Open Access
Subscription Access
Open Access
Subscription Access
Nanosized Ethosomes–A Promising Vesicular Drug Carrier for Transdermal Drug Delivery
Subscribe/Renew Journal
Delivering bioactive molecules via the most resistible barrier like skin is the major difficulty that needs to be combatted for the transdermal delivery in order to achieve the desired systemic therapeutic action. This obstacle was overcome by the innovation of a vesicular carrier called ethosome which non-invasively enable the active agent to reach the deeper layers of the skin. Ethosomal systems are phospholipid based, soft malleable vesicles which can deliver drug of different physicochemical characteristics, both in terms of quantity and depth when compared to other vesicular systems. Because of their unique structure and high content of ethanol, transdermal drug delivery has become easy, improving the drug efficacy and patient compliance. This article reviews various aspects of ethosomes including the ethosomal composition, mechanism of penetration, preparation methods, advantages, applications, marketed products of ethosomes. Characterization of ethosomes include particle size, zeta potential, entrapment efficiency, penetration studies etc. These ethosomal nanocarriers opens numerous challenges in the research area for developing improved therapies in the future.
Keywords
Transdermal, Ethosome, Vesicles, Phospholipid, Skin Permeation.
Subscription
Login to verify subscription
User
Font Size
Information
- Schoellhammer CM, Blankschtein D, Langer R. Skin permeabilization for transdermal drug delivery: recent advances and future prospects. Expert Opin Drug Deliv 2014;11(3):393-407.
- Rakesh R, Anoop KR. Ethosomes for Transdermal and Topical Drug Delivery. Int J Pharm Sci 2012;4:17–24.
- Barry BW. Novel mechanisms and devices to enable successful transdermal drug delivery. Eur J Pharm Sci 2001;14(2):101–14.
- Tiwari RK, Chauhan NS. Ethosomes: A potential carries for transdermal drug delivery. Int J Drug Dev Res 2010;2(2):448–52.
- Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 2000;65(3):403–18.
- Abdulbaqi IM, Darwis Y, Khan NAK, Assi RA, Khan AA. Ethosomal nanocarriers: the impact of constituents and formulation techniques on ethosomal properties, in vivo studies, and clinical trials. Int J Nanomedicine 2016;11:2279–304.
- Akhtar N, Pathak K. Cavamax W7 Composite Ethosomal Gel of Clotrimazole for Improved Topical Delivery: Development and Comparison with Ethosomal Gel. AAPS Pharm Sci Tech 2012;13(1):344–55.
- Sudhakar CK, Jain S, Charyulu RN. A Comparison Study of Liposomes, Transfersomes and Ethosomes Bearing Lamivudine. Int J Pharm Sci Res 2016;7(10):4214–21.
- Chourasia MK, Kang L, Chan SY. Nanosized ethosomes bearing ketoprofen for improved transdermal delivery. Results Pharma Sci 2011;1(1):60–7.
- López-Pinto JM, González-Rodríguez ML, Rabasco AM. Effect of cholesterol and ethanol on dermal delivery from DPPC liposomes. Int J Pharm 2005;298(1):1–12.
- Nagadevi B, Kumar KS, Venkanna P, Prabhakar D. Formulation and characterisation of Tizanidine hydrochloride loaded ethosomes patch. Int J Pharm Pharm Sci 2014;6(4):199–205.
- Shukla T, Verma A, Upmanyu N, Mishra SS, Shilpi S. Development and characterization of clopidogrel-loaded ethosomal transdermal patch for antiplatelet effect. Asian J Pharm 2016;10(4):S480–86.
- Vijayakumar KS, Parthiban S, Senthilkumar GP, Tamiz Mani T. Gliclazide loaded ethosomes as transdermal drug delivery carriers. Asian J Res Biol Pharm Sci 2014;2(2):89-98.
- Liu X, Liu H, Liu J, He Z, Ding C, Huang G, et al. Preparation of a ligustrazine ethosome patch and its evaluation in vitro and in vivo. Int J Nanomedicine 2011;6:241–7.
- Verma DD, Fahr A. Synergistic penetration enhancement effect of ethanol and phospholipids on the topical delivery of cyclosporin A. J Control Release 2004;97(1):55–66.
- Mura S, Manconi M, Fadda AM, Sinico C, Valenti D. Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil. Int J Pharm 2009;380:72-79.
- Bhalaria MK, Naik S, Misra AN. Ethosomes: A novel delivery system for antifungal drugs in the treatment of topical fungal diseases. Indian J Exp Biol 2009;47:368–75.
- Nandure HP, Puranik P, Giram P, Lone V. Ethosome : A Novel Drug Carrier. Int J Pharm Res Allied Sci 2013;2(3):18–30.
- Brown MB, Martin GP, Jones SA, Akomeah FK. Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects. Drug Deliv 2006;13(3):175–87.
- Horwitz E, Pisanty S, Czerninski R, Helser M, Eliav E, Touitou E. A clinical evaluation of a novel liposomal carrier for acyclovir in the topical treatment of recurrent herpes labialis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;87(6):700–5.
- Touitou E, Godin B, Dayan N, Weiss C, Piliponsky A, Levi-Schaffer F. Intracellular delivery mediated by an ethosomal carrier. Biomaterials 2001;22:3053–9.
- Fang JY, Hong CT, Chiu WT, Wang YY. Effect of liposomes and niosomes on skin permeation of enoxacin. Int J Pharm 2001;219:61–72.
- Ainbinder D, Touitou E. Testosterone ethosomes for enhanced transdermal delivery. Drug Deliv 2005;12:297–303.
- Mohammed MI, Makky AMA, Abdellatif MM. Formulation and characterization of ethosomes bearing vancomycin hydrochloride for transdermal delivery. Int J Pharm Pharm Sci 2014;6(11):190–4.
- Vijayakumar MR, Sathalia AH, Arun K. Formulation and Evaluation of Diclofenac Potassium Ethosomes. Int J Pharm Pharm Sci. 2010; 2(4): 82–6.
- Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs liposomes 2000;21:1879–85.
- Sujitha B, Krishnamoorthy B, Muthukumaran M. Formulation and Evaluation of Piroxicam Loaded Ethosomal Gel for Transdermal Delivery. Int J Adv Pharm Gen Res. 2014; 2(1): 34–45.
- Rouf MA, Vural I, Renoir JM, Hincal AA. Development and characterization of liposomal formulations for rapamycin delivery and investigation of their antiproliferative effect on MCF7 cells. J Liposome Res 2009;19(4):322–31.
Abstract Views: 228
PDF Views: 0