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Concise Overview:A Review on Natural Antioxidants and Important Herbal Plants on Gastrointestinal System


Affiliations
1 Community Medicine Department, Lorestan University of Medical Science, Khorramabad, Iran, Islamic Republic of
2 Student Research Committee Lorestan University of Medical Sciences, Khorramabad, Iran, Islamic Republic of
3 Hormozgan University Faculty of Medical Sciences, Bandar Abbas, Iran, Islamic Republic of
     

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The digestive system is one of the most important organs in the human body and is vulnerable to various diseases. Available drugs often have less efficacy or lead to many side effects. Therefore, alternative drugs are needed to treat gastrointestinal complications.The aim of this study was to introduce the most important medicinal plants on gastrointestinal disorders and to report medicinal plants used to treat common gastrointestinal diseases and disorders across the world. These plants play a traditional medical role in the treatment of parasitic diseases, diarrhea, reflux, gastroenteritis, digestive cancer, digestive disorders. Some of the most important medicinal plants in this article were addressed for the effect and mechanism of action. Based on the results obtained from the review of numerous articles, a number of plants have been reported to prevent digestive disorders and gastrointestinal cancers, including Glycyrrhiza glabra, Ribes nigrum ,Phyllanthus niruri , Newtonia hildebrandtii , Lantana camara, Persea , Maytenus , Streblus asper , Cordia myxa , Coriandrum sativum , Cyperus rotuntdus , Azadirachta indica , Aloe vera , Plantago asiatica , Passiflora spp. Pharmacological studies are strongly recommended to investigate the therapeutic effects of herbal drugs so that their clinical effects and the use of their active ingredients are taken into account for the production of natural and useful drugs. The results of phytochemical studies of the herbs indicated that compounds such as kobusone, and isokobusone , rotundone, auxins and phenolic compounds, isoflavene glabrene, glabridin, phytoestrogens, glycosides, flavonoids, and saponins ,and etc are the most important active and active compounds of these plants. In this way, herbs and herbs can produce natural drugs that affect the system and digestive disorders and reduce the pain and suffering of the patients.

Keywords

Gastrointestinal Disorders, Gastrointestinal Diseases, Natural Antioxidants, Phytotherapy, Herbal Medicine.
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  • Drossman, Douglas A. Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV. Gastroenterology, 2016; 150(6): 1262-1279. e2.

  • Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, Walker LS. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology, 2016; 150(6): 1456-1468. e2.

  • Drossman DA.. Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV. Gastroenterology, 2016; 150(6): 1262-1279. e2.

  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: a cancer journal for clinicians, 2011; 61(2): 69-90.

  • Zabaleta J.Multifactorial etiology of gastric cancer. In: Cancer Epigenetics. Humana Press, Totowa, NJ, 2012; 411-435.

  • Huang JQ, Sridhar S, Chen Y, Hunt RH. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology, 1998; 114(6): 1169-1179.

  • Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland. New England journal of medicine, 2000; 343(2): 78-85.

  • Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R.Identification and expansion of human colon-cancer-initiating cells. Nature, 2007; 445(7123): 111.

  • Stein U, Walther W, Arlt F, Schwabe H, Smith J, Fichtner I, Birchmeier W, Schlag PM. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nature medicine, 2009; 15(1): 59.

  • Bahmani M, Zargaran A, Rafieian-Kopae M. Identification of medicinal plants of Urmia for treatment of gastrointestinal disorders. Revista Brasileira de Farmacognosia, 2014; 24(4): 468-480.

  • Askarian, F., et al. The effect of lactic acid bacteria administration on growth, digestive enzyme activity and gut microbiota in Persian sturgeon (Acipenser persicus) and beluga (Huso huso) fry. Aquaculture Nutrition, 2011; 17(5): 488-497.

  • Kargar, Mohammad, et al. Evaluation of cagA tyrosine phosphorylation DNA motifs in Helicobacter pylori isolates from gastric disorder patients in West of Iran. Scientific Research and Essays, 2011; 6(31): 6454-6458.

  • Lin HC, Prather C, Fisher RS, Meyer JH, Summers RW, Pimentel M, McCallum RW, Akkermans LM, Loening-Baucke V. Measurement of gastrointestinal transit. Digestive diseases and sciences, 2005; 50(6): 989-1004.

  • Lembo, Anthony; Camilleri, Michael. Chronic constipation. New England Journal of Medicine, 2003; 349(14): 1360-1368.

  • Levy RL, Olden KW, Naliboff BD, Bradley LA, Francisconi C, Drossman DA, Creed F Psychosocial aspects of the functional gastrointestinal disorders. Gastroenterology, 2006; 130(5): 1447-1458.

  • Repetto, M. G.; Llesuy, S. F. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Brazilian journal of medical and biological research, 2002; 35(5): 523-534.

  • Ivanova D, Gerova D, Chervenkov T, Yankova T. Polyphenols and antioxidant capacity of Bulgarian medicinal plants. Journal of ethnopharmacology, 2005; 96(1-2): 145-150.

  • Zeineldin, Mohamed, et al. A Review: Herbal Medicine as an Effective Therapeutic Approach for Treating Digestive Disorders in Small Ruminants. Alexandria Journal for Veterinary Sciences, 2018; 56.1.

  • Karkanis, Anestis, et al. Phytochemical composition, health effects, and crop management of liquorice (Glycyrrhiza glabra L.): Α medicinal plant. Food Reviews International, 2018; 34(2): 182-203.

  • Miladinovic B, Brankovic S, Kostic M, Milutinovic M, Kitic N, Šavikin K, Kitic D. Antispasmodic Effect of Blackcurrant (Ribes nigrum L.) Juice and Its Potential Use as Functional Food in Gastrointestinal Disorders. Medical Principles and Practice, 2018; 27(2): 179-185.

  • Mostofa R, Ahmed S, Begum MM, Sohanur Rahman M, Begum T, Ahmed SU, et al. Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L.(Euphorbiaceae) leaves in experimental rats. BMC complementary and alternative medicine, 2017; 17(1): 267.

  • Motlhatlego, K. E., et al. The potential use of leaf extracts of two Newtonia (Fabaceae) species to treat diarrhoea. South African Journal of Botany, 2018; 116: 25-33.

  • Sagar, Lenika; Sehgal, Rajesh; Ojha, Sudarshan. Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice. BMC Complementary and Alternative Medicine, 2005; 5.1: 18.

  • Somensi LB, Boeing T, Cury BJ, Steimbach VMB, Niero R, de Souza LM, da Silva LM, de Andrade SF. Hydroalcoholic extract from bark of Persea major (Meisn.) LE Kopp (Lauraceae) exerts antiulcer effects in rodents by the strengthening of the gastric protective factors. Journal of ethnopharmacology, 2017; 209: 294-304.

  • Tabach R, Duarte-Almeida JM, Carlini EA. Pharmacological and Toxicological Study of Maytenus ilicifolia Leaf Extract. Part I–Preclinical Studies. Phytotherapy Research, 2017; 31(6): 915-920.

  • Shahed-AL-Mahmud, Md, et al. In Vivo Anti-diarrheal Activity of Methanolic Extract of Streblus asper Leaves Stimulating the Na+/K+-ATPase in Swiss Albino Rats. Indian Journal of Clinical Biochemistry, 2018; 1-8.

  • AL-Snafi, Ali Esmail. Beneficial medicinal plants in digestive system disorders (part 2): plant based review. IOSR Journal of Pharmacy, 2016; 6(7): 85-92.

  • Duangjai, Acharaporn, et al. Relaxant effects of Azadirachta indica A. Juss var. siamensis Valeton flower extract on isolated rat ileum contractions and the mechanisms of action. Journal of Traditional and Complementary Medicine, 2018.

  • Akinbo, Frederick; EZE, Gerald. Combined Effects of Medicinal Plants on Induced Upper Gastrointestinal Tract Injury in Wistar Rats. Ethiopian journal of health sciences, 2016; 26(6): 573-580.

  • HU, Jie-Lun; NIE, Shao-Ping; XIE, Ming-Yong. Antidiabetic mechanism of dietary polysaccharides based on their gastrointestinal functions. Journal of agricultural and food chemistry, 2018; 66(19): 4781-4786.

  • Mahady GB, Pendland SL, Stoia A, Hamill FA, Fabricant D, Dietz BM, Chadwick LR. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. 2005; 19(11): 988-991.

  • Mohsenzadeh A, Ahmadipour S, Ahmadipour SH, Asadi-Samani M. Iran's medicinal plants effective on fever in children: A review. Der Pharmacia Lettre, 2016; 8(1): 129-134.

  • Shayganni E, Bahmani M, Asgary S, Rafieian-Kopaei M. Inflammaging and cardiovascular disease: Management by medicinal plants. Phytomedicine, 2016; 23(11): 1119-1126.

  • Bahmani M, Sarrafchi A, Shirzad H, Rafieian-Kopaei M. Autism: Pathophysiology and promising herbal remedies. Current pharmaceutical design, 2016; 22(3): 277-285.

  • Jivad N, Asadi-samani M, Moradi M. The most important medicinal plants effective on migraine: A review of ethnobotanical studies in Iran. Der Pharma Chemica, 2016; 8(2): 462-466.

  • Jivad N, Asadi-samani M, Moradi M, Taghi M. The most important medicinal plants effective on migraine: A review of ethnobotanical studies in Iran. Der Pharma Chemica, 2016; 8(2): 462-466.

  • Naserifar, Razi, et al. A review of the most important native medicinal plants of Iran effective on leishmaniasis according to Iranian ethnobotanical references. International Journal of Advanced Biotechnology and Research, 2017; 8: 1330-1336.

  • Moradi, Behzad, et al. The most useful medicinal herbs to treat diabetes. Biomedical Research and Therapy, 2018; 5(8): 2538-2551.

  • Tajallaie-ASL, Faeghe, et al. Menstruation phytotherapy according to iran ethnobotanical sources. J. Pharm. Sci. & Res, 2017; 9(6): 986-990.

  • Rafieian-Kopaei, Mahmoud. Medicinal plants and the human needs. Journal of HerbMed Pharmacology, 2012; 1.

  • Nasri, Hamid, et al. Antioxidant plants and diabetes mellitus. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences, 2015; 20(5): 491.

  • Nasri, Hamid; Rafieian-Kopaei, Mahmoud. Medicinal plants and antioxidants: why they are not always beneficial?. Iranian journal of public health, 2014; 43(2): 255.

  • Zaman, Sameer Uz; Mirje, Mrutyunjay M.; Ramabhimaiah, S. Evaluation of the anti-ulcerogenic effect of Zingiber officinale (Ginger) ischolar_main in rats. Int J Curr Microbiol App Sci, 2014, 3.1: 347-354.

  • Kang, Hee, et al. Upregulation of interferon-γ and interleukin-4, Th cell-derived cytokines by So-Shi-Ho-Tang (Sho-Saiko-To) occurs at the level of antigen presenting cells, but not CD4 T cells. Journal of ethnopharmacology, 2009; 123.1: 6-14.

  • Snehlata, Helambe S.; Payal, Dande R. Fenugreek (Trigonella foenum-graecum L.): an overview. Int J Curr Pharm Rev Res, 2012; 2(4): 169-87.

  • Benedek, Birgit; Kopp, Brigitte. Achillea millefolium L. sl revisited: recent findings confirm the traditional use. Wiener Medizinische Wochenschrift, 2007, 157.13-14: 312-314.

  • Sulaiman, Shaida Fariza; OOI, Kheng Leong. Antioxidant and anti food-borne bacterial activities of extracts from leaf and different fruit parts of Myristica fragrans Houtt. Food Control, 2012; 25(2): 533-536.

  • Pourjabali, Masoumeh, et al. Medicinal plants used for hypertension. Journal of Pharmaceutical Sciences and Research, 2017; 9(5): 537-541.

  • Ebrahimie, Marzieh, et al. A review study on the effect of Iranian herbal medicines on opioid withdrawal syndrome. Journal of evidence-based complementary & alternative medicine, 2015; 20(4): 302-309.

  • Bahmani, Mahmoud, et al. A review on promising natural agents effective on hyperlipidemia. Journal of evidence-based complementary & alternative medicine, 2015; 20(3): 228-238.

  • Delfan, Bahram; Kazemeini, Hamidreza; Bahmani, Mahmoud. Identifying effective medicinal plants for cold in Lorestan province, West of Iran. Journal of evidence-based complementary & alternative medicine, 2015; 20(3): 173-179.

  • Bahmani M et al. Ethenobothanical study of medicinal plants against parasites detected in Shiraz, southern part of Iran. Der Pharmacia Lettre, 2016; 8(1): 153-160.

  • Nasri H, Ahmadi A, Baradaran A, Momeni A, Nasri P, Mardani S, Rafieian-Kopaei M, Mubarak M. Clinicopathological correlations in lupus nephritis; a single center experience. Journal of nephropathology, 2014; 3(3): 115.

  • Delfan B, et al. Ethnobotany study of effective medicinal plants on gastric problems in Lorestan province, West of Iran. Journal of Chemical and Pharmaceutical Research, 2015, 2: 483-492.

  • Salimzadeh L, Bagheri N, Zamanzad B, Azadegan-Dehkordi F, Rahimian G, Hashemzadeh-Chaleshtori M, Rafieian-Kopaei M, Sanei MH, Shirzad H. Frequency of virulence factors in Helicobacter pylori-infected patients with gastritis. Microbial pathogenesis, 2015, 80: 67-72.

  • Rahimian G, Sanei MH, Shirzad H, Azadegan-Dehkordi F, Taghikhani A, Salimzadeh L, Hashemzadeh-Chaleshtori M, Rafieian-Kopaei M, Bagheri N. Virulence factors of Helicobacter pylori vacA increase markedly gastric mucosal TGF-β1 mRNA expression in gastritis patients. Microbial pathogenesis, 2014, 67: 1-7.

  • Aleebrahim-Dehkordy E, Nasri H, Baradaran A, Nasri P, Tamadon MR, Hedaiaty M, Beigrezaei S, Rafieian-Kopaei M. Medicinal plants, effective plant compounds (compositions) and their effects on stomach cancer. International journal of preventive medicine, 2017, 8.

  • Chaleshtori, Sharafati, et al. Antioxidant and antibacterial activity of basil (Ocimum basilicum L.) essential oil in beef burger. Journal of Agricultural Science and Technology, 2015, 17.4: 817-826.

  • Ghamari S, Abbaszadeh S, Mardani M, Shahsavari S. Identifying medicinal plants affecting the teeth from the Southern district of Ilam province, Iran. Journal of Pharmaceutical Sciences and Research, 2017, 9(6): 800-803.

  • Moayeri A, Azimi M, Karimi E, Aidy A, Abbasi N. Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats. Medical science monitor basic research 2018; 24: 151-158.

  • Bahmani, M., Khaksarian, M., Rafieian-Kopaei M, Abbasi N. Overview of the Therapeutic Effects of Origanum vulgare and Hypericum perforatum Based on Iran's Ethnopharmacological Documents. Journal of Clinical and Diagnostic Research 2018; 12 (7): 1-4.

  • Tajbakhsh M, Karimi A, Tohidpour A. et al. J Microbiol. The antimicrobial potential of a new derivative of cathelicidin from Bungarus fasciatus against methicillin-resistant Staphylococcus aureus. J Microbiol. 2018; 56(2): 128-137.

  • Abbasi N, Mohammadpour S, Karimi E, Aidy A, Karimi P, Azizi M, et al. Protective effects of Smyrnium cordifolium Boiss essential oil on pentylenetetrazol-induced seizures in mice: Involvement of benzodiazepine and opioid antagonists. J Biol Regul Homeost Agents 2017; 31:683-9.

  • Faryadian S, Sydmohammadi A, Khosravi A, Kashiri M, Faryadayn P, Abasi N. Aqueous Extract of Echium amoenum Elevate CSF Serotonin and Dopamine Level in Depression rat. Biomed Pharmacol J 2014; 7(1): Available from: http://biomedpharmajournal.org/?p=2875

  • Shokri Z, Khoshbi M, Koohpayeh A, Abbasi N, Bahmani F, Rafieian-Kopaei M, Beyranvand F. Thyroid diseases: Pathophysiology and new hopes in treatment with medicinal plants and natural antioxidants. Intern J Green Pharmacy 2018; 12 (3): 473-483.


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  • Concise Overview:A Review on Natural Antioxidants and Important Herbal Plants on Gastrointestinal System

Abstract Views: 194  |  PDF Views: 0

Authors

Khatereh Anbari
Community Medicine Department, Lorestan University of Medical Science, Khorramabad, Iran, Islamic Republic of
Afshin Hasanvand
Student Research Committee Lorestan University of Medical Sciences, Khorramabad, Iran, Islamic Republic of
Ali Nosrati Andevari
Hormozgan University Faculty of Medical Sciences, Bandar Abbas, Iran, Islamic Republic of
Mona moghadasi
Student Research Committee Lorestan University of Medical Sciences, Khorramabad, Iran, Islamic Republic of
Saber Abbaszadeh
Student Research Committee Lorestan University of Medical Sciences, Khorramabad, Iran, Islamic Republic of

Abstract


The digestive system is one of the most important organs in the human body and is vulnerable to various diseases. Available drugs often have less efficacy or lead to many side effects. Therefore, alternative drugs are needed to treat gastrointestinal complications.The aim of this study was to introduce the most important medicinal plants on gastrointestinal disorders and to report medicinal plants used to treat common gastrointestinal diseases and disorders across the world. These plants play a traditional medical role in the treatment of parasitic diseases, diarrhea, reflux, gastroenteritis, digestive cancer, digestive disorders. Some of the most important medicinal plants in this article were addressed for the effect and mechanism of action. Based on the results obtained from the review of numerous articles, a number of plants have been reported to prevent digestive disorders and gastrointestinal cancers, including Glycyrrhiza glabra, Ribes nigrum ,Phyllanthus niruri , Newtonia hildebrandtii , Lantana camara, Persea , Maytenus , Streblus asper , Cordia myxa , Coriandrum sativum , Cyperus rotuntdus , Azadirachta indica , Aloe vera , Plantago asiatica , Passiflora spp. Pharmacological studies are strongly recommended to investigate the therapeutic effects of herbal drugs so that their clinical effects and the use of their active ingredients are taken into account for the production of natural and useful drugs. The results of phytochemical studies of the herbs indicated that compounds such as kobusone, and isokobusone , rotundone, auxins and phenolic compounds, isoflavene glabrene, glabridin, phytoestrogens, glycosides, flavonoids, and saponins ,and etc are the most important active and active compounds of these plants. In this way, herbs and herbs can produce natural drugs that affect the system and digestive disorders and reduce the pain and suffering of the patients.

Keywords


Gastrointestinal Disorders, Gastrointestinal Diseases, Natural Antioxidants, Phytotherapy, Herbal Medicine.

References