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The GC MS Study of one Ayurvedic Medicine, Khadirarishtam


Affiliations
1 Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600092, India
2 Department of Anatomy, Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600092, India
3 Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
4 Central Research Facility, Sri Ramachandra Medical College and Research Institute, Purur, Chennai - 600116, India
     

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The present study of GC MS analysis of one Ayurvedic formulation, Khadirarishtam, was undertaken to know the types of biomolecules present in it. This medicine is used to treat chronic skin ailments. The GC MS profile of Khadirarishtam indicated the presence of some important biomolecules such as Eucalyptol, Phnylethyl alcohol, Ethyl hydrogen succinate, .alpha.-Terpineol, 5-Hydroxymethylfurfural, Acetic acid, chloro-,3-phenylpropyl ester, Eugenol, Benzeethanol,4-hydroxy-, Propanoic acid, anhydride, Benzoic acid, 4-hydroxy-, Disulphide, methyl (methylthio)phenylmethyl, Hexadecnoic acid, 2-hydroxy-1-(hydroxymethyl) ethyl ester, Octadecanoic acid and 2,3-dihydropropyl ester etc. These biomolecules have been reported to have the medicinal properties which represent those of Khadirarishtam. Further study to establish the molecular mechanism of these compounds is warranted.

Keywords

GC MS, Ayurvedic, Khadirarishtam, Eucalyptol, Phnylethyl Alcohol, Ethyl Hydrogen Succinate, Alpha.-Terpineol, 5-Hydroxymethylfurfural.
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  • Stohs SJ, Bagchi D. Antioxidant, Anti-inflammatory, and Chemo protective Properties of Acacia catechu Heartwood Extracts. Phytotherapy Research, 2015; 29(6): 818-824.
  • Saifullah, Naveeda Bibi, Malik Jan, Waqar Ahmad, Zeeshan Niaz, Naveed Akhtar, Kausar Saeed. Antibacterial activity of oils of Cedrus deodara and Ricinus communis. International Journal of Recent Scientific Research, 2014; 5(9): 1573-1577
  • Chandur U, Shashidhar S, Chandrasekar SB, Rao MN. Studies of preliminary phytochemical and anti-arthritic activity of heart wood of Cedrus deodar (Roxb.). RJPBCS, 2011; 2(3): 654-660.
  • Saxena A, Saxena AK, Singh J, Bhushan S. Natural antioxidants synergistically enhance the anticancer potential of AP9-cd, a novel lignan composition from Cedrus deodara in human leukemia HL-60 cells. Chemico-Biological Interactions, 2010; 188(3): 580–590.
  • Zeng WC, Zhang Z, Gao H, Jia LR, He Q. Chemical composition, antioxidant, and antimicrobial activities of essential oil from pine needle (Cedrus deodara). J Food Sci, 2012; 77(7): C824-829.
  • Kumar A, Singh V, Chaudhary AK. Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats. Journal of Ethnopharmacology, 2011; 134(2): 294–297
  • Sadia Chishty, Monika. A Review on Medicinal Importance of Babchi (Psoralea corylifolia). Int J Recent Sci Res. 2016; 7(6):11504-11512.
  • Zhang X, Zhao W, Wang Y, Lu J and Chen X. “The Chemical Constituents and Bioactivities of P. corylifolia Linn.: A Review”, Am J Chin Med., 2016; 44(1):35-60.
  • Sharma K, Bairwa R, Chauhan N, Srivastava B, Saini NK. Berberis aristata: A Review. Int J of Res in Ayurveda and Pharmacy, 2011; 2(2): 383-388.
  • Bag A, Bhattacharya SK, Chattopadhyay RR. The development of Terminalia chebula Retz. (Combretaceae) in clinical research. Asian Paci J Tropical Biomed, 2013; 3(3):244.
  • Saraswathi NM, Karthikeyan M, Kannan M, Rajasekar S. Terminalia belerica Roxb. A Phytopharmacological Review. International Journal of Research in Pharmaceutical and Biomedical Science, 2012: 3(1): 96.
  • Bhide MM, Nitave SA. Roles of Embelica officinalis (Amla) in medicine. World Journal of Pharmacy and Pharmaceutical Sciences, 2014; 3(6): 604-615.
  • Dasaroju S, Gottumukkala KM. Current Trends in the Research of Emblica officinalis (Amla): A Pharmacological Perspective. Int J Pharm Sci Rev Res, 2014; 24(2): 150.
  • Dubey D, Patnaik R, Ghosh G, Padhy RN. In Vitro Antibacterial Activity, Gas Chromatography–Mass Spectrometry Analysis of Woodfordia fruticosa Kurz. Leaf Extract and Host Toxicity Testing With In Vitro Cultured Lymphocytes from Human Umbilical Cord Blood. Osong Public Health and Research Perspectives, 2014; 5(5): 298-312.
  • Grover N, Patni V. Phytochemical characterization using various solvent extracts and GC MS analysis of methanolic extract of Woodfordia fruticosa (L.) KURZ. Leaves. Int J Pharm Pharm Sci, 2013; 5(4): 291-295.
  • Alsaid M, Mothana R, Raish M, AlSohaibani M, Al-Yhya M, Ahmed A, Al-Dosari, Rafatullah S. Evaluation of the effectiveness of Piper cubeda extact in the amelioration of CCl4- induced liver injuries and oxidative stress in the rodent model. BioMed Res International, 2015: Article ID 359358, 11 pages. http://dx.doi.org/10.1155/2015/359358
  • Nahak G, Sahu RK. “Phytochemical evaluation and antioxidant activity of Piper cubeba and Piper nigrum.” Journal of Applied Pharmaceutical Science, 2011; 1(8): 153–157, 2011.
  • Ahmad QZ, Jahan N, Ahmad G. “Nephroprotective effect of Kabab chini (Piper cubeba) in gentamycin-induced nephrotoxicity. Saudi Journal of Kidney Diseases and Transplantation, 2012; 23(4):773–781
  • Chahar K, Kumar SDS, Geetha L, Lokesh T, Manohara KP. Mesua ferrea L.: A review of the medical evidence for its phytochemistry and pharmacological actions. African Journal of Pharmacy and Pharmacology, 2013; 7(6): 211-219.
  • Iyer RI, Jayaraman G, Ramesh A. Direct Somatic Embryogenesis in Myristica malabarica Lam., an Endemic, Threatened Medicinal Species of Southern India and Detection of Phytochemicals of Potential Medicinal Value. Indian Journal of Science and Technology, 2009; 2 (4): 65-70
  • C Chirathaworn; W Kongcharoensuntorn; T Dechdoungchan; A Lowanitchapat; P Sa-Nguanmoo; P Yong. Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. J. Med. Assoc. Thai. 2007; 90: 2422-2428.
  • Gülçin I, Elmastas M, boul-Enein HY. Antioxidant activities of clove oil- A powerful antioxidant source. Arab J Chem, 2012; 5(4): 489–499.
  • Verma SK, Jain V, Katewa SS. Blood pressure lowering, fibrinolysis enhancing and antioxidant activities of cardamom (Elettaria cardamomum). Indian Journal of Biochemistry and Biophysics, 2009; 46(6): 503-506.
  • Khan A, Khan QJ, Gilani A. Pharmacological basis for the medicinal use of cardamom in asthma. Bangladesh J Pharmacol, 2011; 6: 34-37.
  • Ranasinghe P, Pigera S, Sirimal GA, Galappaththy PP, Constantine GR, Prasad K. Medicinal properties of ‘true’cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complementary and Alternative Medicine, 2013; 13: 275.
  • Jayaprakasha GK, Rao LJ. Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Crit Rev Food Sci Nutr, 2011; 51: 547–562.
  • Lima ZP, Severi JA, Pellizzon CH, Brito AR, Solis PN. Gastroprotective activity of Cinnamomum tamala leaves on experimental gastric ulcers in rats, J. Ethnopharmacol. 2010; 128: 537-40.
  • Hemayet H, Howlader MSI, Dey SK, Hira A. Evaluation of anti-inflammatory activity of Cinnamomum tamala (Buch.-Ham.) Leaves growing in Bangladesh, Int. J Pharmachol., 2012; 1(2):114-21.
  • Jamiuddin A, Sultana N, Dewan SMR, Amin MN, Uddin SMN. Determination of Chemical Groups and Investigation of Anthelmintic, Cytotoxic, and Antibacterial Activities of Leaves of Cinnamomum tamala (Family: Lauraceae), Int J Pharmamedix Ind., 2013; 1(2): 222-32
  • Ankurdeep Preety, Sandeep Sharma. A Brief Review on Cinnamomum tamala (Buch.-Ham.) Nees and Eberm.: An Important Medicinal Tree. International Journal of Research in Biological Sciences, 2016; 6(2): 26-31
  • Kumar S, Kamboj J, Sharma SS. Overview for Various Aspects of the Health Benefits of Piper Longum Linn. Fruit. J of Acupuncture and Meridian Studies. 2011; 4(2): 134-14.
  • Hai Gu, Zequn Jiang, Mingyan Wang MD, Haiying Jiang, Fengming Zhao, Xia Ding, Baochang Cai, Zhen Zhan MD. 5- Hydroxymethylfurfural from wine-processed Fructus corniinhibits hippocampal neuron apoptosis. Neural Regen Res. 2013; 8(28): 2605–2614.
  • Lee SJ, Han JI, Le GS, Park MJ, Ghoi IG, Na KJ, Jeung EB. Antifungal effect of engenol and nerolidol against Microsporum gypseum in a guinea pig model. Biol Pharm Bull., 2007; 30: 184-188.
  • Gulcin I. Antioxidant activity of eugenol: A structure –activity relationship study. Journal of Medicinal Food, 2011; 14(9): 975-985
  • Dallmeier K, Carlini CA. Anesthetic, Hypothermic, myo-relaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues. Pharmacology, 1981; 22: 113-127
  • Zheng GQ, Kenney PM, Lam LK. Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod, 1992; 55: 999-1003
  • Brodin P, Roed A. Effects of eugenol on rat phrenic nerve and phrenic nerve-diaphragm preparations. Arch Oral Biol, 1984; 611-615
  • Pandey BN, Lathika KM, Mishra KP. .Modification of radiation induced oxidative damage in liposormal and microsomal membrane by eugenol. Rad Physics Chem, 2006; 75: 384-391.
  • Okada N, Hirata A, Murakami Y, Shoji M, Sakagami H, Fujisawa S. Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression by eugenol-related compounds. Anticancer Res., 2005; 25: 3263-3270.

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  • The GC MS Study of one Ayurvedic Medicine, Khadirarishtam

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Authors

Hassan Mohammad
Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600092, India
K. Prabhu
Department of Anatomy, Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600092, India
Mudiganti Ram Krishna Rao
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
R. Lakshmi Sundaram
Central Research Facility, Sri Ramachandra Medical College and Research Institute, Purur, Chennai - 600116, India
Sampad Shil
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
N. Vijayalakshmi
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India

Abstract


The present study of GC MS analysis of one Ayurvedic formulation, Khadirarishtam, was undertaken to know the types of biomolecules present in it. This medicine is used to treat chronic skin ailments. The GC MS profile of Khadirarishtam indicated the presence of some important biomolecules such as Eucalyptol, Phnylethyl alcohol, Ethyl hydrogen succinate, .alpha.-Terpineol, 5-Hydroxymethylfurfural, Acetic acid, chloro-,3-phenylpropyl ester, Eugenol, Benzeethanol,4-hydroxy-, Propanoic acid, anhydride, Benzoic acid, 4-hydroxy-, Disulphide, methyl (methylthio)phenylmethyl, Hexadecnoic acid, 2-hydroxy-1-(hydroxymethyl) ethyl ester, Octadecanoic acid and 2,3-dihydropropyl ester etc. These biomolecules have been reported to have the medicinal properties which represent those of Khadirarishtam. Further study to establish the molecular mechanism of these compounds is warranted.

Keywords


GC MS, Ayurvedic, Khadirarishtam, Eucalyptol, Phnylethyl Alcohol, Ethyl Hydrogen Succinate, Alpha.-Terpineol, 5-Hydroxymethylfurfural.

References