Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Floating Osmotic Drug Delivery System:A Review


Affiliations
1 SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, India
2 Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, India
     

   Subscribe/Renew Journal


Floating Osmotic Drug Delivery System (FODDS) is a controlled oral drug delivery system which comes under the category of Gastroretentive Drug Delivery (GRDDS). It is based upon the osmotically controlled release mechanism which offers a sustained therapeutic action while reducing the side effects. Various drugs with a shorter half-life and a small absorption window get highly benefited By FODDS. FODDS also finds a unique place among the other GRDDS by surpassing their performance. FODDS incorporates a variety of ingredients such as osmotic agents, semi permeable substance, gas generating Agent and a gel forming agent. The preparation of the system involves techniques like direct compression and coating process. Characterisation studies like in-vitro dissolution study, in-vivo radiological study and pharmacokinetic study were adapted for evaluation of FODDS. Many studies have been carried out to illustrate the efficiency of the FODDS in overcoming the drawbacks such as poor bioavailability, drug wastage etc. Active agents derived from the field of pharmacognosy have also been benefited by FODDS since they prevent the enzymatic degradation of the active agents and and improve their bioavailability. FODDS also provides a robust pharmacokinetic profile with both in-vitro and in-vivo drug release rate which results in excellent in-vitro/in-vivo correlation due to its controlled release mechanism. This review is primarily focused on providing an overall insight into FODDS while giving detailed information regarding its design, development, mechanism, characterisation and a precise overview of various studies carried out using FODDS.

Keywords

Drug Delivery System, Intragastric System, Gastro Retentive, Floating Osmotic System, Controlled Drug Delivery.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ratnaparkhi M. P and Gupta J. P. Sustained-release oral drug delivery system - an overview. International Journal of pharmacy review and research. 2013; 2(3): 11- 21.

  • Khatri N , Nikam S and Bilandi A . Oral osmotic drug delivery system: a review. International Journal of Pharmaceutical sciences and research. 2016; 7(6): 2302-2312.

  • Rastogi S.K, Vaya N, and Mishra B. Osmotic pump: a novel concept in rate controlled oral drug delivery. Eastern Pharmacist 1995; 38:79–82.

  • Keraliya R.A et al., Osmotic drug delivery systems a part of modified release dosage form. ISRN Pharmaceutics 2012; 2012:528079

  • Reddy P. D and Swarnalatha D. Recent advances in novel drug delivery systems. International Journal of PharmTech Research, 2010; 2(3):2025–2027.

  • Gupta P.B, Thakur N, Jain N.P. Osmotically Controlled Drug Delivery System with Associated Drugs. Journal of pharmacy and pharmaceutical sciences. 2010; 13(3): 571-580.

  • Pawar V. K et al ., Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems. Drug Delivery. 2011; 18(2): 97–110

  • Khan ZA, Tripathi R, Mishra B. Floating elementary osmotic pump tablet (FEOPT) for controlled delivery of diethylcarbamazine citrate: a water-soluble drug. American association of pharmaceutical scientists.2011; 12(4):1312-23.

  • Davis SS, Hardy JG, Far JW. Transit of pharmaceutical dosage forms through the small intestine. Gut. 1986; 27:886–92.

  • Bardonnet PL et al., Gastroretentive dosage forms: overview and special case of Helicobacter pylori. Journal of Control Release. 2006; 111:1 –18.

  • Desai S, Bolton S. A floating controlled-release drug delivery systems: in vitro–in vivo evaluation. Pharmaceutical Research. 1993; 10:1321-1325.

  • Guan J et al., A novel gastric-resident osmotic pump tablet: In vitro and in vivo evaluation. International Journal of Pharmaceutics. 2010; 383:30–36.

  • Chueh H.R, Zia H, Rhodes C.T. Optimization of sotalol floating and bioadhesive extended-release tablet formulations. Drug Development and Industrial Pharmacy. 1995; 21:1725–1747.

  • Iannuccelli V et al., Air compartment multiple-unit system for prolonged gastric residence. Part I. Formulation study. International Journal of Pharmaceutics. 1998; 174:47–54.

  • Arora S et al., Floating Drug Delivery Systems: A Review. American association of pharmaceutical scientists. 2005; 6 (3): 47.

  • Kumar P, Singh S, Mishra B. Floating osmotic drug delivery system of ranitidine hydrochloride: development and evaluation— a technical note. American association of pharmaceutical scientists. 2008; 9:480–5.

  • Chien Y.W. Novel drug delivery systems, Second edition.Taylor and Francis. Boca Rosa.1993

  • Michaels A.S; Drug delivery device with self-activated mechanism for retaining device in selected area. U.S. Patent 3,786,813, 1974

  • Mehta B.P, Doshi A.M, Joshi M.D. Floating osmotic device for controlled release drug delivery. United States Patent Application Publication. US 20030064101A1, 2003.

  • Falk et al., An oral formulation for gastric antibacterial treatment as well as a process thereof and the use. PCT Publication No. WO94/00112, 1994.

  • Verma R.K, Mishra B and Garg S. Osmotically Controlled Oral Drug Delivery. Drug Development and Industrial Pharmacy. 2000; 26(7):695-708.

  • N. Mazerne et al., Intragastric behavior and absorption kinetics of a normal and ‘floating’ modified-release capsule of Isradipine under fasted and fed conditions. 1988. Journal of Pharmaceutical Sciences. 77(8):647–657.

  • Theeuwes F et al., Osmotic delivery systems for the β-adrenoceptor antagonists metoprolol and oxprenolol, design and evaluation of systems for once-daily administration. British Journal of Clinical Pharmacology. 1985; 19:69S–76S.

  • Gupta S. K., Atkinson L., Theeuwes F, Wong P., Longstreth J. Pharmacokinetics of verapamil from an osmotic system with delayed onset. European Journal of Pharmacy and Biopharmaceutics. 1996; 42:74–81.

  • Chao S. T et al., Effect of food on bioavailability of pseudoephedrine and brompheniramine administered from a gastrointestinal therapeutic system Journal of Pharmaceutical Sciences. 1991; 80: 432–435.

  • Swanson DR et al., Nifedipine gastrointestinal therapeutic system. Am J Med 1987; 83 Suppl. 6B: 3–9

  • Kuczynski et al., One approach for delivering pharmaceutical agents that are insoluble in aqueous solvents. U.S. Pat. No. 5,545,413.

  • W.A. Ritschel W A, Menon A, Sakr A. Biopharmaceutic evaluation of furosemide as a potential candidate for a modified release peroral dosage form, Methods and Findings in Experimental and Clinical Pharmacology. 1991; (13):629–636.

  • Blaser M J. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology. 1992; 102:720–727.

  • C.G. Wilson, N. Washington. The stomach: its role in oral drug delivery, in M.H. Rubinstein (Ed.). Physiological Pharmaceutics: Biological Barriers to Drug Absorption. Ellis Horwood, Chichester. 1989; 47–70.

  • Deshpande A.A et al., Controlled-release drug delivery systems for prolonged gastric residence: an overview, Drug Development and Industrial Pharmacy.1996; 22:531–539.

  • Haring N, Salama Z, Jaeger H. Triple stage quadropole mass spectrometric determination of bromocriptine in human plasma with negative ion chemical ionization, Arzneim. Forsch. 1988; 38:1529–1532.

  • Rouge N, Buri P and Doelker E. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. International Journal of Pharmaceutics. 1996; 136:117–139.

  • Singla D, Hari Kumar SL and Nirmala. Osmotic pump drug delivery- a novel approach. International journal of research in pharmacy and chemistry. 2012; 2(2):661-670.

  • McClelland GA et al., The solubility modulated osmotic pump: In vitro/ in vivo release of diltiazem HCl, Pharmaceutical Research. 1991; 8:88-92

  • Bauer K, Kaik G and Kaik B. Osmotic-release oral drug delivery system of metoprolol in hypertensive asthmatic patients. Pharmacodynamic effects on beta 2-adrenergic receptors, Hypertension. 1994; 24:339-346

  • Rudnic EM et al., Osmotic drug delivery system. US Patent 6110498; 2000.

  • Thombre AG, DeNoto AR and Gibbes DG. Delivery of glipizide from asymmetric membrane capsules using encapsulated excipients, Journal of Controlled Release. 1999; 60:333-341

  • Tripathi P et al., Floating drug delivery system. International Journal of Reearch and Development in Pharmacy and Life Sciences. 2012; 1(1):1-10.

  • Li S et al., Statistical optimization of gastric floating system for oral controlled delivery of calcium. American Association of Pharmaceutical Scientists. 2001; 2(1):1.

  • Talukder R and Fassihi R. Gastroretentive Delivery Systems: A mini Review. Drug Development and Industrial Pharmacy. 2004; 30(10):1019-1028.

  • Hejazi R and Amiji N. Stomach specific anti H.Pylori therapy. I: Preparation and characterization of tetracycline of a floating multiple unit capsule, a high density loaded chitosan microspheres. International Journal of Pharmaceutics. 2002; 235:87-94.

  • Cooerman M P, Krausgrill P and Hengels K J. Local gastric and serum amoxicillin concentration after different oral application forms. Antimicrobial Agents and Chemotherapy. 1993; 37:1506-1509.

  • Dave B S, Amin A F and Patel M. Gastroretentive drug delivery system of Ranitidine HCl formulation and in vitro evaluation. ; American Association of Pharmaceutical Scientists. 2004; 5:1-10.

  • Sawicki W. Pharmacokinetics of verapamil and norverapamil from controlled release floating pellets in humans. European Journal of Pharmaceutics and Biopharmaceutics. 2002; 53:29-35.

  • Singh B M and Kim K H. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release. 2000; 63:235-259.

  • Jain S K, Agarwal G P, Jain N K. Evaluation of porous carrier based floating orlistat microspheres for gastric delivery. American Association of Pharmaceutical Scientists. 2006; 7(4):90.

  • Sriamornsak P, Thirawong N, Puttipipatkhachorn S. Morphology and buoyancy of oil entrapped calcium pectinate gel beads. American Association of Pharmaceutical Scientists. 2004; 6(3):24.

  • Patil J M et al., Trends in floating drug delivery systems. Journal of scientific and industrial research. 2006; 65:11-21.

  • Garg R, Gupta GD. Progress in Controlled Gastroretentive Delivery Systems. Tropical Journal of Pharmaceutical Research. 2008; 7(3):1055-1066.

  • Eckenhoff B, Theeuwes F and Urquhart J. Osmotically actuated dosage forms for rate-controlled drug delivery. Pharmaceutical Technology. 1987; 11:96–105.

  • Jensen JL et al.,Variables that affect the mechanism of drug release from osmotic pumps coated with acrylate/methacrylate copolymer latexes. Journal of Pharmaceutical Sciences. 1995; 84(5):530-533.

  • Sastry S, Phanidhar K, Brian B. Osmotic controlled drug delivery system, in Li Xiaoling, Jasti Bhaskara R (eds). Design of Controlled Release Drug Delivery Systems. McGraw-Hill Companies, INC, New York. 2006; 203-229.

  • Avinash Y et al., Role of excipients and polymeric advancements in preparation of floating drug delivery systems. International Journal of Pharmaceutical Investigation. 2015 ; 5(1):1–12.

  • Rania A, Ishak H. Buoyancy-Generating Agents for Stomach-specific Drug Delivery: An Overview with Special Emphasis on Floating Behavior. Journal of Pharmacy and Pharmaceutical Sciences. 2015; 18(1):77 – 100.

  • Rabadia N et al., The floating drug delivery system and it's impact on calcium channel blocker: A review article. Journal of pharmaceutical Science and Technology. 2012; 4:835–67.

  • Shah SH, Patel JK and Patel NV. Stomach specific floating drug delivery system: A review. International Journal of Pharmtech Research. 2009; 1:623–33.

  • Ozdemir N and Sahin J. Design of a controlled release osmotic pump system of ibuprofen. International Journal of Pharmaceutics. 1997; 158:91–97.

  • Krishnaiaha Y. S. R. et al., Studies on development of oral colon targeted drug delivery systems for metronidazole in treatment of amoebiasis. International Journal of Pharmaceutics. 2002; 236:43–55.

  • Bandameedi R and Pandiyan S. Formulation and Evaluation of Floating Osmotic Tablets of Nizatidine. Journal of Applied Pharmaceutical sciences. 2015; 8:1.

  • Narang N, An updated review on floating drug delivery system. International Journal of applied pharmaceutical science. 2011; 3(1):17.

  • R. K. Verma and S. Garg. Development and evaluation of osmotically controlled oral drug delivery systems of glipizide, European Journal of Pharmaceutics and Biopharmaceutics. 2004; 57:513–525.

  • Srivastava A K. Oral sustained delivery of Atenolol from floating matrix tablets—formulation and in-vitro evaluation. Drug Development and Industrial Pharmacy 2005; 31:367–374.

  • Freidman M and Hoffman A. Furosemide pharmacokinetics and pharmacodynamics following gastro-retentive dosage form administration to healthy volunteers. Journal of Clinical Pharmacology. 2003; 43: 711‐720

  • Rosen Y, Gurman P, Elman N M .Drug Delivery An Integrated Clinical and Engineering Approach. New York. 2017.

  • Klausner E et al., Novel Gastroretentive Dosage Forms: Evaluation of Gastroretentivity and Its Effect on Levodopa Absorption in Humans. Pharmaceutical research. 2003; 20(9):1466–73.

  • Dorożyński P et al., Development of a system for simultaneous dissolution studies and magnetic resonance imaging of water transport in hydrodynamically balanced systems: A technical note. American Association of Pharmaceutical Scientists. 2007; 8(1):E109–E12.

  • Goole J et al. Pharmacoscintigraphic and pharmacokinetic evaluation on healthy human volunteers of sustained-release floating minitablets containing levodopa and carbidopa. International Journal of Pharmaceutics. 2008; 364(1):54–6.

  • Klausner EA et al., Novel levodopa gastro-retentive dosage form: In-vivo evaluation in dogs. Journal of Controlled Release.2003; 88(1):117–26.

  • Sanja S et al., Development and Evaluation of Novel Floating Osmotic Capsule for Zero-Order Delivery of Andrographis Paniculata Extract. American Journal of PharmTech Research. 2014; 4(6).

  • Fang Y, Shi QW. Studies on preparation and dissolution test in vitro of intragastric floating two-chamber osmotic pump tablets of total alkaloids of Coptis chinensis and Evodia rutaecarpa. Zhong Yao Cai. 2011; 34(5):779-82.

  • Fang Y, Pan ZH, Cao DY. Study on Preparation and Pharmacokinetics of Irbesartan Intragastric Floating Osmotic Pump Tablets in Dogs. China Pharmacy. 2013; 01.

  • Zhang Z et al., Design and Evaluation of a Novel Floating Osmotic Pump System. Journal of Pharmaceutical Sciences. 2009; 12(1): 129 – 137.

  • Zhao F et al., Optimization of a floating osmotic pump system of ambroxol hydrochloride using central composite design-response surface methodology and its pharmacokinetics in Beagle dogs. Yao Xue Xue Bao. 2011; 46(12):1507-14.

  • Zhang Z et al., Optimization of a floating osmotic pump system of dipyridamole using central composite design-response surface methodology. Yao xue xue bao. 2009; 44:203-7.

  • Manvendra S et al., Osmotically Regulated Floating Asymmetric Membrane Capsule for Controlled Site-Specific Delivery of Ranitidine Hydrochloride: Optimization by Central Composite Design. American Association of Pharmaceutical Scientists. 2012; 13(4).

  • Kamble M S et al., Optimization Of Floating Osmotic Drug Delivery System Of Diltiazem Hydrochloride Using 32 Factorial Design. Indo American Journal of Pharmaceutical Research. 2013; 3(6):4585-4593.

  • Patel M et al., Osmotically regulated floating capsule for controlled delivery of acyclovir: a water-soluble drug. International research journal of pharmacy. 2017, 8 (9).

  • Vivek K Pawar, Shaswat Kansal, Shalini Asthana and Manish K Chourasia. Industrial perspective of gastroretentive drug delivery systems: Physicochemical, biopharmaceutical, technological and regulatory consideration. Expert Opinion on Drug Delivery. 2012; 9(5).

  • Available from : https://www.drugs.com/availability/generic-coreg-cr.html.


Abstract Views: 170

PDF Views: 0




  • Floating Osmotic Drug Delivery System:A Review

Abstract Views: 170  |  PDF Views: 0

Authors

Bharadhwaj Ramesh Iyer
SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, India
N. Damodharan
Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chennai, India

Abstract


Floating Osmotic Drug Delivery System (FODDS) is a controlled oral drug delivery system which comes under the category of Gastroretentive Drug Delivery (GRDDS). It is based upon the osmotically controlled release mechanism which offers a sustained therapeutic action while reducing the side effects. Various drugs with a shorter half-life and a small absorption window get highly benefited By FODDS. FODDS also finds a unique place among the other GRDDS by surpassing their performance. FODDS incorporates a variety of ingredients such as osmotic agents, semi permeable substance, gas generating Agent and a gel forming agent. The preparation of the system involves techniques like direct compression and coating process. Characterisation studies like in-vitro dissolution study, in-vivo radiological study and pharmacokinetic study were adapted for evaluation of FODDS. Many studies have been carried out to illustrate the efficiency of the FODDS in overcoming the drawbacks such as poor bioavailability, drug wastage etc. Active agents derived from the field of pharmacognosy have also been benefited by FODDS since they prevent the enzymatic degradation of the active agents and and improve their bioavailability. FODDS also provides a robust pharmacokinetic profile with both in-vitro and in-vivo drug release rate which results in excellent in-vitro/in-vivo correlation due to its controlled release mechanism. This review is primarily focused on providing an overall insight into FODDS while giving detailed information regarding its design, development, mechanism, characterisation and a precise overview of various studies carried out using FODDS.

Keywords


Drug Delivery System, Intragastric System, Gastro Retentive, Floating Osmotic System, Controlled Drug Delivery.

References