Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Hair Tonic Formulation of Anti-alopecia of Angiopteris evecta Extract


Affiliations
1 Pharmaceutical Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
2 Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
     

   Subscribe/Renew Journal


Synthetic cosmetic products have been used to unravel the problem of alopecia, yet synthetics are potential to give side effects such as local irritation), whilst herbal products are generally safer. Our previous research showed that water fraction of Angiopteris evecta extract had been proved as had growth hair characteristic. The aim of this study was to formulate hair tonic from water fraction of A.evecta extract which was stable, effective towards hair growth, and safe. The water fraction was into varied of 7.5%, 10.0, and 12.5%. Physical stability test performed was cycling test, storage in high temperature (40°C ± 2°C), room temperature (25°C ± 2°C), and low temperature (4°C ± 2°C). The activity of hair growth test was conducted by hair length measurements using rabbit based on Tanaka method on day 3, 6, 9, 12, 15 and 18 days. Results showed the hair tonic was stable in storage. In addition to giving hair growth activity, the formula had greater activity equal and higher activity compared to controlled minoxidil synthetic drug. The hair tonics were safe and did not irritate skin. The best formulation was formula F3 with a water fraction of 10.0%. It is suggested to carry our hair growth test to bald volunteers in order to verify the effectiveness of this formula before it could be marketed.

Keywords

Angiopteris evecta, Hair Tonic, Formulation, Anti-Alopecia, Hair Growth, Minoxidil.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Dalimartha S. Atlas of Indonesian Medicinal Plants, Volume 5. Jakarta: Puspa Swara, 2006

  • Stough D, Stenn K, Haber R, Parsley WM, Vogel JE, Whiting DA, Washenik K. Mayo Clin Proc., 2005; 80(10): 1316-22

  • Rossi A, Iorio A, Scarno M, Fortuna MC, Priolo L, Di Nunno D, et.al. Use of topical Minoxidil, 17α-Estradiol and hydrocortisone butyrate in frontal fibrosing alopecia, European Journal of Inflammation 2014; 12(2): 399-404

  • Goenka S. 10 Best Hair Growth Tonics That Actually Work – 2018. Available from: https://www.stylecraze.com/articles/best-hair-growth-tonics/#gref (Accessed on October 27, 2018)

  • Amin J, Simamora ELP, Anwar E, Djajadisastra J. Green tea (Camellia sinensis L.) ethanolic extract as hair tonic in nutraceutical: Physical stability, hair growth activity on rats, and safety test, Int J Pharm Pharm Sc 2014; 6(5): 94-9

  • Esfandiari A, & Kelly AP. The effects of tea polyphenolic compounds on hair loss among rodents. J Natl Med Assoc 2005;97:1165–9

  • Kim KHA, Kwon OS, Han JH, Yoo HG, Chung JH, Cho KH, et al. Human hair growth enhancement in vitro by green tea epigallocatechin-3-gallate (EGCG). Phytomedicine 2007;14:551–5

  • Asyarie S, Immaculata MI, Triwahyuni E. Formulation of Green Tea and Celery Extract Gel and Test Its Benefits to Hair Growth. Acta Pharmaceutica Indonesia 2007;32:12-7

  • Sulastri L, Indrawati T, and Taurhesia S. Test of Hair Fertilizer Combination of Green Tea and Centella Herba Tea Extract (Indonesian: Uji Aktivitas Penyubur Rambut Kombinasi Ekstrak Air Teh Hijau dan Herba Pegagan), Pharmaciana. 2016; 6(1): 36-49

  • Mustarichie R, Indriyati W, Mukmin A, and Ramdhani D. Activity of Angiopteris evecta for baldness treatment. J Chem Pharm Res. 2016; 8: 821-30

  • Tanaka S, Saito M, Tabata M. Bioassay of Crude Drugs for HairGrowth Promoting Activity in Mice by a New Simple Method, Planta Med 1980; 40: 84-90

  • Federer WT. Randomization and sample size in experimentation. 1966. Available from: https://core.ac.uk/download/pdf/79037489.pdf (Accessed on July 20, 2018)

  • Farnsworth NR. Biological and phytochemical screening of plants. J Pharm Sci. 1966; 55: 225-276.

  • Mustarichie R, Runadi D, Ramdhani D. The Antioxidant Activity and Phytochemical Screening of Ethanol Extract, Fractions of Water, Ethyl Acetate and n-Hexane from Mistletoe tea (Scurrula atropurpurea BL. Dans), Asian J Pharm Clin Res, 2017; 10(2): 1-5

  • Departemen Kesehatan RI. Farmakope Herbal Indonesia 1st Ed. 2008: p.157-78

  • BPOM RI. Monografi Ekstrak Tumbuhan Obat Indonesia. Volume I. Jakarta: BPOM RI. 2004: p. 83-84

  • Tanaka S, Saito M, Tabata M. Bioassay of Crude Drugs for HairGrowth Promoting Activity in Mice by a New Simple Method, Planta Med 1980; 40: 84-90

  • Mottram FJ and Lees CE. Hair treatments in POUCHER's Perfumes, Cosmetics, and soaps (Edited by Hilda Butler) 10 the Ed, Kluwer Academic Publisher 2000: p. 255-290

  • Rowe RC, Sheskey PJ, Quinn ME. Handbook of Pharmaceutical Excipients, 6th Ed., London: Pharmaceutical Press, 2009.

  • Wright DB. Comparing groups in a before-after design: When t-test and ANCOVA produce different results. British Journal of Educational Psychology, 2006; 76, 663-675

  • Sig F. Post Hoc Tests in ANOVA. Available from: https://pages.uoregon.edu/stevensj/posthoc.pdf (Accessed on January 15, 2018)

  • Wahyuni R, Guswandi G, and Rivai H. Effect of Drying With Oven, Dry Wind and Sunlight Directly To Quality Simplicia (Indonesian: Pengaruh Cara Pengeringan Dengan Oven, Kering Angin Dan Cahaya Matahari Langsung Terhadap Mutu Simplisia), Jurnal Farmasi Higea 2017; 6(2): 126-33

  • Abah SE and Egwari LO. Methods of Extraction and Antimicrobial Susceptibility Testing of Plant Extracts. African Journal Of Basic & Applied Sciences 2011; 3 (5): 205-9

  • Sapri AF and Narulita R. Effects of Soybean Powder on Soursop Ethanol Extract Yields (Annona muricata L.) Using Maceration Method (Indonesian: Pengaruh Ukuran Serbuk Simplisia Terhadap Rendemen Ekstrak Etanol Daun Sirsak (Annona muricata L.) Dengan Metode Maserasi), Prosiding Seminar Nasional Kimia 2014: 1-4

  • Maulida R and Guntarti A. Influence of Black Rice Particle Size (Oryza sativa L.) Against Extract Yields And Total Content of Anthocyanin (Indonesian: Pengaruh Ukuran Partikel Beras Hitam (Oryza sativa L.) Terhadap Rendemen Ekstrak Dan Kandungan Total Antosianin), Pharmaҫiana 2015; 5(1):9-16

  • Sa'adah H and Nurhasnawati H. 2015. Comparison of Ethanol and Water Solvents in Making Tiwai Onion Bulbs Extract (Eleutherine americana Merr) Using the Maceration Method. Jurnal Ilmiah Manuntung, 2015; 1(2): 149-53

  • Susanti NMP, Budiman INA, Warditiani NK. Phytochemical screening of katuk (Sauropus androgynus (L.) leaves ethanol 90% extract (Indonesian: Skrining fitokimia ekstrak etanol 90% katuk (Sauropus androgynus (L.) Merr.) leaves, Jurnal Farmasi Udayana 2014; 3: 83-6

  • Mismawati A, Sri Suwannaket C, Mingvanish W, Kuspradini H, Kusuma IW, Niamnont N. Phytochemical screening and bioactivity of Angiopteris evecta leaves from East Kalimantan, Pure and Applied Chemistry International Conference 2015 (PACCON2015). P. 1-4

  • Molla MF, Rahman S, Bashar ABMA, Rahmatullah M. Phytochemical screening and pharmacological studies with angiopteris evecta, World Journal of Pharmaceutical Research 2014, 3(8), 105-15

  • Saleride C, Paul Raj K, and Johnson M. Phytochemical profiles of Adiantum latofolium Lam., Angiopteris evecta (Forst) Hoffffm. And Maratttia fraxinea SM, European Journal of Biomedical and Pharmaceutical Sciences 2017; 4(12): 571-5

  • Rahmawati RP and Mustarichie R. Determination of anti-alopecia compounds from water fraction of the Angiopteris evecta (G. Forst.) Hoffm. L ischolar_mains, Drug Invention Today 2018; 10(9): 1869-75

  • Yazid E. Paramedic physical chemistry (Indonesian: Kimia Fisika Paramedis). Yogyakarta: Andi, 2005: p. 127-9

  • Microchemlab. Freeze-Thaw Stability Testing. Available from: http://microchemlab.com/test/freeze-thaw-stability-testing (Accessed on January 10, 2018)

  • Septiani SN, Wathoni N, Mita SR. Formulation of Masks of Antioxidant Gel from Melinjo Seed Ethanol Extract (Gnetum gnemon Linn.) 2012. Available from: http://jurnal.unpad.ac.id/ejournal/article/view/1175/1159 (Accessed on September 12, 2018)

  • IBM SPSS Statistic 24. Available from: https://ad4msan.com/ibm-spss-statistic-24 (Accessed on January 7, 2018)

  • Purwal L, Gupta SPBN, and Pande MS. Development and Evaluation of Herbal Formulations for Hair Growth, E-Journal of Chemistry 2008; 5(1): 34-8

  • Sekar M, Vishnu Priya N, Ramesh R, Suresh Kumar G, Divya Bharati A, and Abidha afsha S. Formulation and evaluation of hair tonic from ziziphus jujuba leaf extract, IJPCBS 2016, 6(4), 447-54

  • Badhe N, Shirode L, Lale S. Formulation and Evaluation of Herbal Hair Tonic, Research J. Topical and Cosmetic Sci. 2015; 6(2): 86-90

  • Chakraborty A, Bhattacharjee A, Sodani A, Jain D, Mukhopadhyay G and Sepay N. Herbal Hair Gel Formulation having 5α-Reductase Inhibitory Activity and its Standardization by HPTLC, J Anal Bioanal Tech 7: 341. doi: 10.4172/2155-9872.1000341

  • Punjani B and Kumar V. Plants used in traditional phytotherapy for hair care by tribals in Sabarkantha district, Gujarat, India, Indian Journal of Traditional Knowledge 2003; 2(1): 74-8.


Abstract Views: 248

PDF Views: 0




  • Hair Tonic Formulation of Anti-alopecia of Angiopteris evecta Extract

Abstract Views: 248  |  PDF Views: 0

Authors

Dolih Gozali
Pharmaceutical Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Resmi Mustarichie
Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia

Abstract


Synthetic cosmetic products have been used to unravel the problem of alopecia, yet synthetics are potential to give side effects such as local irritation), whilst herbal products are generally safer. Our previous research showed that water fraction of Angiopteris evecta extract had been proved as had growth hair characteristic. The aim of this study was to formulate hair tonic from water fraction of A.evecta extract which was stable, effective towards hair growth, and safe. The water fraction was into varied of 7.5%, 10.0, and 12.5%. Physical stability test performed was cycling test, storage in high temperature (40°C ± 2°C), room temperature (25°C ± 2°C), and low temperature (4°C ± 2°C). The activity of hair growth test was conducted by hair length measurements using rabbit based on Tanaka method on day 3, 6, 9, 12, 15 and 18 days. Results showed the hair tonic was stable in storage. In addition to giving hair growth activity, the formula had greater activity equal and higher activity compared to controlled minoxidil synthetic drug. The hair tonics were safe and did not irritate skin. The best formulation was formula F3 with a water fraction of 10.0%. It is suggested to carry our hair growth test to bald volunteers in order to verify the effectiveness of this formula before it could be marketed.

Keywords


Angiopteris evecta, Hair Tonic, Formulation, Anti-Alopecia, Hair Growth, Minoxidil.

References