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Pharmaceutical Excipient Behaviour of Chickpea (Cicer arietinum) Starch in Losartan Potassium Fast Disintegrating Tablet


Affiliations
1 Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode, India
2 Lincoln University College, Petaling Jaya,, Malaysia
3 School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur,, Malaysia
     

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The aim and objective of the research work is to find out the suitability of starch extracted from Chickpea (Cicer arietinum) as super disintegrant in Losartan Potassium Fast Disintegrating Tablet. The study includes preformulation characterization of starch extracted from Chickpea (Cicer arietinum) and its compatibility with drug Losartan potassium and other excipients of the formulation. Compatibility of formulation ingredients were observed by using Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC) studies. The disintegrant activity of Chickpea (Cicer arietinum) is compared parallely with the disintegrant crospovidone. Losartan potassium fast disintegrating tablet (LCP01, LCP02 and LCP03) were formulated with crospovidone and Losartan potassium fast disintegrating tablet (LCS01, LCS02, LCS03. LCS04, LCS05, LCS06) were formulated with chickpea starch as disintegrant. Physicochemical characterisation of formulated Losartan potassium fast disintegrating tablets was performed to find out the better formulation.

Keywords

Chickpea (Cicer arietinum), Disintegrant, Derived Properties, Theogram, Dissolution.
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  • Pharmaceutical Excipient Behaviour of Chickpea (Cicer arietinum) Starch in Losartan Potassium Fast Disintegrating Tablet

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Authors

Senthil Rajan
Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode, India
Satheesh Babu
Lincoln University College, Petaling Jaya,, Malaysia
Nurliana Binti Ali
School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur,, Malaysia
Venkata Srikanth Meka
School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur,, Malaysia
B. Arul Kumar
Department of Pharmaceutics, Swamy Vivekanandha College of Pharmacy, Tiruchengode, India

Abstract


The aim and objective of the research work is to find out the suitability of starch extracted from Chickpea (Cicer arietinum) as super disintegrant in Losartan Potassium Fast Disintegrating Tablet. The study includes preformulation characterization of starch extracted from Chickpea (Cicer arietinum) and its compatibility with drug Losartan potassium and other excipients of the formulation. Compatibility of formulation ingredients were observed by using Fourier transform infrared spectroscopy (FTIR) and Differential scanning calorimetry (DSC) studies. The disintegrant activity of Chickpea (Cicer arietinum) is compared parallely with the disintegrant crospovidone. Losartan potassium fast disintegrating tablet (LCP01, LCP02 and LCP03) were formulated with crospovidone and Losartan potassium fast disintegrating tablet (LCS01, LCS02, LCS03. LCS04, LCS05, LCS06) were formulated with chickpea starch as disintegrant. Physicochemical characterisation of formulated Losartan potassium fast disintegrating tablets was performed to find out the better formulation.

Keywords


Chickpea (Cicer arietinum), Disintegrant, Derived Properties, Theogram, Dissolution.

References