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A Facile and An Efficient Synthesis of 3,3-Disubstituted Oxindole Scaffolds and their Cytotoxic Properties
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A facile and an efficient synthesis of 3,3-disubstituted oxindole derivatives were synthesised by treating isatins with electron rich benzene derivatives at room temperature. The compounds were evaluated for cytotoxic activity against human breast cancer cells (MCF7) and human ovarian carcinoma cells (SKVO3) by using MTT assay. Compounds 5(9.2μM and 9.5μM) and 7(8.0μM and 10.4μM) exhibited relatively higher cytotoxic activity against both MCF7 and SKVO3 cell lines, respectively.
Keywords
Isatins, Methoxy Benzenes, Boron Trifluoride Diethyl Etherate, MCF7 and SKVO3.
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