Research Journal of Pharmacy and Technology

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Test Activity of Hair Tonic of Ethyl Acetate Fraction from the Ethanol Extract of Meniran (Phyllanthus niruri L.) as Hair Grower to Male White Rat (Rattus norvegicus) wistar strain


Affiliations
1 Department of Pharmacy, Tanjungpura University, Pontianak, Indonesia
     

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Hair loss is a problem that is often found in the hair. As for plants that have the potential to stimulate hair growth is meniran (Phyllanthus niruri L.). This study aims to determine the activity of hair tonic of the ethyl acetate fraction meniran and the influence of menthol enhancer in stimulating hair growth. Hair tonic smeared on the backs of test animals that have been shaved. Parameters used are length and weight of hair. Hair length observers performed on day 7, 14 and 21, while for hair weight on day-to-21. The results of this study show that formula 1 has a smaller hair length compared to formula 2 containing menthol enhancer. Meanwhile, on hair weight, formula 1 gives greater value than formula 2. Although based on calculations using statistics do not show any significant difference between the two formulas.

Keywords

Phyllanthus niruri L., Tonic, Ethyl Acetate Fraction, Hair Growth.
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  • Ornelas J, Sivamani RK. The role of botanical products in the treatment of alopecia. Hair Ther Transpl. 2015;5(2):2–7.

  • Villasante Fricke AC, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol. 2015;8:397–403.

  • Amin J, Lamria E, Simamora P, Anwar E, Djajadisastra J. Green tea (Camellia sinensis L.) ethanolic extract as hair tonic in nutraceutical: physical stability, hair growth activity on rats, and safety test. Innovare Acad Sci. 2014;6(5):94–9.

  • Kumar N, Singh S, Gupta R. Hair growth activity of Trichosanthes dioica R . leaves. RJPP. 2011;3(1):30–3.

  • Kaushik R, Gupta D, Yadav R. Alopecia: Herbal remedies. IJPSR. 2011;2(7):1631–7.

  • Patel S, Sharma V, Chauhan NS, Thakur M, Kumar V. Evaluation of hair growth promoting activity of Phyllanthus niruri. Avicenna J Phytomedicine. 2015;5(6):1–8.

  • Jain AK, Thomas NS, Panchagnula R. Transdermal drug delivery of imipramine hydrochloride . I . Effect of terpenes. J Control Release. 2002;79:93–101.

  • Supomo, Supriningrum R, Junaid R. Karakterisasi dan skrining fitokimia daun kerehau (Callicarpa longifolia Lamk.). J Kim Mulawarman. 2016;13(2):89–96.

  • Alegantina S, Setyorini HA, Triwahyuni. Pengujian mutu dan penetapan kadar filantin pada ekstrak etanol herba meniran (Phyllanthus niruri Linn). Bul Penelit Kesehat. 2015;43(1):11–6.

  • Dwitiyanti, Kusmardi, Pertamawati PA. Uji sitotoksisitas fraksi etil asetat ekstrak etanol 70% herba ceplukan (Physalis angulata Linn.) terhadap sel kanker payudara T47D secara in vitro. Farmasains. 2015;2(6):295–9.

  • Amin J, Simamora ELP, Anwar E, Djajadisastra J. Green tea (Camellia sinensis L.) ethanolic extract as hair tonic in nutraceutical: Physical stability, hair growth activity on rats, and safety test. Int J Pharm Pharm Sci. 2014;6(5):94–9.

  • Nusmara K. Uji stabilitas fisik dan aktivitas pertumbuhan rambut tikus putih dari sediaan hair tonic yang mengandung ekstrak etanol daun pare (Momordica charantia). Universitas Indonesia; 2012.

  • Rifkia V, Jufri M, Mun’in A. Hair growth promoting activity of Nothopanax scutellarium Merr. leaves. J Young Pharm. 2017;9(3):436–40.

  • Sulastri L, Indrawati T, Taurhesia S. Uji aktivitas penyubur rambut kombinasi ekstrak air teh hijau dan herba pegagan. Pharmaciana. 2016;6(1):39–46.

  • Subekhi R, Sudarso, Hartanti D. Uji pendahuluan efek hair tonic minyak biji wijen (Sesamum indicum L) terhadap pertumbuhan rambut kelinci jantan. Pharmacy. 2009;6(3):22–32.

  • Kuncari ES, Iskandarsyah, Praptiwi. Uji iritasi dan aktivitas pertumbuhan rambut tikus putih: efek sediaan gel apigenin dan perasan herba seledri. Media Litbangkes. 2015;25(1):15–22.

  • Haseloff J. Old botanical techniques for new microscopes. Biotechniques. 2003;34(6).

  • Departemen Kesehatan Republik Indonesia. Farmakope Herbal Indonesia. Kesatu. Jakarta: Departemen Kesehatan Republik Indonesia; 2008. 97-100 p.

  • Hanani E. Analisis fitokimia. Jakarta: Penerbit Buku Kedokteran EGC; 2016. 10-13, 21-22, 69, 71, 83, 113, 122, 148, 203, 239 p.

  • Dragicevic N, Maibach HI. Percutaneous penetration enhancers chemical methods in penetration enhancement. Berlin: Springer; 2015. 15, 17 p.

  • Kurniawan S, Sukariani K, Mudjiharni A. SNI 16-4955-1998: Losio tonik rambut. In Jakarta: Badan Standardisasi Nasional; 1998. p. 2.

  • Rivai H, Septika R, Boestari A. Karakterisasi ekstrak herba meniran (Phyllanthus niruri Linn) dengan analisa fluoresensi. J Farm Higea. 2013;5(2):15–23.

  • Yamato K, Takahashi Y, Akiyama H, Tsuji K, Onishi H, Machida Y. Effect of penetration enhancers on transdermal delivery of propofol. Biol Pharm Bull. 2009;32(4):677–83.

  • Uno H, Cappas A, Brigham P. Action of topical minoxidil in the bald stump-tailed macaque. J Am Acad Dermatol. 1987;16(3):657–68.


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  • Test Activity of Hair Tonic of Ethyl Acetate Fraction from the Ethanol Extract of Meniran (Phyllanthus niruri L.) as Hair Grower to Male White Rat (Rattus norvegicus) wistar strain

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Authors

Sri Luliana
Department of Pharmacy, Tanjungpura University, Pontianak, Indonesia
Rani Rawinda
Department of Pharmacy, Tanjungpura University, Pontianak, Indonesia
Sehro
Department of Pharmacy, Tanjungpura University, Pontianak, Indonesia
Syaazaratul Qamelia Innas
Department of Pharmacy, Tanjungpura University, Pontianak, Indonesia

Abstract


Hair loss is a problem that is often found in the hair. As for plants that have the potential to stimulate hair growth is meniran (Phyllanthus niruri L.). This study aims to determine the activity of hair tonic of the ethyl acetate fraction meniran and the influence of menthol enhancer in stimulating hair growth. Hair tonic smeared on the backs of test animals that have been shaved. Parameters used are length and weight of hair. Hair length observers performed on day 7, 14 and 21, while for hair weight on day-to-21. The results of this study show that formula 1 has a smaller hair length compared to formula 2 containing menthol enhancer. Meanwhile, on hair weight, formula 1 gives greater value than formula 2. Although based on calculations using statistics do not show any significant difference between the two formulas.

Keywords


Phyllanthus niruri L., Tonic, Ethyl Acetate Fraction, Hair Growth.

References