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Evaluation of In vivo Wound Healing Activity of dried leaf Ethanolic extract of Indigofera tinctoria on Albino Wistar Rat
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Aim of the present study was to evaluate the wound healing properties of ethanolic extract of Indigofera tinctoria on Albino wistar rat. The preliminary Phytochemical evaluation was carried out by standard methods. Burn was induced in wistar rat divided in to five groups as follow: Normal control Group-I received petroleum jelly. Group II Received Silver sulphadiazine-1%w/w,Group III received 5% extract of Indigofera tinctoria ointment, Group IV received 10% w/w Indigofera tinctoria ointment and GroupV received 20% w/w Indigofera tinctoria ointment topically twice daily for 16 days. The topical application of 20% w/w Indigofera tinctoria ointment, shows significant (P<0.001) reduction in the wound breaking strength when compared to III received 5% extract of Indigofera tinctoria ointment but not comparable with Silver sulphadiazine-1%w/w treated group.
Keywords
Wound Healing Activity, Indigofera tinctoria, Hydroxyproline, Epithelialization.
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- V. Jain, V. Prasad and R.S. Pandey. Wound Healing Activity of Desmodium gangeticum in Different Wound Models. Journal of Plant Sciences.2006; 1(6) : 247-253.
- Rozaini, M.Z.The effects of different types of honey on tensile strength evaluation of burn wound tissue healing. International Journal of Applied Research in VeterinaryMedicine.2004;3(7): 290–296
- Sunilkumar, Parameshwaraiah S, Shivakumar HG. Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats. Indian J Exp Biol. 1998 ; 36(6) :569-72.
- Willi Paul and Chandra P. Sharma. Chitosan and Alginate Wound Dressings: A Short Review. Trends Biomater. Artif. Organs.2004; 18 (1):18-23.
- P. Manimekalai, P. Maheshwari, R. Velmurugan, M. Gurumoorthy, S. Hansraj Kumar, G. Vijayakumar. Gastro Protective effect of Standardized Ethanolic leaf extract of Indigofera Tinctoriao on experimental Gastric Ulcers in Rats. Research J. Pharm. and Tech 2018; 11(2):527-531.
- Sandeep B. Patil, N.S. Naikwade, M.S. Kondawar, C.S.Magdum and V.B. Awale. Traditional uses of plants for wound healing in the Sangli district, Maharashtra. Pharm Tech, 2009; 1(3): 876-878.
- Natasa Skalko-Basnet, Shila Gurung. Wound healing properties of Carica papaya latex: In vivo evaluation in mice burn model. Journal of Ethnopharmacology 2008; 121(2):338-41.
- Neuman Re, Logan Ma. The determination of hydroxyproline. J Biol Chem. 1950; 184(1):299-306.
- Asif et al., 2007 A. Asif G. Kakub S. Mehmood R. Khunum M. Gulfraz. Wound healing activity of ischolar_main extracts of Berberis lyceum royle in rats. 2007;21(6): 589-591.
- Xiujuan, .Role of Indigofera tinctoria against lewis lung carcinoma, carcinogenesis.1981; 9 (6): 431-438.
- K.ShanmugaPriya, Gnanamani, Radhakrishnan, MaryBabu Healing potential of Datura alba on burn wounds in albino rats. Journal of Ethnopharmacology. 2002;83(3):193-199.
- C. Michael DiPersio, Rui Zheng, James Kenney, Livingston Van De Water Integrin-mediated regulation of epidermal wound functions. Cell Tissue Res. 2016 ; 365(3): 467–482.
- Kamal M, Wazir SM, Hassan M, Subhan M, Khan SU, Muhammad M, Taj S Ethnobotanically important plants of District Bannu, Pakistan. Pak. J. Plant Sci. 2009; 15: 87-93.
- D. Senthil Rajan, M. Rajkumar, C. T. Kumarappan, K. L. Senthil Kumar. Wound healing activity of an herbal ointment containing the leaf extract of Ziziphus Mauritiana Lam. African Journal of Pharmacy and Pharmacology.2013; 7(3): 98-103.
- Singhai A.K .Wound healing potential of Tephrosia purpurea pers. in Rats. Journal of Ethno pharmacology .2006 ;108.: 204-210.
- A. Puratchikody. Nithya devi,. Nagalakshmi wound healing activity of Cyperus rotundus linn. indian Journal of pharmaceutical sciences.2006 ;68 (1 ): 97-101
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