Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Hypolipidemic Activity of Stem Bark of Ailanthus excelsa Roxb in Triton WR 1339 Induced Hyperlipidemic Rats


Affiliations
1 Department of Pharmacognosy, Smt. Vidyawati College of Pharmacy, Jhansi, India
2 School of Pharmacy, ITM University, Gwalior, India
3 Institute of Biomedical Science, Bundelkhand University, Jhansi, India
     

   Subscribe/Renew Journal


Ailanthus excelsa, Roxb (Family-Simaroubaceae) commonly known as “Mahaneem” is a large deciduous tree with rough and light grey stem bark. It has a large panel of indications to evaluate its stem bark as it contains variety of important phytoconstituents which are used in treating diarrhoea, dysentery, cholera, astringent, febrifuge, anthelmintic and liver tonic. Background: The stem bark of the Ailanthus excelsa, Roxb was investigated for hyperlipidemia related disorders which is one of the major risk factor of coronary heart disease and atherosclerosis Hypothesis / Purpose: The purpose of present investigation is the reduction of elevated lipid profiles through various prepared plant extracts in triton WR 1339 induced hyperlipidemic model. Study Design: In the present investigations, stem bark was collected, authenticated, extracted with solvent and in vivo studies in correlation with triton injected experimental animals were carried out in decreasing the elevated lipid profiles. Methods: The study pertains the hypolipidemic activity of ethanolic extract and its fractions of stem bark of Ailanthus excelsa, Roxb on triton WR 1339 induced hyperlipidemic model. Results: The results obtained are significant with fractionated part of ethonolic extract of Ailanthus excelsa Roxb (200 + 200 mg/kg) in lowering total cholesterol, triglycerides, High density lipoprotein, low density lipoprotein and Very low density lipoprotein. Conclusion: The observation enables to evaluate the biological and molecular approaches to restrain the adverse effects of cardiovascular disorder particularly complications related to lipidemia.

Keywords

Ailanthus excelsa, Roxb, Stem Bark, Atherosclerosis, Phytoconstituents, Hypolipidemic, Triton.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Brown MS., Goldstein JL., 1986.A receptor mediated pathway for cholesterol homeostasis. Science. ; 232:34–47. doi: 10.1126/ science.3513311.

  • Chaturvedi V., Bhargava B., 2007 Health care delivery for coronary heart disease in India: Where are we headed? Am Heart Hosp J; 5:32–7.

  • Kirtikar, K.R. and Basu, B.D., 1976. Indian Medicinal Plants, 2nd edition, Plates series M/s Bishwas Singh, N.P. Singh, Dehradun, 855, 878,

  • Kumar, D., Bhujbal S.S., Patil P.S., and Buge P.V., 2010 .In vitro and in vivo activities of stem bark of methanolic extract of Ailanthus excelsa Roxb. In the management of asthma. Int. J. Pharmacol., 6, 284-289.

  • Kumar V., Singh S., Khanna AK., Khan MM., Chander R., Mahdi F., Saxena JK., Singh S., Singh R., Singh RK., 2008.Hypolipidemic activity of Anthocephalus indicus (Kadam) in hyperlipidemic rats. Med Chem Res. ;17:152–158. doi: 10.1007/s00044-007-9045-4.

  • Nitayanand, S., and Kapoor N.K.., 1971 Antihyperlipidemic effect of diabetic rats by ischolar_mains of Cyprus rotandus Ind. J.Exp. Biol., 9,376.

  • Patil UK., Saraf S., Dixit VK., 2004. Hypolipidemic activity of seeds of Cassia tora Linn. J Ethnopharmacol.. 90: 249–252. doi: 10.1016/j.jep.2003.10.007.

  • Rall TW., Goodman and Gilllman's., 1990. The Pharmacological basis of therapeutics. In: Gillman AG, Rall TW, Nies AS, Taylor P, editors. New York: Pergamon Press.

  • Schurr PE., Schultz JR., Parkinson TM., 1972. Triton induced hyperlipidemia in rats as an animal model for screening of hypolipermic drugs. Lipids. ;7:68–74. doi: 10.1007/BF02531272.

  • Verma S.K., and Bordia, 1988. Hypolipidemic effect of Zingeber officinale on Triton induced hyperlipidemia. Ind. J. Med. Res., 87,356.

  • Vogel’s I.J., 1998.Drug discovery and Evaluation, 10th Edition, 1106-1107.

  • Woodson RF., 1957.Statistical methods for the analysis of biochemical data. Chichester: Wiley; .P. 315.


Abstract Views: 205

PDF Views: 0




  • Hypolipidemic Activity of Stem Bark of Ailanthus excelsa Roxb in Triton WR 1339 Induced Hyperlipidemic Rats

Abstract Views: 205  |  PDF Views: 0

Authors

Srivastava Vaibhav
Department of Pharmacognosy, Smt. Vidyawati College of Pharmacy, Jhansi, India
Dubey Subodh
School of Pharmacy, ITM University, Gwalior, India
Singh Vigyan
Institute of Biomedical Science, Bundelkhand University, Jhansi, India

Abstract


Ailanthus excelsa, Roxb (Family-Simaroubaceae) commonly known as “Mahaneem” is a large deciduous tree with rough and light grey stem bark. It has a large panel of indications to evaluate its stem bark as it contains variety of important phytoconstituents which are used in treating diarrhoea, dysentery, cholera, astringent, febrifuge, anthelmintic and liver tonic. Background: The stem bark of the Ailanthus excelsa, Roxb was investigated for hyperlipidemia related disorders which is one of the major risk factor of coronary heart disease and atherosclerosis Hypothesis / Purpose: The purpose of present investigation is the reduction of elevated lipid profiles through various prepared plant extracts in triton WR 1339 induced hyperlipidemic model. Study Design: In the present investigations, stem bark was collected, authenticated, extracted with solvent and in vivo studies in correlation with triton injected experimental animals were carried out in decreasing the elevated lipid profiles. Methods: The study pertains the hypolipidemic activity of ethanolic extract and its fractions of stem bark of Ailanthus excelsa, Roxb on triton WR 1339 induced hyperlipidemic model. Results: The results obtained are significant with fractionated part of ethonolic extract of Ailanthus excelsa Roxb (200 + 200 mg/kg) in lowering total cholesterol, triglycerides, High density lipoprotein, low density lipoprotein and Very low density lipoprotein. Conclusion: The observation enables to evaluate the biological and molecular approaches to restrain the adverse effects of cardiovascular disorder particularly complications related to lipidemia.

Keywords


Ailanthus excelsa, Roxb, Stem Bark, Atherosclerosis, Phytoconstituents, Hypolipidemic, Triton.

References