Research Journal of Pharmacy and Technology

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Preparation and Characterization of Novel Disubstituted 1,3- Oxazepinetetra- One from Schiff Bases Reaction with 3-Methylfuran-2,5-Dione and 3- Phenyldihydrofuran-2,5-Dione


Affiliations
1 Pharmacy College, University Of Anbar, Anbar, Iraq
2 Department of Ecology, College of Applied Sciences-Hit, University Of Anbar, Anbar, Iraq
3 Department of Chemistry, College of Science, University Of Anbar, Anbar, Iraq
     

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This research includes synthesis of new heterocyclic derivatives of novel disubstituted 1,3- oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2,5-dione and 3-phenyldihydrofuran-2,5-dione. Schiff bases [A1- A5] were synthesized by the reaction of aromatic aldehydes with primary aromatic amines, in the presence of glacial acetic acid as catalyst in absolute ethanol. The novel derivatives[A6-A10] were obtained from treatment of Schiff bases with anhydrides. The synthesized compounds were identified by TLC and via spectral methods, their (FT-IR, 1H-NMR and 13C-NMR) and measurements of some of its physical properties.

Keywords

1H-NMR, 13C-NMR, TLC, Schiff Bases, Oxazepine-Tetra-One.
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  • Preparation and Characterization of Novel Disubstituted 1,3- Oxazepinetetra- One from Schiff Bases Reaction with 3-Methylfuran-2,5-Dione and 3- Phenyldihydrofuran-2,5-Dione

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Authors

Abdul Kareem Hamad Ayfan
Pharmacy College, University Of Anbar, Anbar, Iraq
Rasim Farraj Muslim
Department of Ecology, College of Applied Sciences-Hit, University Of Anbar, Anbar, Iraq
Noor Sabah Noori
Department of Chemistry, College of Science, University Of Anbar, Anbar, Iraq

Abstract


This research includes synthesis of new heterocyclic derivatives of novel disubstituted 1,3- oxazepine-tetra-one from Schiff bases reaction with 3-methylfuran-2,5-dione and 3-phenyldihydrofuran-2,5-dione. Schiff bases [A1- A5] were synthesized by the reaction of aromatic aldehydes with primary aromatic amines, in the presence of glacial acetic acid as catalyst in absolute ethanol. The novel derivatives[A6-A10] were obtained from treatment of Schiff bases with anhydrides. The synthesized compounds were identified by TLC and via spectral methods, their (FT-IR, 1H-NMR and 13C-NMR) and measurements of some of its physical properties.

Keywords


1H-NMR, 13C-NMR, TLC, Schiff Bases, Oxazepine-Tetra-One.

References