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A Review on the Effect of Immunosuppressants on Fertility


Affiliations
1 Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, India
2 Department of Pharmacology, J.K.K. Nattraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, India
3 Department of Pharmaceutics, J.K.K. Nattraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, India
     

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Background: Infertility is defined as not being able to get pregnant (conceive) after one year (or longer) of unprotected sex. Many studies had showed that extensive use of immunosuppressant’s may result in infertility. Immunosuppressive drugs are used in the treatment of inflammatory and autoimmune diseases, as well as in transplantation. Frequently prescribed in young people, these treatments may have deleterious effects on fertility, pregnancy outcomes and the unborn child. Aim: The aim of this study is to review the literatures depicting the about immunosuppressant’s, its impact on fertility and related pregnancy outcomes. Methods: A systematic literature search of the Pub Med database was performed using a combination of relevant terms related to ‘infertility’, 'conception', 'reproduction', 'immunosuppressant’s. Conclusion: From the review of many literatures this study concludes that immunosuppressants has varying effect on pregnancy. Some of the immunosuppressants at therapeutic doses can cause infertility when used for a long time.

Keywords

Fertility, Reproduction, Conception, Immunosuppressants.
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  • A Review on the Effect of Immunosuppressants on Fertility

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Authors

S. Shenuka
Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, India
T. Thiyagarajan
Department of Pharmacology, J.K.K. Nattraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, India
R. Sambath Kumar
Department of Pharmaceutics, J.K.K. Nattraja College of Pharmacy, Komarapalayam-638183, Tamil Nadu, India

Abstract


Background: Infertility is defined as not being able to get pregnant (conceive) after one year (or longer) of unprotected sex. Many studies had showed that extensive use of immunosuppressant’s may result in infertility. Immunosuppressive drugs are used in the treatment of inflammatory and autoimmune diseases, as well as in transplantation. Frequently prescribed in young people, these treatments may have deleterious effects on fertility, pregnancy outcomes and the unborn child. Aim: The aim of this study is to review the literatures depicting the about immunosuppressant’s, its impact on fertility and related pregnancy outcomes. Methods: A systematic literature search of the Pub Med database was performed using a combination of relevant terms related to ‘infertility’, 'conception', 'reproduction', 'immunosuppressant’s. Conclusion: From the review of many literatures this study concludes that immunosuppressants has varying effect on pregnancy. Some of the immunosuppressants at therapeutic doses can cause infertility when used for a long time.

Keywords


Fertility, Reproduction, Conception, Immunosuppressants.

References