Research Journal of Pharmacy and Technology

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The GC MS Study of one Ayurvedic Medicine, Aragwadharishtam


Affiliations
1 Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600092, India
2 Department of Anatomy, Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600 092, India
3 Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
4 Central Research Facility, Sri Ramachandra Medical College and Research Institute, Purur, Chennai - 600116, India
5 Ayurvedic Practitioner, Kottakkal Arya Vaidya Sala, Chennai, India
     

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Aragwadharishtam is an Ayurvedic preparation used mainly to detoxify the body. Its main use is in the cure of skin diseases, ulcers and piles. The present study deals with the GC MS analysis of Aragwadharishtam to know the presence of phytochemicals present in this medicine. The GC MS profile indicated the presence of some very important molecules such as Phnylethyl alcohol, Ethyl hydrogen succinate, Butanedioic acid diethyl ester, 4-Ethyl-2-hydroxycyclopent-2-en-1-one, Eugenol, Ethyl gallate, 1,2,3- Benzenetriol, Benzeethanol,4-hydroxy-, Hexadecanoic acid, 2-hydroxy -1-(hydroxymethyl) ethyl ester and Octadecanoic acid, 2,3-hydroxypropyl ester etc. These molecules have a number of important medicinal roles which could substantiate their participation towards the medicinal activity of Aragwadharishtam as a detoxifying formula as claimed by Ayurveda. However, further work in this direction is warranted to prove the medicinal efficacy of the medicine.

Keywords

Aragwdharishtam, Ayurvedic, GC MS, Phnylethyl Alcohol, Ethyl Hydrogen Succinate, Butanedioic Acid Diethyl Ester, 4-Ethyl-2-Hydroxycyclopent-2-en-1-One, Eugenol.
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  • Aarti V. Pawar, Sayali J Patil, Suresh G. Killedar. Uses of Cassia fistula Linn as a Medicinal Plant. International Journal of Advance Research and Development. 2017; 2(3): 85-91.

  • Ali M. Cassia fistula Linn: a review of phytochemical and pharmacological studies. Int. J of Pharm Sci and Res, 2014; 5(6): 2125-2130

  • Dutta A, De B, Seasonal variation in the content of sennosides and rhein in leaves and pods of Cassia fistula, Ind. J. Pharmacol. Sci., 1980; 60: 388-390.

  • Souravi K, Rajasekharan PE. Ethnopharmacological Uses of Embelia ribes Burm. F. A Review. IOSR Journal of Pharmacy and Biological Sciences. 2014; 9(3):23-30.

  • Bhide MM, Nitave SA. Roles of Embelica officinalis (Amla) in medicine. World Journal of Pharmacy and Pharmaceutical Sciences, 2014; 3(6):604-615.

  • Dasaroju S, Gottumukkala KM. Current Trends in the Research of Emblica officinalis (Amla): A Pharmacological 1. Perspective. Int J Pharm Sci Rev Res, 2014; 24(2): 150.

  • Bag A, Bhattacharya SK, Chattopadhyay RR. The development of Terminalia chebula Retz. (Combretaceae) in clinical research. Asian Paci J Tropical Biomed, 2013; 3(3):244.

  • Sweta Gupta and Akash Ved. Operculina turpethum (Linn.) Silva Manso as a Medicinal Plant Species: A Review on Bioactive Components and Pharmacological Properties. Pharmacogn Rev, 2017; 11(22): 158–166.

  • Alam JM, Alam I, Sharmin AS, Rahman MM, Anisuzzaman M, Alam FM. Micropropagation and antimicrobial activity of Operculina turpethum (syn. Ipomoea turpethum), an endangered medicinal plant. Plant Omics. 2010; 3: 40–6

  • Kostova I, Bhatia S, Grigorov P, Balkansky S, Parmar VS, Prasad AK, et al. Coumarins as antioxidants. Curr Med Chem. 2011; 18: 3929–51.

  • Kumari S, Meena AK, Shukla VJ, Ota S, Rao MM. Quality assessment of Ipomoea species plants by HPTLC. J Anal Chem. 2010; 1:1-8.

  • Prabhavathi NB, Kowsalya B, Kumar SR, Sravani BJ, Sri GD, Sakila A, et al. Analgesic activity of different solvent extract of Operculina turpethum by using swiss albino mice. Asian J Pharm Clin Res. 2012; 5:215–8.

  • Sharma V, Singh M. Non-opiodergic like mechanism for antinociceptive analgesic and antipyretic activity of ethanolic ischolar_main extract of Operculina turpethum in swiss albino mice. Int J Pharm Bio Sci. 2013; 4:104–2.

  • Venugopala KN, Rashmi V, Odhav B. Review on natural Coumarin lead compounds for their pharmacological activity. Biomed Res Int. 2013; 2013:1–14.

  • Anbuselvam C, Vijayavel K, Balasubramanian MP. Protective effect of Operculina turpethum against 7,12-dimethyl benz (a) anthracene induced oxidative stress with reference to breast cancer in experimental rats. Chem Biol Interact. 2007; 168: 229–36.

  • Kumar SV, Sujatha C, Syamala J, Nagasudha B, Mishra SH. Protective effect of ischolar_main extract of Operculina turpethum Linn. against paracetamol-induced hepatotoxicity in rats. Indian J Pharm Sci. 2006; 68:32–5.

  • Pulipaka S, Challa SR, Pingili RB. Comparative antidiabetic activity of Operculina turpethum stem and ischolar_main against healthy and streptozotocin induced diabetic rats. Int Curr Pharma J, 2012; 1:272–8.

  • Sharma V, Singh M. Attenuation of N-nitrosodimethylamine induced hepatotoxicity by Operculina turpethum in Swiss Albino mice. Iran J Basic Med Sci. 2014; 17:73–80.

  • Verma SK, Jain V, Katewa SS. Blood pressure lowering, fibrinolysis enhancing and antioxidant activities of cardamom (Elettaria cardamomum). Indian Journal of Biochemistry and Biophysics, 2009; 46(6): 503-506.

  • Khan A, Khan QJ, Gilani A. Pharmacological basis for the medicinal use of cardamom in asthma. Bangladesh J Pharmacol, 2011; 6: 34-37.

  • Gülçin I, Elmastas M, boul-Enein HY. Antioxidant activities of clove oil- A powerful antioxidant source. Arab J Chem, 2012; 5(4): 489-499.

  • Shamkuwar PB, Shahi SR, Jadhav ST. Evaluation of anti-diarrheal effect of Black pepper (Piper nigrum L.). Asian Journal of Plant Science and Research, 2012; 2(1): 48-53.

  • Gruenwald J. Medicines PDR for Herbal. 1st Ed. Physician’s Desk Reference Inc., Montvale,

  • New Jersey, 1998; 850-852.

  • Sharma P.C. et al., Medicinal Plants Used in Ayurveda. Central Council of Ayurveda and

  • Siddha, New Delhi, India. 2002.

  • Meghwal M, Goswami TK. Chemical Composition, Nutritional, Medicinal and

  • Functional Properties of Black Pepper: A Review. 1; 2012: 172. doi:10.4172/scientificreports.17.

  • Lee SJ, Han JI, Le GS, Park MJ, Ghoi IG, Na KJ, Jeung EB. Antifungal effect of engenol and nerolidol against Microsporum gypseum in a guinea pig model. Biol Pharm Bull., 2007; 30: 184-188.

  • Gulcin I. Antioxidant activity of eugenol: A structure –activity relationship study. Journal of Medicinal Food, 2011; 14(9): 975-985

  • Dallmeier K, Carlini CA. Anesthetic, Hypothermic, myo-relaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues. Pharmacology, 1981; 22: 113-127

  • Zheng GQ, Kenney PM, Lam LK. Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod, 1992; 55: 999-1003

  • Brodin P, Roed A. Effects of eugenol on rat phrenic nerve and phrenic nerve-diaphragm preparations. Arch Oral Biol, 1984; 611-615

  • Pandey BN, Lathika KM, Mishra KP. Modification of radiation induced oxidative damage in liposormal and microsomal membrane by eugenol. Rad Physics Chem, 2006; 75: 384-391.

  • Okada N, Hirata A, Murakami Y, Shoji M, Sakagami H, Fujisawa S. Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression by eugenol-related compounds. Anticancer Res., 2005; 25: 3263-3270.


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  • The GC MS Study of one Ayurvedic Medicine, Aragwadharishtam

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Authors

Hassan Mohammad
Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600092, India
K. Prabhu
Department of Anatomy, Sree Balaji Medical College and Hospital, Bharath University, Chrompet, Chennai - 600 092, India
Mudiganti Ram Krishna Rao
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
R. Lakshmi Sundaram
Central Research Facility, Sri Ramachandra Medical College and Research Institute, Purur, Chennai - 600116, India
Sampad Shil
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
N. Vijayalakshmi
Department of Industrial Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India
Sruthi Dinakar
Ayurvedic Practitioner, Kottakkal Arya Vaidya Sala, Chennai, India

Abstract


Aragwadharishtam is an Ayurvedic preparation used mainly to detoxify the body. Its main use is in the cure of skin diseases, ulcers and piles. The present study deals with the GC MS analysis of Aragwadharishtam to know the presence of phytochemicals present in this medicine. The GC MS profile indicated the presence of some very important molecules such as Phnylethyl alcohol, Ethyl hydrogen succinate, Butanedioic acid diethyl ester, 4-Ethyl-2-hydroxycyclopent-2-en-1-one, Eugenol, Ethyl gallate, 1,2,3- Benzenetriol, Benzeethanol,4-hydroxy-, Hexadecanoic acid, 2-hydroxy -1-(hydroxymethyl) ethyl ester and Octadecanoic acid, 2,3-hydroxypropyl ester etc. These molecules have a number of important medicinal roles which could substantiate their participation towards the medicinal activity of Aragwadharishtam as a detoxifying formula as claimed by Ayurveda. However, further work in this direction is warranted to prove the medicinal efficacy of the medicine.

Keywords


Aragwdharishtam, Ayurvedic, GC MS, Phnylethyl Alcohol, Ethyl Hydrogen Succinate, Butanedioic Acid Diethyl Ester, 4-Ethyl-2-Hydroxycyclopent-2-en-1-One, Eugenol.

References