Research Journal of Pharmacy and Technology

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Vulnerability of Hydro-Alcoholic Media on In Vitro Drug Release from Galantamine HBr Pellets Comprising of Compritol 888 ATO and Ethocel


Affiliations
1 Department of Pharmaceutics, Anand Pharmacy College, Anand - 388001, Gujarat, India
2 Institute of Pharmacy, Dharmasinh Desai University, Nadiad - 387001, Gujarat, India
3 The Novel Drug and Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, Canada
     

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Objective: The objective of the present study was to assess the interaction between the Galantamine HBr pellets and alcohol. Concomitant administration of alcohol and formulation can affect the plasma concentration of drug or give dose dumping effect or failure of the dosage form as the number of excipients especially polymers used in the modified dosage form cannot withstand in the presence of alcohol. Materials and Methods: The modified release pellets of galantamine hydrobromide were formulated incorporating a waxy polymer – Compritol 888 ATO and a hydrophobic polymer – Ethocel using extrusion spheronization technique. In vitro drug release of galntamine pellets was performed in distilled water and 10-40% ethanol containing distilled water. The saturated solubility of galantamine was measured in different dissolution media and pure ethanol. Results and Discussion: In vitro drug release study showed similarity at all the levels of alcohol (10-40%) as f2 value was found to be more than 50. In vitro drug release was slightly reduced in the presence of alcohol as the galantamine is slightly less soluble in ethanol compared to distilled water. There was change observed in drug release kinetics and mechanism but no significant change was observed in drug release. Conclusion: The suitability of Compritol 888 ATO and Ethocel as a matrix forming excipient in the formulation of pellets can resist the effect of alcohol makes it suitable for the alternative polymer in the wider application for designing of modified release dosage form.

Keywords

Hydroalcoholic Media, Compritol 888 ATO, Ethocel, Sustained Release Pellets, Galantamine HBr
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  • Vulnerability of Hydro-Alcoholic Media on In Vitro Drug Release from Galantamine HBr Pellets Comprising of Compritol 888 ATO and Ethocel

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Authors

Hardik B. Rana
Department of Pharmaceutics, Anand Pharmacy College, Anand - 388001, Gujarat, India
Mukesh C. Gohel
Department of Pharmaceutics, Anand Pharmacy College, Anand - 388001, Gujarat, India
Mansi S. Dholakia
Institute of Pharmacy, Dharmasinh Desai University, Nadiad - 387001, Gujarat, India
Abdelwahab Omri
The Novel Drug and Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, Canada
Vaishali T. Thakkar
Department of Pharmaceutics, Anand Pharmacy College, Anand - 388001, Gujarat, India

Abstract


Objective: The objective of the present study was to assess the interaction between the Galantamine HBr pellets and alcohol. Concomitant administration of alcohol and formulation can affect the plasma concentration of drug or give dose dumping effect or failure of the dosage form as the number of excipients especially polymers used in the modified dosage form cannot withstand in the presence of alcohol. Materials and Methods: The modified release pellets of galantamine hydrobromide were formulated incorporating a waxy polymer – Compritol 888 ATO and a hydrophobic polymer – Ethocel using extrusion spheronization technique. In vitro drug release of galntamine pellets was performed in distilled water and 10-40% ethanol containing distilled water. The saturated solubility of galantamine was measured in different dissolution media and pure ethanol. Results and Discussion: In vitro drug release study showed similarity at all the levels of alcohol (10-40%) as f2 value was found to be more than 50. In vitro drug release was slightly reduced in the presence of alcohol as the galantamine is slightly less soluble in ethanol compared to distilled water. There was change observed in drug release kinetics and mechanism but no significant change was observed in drug release. Conclusion: The suitability of Compritol 888 ATO and Ethocel as a matrix forming excipient in the formulation of pellets can resist the effect of alcohol makes it suitable for the alternative polymer in the wider application for designing of modified release dosage form.

Keywords


Hydroalcoholic Media, Compritol 888 ATO, Ethocel, Sustained Release Pellets, Galantamine HBr

References