Research Journal of Pharmacy and Technology

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Applications of Magnetically Modulated Systems


Affiliations
1 Nirmala College of Pharmacy, Department of Pharmaceutics, Muvattupuzha, Kerala, India
     

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Magnetically modulated system is a promising targeted drug delivery approach which uses an external magnetic field to control the delivery of drug at a specific site avoiding other cellular toxicities. These magnetic particles have the ability to accumulate at a desired site by the guidance of an external magnetic field. So, magnetically modulated materials can be used for diagnostic and targeted drug delivery approaches. This review describes about various applications of magnetically modulated system. Magnetic nanoparticles can be used in a wide variety of applications ranging from contrast agents for magnetic resonance imaging to the destruction of cancer cells via hyperthermia treatment and targeted therapy. Superparamagnetic nanoparticles are promising candidates for gene delivery. The immobilization of enzymes on magnetic nanoparticles helps to increase the enzyme activity and stability which enhances their applicability in bioreactors and biosensors. Magnetically responsive microspheres can be used in bio-separation techniques to remove cells and molecules. Magnetic bead-based immunoassay can be applied to bio-molecule detection and analysis systems. Magnetic polymeric microspheres have the capacity to bind biological molecules which helps to separate RBC from the whole blood. Magnetic arterial embolization hyperthermia can target liver cancers through duel effects of local hyperthermia and arterial embolization. Magnetic nanoparticles is also a good tool for the treatment of water polluted with metal and organic materials.

Keywords

Magnetite, Superparamagnetic Iron Oxide Nanoparticles, Magnetic Targeting, Nanomagnetosols, Magnetic Resonance Imaging.
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  • Enriquez G, Rizvi SA, D’Souza MJ, Do DP et al. Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy. International Journal of Nanomedicine. 2013; 8:1393-02.

  • Naqvi S, Samim M, Dinda AK et al. Impact of magnetic nanoparticles in biomedical applications. Recent Patents on Drug Delivery and Formulation. 2009; 3(2):153-61.

  • Barakat NS. Magnetically modulated nanosystems: a unique drug delivery platform. Nanomedicine. 2009; 4(7).

  • Alexiou C, Tietze R, Schreiber E et al. Cancer therapy with drug loaded magnetic nanoparticles-magnetic drug targeting. Journal of Magnetism Magnetic Mater. 2011; 1404-07.

  • Liang PC, Chen YC, Chiang CF et al. Doxorubicin-modified magnetic nanoparticles as a drug delivery system for magnetic resonance imaging-monitoring magnet-enhancing tumor chemotherapy. International Journal of Nanomedicine. 2016; 11; 2021–37.

  • SabnisS, Sabnis NA, Raut S et al. Superparamagnetic reconstituted high-density lipoprotein nanocarriers for magnetically guided drug delivery. International Journal of Nanomedicine. 2017;12: 1453–64.

  • Eguchi H, Umemura M, Kurotani R et al. A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging. Scientific Reports. 2015; 5: 1-14.

  • Shi C, Thum C, Zhang Qet al. Inhibition of the cancer-associated TASK 3 channels by magnetically induced thermal release of Tetrandrine from a polymeric drug carrier. Journal of Controlled Release. 2016; 237: 50-60.

  • Vinod KR, Sridhar D, Sandhya S, Banji D, Reddy TR. Essentials of Pharmaceutical Product Development for Magnetically Modulated Drug Delivery Systems, A review. International Journal of Pharmaceutical Sciences and Nanotechnology. 2012; 4(4):1519-27.

  • Gkanas EI. In vitro magnetic hyperthermic response of iron oxide MNP’s incorporated in DA3, MCF-7 and HeLa cancer cell lines. Central European Journal of Chemistry. 2013; 11(7): 1042-54.

  • Sanchez J, Cortes-Hernandez DA, Jasso-Terran RA et al. Bioactive magnetic nanoparticles of Fe-Ga synthesized by sol-gel for their potential use in hyperthermia treatment. Journal of Materials Science: Materials in Medicine. 2014; 25: 2237-42.

  • Kawashita M, Li Z, Hiraoka M. Preparation of Size-Controlled Magnetite Nanoparticles for Hyperthermia of Cancer. Transaction of the Materials Research Society of Japan. 2009; 34[1]: 77-80.

  • Huang HS, Hainfeld JF. Intravenous magnetic nanoparticle cancer hyperthermia. International Journal of Nanomedicine. 2013; 3(8): 2521-32.

  • Sivakumar B, Aswathy RG, Sreejith R et al. Bacterial exopolysaccharide based magnetic nanoparticles: a versatile nanotool for cancer cell imaging, targeted drug delivery and synergistic effect of drug and hyperthermia mediated cancer therapy. Journal of Biomedical Nanotechnology. 2014; 10(6): 885-99.

  • Matsuoka F, Shinkai M, Honda H et al. Hyperthermia using magnetite cationic liposomes for hamster osteosarcoma. Bio Magnetic Research and Technology. 2004; 2(1): 3.

  • Balasubramanian S, Girija AR, Nagaoka Y et al. Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. International Journal of Nanomedicine. 2014; 9(1): 437-59.

  • Wang J, Chen Y, Chen B et al. Pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles in mice. International Journal of Nanomedicine. 2010; 5: 861–66.

  • Kong SD, Lee J, Ramachandran S et al. Magnetic targeting of nanoparticles across the blood brain barrier. Journal of Control Release. 2012; 164(1): 49-57.

  • Saiyed Z, Gandhi N, Nair MPN. Magnetic nanoformulation of azidothymidine 5’-triphosphate for targeted delivery across the blood brain barrier. International Journal of Nanomedicine. 2010; 5: 157-66.

  • Ding H, Sagar V, Agudelo M et al. Enhanced blood brain barrier transmigration using a novel transferrin embedded fluorescent magneto-liposome nanoformulation. Nanotechnology. 2014; 25(5): 055101.

  • Mu K, Zhang S, Ai T et al. Monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles for imaging of epidermal growth factor receptor- targeted cells and gliomas. Molecular Imaging. 2015; 14(4): 2-12.

  • Chertok B, David AE, Yang VC et al. Brain tumor targeting of magnetic nanoparticles for potential drug delivery: Effect of administration route and magnetic field topography. Journal of Control Release. 2011; 155(3): 393- 99.

  • Dames P, Gleich B, Flemmer AW, Rudolph C. Targeted delivery of magnetic aerosol droplets to the lungs. Nature Nanotech. 2007; 2(8): 1-5.

  • Sanna V, Singh CK, Jashari R et al. Targeted nanoparticles encapsulating (-)-epigallocatechin-3-gallate for prostate cancer prevention and therapy. Science Reports. 2017: 1-15.

  • Li C, Li L, Keates AC. Targeting cancer gene therapy with magnetic nanoparticles. Oncotarget. 2012; 3: 365-70.

  • Uthaman S, Lee ST, Cherukula K et al. Polysaccharide-coated magnetic nanoparticles for imaging and gene therapy. BioMed Research International. 2015: 1-14.

  • Wang Y, Cui H, Li K et al. A magnetic nanoparticle-based multiple gene delivery system for transfection of porcine kidney cells. Plos one. 2014; 9(7): 1-9.

  • Tang Y, Wang D, Zhang S. Bacterial magnetic particles as a novel and efficient gene vaccine delivery system. Gene Therapy. 2012; 19: 1187-95.

  • Przybylski S, Gasch M, Marschner Aet al. Influence of nanoparticle-mediated transfection on proliferation of primary immune cells in vitro and in vivo. Plos one. 2017: 1-16.

  • Davaran S, Akbarzadeh A, Nejati-Koshki K et al. In vitro studies of NIPAAM-MAA-VP copolymer coated magnetic nanoparticles for controlled anticancer drug release. 2013; 3: 108-15.

  • Ebrahimnezhad Z, Zarghami N, Keyhani M et al. Inhibition of hTERT gene expression by silibinin-loaded PLGA-PEG-Fe3O4 in T47D breast cancer cell line. Bioimpacts. 2013; 3(2): 67-74.

  • Das M, Wang C, Bedi R et al. Magnetic micelles for DNA delivery to rat brains after mild traumatic brain injury. Nanomedicine. 2014; 10(7): 1539-48.

  • Ghosh S, Ahmad R, Gautam VK, Khare SK et al. Cholesterol-oxidase-magnetic nanobioconjugates for the production of 4-cholesten-3-one and 4-cholesten-3, 7-dione. Bioresource Technology. 2018; 254: 91–96.

  • Xiao A, Xua C, Lin Y, Ni H et al. Preparation and characterization of κ-carrageenase immobilized onto magnetic iron oxide nanoparticles. Electronic Journal of Biotechnology. 2016; 19: 1–7.

  • Xiao A, Xiao Q, Lin Y et al. Efficient immobilization of agarase using carboxyl-functionalized magnetic nanoparticles as support. Electronic Journal of Biotechnology. 2017; 25: 13-20.

  • Liao MH, Chen DH. Immobilization of yeast alcohol dehydrogenase on magnetic nanoparticle for improving its stability. Biotechnology Letters. 2001; 23(20): 1723-27.

  • Huang SH, Liao MH, Chen DH. Direct binding and characterization of lipase on to magnetic nanoparticles. Biotechnology Progress. 2003; 19 (3): 1095-100.

  • Choi JW, Kwang W, Jennifer H et al. An integrated microfluidic biochemical detection system for protein analysis with magnetic bead based sampling capabilities. Royal Society of Chemistry. 2002; 2:27-37.

  • Petrakova AV, Urusov AE, Zherdev AV et al. Application of magnetic nanoparticles for the development of highly sensitive immunochromatographic test systems for mycotoxin detection. Applications of Biochemistry and Microbiology. 2017; 53: 420-26.

  • Chen Y, Xianyu Y, Wang Y et al. One-Step Detection of Pathogens and Viruses: Combining Magnetic Relaxation Switching and Magnetic Separation. ACS Nano. 2015; 9 (3):3184–91.

  • Bhalla N, Chung WYD, Wang K et al. Electrowetting enabled magnetic particle immunoassay with on-chip magnetic washing. IEEE Sensors. 2013.

  • Bhalla N, Chung DWY, Chang YJ et al. Microfluidic platform for enzyme-linked and magnetic particle-based immunoassay. Micromachines. 2013; 4: 257-71.

  • Kongsuphol P, Liu Y, Ramadan Q. On-chip immune cell activation and subsequent time-resolved magnetic bead-based cytokine detection. Biomedical Microdevices. 2016; 18(5): 93.

  • Bruls DM, Evers TH, Kahlman JA et al. Rapid integrated biosensor for multiplexed immunoassays based on actuated magnetic nanoparticles. Lab Chip. 2009; 9(24): 3504-10.

  • Dittmer WU, De Kievit P, Prins MW et al. Sensitive and rapid immunoassay for parathyroid hormone using magnetic particle labels and magnetic actuation. Journal of Immunological Methods. 2008; 338(1-2): 40-46.

  • Aytur T, Foley J, Anwar M et al. A novel magnetic bead bioassay platform using a microchip-based sensor for infectious disease diagnosis. Journal of Immunological Methods. 2006; 314(1-2): 21-29.

  • Svobodova Z, Jankovicova B, Krulisova P et al. On-chip ELISA on magnetic particles: isolation and detection of specific antibodies from serum. Nanocon. 2015: 1-6.

  • Chattopadhyay D, Sarkar K. Purification of quality DNA from citrus plant using iron oxide nanoparticles as solid support. Journal of Plant Development Sciences. 2018; 10(3): 149-56.

  • Shi R, Wang Y, Hu Y et al. Preparation of magnetite-loaded silica microspheres for solid-phase extraction of genomic DNA from soy-based foodstuffs. Journal of Chromatography. 2009; 1216: 6382-86.

  • Felinto MC, Parra DF, Lugao AB et al. Magnetic polymeric microspheres for protein adsorption. Nuclear Instruments and Methods in Physics Research Section B: Beam Interaction with Materials and Atoms. 2005; 236: 495-500.

  • Chatterjee J, Chen CJ. Modification and characterization of polystyrene-based magnetic microspheres and comparison with albumin-based magnetic microspheres. 2001; 225(1-2): 21-29.

  • Shen CR, Wu ST, Tsai ZT et al. Characterization of a quaternized chitosan imaging contrast agent for cell tracking. Polymer International. 2011; 60(6): 945-50.

  • Tsai ZT, Tsai FU, Yang WC et al. Preparation and characterization of ferrofluid stabilized with biocompatible chitosan and dextran sulfate hybrid biopolymer as a potential magnetic resonance imaging T2 contrast agent. Marine Drugs. 2012; 10(11): 2403-14.

  • Wang H, Fan TY. Preparation and evaluation of MRI detectable poly (acrylic acid) microspheres loaded with superparamagnetic iron oxide nanoparticles for trans catheter arterial embolization. International Journal of Pharmaceutics. 2016; 511(2): 831-39.

  • Li Z, Kawashita M, Araki N et al. Magnetic SiO2 gel microspheres for arterial embolization hyperthermia. Biomedical Materials. 2010; 5.

  • Li D, Wang K, Wang X et al. Magnetic arterial embolization hyperthermia mediated by carbonyl iron powder for liver carcinoma. World Congress Medicine Physics and Biomedical Engineering. 2012: 1624-27.

  • Shomura Y, Tanigawa N, Shibutani M et al. Water soluble polyvinyl alcohol (PVA) microspheres for temporary embolization: development and in vivo characterization in a pig kidney model. Journal of Vascular and Interventional Radiology. 2011.

  • Qiu S, Ge NJ, Sun DK et al. Synthesis and characterization of magnetic polyvinyl alcohol hydrogel microspheres for the embolization of blood vessels. Trans Biomed Eng. 2015; 63(4): 730-36.

  • Gregorio-Jauregui KM, Pineda MG, Rivera-Salinas JE et al. One-Step Method for Preparation of Magnetic Nanoparticles Coated with Chitosan. Journal of Nanomaterials 60. Podzus PE, Daraio ME, Jacobo SE. Chitosan magnetic microspheres for technological applications: preparation and characterization. Physica B: Condensed Matter. 2009; 404(18): 2710-12.

  • Reddy DH, Lee SM. Application of magnetic chitosan composites for the removal of toxic metal and dyes from aqueous solutions. Advanced Colloid Interface Science. 2013; 201-202: 68-93.

  • Yin Y, Wang J, Yang X, Li W. Removal of Strontium Ions by Immobilized Saccharomyces Cerevisiae in Magnetic Chitosan Microspheres. Nuclear Engineering and Technology. 2017; 49(1): 172-77.

  • Jain H, Panchal R, Pabla D et al. Magnetic Nanoparticles: As a Drug Targeting Carrier. Research Journal of Pharmacy and Technology. 2011; 4(7): 1040-45.

  • Magdum SV, Patil SV, Patil SS. Magnetic Nanoparticles for Cancer Therapy. Asian Journal of Pharmacy and Technology. 2017; 7(4): 251-60.

  • Jangde R. Magnetically Modulated Drug Delivery Systems: An Overview. Research Journal of Pharmacy and Technology. 2011; 4(11): 1649-57.

  • Jaiswal R, Singh S, Pande H. Magnetic Nanoparticles Activated Carbon: Preparation, Characterization and Application: A Review article. Asian Journal of Research in Chemistry. 2015; 8(12): 457-768.

  • Sonkamble SG, Tigote RM. Mild and Efficient Enamination of β-Dicarbonyl Compounds Catalyzed by Fe3O4 nanoparticles under Solvent-Free Conditions. Asian Journal of Research in Chemistry. 2014; 7(11): 899-904.

  • Seenuvasan M, Balaji N, Kumar MA. Review on Enzyme Loaded Magnetic Nanoparticles. Asian Journal of Pharmacy and Technology. 2013; 3(4): 200-208.

  • Ramya D, Varsha KR, Ranjitha V. Magnetic Nanoparticles as Versatile Carriers for Immobilization of Laccase. Research Journal of Engineering and Technology. 2013; 4(4): 279-283.

  • Ramankannan A, Suganthi RG, Balaji N, Seenuvasan M. Preparation and Characterization of Pectinase bound Co-precipitated Magnetic Nanoparticles. Asian Journal of Pharmacy and Technology. 2013; 3(40: 175-180.


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  • Applications of Magnetically Modulated Systems

Abstract Views: 237  |  PDF Views: 0

Authors

Dhanish Joseph
Nirmala College of Pharmacy, Department of Pharmaceutics, Muvattupuzha, Kerala, India
Maria Jose
Nirmala College of Pharmacy, Department of Pharmaceutics, Muvattupuzha, Kerala, India

Abstract


Magnetically modulated system is a promising targeted drug delivery approach which uses an external magnetic field to control the delivery of drug at a specific site avoiding other cellular toxicities. These magnetic particles have the ability to accumulate at a desired site by the guidance of an external magnetic field. So, magnetically modulated materials can be used for diagnostic and targeted drug delivery approaches. This review describes about various applications of magnetically modulated system. Magnetic nanoparticles can be used in a wide variety of applications ranging from contrast agents for magnetic resonance imaging to the destruction of cancer cells via hyperthermia treatment and targeted therapy. Superparamagnetic nanoparticles are promising candidates for gene delivery. The immobilization of enzymes on magnetic nanoparticles helps to increase the enzyme activity and stability which enhances their applicability in bioreactors and biosensors. Magnetically responsive microspheres can be used in bio-separation techniques to remove cells and molecules. Magnetic bead-based immunoassay can be applied to bio-molecule detection and analysis systems. Magnetic polymeric microspheres have the capacity to bind biological molecules which helps to separate RBC from the whole blood. Magnetic arterial embolization hyperthermia can target liver cancers through duel effects of local hyperthermia and arterial embolization. Magnetic nanoparticles is also a good tool for the treatment of water polluted with metal and organic materials.

Keywords


Magnetite, Superparamagnetic Iron Oxide Nanoparticles, Magnetic Targeting, Nanomagnetosols, Magnetic Resonance Imaging.

References