaceutical Sciences, 20:83, 2012.
- Gupta UC, Jain GC, Study on hypolipidemic activity of Cassia fistula legume in rats, Asian Journal of Experimental Sciences, 23(1), 2009.
- Gobianand K, Vivekababdan P, Pradeep K, Mohan CV, Karthikeyan S, Anti-inflammatory and Antipyretic activities of Indian medicinal plant Cassia fistula Linn (Golden shower) in Wister albino rats, International Journal of Pharmacology, 6(7), 2010.
- Bhalodia NR, Nariya PB, Acharya RN, Shukla VJ, In vitro antibacterial and antifungal activities of Cassia fistula Linn. fruit pulp extracts, An International Quarterly Journal of Research in Ayurveda (AYU), 33(1), 2012.
- Basvaraj Poojar, Balaji Ommurugan, Shalini Adiga, Huban Thomas, Evaluation of Antiurolithiatic Property of Ethanolic Extract of Fennel Seeds in Male Wistar Albino Rats, Asian Journal of Pharmaceutical and Clinical Research, Vol 10(8), 2017.
- Sirisha N, Sreenivasulu M, Sangeeta K, Swarna Latha G, Lakshmi Devi A, Madhusudhana Chetty C, A Review on Herbal Diuretics, Research Journal of Pharmacy and Technology, 4(3), 2011.
- Sadrefozalayi S, Farokhi F, Effect of the aqueous extract of Foeniculum vulgare (fennel) on the kidney in experimental PCOS female rats, Avicenna Journal of Phytomedicine, 4 (2), 2014.
- Arul Amutha Elizabeth, Glory Josephine, Muthiah NS, Muniappan M, Evaluation of Analgesic and Anti-Inflammatory effect of Foeniculum vulgare, Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5(2), 2014.
- Renu Agarwal, Suresh Kumar Gupta, Shyam Sunder Agrawal, Sushma Srivastava, Rohit Saxena, Oculohypotensive effects of Foeniculum Vulgare in Experimental Models of Glaucoma, Indian journal of Physiology and Pharmacology, 52(1), 2008.
- Dolly Agarwal, Sharma LK, Saxena SN, Anti-microbial properties of fennel (Foeniculum vulgare Mill.) seed extract, Journal of Pharmacognosy and Phytochemistry, 6(4), 2017.
- Pankaj Kumar, Jitendra Kumar, Raghuveer Kumar, Dubey RC, Studies on Phytochemical constituents and Antimicrobial activities of leaves, fruits and stems of Solanum nigrum L., Asian Journal of Plant Science and Research, 6(4), 2016.
- Hema Harika C, Raju D, Gopala krishna, YesuBabu, Priyanka A, Nephrotoxicity and Urolithiasis Activity of Solanum nigrum, International journal of Research in Pharmacy and Science, 4(1), 2013.
- Aryaa, Viswanathswamy, Effect of Solanum nigrum Linn on Acute and Sub-Acute Models of Inflammation, Journal of Young Pharmacists, Vol 9, Issue 4, 2017.
- Fariba Azarkish, Kobra Hashemi, Ardashir Talebi, Mohammed Kamalinejad, Nepton Soltani, Nima Pouladian, Effect of the Administration of Solanum nigrum Fruit on Prevention of Diabetic Nephropathy in Streptozotocin-induced Diabetic Rats, Pharmacognosy Research, 9(4), 2017.
- Rahul V. Takawale, Vishal R. Mali, Chinmay U. Kapase, Subhash L. Bodhankar, Effect of Lagenaria siceraria fruit powder on sodium oxalate induced Urolithiasis in Wistar rats, Journal of Ayurveda and Integrative Medicine, Vol 3, Issue 2, 2012.
- Jayasree T, Naveen A, Shaikh Ubedullah, Chandra Sekhar N, Effect of aqueous extract of seeds of Lagenaria siceraria on urine volume and urinary electrolytes in swiss albino rats, International research journal of Pharmacy, 5(5), 2014.
- Manglesh Kumar Singh, Faisal Mohd, Ahmad Ayaz, Sonkar Ankur, Yadav Jyoti, Protective effect of Lagenaria siceraria against doxorubicin induced cardiotoxicity in wistar rats, International Journal of Drug Development and Research, Vol. 4, Issue 2, 2012.
- Saha P, Mazumder UK, Haldar PK, Evaluation of Anti-inflammatory and Antinociceptive properties of L. siceraria aerial parts, International Journal of Pharma Sciences and Research, Vol 6, Issue 5, 2015.
- Shriram Ramesh Pethakar, Pramod Jayadevappa Hurkadale, Ravindra Durdundayya Hiremath, Evaluation of Antiurolithiatic potentials of hydro-alcoholic extracts of Cucumis sativus L, Indian Journal of Pharmaceutical Education and Research, Vol 51, Issue 4S, 2017.
- Subasini U, Thenmozhi S, Mohamed ShabimM, Sundaraganapathy R, Victor Rajamanickam G, Effect of Cucumis sativus Linn. on Heat Stress in Albino Rats, International Journal of Drug Discovery and Herbal Research, Vol 3, Issue 1, 2013.
- Doppalapudi Prasanthi , Sreedevi Adikay, Amelioration of Cisplatin And Gentamicin –induced Nephrotoxicity by seeds of Cucumis sativus., International Journal of Pharma and Bio Sciences, Vol 7 (4), 2016.
- Anwesa Bag, Subir Kumar Bhattacharyya, Nishith Kumar Pal and Rabi Ranjan Chattopadhyay, Anti-inflammatory, anti-lipid peroxidative, antioxidant and membrane stabilizing activities of hydroalcoholic extract of Terminalia chebula fruits, Pharmaceutical Biology, 51(12), 2013.
- Kishu Tripathi, Herbs for Obesity: A Review, Research Journal of Pharmacognosy and Phytochemistry, 1(2), 2009.
- Mary Grace Jinukuti and Archana Giri, Antimicrobial activity of aqueous extract of Terminalia chebula Retz, Recent Research in Science and Technology, 5(4), 2013.
- Anil Pawar, Gayatri D. Gaikwad, Kavita S. Metkari, Bhanudas Kuchekar, Effect of Terminalia chebula fruit extract on ethylene glycol induced urolithiasis in rats, Biomedicine and Aging Pathology, 2(3), 2012.
- Karunasree Varicola, Sushmitha Metla, Urmila Sri Syamala and Sravya Rajulapati, Assessment of Potential Antiurolithiatic Activity of Some Selected Medicinal Plants by In vitro Techniques, Acta Scientific Pharmaceutical Sciences, Vol 1(1), 2017.
- Tayal S, Duggal S, Bandyopadhyay P, Aggarwal A, Tandon S, Tandon C, Cytoprotective role of the aqueous extract of Terminalia chebula on renal epithelial cells, International Brazilian Journal of Urology, Vol 38 (2), 2012.
- Vaidehi N.Sarvaiya, Kamlesh A.Sadariya, Prakash G.Pancha, Aswin M.Thaker, Aashish C.Patel, Ankit S.Prajapati, Evaluation of antigout activity of Phyllanthus emblica fruit extracts on potassium oxonate-induced gout rat model, Veterinary World, 8 (10), 2015.
- Adis Tasanarong, Supranee Kongkham, Arunporn Itharat, Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury, BMC Complementary and Alternative Medicine, 14 (138), 2014.
- Bindhu B, Swetha A.S, Veluraja K, Studies on the effect of Phyllanthus emblica extract on the growth of urinary type struvite crystals in vitro, Clinical Phytoscience, 1(3), 2015.
- Xiaoli Liu, Mouming Zhao, Kegang Wu, Xianghua Chai, Hongpeng Yu, Zhihua Tao, Jinshui Wang, Immunomodulatory and anticancer activities of phenolics from emblica fruit (Phyllanthus emblica L.), Food Chemistry, www.elsevier.com/locate/foodchem, 131, 2012.
- Rupali Kirtawade, Pallavi Salve, Anita Kulkarni, Pandurang Dhabale, Herbal Antioxidant : Vitamin C, Research Journal of Pharmacy and Technology, 3(1), 2010.
- Nishat Fatima, Hajera Sultana, Evaluation of protective effect of Terminalia bellerica against gentamicin induced nephrotoxicity in albino rats, Pharmaceutical and Biological Evaluations, Vol 3(5), 2016.
- Upadhyay Neha, Tiwari Shashi Kant, Srivastava Anant, Seth Ankit, Maurya Santosh Kumar, Anti-Urolithiatic effect of Terminalia bellirica Roxb. Fruits on Ethylene glycol-induced Renal Calculi in Rats, Indo American Journal of Pharmaceutical Research, Vol 5(5), 2015.
- Shivakumar S, Jayashree K, Bharathi P. Salimath, Inhibition of Tumor Growth and Angiogenesis by an Aqueous Extract of Terminalia bellirica, Current Trends in Biotechnology and Pharmacy, Vol 4 (1), 2010.
- Geetha K, Manavalan R, Venkappaya D, Effects and causes of Lithiasis, Research Journal of Pharmacology and Pharmacodynamics, 2(4), 2010.
Abstract Views: 343
PDF Views: 0