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Hair Tonic Formulation of Anti-alopecia of Angiopteris evecta Extract


Affiliations
1 Pharmaceutical Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
2 Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
     

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Synthetic cosmetic products have been used to unravel the problem of alopecia, yet synthetics are potential to give side effects such as local irritation), whilst herbal products are generally safer. Our previous research showed that water fraction of Angiopteris evecta extract had been proved as had growth hair characteristic. The aim of this study was to formulate hair tonic from water fraction of A.evecta extract which was stable, effective towards hair growth, and safe. The water fraction was into varied of 7.5%, 10.0, and 12.5%. Physical stability test performed was cycling test, storage in high temperature (40°C ± 2°C), room temperature (25°C ± 2°C), and low temperature (4°C ± 2°C). The activity of hair growth test was conducted by hair length measurements using rabbit based on Tanaka method on day 3, 6, 9, 12, 15 and 18 days. Results showed the hair tonic was stable in storage. In addition to giving hair growth activity, the formula had greater activity equal and higher activity compared to controlled minoxidil synthetic drug. The hair tonics were safe and did not irritate skin. The best formulation was formula F3 with a water fraction of 10.0%. It is suggested to carry our hair growth test to bald volunteers in order to verify the effectiveness of this formula before it could be marketed.

Keywords

Angiopteris evecta, Hair Tonic, Formulation, Anti-Alopecia, Hair Growth, Minoxidil.
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  • Hair Tonic Formulation of Anti-alopecia of Angiopteris evecta Extract

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Authors

Dolih Gozali
Pharmaceutical Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Resmi Mustarichie
Pharmaceutical Analysis and Medicinal Chemistry Department, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia

Abstract


Synthetic cosmetic products have been used to unravel the problem of alopecia, yet synthetics are potential to give side effects such as local irritation), whilst herbal products are generally safer. Our previous research showed that water fraction of Angiopteris evecta extract had been proved as had growth hair characteristic. The aim of this study was to formulate hair tonic from water fraction of A.evecta extract which was stable, effective towards hair growth, and safe. The water fraction was into varied of 7.5%, 10.0, and 12.5%. Physical stability test performed was cycling test, storage in high temperature (40°C ± 2°C), room temperature (25°C ± 2°C), and low temperature (4°C ± 2°C). The activity of hair growth test was conducted by hair length measurements using rabbit based on Tanaka method on day 3, 6, 9, 12, 15 and 18 days. Results showed the hair tonic was stable in storage. In addition to giving hair growth activity, the formula had greater activity equal and higher activity compared to controlled minoxidil synthetic drug. The hair tonics were safe and did not irritate skin. The best formulation was formula F3 with a water fraction of 10.0%. It is suggested to carry our hair growth test to bald volunteers in order to verify the effectiveness of this formula before it could be marketed.

Keywords


Angiopteris evecta, Hair Tonic, Formulation, Anti-Alopecia, Hair Growth, Minoxidil.

References