Research Journal of Pharmacy and Technology

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Development and Evaluation of Nanoemulsion Gel for Transdermal Delivery of Valdecoxib


Affiliations
1 Department of Pharmaceutics, Research Scholar, Pacific University, Udaipur, Rajastan, India
2 Department of Pharmaceutics, Malla Reddy college of Pharmacy (Affiliated to Osmania University), Maisammaguda, Hyderabad, Telangana State, India
3 Hi-Tech College of Pharmacy, Bhubaneswar, Odisha, India
     

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To enhance the solubility and permeability of poorly water soluble Valdecoxib, Nanoemulsion gel was formulated for the treatment of rheumatoid arthritis. Among the oils,surfactants and co-surfactants elainic acid, tween80 and ethanol were selected as they showed maximum solubility to Valdecoxib.The pseudo ternary phase-diagrams was constructed to find optimal concentration that provided the highest drug loading. The prepared Nanoemulsions were subjected trough thermodynamic stability testing.The droplet size, scanning electron microscopy (SEM) and zeta-potential were investigated.The optimized formulation of Nanoemusion NE2 which was showing 87.63% drug release was incorporated into polymeric gel of Carbopol940 for convenient application and evaluated for viscosity, PH, in-vitro permeations studies, skin irritation test and anti-inflammatory activity. The in-vitro skin permeations profile of optimized formulation was compared with normal Valdecoxib gel and Nanoemulsiongel NG2.The significant increase in permeability ratio (Kp),flux (Jss) and enhancement ratio (Er) was observed.The anti-inflammatory effect of formulation NG2 showed significant increase 72% inhibition effect in 24hrs when compared to Valdecoxib gel on Carrgeenan induced paw edema in rats. The results suggested that Nanoemulsion gels are potential vehicles for improved transdermal delivery of Valdecoxib.

Keywords

Nanoemulsion, Nanoemulsiongel, Scanning Electron Microscopy, in-vitro Permeations Studies, in-vivo Studies.
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  • Development and Evaluation of Nanoemulsion Gel for Transdermal Delivery of Valdecoxib

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Authors

Vikram V. B. K. Mishra
Department of Pharmaceutics, Research Scholar, Pacific University, Udaipur, Rajastan, India
S. B. Bhanja
Department of Pharmaceutics, Malla Reddy college of Pharmacy (Affiliated to Osmania University), Maisammaguda, Hyderabad, Telangana State, India
B. B. Panigrahi
Hi-Tech College of Pharmacy, Bhubaneswar, Odisha, India

Abstract


To enhance the solubility and permeability of poorly water soluble Valdecoxib, Nanoemulsion gel was formulated for the treatment of rheumatoid arthritis. Among the oils,surfactants and co-surfactants elainic acid, tween80 and ethanol were selected as they showed maximum solubility to Valdecoxib.The pseudo ternary phase-diagrams was constructed to find optimal concentration that provided the highest drug loading. The prepared Nanoemulsions were subjected trough thermodynamic stability testing.The droplet size, scanning electron microscopy (SEM) and zeta-potential were investigated.The optimized formulation of Nanoemusion NE2 which was showing 87.63% drug release was incorporated into polymeric gel of Carbopol940 for convenient application and evaluated for viscosity, PH, in-vitro permeations studies, skin irritation test and anti-inflammatory activity. The in-vitro skin permeations profile of optimized formulation was compared with normal Valdecoxib gel and Nanoemulsiongel NG2.The significant increase in permeability ratio (Kp),flux (Jss) and enhancement ratio (Er) was observed.The anti-inflammatory effect of formulation NG2 showed significant increase 72% inhibition effect in 24hrs when compared to Valdecoxib gel on Carrgeenan induced paw edema in rats. The results suggested that Nanoemulsion gels are potential vehicles for improved transdermal delivery of Valdecoxib.

Keywords


Nanoemulsion, Nanoemulsiongel, Scanning Electron Microscopy, in-vitro Permeations Studies, in-vivo Studies.

References