Research Journal of Pharmacy and Technology

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Novel Floating Insitu gel of Antihyperlipidemic Agent


Affiliations
1 Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, India
     

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Simvastatin is an antihypertensive agent used in treatment of hyperlipidemia. It has very short biological half life and it undergoes extensive first pass metabolism. The aim of present work is formulation and characterization of Gastroretentive Insitu gel based system of simvastatin. Different polymers like gellan gum, sodium alginate and HPMC were screened at different concentration to arrive at optimized formulation. Formulations were screened based on invitro gelling time and behavior and drug release. All the batches were evaluated for pH, viscosity, floating lag time and total floating time, water uptake The optimized batch (F8) followed the release as per Korsemeyer-Peppas model and drug release from the formulation can be best explained by the Higuchi model due to highest R-square value among all the models.

Keywords

Simvastatin, gastroretentive, insitu Gel.
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  • Novel Floating Insitu gel of Antihyperlipidemic Agent

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Authors

S. R. Singh
Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, India
K. R. Jadhav
Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, India
P. K. Tripathi
Dr. L. H. Hiranandani College of Pharmacy, Opp. Ulhasnagar Railway Station, Ulhasnagar, Maharashtra, 421003, India

Abstract


Simvastatin is an antihypertensive agent used in treatment of hyperlipidemia. It has very short biological half life and it undergoes extensive first pass metabolism. The aim of present work is formulation and characterization of Gastroretentive Insitu gel based system of simvastatin. Different polymers like gellan gum, sodium alginate and HPMC were screened at different concentration to arrive at optimized formulation. Formulations were screened based on invitro gelling time and behavior and drug release. All the batches were evaluated for pH, viscosity, floating lag time and total floating time, water uptake The optimized batch (F8) followed the release as per Korsemeyer-Peppas model and drug release from the formulation can be best explained by the Higuchi model due to highest R-square value among all the models.

Keywords


Simvastatin, gastroretentive, insitu Gel.

References