Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

The OGG 1 Ser326cys Gene Polymorphism and Breast Tumor Risk of Iraqi Women


Affiliations
1 Chemistry Department, College of Science, University of Mustansiriyah, Iraq
2 Biotechnology Research Center, University of Al-Nahrian, Baghdad, Iraq
     

   Subscribe/Renew Journal


The purpose of this study was to test the association between human 8-oxoguanine glycosylase 1 (OGG1) gene polymorphisms to the breast tumor in the Iraqi women. One-hundred-three Sample were obtained from patients with breast cancer (28 women malignant breast tumor patients group) ,(28 control group),(28 benign group) and (19 Radiotherapy group) of (30-59) years old in Al-Eluia hospital for woman care, oncology teaching hospital between September 2016 to January 2017. The results showed that there was a significant difference when comparing the control with benign and the radiotherapy patients, and there was a non- significant change in the comparison between the control and the malignant groups.

Keywords

Breast Cancer, OGG1gene.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Siegel ,R., Ma J., Zou, Z., Jemal, A. “Cancer statistics ”. CA Cancer J Clin,64(1);2014:9–29.

  • Sapkota, Y. “Germline DNA variations in breast cancer predisposition and prognosis: a systematic review of the literature”. Cytogenet Genome Res.,144(2); 2014:77–91.

  • Pharoah, PD., Antoniou, A., Bobrow, M., Zimmern, RL., Easton, DF., Ponder, BA.. Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet,31(1) ;2002:33–6.

  • Koval, V., Knorre, D. G., Fedorova ,O. S. “Structural Features of the Interaction between human 8-Oxoguanine DNA Glycosylase hOGG1 and DNA”, 2014.

  • Rossner, P. et al., “OGG1 Polymorphisms and Breast Cancer Risk OGG1 Polymorphisms and Breast Cancer Risk”,15;2006 : 811–815.

  • Kasznicki., Krupa, R., Błasiak, J., and Drzewoski, J.“ Association. between polymorphisms of the DNA repair genes XRCC1 and hOGG1 .and type 2 diabetes mellitus in the Polish population”.Pol. Arch. Med. .Wewnętrznej, 119 (3);2009:122–8.

  • Yang, Y. et al., “Development of a reverse transcription quantitative polymerase chain reaction-based assay for broad coverage detection of African and Asian Zika virus lineages”,32(3);2017: 199–206.

  • Choi, JY., Hamajima, N., Tajima,K., et al. “ OGG1 Ser326Cys polymorphism and breast cancer risk among Asian women”. Breast Cancer Res treat,79; 2003:59 – 62.

  • Wilson, D.M.,and Bohr, V.A. “The mechanics of base excision repair, and its relationship to aging and disease”. DNA Repair (Amst), 6 (4);2007:544–559.

  • Alanazi, M.et al. “The hOGG1 Ser326Cys Gene Polymorphism and Breast Cancer Risk in Saudi Population”. Pathol. Oncol. Res, 23 (3); 2017: 525–535.

  • Cai, Q., et al. “Functional Ser326Cys polymorphism in the hOGG1 gene is not associated with breast cancer risk”.Cancer Epidemiol. Biomarkers Prev,15(2); 2006: 403–404.

  • Rodrigues, P., de Marco, G., Furriol, J., Mansego, ML., Pineda-Alonso, M., Gonzalez-Neira, A., Martin-Escudero, JC., Benitez, J., Lluch, A.,Chaves ,FJ., Eroles, P. “Oxidative stress in susceptibility to breast cancer: study in Spanish population” .BMC Cancer ,14; 2014:861.

  • Choi, JY., Hamajima, N., Tajima, K., et al. “hOGG1 Ser326Cys. polymorphism and breast cancer risk among Asian women”.Breast.Cancer Res Treat,79, 2003:59 – 62.

  • Bose ,S., Tripathi, D.M., Sakhuja P., Kazim S.N., and Sarin, S.K. “Genetic polymorphisms of CYP2E1 and DNA repair genes hOGG1 and XRCC1 : Association with hepatitis B related advanced liver disease and cancer” .Gene,519(2); 2013: 231–237.

  • Press, D. “Association of polymorphisms hOGG1 rs1052133 andhMUTYH rs3219472 with risk of nasopharyngeal carcinoma in a Chinese population ”.2016: 755–760.

  • Jacek Kasznicki,, Renata Krupa., Janusz Błasiak., Jozef Drzewoski. “Association .between polymorphisms of the DNA repair genes XRCC1 and hOGG1 .and type 2 diabetes mellitus in the Polish population”. Pol Arch Med Wewn,119(3);2009:122–8.

  • Jianfeng Xu., Siqun, L., Zheng, Aubrey Turner, Sarah D., Isaacs, Kathy E., et al. “ Associations between hOGG1 sequence variants and prostate cancer susceptibility”. Cancer Research, 62;2002: 2253–2257.


Abstract Views: 170

PDF Views: 0




  • The OGG 1 Ser326cys Gene Polymorphism and Breast Tumor Risk of Iraqi Women

Abstract Views: 170  |  PDF Views: 0

Authors

Ghufran Saad Nsaif
Chemistry Department, College of Science, University of Mustansiriyah, Iraq
Amer Hassan Abdallah
Chemistry Department, College of Science, University of Mustansiriyah, Iraq
Najwa Shehab Ahmed
Biotechnology Research Center, University of Al-Nahrian, Baghdad, Iraq

Abstract


The purpose of this study was to test the association between human 8-oxoguanine glycosylase 1 (OGG1) gene polymorphisms to the breast tumor in the Iraqi women. One-hundred-three Sample were obtained from patients with breast cancer (28 women malignant breast tumor patients group) ,(28 control group),(28 benign group) and (19 Radiotherapy group) of (30-59) years old in Al-Eluia hospital for woman care, oncology teaching hospital between September 2016 to January 2017. The results showed that there was a significant difference when comparing the control with benign and the radiotherapy patients, and there was a non- significant change in the comparison between the control and the malignant groups.

Keywords


Breast Cancer, OGG1gene.

References