Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Review on Pathological State and Herbal Remedies on Ulcerative Colitis


Affiliations
1 Pharmacology, SRM College of Pharmacy, Kattankulathur - 603203, India
     

   Subscribe/Renew Journal


Ulcerative colitis (UC) is a persistent and non-specific sickness appeared typically within the rectum and therefore the entire colon, associated with abnormality of tissue layer towards the resident microorganisms along genital and environmental aspect. Typically presents with bloody diarrhea and is diagnosed by endoscopy and histological findings. Many varieties of medicines are tried to treat tenderness and decrease symptoms. The main aim of management is to induce and maintain remission outlined as resolution of manifestation and scrutiny healing. Herbal drugs add a good vary of remedy compared to western drugs. Though herbal medicines don’t seem to be void of risk, and secure than synthetic drugs. The possible benefits of herbal drugs might exist their huge approval by population owing to its effectiveness, safeness and comparatively lower price. People world wide embraced natural drugs which has been tested in many clinical trials. The evidences on herbal drugs are deficient, complicated and positively related to each risks and benefits there’s a necessity for any controlled clinical trials of the possible effectualness of herbal drugs approaches within the treatment of UC to expand their quality and safety.

Keywords

Herbal Drugs, Tenderness, Remedy, Symptoms, Histological Findings, Ulcerative Colitis.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Truelove SC et al . Cortisone in ulcerative colitis; final report on a therapeutic trial. BMJ. 1955; 2(4947):1041-1048.

  • Travis S et al. European evidence based Consensus on the management of ulcerative colitis: Current management. Journal of Crohns and Colitis. 2008; 2(1):24-62

  • www.spg.pt/wp-content/uploads/2015/11/2013-UC-management.pdf

  • https://www.medicalnewstoday.com/articles/163772.php

  • Sagar Garud and Mark A Peppercorn. Ulcerative colitis: Current Treatment Strategies and Future Prospects. Therapeutic advances in Gastroenterology. 2009 (3): 505-521.

  • Cornish JA, et al. The risk of oral contraceptives in the etiology of inflammatory bowel disease: a meta-analysis. Am J Gastroenterol. 2008;103:2394–2400.

  • Cutolo M, Capellino S, Sulli A, et al. Estrogens and autoimmune diseases. Ann N Y Acad Sci. 2006;1089:538–547.

  • Felder JB, Korelitz BI, Rajapakse R, Schwarz S, Horatagis AP, Gleim G. Effects of nonsteroidal anti-inflammatory drugs on inflammatory bowel disease: a case-control study. Am J Gastroenterol. 2000;95:1949–1954.

  • Cipolla G, Crema F, Sacco S, Moro E, de Ponti F, Frigo G. Nonsteroidal anti-inflammatory drugs and inflammatory bowel disease: current perspectives. Pharmacol Res. 2002;46:1–6.

  • Berg DJ, Zhang J, Weinstock JV, et al. Rapid development of colitis in NSAID-treated IL-10-deficient mice. Gastroenterology. 2002;123:1527–1542.

  • Baumgart DC, Sandborn WJ. Crohn’s disease. Lancet. 2012;380:1590–1605.

  • Basson A. Nutrition management in the adult patient with Crohn’s disease. S Afr J Clin Nutr. 2012;25:164–172.

  • Russel MG, Engels LG, Muris JW, Limonard CB, Volovics A, Brummer RJ, Stockbrügger RW. Modern life’ in the epidemiology of inflammatory bowel disease: a case-control study with special emphasis on nutritional factors. Eur J Gastroenterol Hepatol. 1998;10:243–249. [

  • Sakamoto N, et al. Dietary risk factors for inflammatory bowel disease: a multicenter case-control study in Japan. Inflamm Bowel Dis. 2005;11:154–163.

  • Chan SS, Luben R, et al. Carbohydrate intake in the etiology of Crohn’s disease and ulcerative colitis. Inflamm Bowel Dis. 2014;20:2013–2021.

  • Reif S, Klein I, Lubin F, et al. Pre-illness dietary factors in inflammatory bowel disease. Gut. 1997;40:754–760.

  • Ananthakrishnan AN, Khalili H, Konijeti GG, et al. Long-term intake of dietary fat and risk of ulcerative colitis and Crohn’s disease. Gut. 2014;63:776–784.

  • Tjonneland A, Overvad K, Bergmann MM, et al. Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study. Gut. 2009;58:1606–1611.

  • de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26:11–18.

  • Ananthakrishnan AN, Khalili H, Konijeti GG, Higuchi LM, de Silva P, Korzenik JR, Fuchs CS, Willett WC, Richter JM, Chan AT. A prospective study of long-term intake of dietary fiber and risk of Crohn’s disease and ulcerative colitis. Gastroenterology. 2013;145:970–977.

  • Amre DK, D’Souza S, Morgan K, Seidman G, Lambrette P, Grimard G, Israel D, Mack D, Ghadirian P, Deslandres C, et al. Imbalances in dietary consumption of fatty acids, vegetables, and fruits are associated with risk for Crohn’s disease in children. Am J Gastroenterol. 2007;102:2016–2025.

  • Zhang YZ, Li YY. Inflammatory bowel disease: pathogenesis. World J Gastroenterol. 2014;20:91–99.

  • Rossi T, Gallo C, Bassani B, Canali S, Albini A, Bruno A. Drink your prevention: beverages with cancer preventive phytochemicals. Pol Arch Med Wewn. 2014;124:713–722.

  • El-Tawil AM. Epidemiology and inflammatory bowel diseases. World J Gastroenterol. 2013;19:1505–1507.

  • Han DY, Fraser AG, Dryland P, Ferguson LR. Environmental factors in the development of chronic inflammation: a case-control study on risk factors for Crohn‘s disease within New Zealand. Mutat Res. 2010;690:116–122.

  • Mawdsley JE, Rampton DS. Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut. 2005;54:1481–1491.

  • Lerebours E, Gower-Rousseau C, Merle V, et al. Stressful life events as a risk factor for inflammatory bowel disease onset: A population-based case-control study. Am J Gastroenterol. 2007;102:122–131.

  • Taro Osada, Atsushi Arakawa, Naoto Sakamoto, HiroyaUeyama, Tomoyoshi Shibuya, Tatsuo Ogihara, Takashi Yao, and Sumio Watanabe. Autofluorescence imaging endoscopy for identification and assessment of inflammatory ulcerative colitis, 2011;17(46):5110-6.

  • https://www.mayoclinic.org/diseases-conditions/ulcerative-colitis/diagnosis-treatment/drc-20353331

  • Hyson DA. A comprehensive review of apples and apple components and their relationship to human health. AdvNutr 2011;2:408‑20.

  • Boyer J, Liu RH. Apple phytochemicals and their health benefits. Nutr J 2004;3:5.

  • D’Argenio G, Mazzone G, Tuccillo C, Ribecco MT, Graziani G, Gravina AG, et al. Apple polyphenols extract (APE) improves colon damage in a rat model of colitis. Dig Liver Dis 2012;44:555‑62.

  • Ulbricht C, Basch E, Basch S, Bent S, Boon H, Burke D, et al. An evidence‑based systematic review of bilberry (Vacciniummyrtillus) by the Natural Standard Research Collaboration. J Diet Suppl 2009;6:162‑200.

  • Canter PH, Ernst E. Anthocyanosides of Vacciniummyrtillus (bilberry) for night vision‑A systematic review of placebo‑controlled trials. SurvOphthalmol 2004;49:38‑50.

  • Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak‑Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis ‑ An open pilot study. J Crohns Colitis 2013;7:271‑9.

  • Wang LS, Kuo CT, Cho SJ, Seguin C, Siddiqui J, Stoner K, et al. Black raspberry‑derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells. Nutr Cancer 2013;65:118‑25.

  • Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, Bruno RS, et al. Anti‑inflammatory effects of freeze‑dried black raspberry powder in ulcerative colitis. Carcinogenesis 2011;32:343‑50

  • Andujar I, Recio MC, Giner RM, Cienfuegos‑Jovellanos E, Laghi S, Muguerza B, et al. Inhibition of ulcerative colitis in mice after oral administration of a polyphenol‑enriched cocoa extract is mediated by the inhibition of STAT1 and STAT3 phosphorylation in colon cells. J Agric Food Chem 2011;59:6474‑83.

  • Maity P, Hansda D, Bandyopadhyay U, Mishra DK. Biological activities of crude extracts and chemical constituents of Bael, Aegle marmelos (L.) Corr. Indian J ExpBiol 2009;47:849‑61

  • Baliga MS, Bhat HP, Pereira MM, Mathias N, Venkatesh P. Radioprotective effects of Aegle marmelos (L.) Correa (Bael): A concise review. J Altern Complement Med 2010;16:1109‑16

  • Behera JP, Mohanty B, Ramani YR, Rath B, Pradhan S. Effect of aqueous extract of Aegle marmelos unripe fruit on inflammatory bowel disease. Indian J Pharmacol 2012;44:614‑8.

  • Balentine DA, Wiseman SA, Bouwens LC. The chemistry of tea flavonoids. Crit Rev Food SciNutr 1997;37:693‑704.

  • Kim M, Murakami A, Miyamoto S, Tanaka T, Ohigashi H. The modifying effects of green tea polyphenols on acute colitis and inflammation‑associated colon carcinogenesis in male ICR mice. Biofactors 2010;36:43‑51.

  • Pezzuto JM. Grapes and human health: A perspective. J Agric Food Chem 2008;56:6777‑84.

  • Sanchez‑Fidalgo S, Sanchez de Ibarguen L, Cardeno A, Alarcon de la Lastra C. Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model. Eur J Nutr 2012;51:497‑506.

  • Deshmukh CD, Veeresh B, Pawar AT. Protective effect of Emblica Officinalis fruit extract on acetic acid induced colitis in rats. Journal of Herbal Medicine and Toxicology 2010;4:83‑87

  • Harris JC, Cottrell SL, Plummer S, Lloyd D. Antimicrobial properties of Allium sativum (garlic). ApplMicrobiolBiotechnol 2001;57:282‑6.

  • Filocamo A, Nueno‑Palop C, Bisignano C, Mandalari G, Narbad A. Effect of garlic powder on the growth of commensal bacteria from the gastrointestinal tract. Phytomedicine 2012;19:707‑11.

  • Mukherjee S, Lekli I, Goswami S, Das DK. Freshly crushed garlic is a superior cardioprotective agent than processed garlic. J Agric Food Chem 2009;57:7137‑44.

  • Harisa GE, Abo‑Salem OM, El‑Sayed el SM, Taha EI, El‑Halawany N. L‑arginine augments the antioxidant effect of garlic against acetic acid‑ induced ulcerative colitis in rats. Pak J Pharm Sci 2009;22:373‑80.

  • Brahmbhatt M, Gundala SR, Asif G, Shamsi SA, Aneja R. Ginger phytochemicals exhibit synergy to inhibit prostate cancer cell proliferation. Nutr Cancer 2013;65:263‑72.

  • Baliga MS, Haniadka R, Pereira MM, D’Souza JJ, Pallaty PL, Bhat HP, et al. Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food SciNutr 2011;51:499‑523.

  • El‑Abhar HS, Hammad LN, Gawad HS. Modulating effect of ginger extract on rats with ulcerative colitis. J Ethnopharmacol 2008;118:367‑72.

  • Srivastava R, Ahmed H, Dixit RK, Dharamveer, Saraf SA. Crocus sativus L.: A comprehensive review. Pharmacogn Rev 2010;4:200‑8.

  • Abdullaev FI. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). ExpBiol Med (Maywood) 2002;227:20‑5.

  • Kamalipour M, Akhondzadeh S. Cardiovascular effects of saffron: An evidence‑based review. J Tehran Heart Cent 2011;6:59‑61.

  • Schmidt M, Betti G, Hensel A. Saffron in phytotherapy: Pharmacology and clinical uses. Wien Med Wochenschr 2007;157:315‑9.

  • Kazi HA, Qian Z. Crocetin reduces TNBS‑induced experimental colitis in mice by downregulation of NFkB. Saudi J Gastroenterol 2009;15:181‑7.

  • Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J PhysiolPharmacol 2001;45:345‑50.

  • dos Reis SB, de Oliveira CC, Acedo SC, Miranda DD, Ribeiro ML, Pedrazzoli J, Jr., et al. Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res 2009;23:324‑9.

  • Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Therapeutic applications of fenugreek. Altern Med Rev 2003;8:20‑7.

  • Shishodia S, Aggarwal BB. Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF‑kappa B‑regulated gene expression. Oncogene 2006;25:1463‑73

  • Kumar A, Prakash A, Dogra S. Protective effect of curcumin (Curcuma longa) against D‑galactose‑induced senescence in mice. J Asian Nat Prod Res 2011;13:42‑55.

  • Barzegar A, Moosavi‑Movahedi AA. Intracellular ROS protection efficiency and free radical‑scavenging activity of curcumin. PLoS One 2011;6:e26012

  • Arafa HM, Hemeida RA, El‑Bahrawy AI, Hamada FM. Prophylactic role of curcumin in dextran sulfate sodium (DSS)‑induced ulcerative colitis murine model. Food ChemToxicol 2009;47:1311‑7.

  • Deguchi Y, Andoh A, Inatomi O, Yagi Y, Bamba S, Araki Y, et al. Curcumin prevents the development of dextran sulfate Sodium (DSS)‑induced experimental colitis. Dig Dis Sci 2007;52:2993‑8.

  • Yadav VR, Suresh S, Devi K, Yadav S. Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti‑inflammatory activity in rat colitis model. AAPS PharmSciTech 2009;10:752‑62.

  • Yadav VR, Suresh S, Devi K, Yadav S. Novel formulation of solid lipid microparticles of curcumin for anti‑angiogenic and anti‑inflammatory activity for optimization of therapy of inflammatory bowel disease. J Pharm Pharmacol 2009;61:311‑21.

  • Liu L, Liu YL, Liu GX, Chen X, Yang K, Yang YX, et al. Curcumin ameliorates dextran sulfate sodium‑induced experimental colitis mice by downregulation of NFkB. Saudi J Gastroenterol 2009;15:181‑7. YX, et al. Curcumin ameliorates dextran sulfate sodium‑induced experimental colitis by blocking STAT3 signaling pathway. IntImmunopharmacol 2013;17:314‑20.

  • Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez‑Munoz A, et al. Curcumin attenuates DNB‑induced murine colitis. Am J Physiol Gastrointest Liver Physiol 2003;285:G235‑43.

  • Venkataranganna MV, Rafiq M, Gopumadhavan S, Peer G, Babu UV, Mitra SK. NCB‑02 (standardized Curcumin preparation) protects dinitrochlorobenzene‑ induced colitis through down‑regulation of NFkappa‑B and iNOS. World J Gastroenterol 2007;13:1103‑7.

  • Camacho‑Barquero L, Villegas I, Sanchez‑Calvo JM, Talero E, Sanchez‑Fidalgo S, Motilva V, et al. Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX‑2 and iNOS expression in chronic experimental colitis. IntImmunopharmacol 2007;7:333‑42.

  • Jiang H, Deng CS, Zhang M, Xia J. Curcumin‑attenuated trinitrobenzenesulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase‑2. World J Gastroenterol 2006;12:3848‑53.

  • Larmonier CB, Uno JK, Lee KM, Karrasch T, Laubitz D, Thurston R, et al. Limited effects of dietary curcumin on Th‑1 driven colitis in IL‑10 deficient mice suggest an IL‑10‑dependent mechanism of protection. Am J Physiol Gastrointest Liver Physiol 2008;295:G1079‑91.

  • Ung VY, Foshaug RR, MacFarlane SM, Churchill TA, Doyle JS, Sydora BC, et al. Oral administration of curcumin emulsified in carboxymethyl cellulose has a potent anti‑inflammatory effect in the IL‑10 gene‑deficient mouse model of IBD. Dig Dis Sci 2010;55:1272‑7.

  • Baliga MS, Joseph N, Venkataranganna MV, Saxena A, Ponemone V, Fayad R. Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: Preclinical and clinical observations. Food Funct 2012;3:1109‑17.

  • Nones K, Dommels YE, Martell S, Butts C, McNabb WC, Park ZA, et al. The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene‑deficient (mdr1a‑/‑) mice, a model of inflammatory bowel diseases. Br J Nutr 2009;101:169‑81.


Abstract Views: 171

PDF Views: 0




  • A Review on Pathological State and Herbal Remedies on Ulcerative Colitis

Abstract Views: 171  |  PDF Views: 0

Authors

K. Akshaya
Pharmacology, SRM College of Pharmacy, Kattankulathur - 603203, India
V. Chitra
Pharmacology, SRM College of Pharmacy, Kattankulathur - 603203, India

Abstract


Ulcerative colitis (UC) is a persistent and non-specific sickness appeared typically within the rectum and therefore the entire colon, associated with abnormality of tissue layer towards the resident microorganisms along genital and environmental aspect. Typically presents with bloody diarrhea and is diagnosed by endoscopy and histological findings. Many varieties of medicines are tried to treat tenderness and decrease symptoms. The main aim of management is to induce and maintain remission outlined as resolution of manifestation and scrutiny healing. Herbal drugs add a good vary of remedy compared to western drugs. Though herbal medicines don’t seem to be void of risk, and secure than synthetic drugs. The possible benefits of herbal drugs might exist their huge approval by population owing to its effectiveness, safeness and comparatively lower price. People world wide embraced natural drugs which has been tested in many clinical trials. The evidences on herbal drugs are deficient, complicated and positively related to each risks and benefits there’s a necessity for any controlled clinical trials of the possible effectualness of herbal drugs approaches within the treatment of UC to expand their quality and safety.

Keywords


Herbal Drugs, Tenderness, Remedy, Symptoms, Histological Findings, Ulcerative Colitis.

References