Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

The Neuro-Protective effects of Quercetin


Affiliations
1 Mashhad University of Medical Sciences, Mashhad, Iraq
     

   Subscribe/Renew Journal


Quercetin has a wide array of pharmacological properties such as antioxidant and anti-inflammatory activities. Scientific study has indicated that quercetin possesses protective effects against toxic agents in several tissues, including brain, lung, heart, liver, kidney, etc. The scientific databases such as MEDLINE, PubMed, Scopus, Web of Science and Google Scholar from 1990 to present was searched to identify online scientific literatures about antidotal and protective effects of quercetin against neurotoxic agents. The keywords for the search were: quercetin, toxic agents, and neurodegenerative disease. This review aims to identify the protective effects of quercetin against neurotoxic agents. This study found that quercetin had protective activities against toxic agents-induced neurotoxicity by modulating oxidative stress, inflammation, and apoptosis pathways. The scientific databases such as MEDLINE, PubMed, Scopus, Web of Science and Google Scholar from 1990 to present was searched to identify online scientific literatures about antidotal and protective effects of quercetin against neurotoxic agents. The keywords for the search were: quercetin, toxic agents, and neurodegenerative disease.

Keywords

Quercetin, Toxic Agent, Nervous System, Oxidative Stress, Inflammation.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Aldemir M, Okulu E, Kösemehmetoğlu K, Ener K, Topal F, Evirgen O, Gürleyik E, Avcı A. Evaluation of the protective effect of quercetin against cisplatin-induced renal and testis tissue damage and sperm parameters in rats. Andrologia. 46; 2014: 1089-97.

  • Agrawal M, Saraf S, Antimisiaris SG, Chougule M, Shoyele SA, Alexander A. Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. J Control Release. 2018: pii: S0168-3659(18)30268-2.

  • Darband SG, Kaviani M, Yousefi B, Sadighparvar S, Pakdel FG, Attari JA, Mohebbi I, Naderi S, Majidinia M. Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer. J Cell Physiol. 2018. doi: 10.1002/jcp.26595.

  • Samarghandian S, Farkhondeh T, Samini F. Honey and Health: A Review of Recent Clinical Research. Pharmacognosy Res. 9(2): 2017; 121-127.

  • Samarghandian S, Samini F, Azimi-Nezhad M, Farkhondeh T. Anti-oxidative effects of safranal on immobilization-induced oxidative damage in rat brain. Neurosci Lett. 659: 2017; 26-32.

  • Farkhondeh T, Samarghandian S, Hozeifi S, Azimi-Nezhad M. Therapeutic effects of thymoquinone for the treatment of central nervous system tumors: A review. Biomed Pharmacother. 96: 2017; 1440-1444.

  • Samarghandian S, Azimi-Nezhad M, Borji A, Farkhondeh T. Effect of crocin on aged rat kidney through inhibition of oxidative stress and proinflammatory state. Phytother Res. 30(8):2016; 1345-53.

  • Samarghandian S, Azimi-Nezhad M, Samini F, Farkhondeh T. The Role of Saffron in Attenuating Age-related Oxidative Damage in Rat Hippocampus. Recent Pat Food Nutr Agric. 8(3):2017; 183-189.

  • Samarghandian S, Azimi-Nezhad M, Borji A, Samini M, Farkhondeh T. Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats. BMC Complement Altern Med. 17(1):2017; 249.

  • Samarghandian S, Azimi-Nezhad M, Farkhondeh T. Anti-Carcinogenic Effects of Carnosol-An Updated Review. Curr Drug Discov Technol. 15(1):2018; 32-40

  • Samarghandian S, Afshari JT, Davoodi S. Honey induces apoptosis in renal cell carcinoma. Pharmacogn Mag. 7(25):2011; 46-52.

  • Samarghandian S, Borji A, Farahmand SK, Afshari R, Davoodi S. Crocus sativus L. (saffron) stigma aqueous extract induces apoptosis in alveolar human lung cancer cells through caspase-dependent pathways activation. Biomed Res Int. 2013: 2013;417928. doi: 10.1155/2013/417928.

  • Samarghandian S, Borji A, Farkhondeh T. Attenuation of Oxidative Stress and Inflammation by Portulaca oleracea in Streptozotocin-Induced Diabetic Rats. J Evid Based Complementary Altern Med. 22(4):2017; 562-566.

  • Shaterzadeh-Yazdi H, Farkhondeh T, Samarghandian S. An Overview on Cardiovascular Protective Effects of Catechins. Cardiovasc Hematol Disord Drug Targets. 17(3):2017;154-160.

  • Samarghandian S, Azimi-Nezhad M, Samini F, Farkhondeh T. Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats. Can J Physiol Pharmacol. 94(4):2016; 388-93.

  • Farkhondeh T, Samarghandian S, Azimin-Nezhad M, Samini F. Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats. Int J Clin Exp Med. 8(2):2015; 2465-70.

  • Samarghandian S, Hadjzadeh MA, Afshari JT, Hosseini M. Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line. BMC Complement Altern Med. 14:2014; 192.

  • Samarghandian S, Afshari R, Sadati A. Evaluation of lung and bronchoalveolar lavage fluid oxidative stress indices for assessing the preventing effects of safranal on respiratory distress in diabetic rats. ScientificWorldJournal. 2014:2014; 251378.

  • Farkhondeh T, Samarghandian S, Shahri AMP, Samini F. The Neuroprotective Effects of Thymoquinone: A Review. Dose Response. 16(2):2018; 1559325818761455

  • Samarghandian S, Azimi-Nezhad M, Farkhondeh T. Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats. Indian Heart J. 69(2):2017; 151-159.

  • Samarghandian S, Shabestari MM. DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. Indian J Urol. 29(3): 2013; 177-183.

  • Samarghandian S1, Borji A, Afshari R, Delkhosh MB, gholami A. The effect of lead acetate on oxidative stress and antioxidant status in rat bronchoalveolar lavage fluid and lung tissue. Toxicol Mech Methods. 23(6):2013; 432-6.

  • Samarghandian S, Shoshtari ME, Sargolzaei J, Hossinimoghadam H, Farahzad JA. Anti-tumor activity of safranal against neuroblastoma cells. Pharmacogn Mag. 10(2):2014; S419-24.

  • Samarghandian S, Hadjzadeh MA, Amin Nya F, Davoodi S. Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats. Pharmacogn Mag. 8(29):2012; 65-72.

  • Samarghandian S, Afshari JT, Davoodi S. Modulation of programmed cell death by honey bee in human prostate adenocarcinoma. J Med Plants Res. 4(23): 2010; 2551-2556.

  • Samarghandian S, Borji A, Tabasi SH. Effects of Cichorium intybus linn on blood glucose, lipid constituents and selected oxidative stress parameters in streptozotocin-induced diabetic rats. Cardiovasc Hematol Disord Drug Targets. 13(3):2013; 231-6.

  • Hajzadeh MAR, Rajaei Z , Shafiee S , Alavinejhad A, Samarghandian S, Ahmadi M. Effect of barberry fruit (Berberis Vulgaris) on serum glucose and lipids in streptozotocin-diabetic rats. Pharmacologyonline. 1: 2011; 809-817

  • Samarghandian S, Azimi-Nezhad M, Mehrad-Majd H, Mirhafez SR. Thymoquinone ameliorates acute renal failure in gentamicin-treated adult male rats. Pharmacology. 96(3-4):2015; 112-7.

  • Samarghandian S, Borji A, Farkhondeh T. Evaluation of antidiabetic activity of carnosol (Phenolic Diterpene in Rosemary) in streptozotocin-induced diabetic rats. Cardiovasc Hematol Disord Drug Targets. 17(1):2017; 11-17.

  • Samarghandian S, Azimi-Nezhad M, Farkhondeh T. Crocin attenuate Tumor Necrosis Factor-alpha (TNF-α) and interleukin-6 (IL-6) in streptozotocin-induced diabetic rat aorta. Cytokine. 88:2016; 20-28.

  • Liang W, Luo Z, Ge S, Li M, Du J, Yang M, Yan M, Ye Z, Luo Z. Oral administration of quercetin inhibits bone loss in rat model of diabetic osteopenia. Eur J Pharmacol. 670(1):2011; 317-24.

  • Tang D1, Kang R, Xiao W, Zhang H, Lotze MT, Wang H, Xiao X. Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function. Am J Respir Cell Mol Biol. 41(6):2009; 651-60.

  • Saleem TH, Attya AM, Ahmed EA, Ragab SM, Ali Abdallah MA, Omar HM. Possible protective effects of quercetin and sodium gluconate against colon cancer induction by dimethylhydrazine in mice. Asian Pac J Cancer Prev. 16(14):2015; 5823-8.

  • Abd El-Gawad HM1, Khalifa AE. Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain. Pharmacol Res. 43(3):2001; 257-63.

  • Abdalla FH, Cardoso AM, Pereira LB, Schmatz R, Gonçalves JF, Stefanello N, Fiorenza AM, Gutierres JM, Serres JD, Zanini D, Pimentel VC, Vieira JM, Schetinger MR, Morsch VM, Mazzanti CM. Neuroprotective effect of quercetin in ectoenzymes and acetylcholinesterase activities in cerebral cortex synaptosomes of cadmium-exposed rats. Mol Cell Biochem. 381(1-2):2013; 1-8.

  • Abdel-Raheem IT, Abdel-Ghany AA, Mohamed GA. Protective effect of quercetin against gentamicin-induced nephrotoxicity in rats. Biol Pharm Bull. 32(1):2009; 61-7.

  • El-Nekeety AA, Abdel-Azeim SH, Hassan AM, Hassan NS, Aly SE, Abdel-Wahhab MA.Quercetin inhibits the cytotoxicity and oxidative stress in liver of rats fed aflatoxin-contaminated diet. Toxicol Rep. 1:2014; 319-329.

  • Filho AW, Filho VC, Olinger L, de Souza MM. Quercetin: further investigation of its antinociceptive properties and mechanisms of action. Arch Pharm Res. 31(6):2008; 713-21.

  • Heeba GH, Mahmoud ME. Dual effects of quercetin in doxorubicin-induced nephrotoxicity in rats and its modulation of the cytotoxic activity of doxorubicin on human carcinoma cells. Environ Toxicol. 31(5):2016; 624-36.

  • Kemelo MK, Horinek A, Canová NK, Farghali H. Comparative effects of quercetin and SRT1720 against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in rats: biochemical and molecular biological investigations. Eur Rev Med Pharmacol Sci. 20(2):2016; 363-71.

  • Park HK, Jeong BC, Sung MK, Park MY, Choi EY, Kim BS, Kim HH, Kim JI. Reduction of oxidative stress in cultured renal tubular cells and preventive effects on renal stone formation by the bioflavonoid quercetin. J Urol. 179(4):2008; 1620-6.

  • Kuo YC, Tsao CW. Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin. Int J Nanomedicine. 12:2017; 2857-2869.

  • Samarghandian S, Borji A, Afshari R, Delkhosh MB, gholami A. The effect of lead acetate on oxidative stress and antioxidant status in rat bronchoalveolar lavage fluid and lung tissue. Toxicol Mech Methods. 23(6):2013; 432-6.

  • Samarghandian S, Azimi-Nezhad M, Farkhondeh T, Samini F. Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney. Biomed Pharmacother. 87:2017; 223-229.

  • Farkhondeh T, Samarghandian S, Sadighara P. Lead exposure and asthma: An overview of observational and experimental studies. Toxin Reviews. 34:2015; 6-10

  • Liu CM1, Zheng GH, Cheng C, Sun JM. Quercetin protects mouse brain against lead-induced neurotoxicity. J Agric Food Chem. 61(31):2013; 7630-5.

  • Samarghandia, S, Azimi-Nezhad M, Shabestari MM, Azad FJd, Farkhondeh T, Bafandeh F. Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats. Interdisciplinary Toxicology. 8(3): 2015; 151-154

  • Shaterzadeh-Yazdi H, Noorbakhsh MF, Hayati F, Samarghandian S, Farkhondeh T. Immunomodulatory and anti-inflammatory effects of thymoquinone. Cardiovasc Hematol Disord Drug Targets. 18(1):2018; 52-60.

  • Ben Mimouna S, Chemek M, Boughammoura S, Haouas Z, Messaoudi I.Protective role of zinc against the neurotoxicity induced by exposure to cadmium during gestation and lactation periods on hippocampal volume of pups tested in early adulthood. Drug Chem Toxicol. 2018:1-10. doi: 10.1080/01480545.2018.1461901.

  • Ben Mimouna S, Boughammoura S, Chemek M, Haouas Z, Banni M, Messaoudi I.Disruption of the zinc metabolism in rat foetal brain after prenatal exposure to cadmium. Chem Biol Interact. 286:2018; 88-95.

  • Monaco A, Capriello T, Grimaldi MC, Schiano V, Ferrandino I. Neurodegeneration in zebrafish embryos and adults after cadmium exposure. Eur J Histochem. 61(4):2017 ; 2833.

  • Abdalla FH, Cardoso AM, Pereira LB, Schmatz R, Gonçalves JF, Stefanello N, Fiorenza AM, Gutierres JM, Serres JD, Zanini D, Pimentel VC, Vieira JM, Schetinger MR, Morsch VM, Mazzanti CM. Neuroprotective effect of quercetin in ectoenzymes and acetylcholinesterase activities in cerebral cortex synaptosomes of cadmium-exposed rats. Mol Cell Biochem. 381(1-2):2013; 1-8.

  • Abdalla FH, Schmatz R, Cardoso AM, Carvalho FB, Baldissarelli J, de Oliveira JS, Rosa MM, Gonçalves Nunes MA, Rubin MA, da Cruz IB, Barbisan F, Dressler VL, Pereira LB, Schetinger MR, Morsch VM, Gonçalves JF, Mazzanti CM. Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na(+),K(+)-ATPase activities. Physiol Behav. 135:2014; 152-67.

  • Unsal C, Kanter M, Aktas C, Erboga M. Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats. Toxicol Ind Health. 31(12):2015; 1106-15.

  • Kanter M, Unsal C, Aktas C, Erboga M.Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus. Toxicol Ind Health. 32(3):2016; 541-50.

  • Halder S, Kar R, Galav V, Mehta AK, Bhattacharya SK, Mediratta PK, Banerjee BD. Cadmium exposure during lactation causes learning and memory-impairment in F1 generation mice: amelioration by quercetin. Drug Chem Toxicol. 39(3):2016; 272-8.

  • Gupta R, Shukla RK, Chandravanshi LP, Srivastava P, Dhuriya YK, Shanker J, Singh MP, Pant AB, Khanna VK. Protective role of quercetin in cadmium-induced cholinergic dysfunctions in rat brain by modulating mitochondrial integrity and MAP kinase signaling. Mol Neurobiol. 54(6):2017; 4560-4583.

  • Gupta R, Shukla RK, Pandey A, Sharma T, Dhuriya YK, Srivastava P, Singh MP, Siddiqi MI, Pant AB, Khanna VK. Involvement of PKA/DARPP-32/PP1α and β- arrestin/Akt/GSK-3β signaling in cadmium-induced DA-D2 receptor-mediated motor dysfunctions: Sci Rep. 8(1):2018; 2528.

  • Ghosh A, Mandal AK, Sarkar S, Panda S, Das N. Nanoencapsulation of quercetin enhances its dietary efficacy in combating arsenic-induced oxidative damage in liver and brain of rats. Life Sci. 84(3-4):2009; 75-80.

  • Halder S, Kar R, Mehta AK, Bhattacharya SK, Mediratta PK, Banerjee BD. Quercetin modulates the effects of Chromium exposure on learning, Memory and Antioxidant Enzyme Activity in F1 Generation Mice. Biol Trace Elem Res. 171(2):2016; 391-398.

  • Nday CM, Halevas E, Jackson GE, Salifoglou A.Quercetin encapsulation in modified silica nanoparticles: potential use against Cu(II)-induced oxidative stress in neurodegeneration. J Inorg Biochem. 145:2015; 51-64.

  • Farkhondeh T, Samarghandian S, Samini F. Antidotal effects of curcumin against neurotoxic agents: An updated review. Asian Pac J Trop Med. 9(10):2016; 947-953.

  • Kao TK1, Ou YC, Raung SL, Lai CY, Liao SL, Chen CJ. Inhibition of nitric oxide production by quercetin in endotoxin/cytokine-stimulated microglia. Life Sci. 86(9-10):2010; 315-21.

  • Sun GY, Chen Z, Jasmer KJ, Chuang DY, Gu Z, Hannink M, Simonyi A. Quercetin attenuates inflammatory responses in BV-2 microglial cells: role of MAPKs on the Nrf2 pathway and induction of heme oxygenase-1. PLoS One. 10(10):2015; e0141509.

  • Abd El-Gawad HM, Khalifa AE. Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain. Pharmacol Res. 43(3):2001; 257-63.

  • Ahn TB, Jeon BS. The role of quercetin on the survival of neuron-like PC12 cells and the expression of α-synuclein. Neural Regen Res. 10(7):2015; 1113-9.

  • Singh S, Jamwal S, Kumar P. Neuroprotective potential of Quercetin in combination with piperine against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Neural Regen Res. 12(7):2017; 1137-1144.

  • Farkhondeh T, Samarghandian S, Borji A. An overview on cardioprotective and anti-diabetic effects of thymoquinone. Asian Pac J Trop Med. 10(9):2017; 849-854.

  • Samarghandian S, Afshari R, Farkhondeh T. Effect of long-term treatment of morphine on enzymes, oxidative stress indices and antioxidant status in male rat liver. Int J Clin Exp Med. 7(5):2014; 1449-53.

  • Moghaddam HS, Samarghandian S, Farkhondeh T. Effect of bisphenol A on blood glucose, lipid profile and oxidative stress indices in adult male mice. Toxicol Mech Methods. 25(7):2015; 507-13.

  • Samarghandian S, Azimi-Nezhad M, Afshari R, Farkhondeh T, Karimnezhad F. Effects of buprenorphine on balance of oxidant/antioxidant system in the different ages of male rat liver. J Biochem Mol Toxicol. 29(6):2015; 249-53.

  • Coldiron AD Jr, Sanders RA, Watkins JB 3rd. Effects of combined quercetin and coenzyme Q(10) treatment on oxidative stress in normal and diabetic rats. J Biochem Mol Toxicol. 16(4):2002; 197-202.

  • Anjaneyulu M, Chopra K. Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol. 31(4):2004; 244-8.

  • Bhutada P, Mundhada Y, Bansod K, Bhutada C, Tawari S, Dixit P, Mundhada D. Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats. Neurobiol Learn Mem. 94(3):2010; 293-302.

  • Thipkaew C, Wattanathorn J, Muchimapura S. Electrospun nanofibers loaded with quercetin promote the recovery of focal entrapment neuropathy in a rat model of streptozotocin-induced diabetes. Biomed Res Int. 2017;2017:2017493.

  • Ola MS, Ahmed MM, Shams S, Al-Rejaie SS. Neuroprotective effects of quercetin in diabetic rat retina. Saudi J Biol Sci. 24(6):2017; 1186-1194.

  • Samarghandian S, Farkhondeh T, Azimi-Nezhad M. Protective effects of chrysin against drugs and toxic agents. Dose Response. 15(2):2017; 1559325817711782.

  • Uthra C, Shrivastava S, Jaswal A, Sinha N, Reshi MS, Shukla S. Therapeutic potential of quercetin against acrylamide induced toxicity in rats. Biomed Pharmacother. 86:2017; 705-714.

  • Zargar S, Siddiqi NJ, Ansar S, Alsulaimani MS, El Ansary AK. Therapeutic role of quercetin on oxidative damage induced by acrylamide in rat brain. Pharm Biol. 54(9):2016; 1763-7.

  • Farkhondeh T, Samarghandian S. Antidotal effects of curcumin against agents-induced cardiovascular toxicity. Cardiovasc Hematol Disord Drug Targets. 16(1):2016; 30-37.

  • Ramana BV, Kumar VV, Krishna PN, Kumar CS, Reddy PU, Raju TN. Effect of quercetin on galactose-induced hyperglycaemic oxidative stress in hepatic and neuronal tissues of Wistar rats. Acta Diabetol. 43(4):2006; 135-41.

  • Bournival J, Francoeur MA, Renaud J, Martinoli MG. Quercetin and sesamin protect neuronal PC12 cells from high-glucose-induced oxidation, nitrosative stress, and apoptosis. Rejuvenation Res. 15(3):2012; 322-33.

  • Nassiri-Asl M, Moghbelinejad S, Abbasi E, Yonesi F, Haghighi MR, Lotfizadeh M, Bazahang P. Effects of quercetin on oxidative stress and memory retrieval in kindled rats. Epilepsy Behav. 28(2):2013; 151-5.

  • Sefil F, Kahraman I, Dokuyucu R, Gokce H, Ozturk A, Tutuk O, Aydin M, Ozkan U, Pinar N. Ameliorating effect of quercetin on acute pentylenetetrazole induced seizures in rats. Int J Clin Exp Med. 7(9):2014; 2471-7.

  • Nassiri-Asl M, Hajiali F, Taghiloo M, Abbasi E, Mohseni F, Yousefi F. Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models. Toxicol Ind Health. 32(5):2016; 936-44.

  • Singh T, Kaur T, Goel RK. Adjuvant quercetin therapy for combined treatment of epilepsy and comorbid depression. Neurochem Int. 104:2017; 27-33.

  • Farkhondeh t, Samarghandian S. The hepatoprotective effects of curcumin against drugs and toxic agents: an updated review. Toxin Reviews. 35( 3-4): 2016; 133-140

  • Nabavi SF, Nabavi SM, Latifi AM, Mirzaei M, Habtemariam S, Moghaddam AH. Mitigating role of quercetin against sodium fluoride-induced oxidative stress in the rat brain. Pharm Biol. 50(11):2012; 1380-3.

  • Sandhir R, Mehrotra A. Quercetin supplementation is effective in improving mitochondrial dysfunctions induced by 3-nitropropionic acid: implications in Huntington's disease. Biochim Biophys Acta. 1832(3):2013; 421-30.

  • Denny Joseph KM, Muralidhara. Enhanced neuroprotective effect of fish oil in combination with quercetin against 3-nitropropionicacid induced oxidative stress in rat brain. Prog Neuropsychopharmacol Biol Psychiatry. 40:2013; 83-92.

  • Chakraborty J, Singh R, Dutta D, Naskar A, Rajamma U, Mohanakumar KP. Quercetin improves behavioral deficiencies, restores astrocytes and microglia, and reduces serotonin metabolism in 3-nitropropionic acid-induced rat model of Huntington's Disease. CNS Neurosci Ther. 20(1):2014; 10-9.

  • Sánchez-Reus MI, Gómez del Rio MA, Iglesias I, Elorza M, Slowing K, Benedí J. Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats. Neuropharmacology. 52(2):2007; 606-16.

  • Karuppagounder SS, Madathil SK, Pandey M, Haobam R, Rajamma U, Mohanakumar KP. Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats. Neuroscience. 236:2013; 136-48.

  • Denny Joseph KM, Muralidhara. Combined oral supplementation of fish oil and quercetin enhances neuroprotection in a chronic rotenone rat model: relevance to Parkinson's disease. Neurochem Res.40(5): 2015; 894-905.

  • El-Horany HE, El-Latif RN, ElBatsh MM, Emam MN. Ameliorative effect of quercetin on neurochemical and behavioral deficits in rotenone rat model of Parkinson's Disease: modulating autophagy (Quercetin on Experimental Parkinson's Disease). J Biochem Mol Toxicol. 30(7):2016; 360-9.

  • Valério DA, Georgetti SR, Magro DA, Casagrande R, Cunha TM, Vicentini FT, Vieira SM, Fonseca MJ, Ferreira SH, Cunha FQ, Verri WA Jr. Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production. J Nat Prod. 72(11):2009; 1975-9.

  • Haleagrahara N1, Siew CJ, Ponnusamy K. Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats. J Toxicol Sci. 38(1):2013; 25-33.

  • Haleagrahara N, Siew CJ, Mitra NK, Kumari M. Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum. Neurosci Lett. 500(2):2011; 139-43.

  • Mukai R, Kawabata K, Otsuka S, Ishisaka A, Kawai Y, Ji ZS, Tsuboi H, Terao J. Effect of quercetin and its glucuronide metabolite upon 6-hydroxydopamine-induced oxidative damage in Neuro-2a cells. Free Radic Res. 46(8):2012; 1019-28.

  • Farkhondeh T, Samarghandian S, Azimi-Nezhad M. The effect of lead exposure on some inflammatory biomarkers of lung lavage fluid in rats. Toxin Rev.36(2); 2017: 161-164.

  • Samarghandian S, Shibuya M. Vascular Endothelial Growth Factor Receptor Family in Ascidians, Halocynthia roretzi (Sea Squirt). Its High Expression in Circulatory System-Containing Tissues. Int J Mol Sci. 14(3):2013; 4841-53.

  • Samarghandian S, Azimini-Nezhad M, Farkhondeh T. The Effects of Zataria Multiflora on blood glucose, lipid profile and oxidative stress parameters in adult mice during exposure to bisphenol A. Cardiovasc Hematol Disord Drug Targets. 16(1):2016; 41-46.

  • Samarghandian S, Azimi-Nezhad M, Borji A, Farkhondeh T. Crocus sativus L. (saffron) extract reduces the extent of oxidative stress and proinflammatory state in aged rat kidney. Prog Nutr. 18(3); 2016: 299-310 104. Samarghandian S, Farkhondeh T, Samini F, Borji A. Protective effects of carvacrol against oxidative stress induced by chronic stress in rat's brain, liver, and kidney. Biochem Res Int. 2016;2016:2645237.

  • Samarghandian S, Azimi-Nezhad M, Samini F. Preventive effect of safranal against oxidative damage in aged male rat brain. Exp Anim. 64(1):2015; 65-71.

  • Samarghandian S, Azimi-Nezhad M, Samini F. Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus. Biomed Res Int. 2014;2014:920857.

  • Samarghandian S, Borji A. Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients. Pharmacognosy Res. 6(2):2014; 99-107.

  • Samarghandian S, Nezhad MA, Mohammadi G. Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 human lung adenocarcinoma epithelial cells. Anticancer Agents Med Chem. 14(6):2014; 901-9.

  • Samarghandian S, Borji A, Delkhosh MB, Samini F. Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. J Pharm Pharm Sci. 16(2):2013; 352-62.

  • Samarghandian S, Shabestari MM. DNA fragmentation and apoptosis induced by safranal in human prostate cancer cell line. Indian J Urol. 29(3):2013; 177-83.

  • Farahmand SK, Samini F, Samini M, Samarghandian S. Safranal ameliorates antioxidant enzymes and suppresses lipid peroxidation and nitric oxide formation in aged male rat liver. Biogerontology. 14(1):2013; 63-71.

  • Samini F, Samarghandian S, Borji A, Mohammadi G, bakaian M. Curcumin pretreatment attenuates brain lesion size and improves neurological function following traumatic brain injury in the rat. Pharmacol Biochem Behav. 110:2013; 238-44.

  • Samarghandian S, Afshari JT, Davoodi S. Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. Clinics (Sao Paulo). 66(6):2011; 1073-9.

  • Samarghandian S1, Tavakkol Afshari J, Davoodi S. Suppression of pulmonary tumor promotion and induction of apoptosis by Crocus sativus L. extraction. Appl Biochem Biotechnol. 164(2):2011; 238-47.

  • Samarghandian S, Afshari JT, Davoodi S. Honey induces apoptosis in renal cell carcinoma. Pharmacogn Mag. 7(25):2011; 46-52.

  • Samarghandian S, Ohata H, Yamauchi N, Shibasaki T. Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats. Neuroscience. 116(2):2003; 519-24.

  • Koike K, Shinozawa Y, Yamazaki M, Endo T, Nomura R, Aiboshi J, Samarghandian S, Emmett M, Peterson VM. Recombinant human interleukin-1alpha increases serum albumin, Gc-globulin, and alpha1-antitrypsin levels in burned mice. Tohoku J Exp Med. 198(1):2002; 23-9.


Abstract Views: 199

PDF Views: 0




  • The Neuro-Protective effects of Quercetin

Abstract Views: 199  |  PDF Views: 0

Authors

Mohammad Samini
Mashhad University of Medical Sciences, Mashhad, Iraq

Abstract


Quercetin has a wide array of pharmacological properties such as antioxidant and anti-inflammatory activities. Scientific study has indicated that quercetin possesses protective effects against toxic agents in several tissues, including brain, lung, heart, liver, kidney, etc. The scientific databases such as MEDLINE, PubMed, Scopus, Web of Science and Google Scholar from 1990 to present was searched to identify online scientific literatures about antidotal and protective effects of quercetin against neurotoxic agents. The keywords for the search were: quercetin, toxic agents, and neurodegenerative disease. This review aims to identify the protective effects of quercetin against neurotoxic agents. This study found that quercetin had protective activities against toxic agents-induced neurotoxicity by modulating oxidative stress, inflammation, and apoptosis pathways. The scientific databases such as MEDLINE, PubMed, Scopus, Web of Science and Google Scholar from 1990 to present was searched to identify online scientific literatures about antidotal and protective effects of quercetin against neurotoxic agents. The keywords for the search were: quercetin, toxic agents, and neurodegenerative disease.

Keywords


Quercetin, Toxic Agent, Nervous System, Oxidative Stress, Inflammation.

References