Research Journal of Pharmacy and Technology

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Skin Wound Healing:An update on the Current knowledge and Concepts


Affiliations
1 Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies, VISTAS, Pallavaram, Chennai-117, India
     

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Skin wound healing is a natural biological response to an injury. It is a complex process involving cellular activities. Tissue undergoes fibrotic reactions that result in the production of a scar. Tissue Engineering helps in curing major wounds. In case of chronic burns, stem cell skin is implanted. New tissue gets regenerated. Chronic wound can be healed by collagen. Bio-film acts a microbial reservoir for infection of neighboring tissue. Collagen has many great potential in medical uses. Blood borne oxygen is very much essential for healing and repairing process. Hemostasis phase, Inflammatory phase, Proliferative phase, Maturation phase are the stages of wound healing. Common wound can be cured by antiseptic ointments and dressings. Epidermis gets regenerated and grafting of skin develops over wounded area. However, these biological substitutes helps in restoring, maintaining and improved tissue functioning for healing factor.

Keywords

Bio-Film, Tissue Engineering, Collagen, Wound Healing.
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  • Duan, Huichuan, et al. "Engineering of epidermis skin grafts using electrospun nanofibrous gelatin/polycaprolactone membranes." International journal of nanomedicine 8 (2013): 2077.

  • LeRoy, E. Carwile. "Increased Collagen Synthesis by Scleroderma Skin Fibroblasts in Vitro a Possible Defect in the Regulation or Activation of the Scleroderma Fibroblast." The Journal of clinical investigation 54.4 (1974): 880-889.

  • Czaja, Wojciech, et al. "Microbial cellulose—the natural power to heal wounds." Biomaterials 27.2 (2006): 145-151.

  • Boateng, Joshua S., et al. "Wound healing dressings and drug delivery systems: a review." Journal of pharmaceutical sciences 97.8 (2008): 2892-2923.

  • Barrientos, Stephan, et al. "Growth factors and cytokines in wound healing." Wound repair and regeneration 16.5 (2008): 585-601.

  • MacKay, Douglas J., and Alan L. Miller. "Nutritional support for wound healing." Alternative medicine review 8.4 (2003).

  • Böttcher-Haberzeth, Sophie, Thomas Biedermann, and Ernst Reichmann. "Tissue engineering of skin." Burns 36.4 (2010): 450-460.

  • MacNeil, Sheila. "Biomaterials for tissue engineering of skin." Materials today 11.5 (2008): 26-35.

  • Murdoch, R., and K. M. Lagan. "The role of povidone and cadexomer iodine in the management of acute and chronic wounds." Physical Therapy Reviews 18.3 (2013): 207-216.

  • Metcalfe, Anthony D., and Mark WJ Ferguson. "Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration." Journal of the Royal Society Interface4.14 (2007): 413-437.

  • Kremer, Michael, Ekkehard Lang, and Alfred Berger. "Evaluation of dermal—epidermal skin equivalents (‘composite-skin’) of human keratinocytes in a collagen-glycosaminoglycan matrix (integra™ artificial skin)." British journal of plastic surgery 53.6 (2000): 459-465.

  • Stiefel, Dorothea, Clemens Schiestl, and Martin Meuli. "Integra Artificial Skin® for burn scar revision in adolescents and children." Burns 36.1 (2010): 114-120.

  • Loss, M., et al. "Artificial skin, split-thickness autograft and cultured autologous keratinocytes combined to treat a severe burn injury of 93% of TBSA." Burns 26.7 (2000): 644-652.

  • Besner, Gail E., and Jan E. Klamar. "Integra artificial skin as a useful adjunct in the treatment of purpura fulminans." The Journal of burn care & rehabilitation 19.4 (1998): 324-329.

  • Sheridan, R. L., et al. "Artificial skin in massive burns—results to ten years." European Journal of Plastic Surgery 17.2 (1994): 91-93.

  • Kim, P. J., et al. "Integra® bilayer wound matrix application for complex lower extremity soft tissue reconstruction." Surgical technology international 24 (2014): 65-73.

  • Liu, Haifeng, et al. "A study on a chitosan-gelatin-hyaluronic acid scaffold as artificial skin in vitro and its tissue engineering applications." Journal of Biomaterials Science, Polymer Edition 15.1 (2004): 25-40.

  • Sun, Guoming, et al. "Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing." Proceedings of the National Academy of Sciences 108.52 (2011): 20976-20981.

  • Huang, Sha, and Xiaobing Fu. "Naturally derived materials-based cell and drug delivery systems in skin regeneration." Journal of Controlled Release 142.2 (2010): 149-159.

  • Delavary, Babak Mahdavian, et al. "Macrophages in skin injury and repair." Immunobiology 216.7 (2011): 753-762.

  • Gilmore, M. A. "Phases of wound healing." Dimensions in oncology nursing: journal of the Division of Nursing 5.3 (1991): 32-34.

  • Nissen, Nicholas N., et al. "Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing." The American journal of pathology 152.6 (1998): 1445.

  • Cheon, Sophia S., et al. Growth factors regulate β-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. Experimental cell research 293.2 (2004): 267-274.

  • Greenhalgh, David G. The role of apoptosis in wound healing. The international journal of biochemistry & cell biology 30.9 (1998): 1019-1030.

  • Lansdown, Alan BG. Calcium: a potential central regulator in wound healing in the skin. Wound repair and regeneration10.5 (2002): 271-285.

  • Bloch, Wilhelm, et al. The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. The FASEB Journal 14.15 (2000): 2373-2376.

  • Ruszczak, Z., and R. A. Schwartz. Collagen uses in dermatology–an update. Dermatology 199.4 (1999): 285-289.

  • Fratzl, Peter. Collagen: structure and mechanics, an introduction. Collagen. Springer, Boston, MA, 2008. 1-13.

  • Masci, Valentina Laghezza, et al. Ultrastructural investigation on fibroblast interaction with collagen scaffold. Journal of Biomedical Materials Research Part A 104.1 (2016): 272-282.

  • Tati, Ramesh, et al. Biological wound matrices with native dermis-like collagen efficiently modulate protease activity. Journal of wound care 27.4 (2018): 199-209.

  • Doillon, Charles J., and Frederick H. Silver. Collagen-based wound dressing: Effects of hyaluronic acid and firponectin on wound healing. Biomaterials 7.1 (1986): 3-8.

  • Solis-Herruzo, J. A., D. A. Brenner, and M. Chojkier. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Journal of Biological Chemistry 263.12 (1988): 5841-5845.

  • Ruszczak, Zbigniew. Effect of collagen matrices on dermal wound healing. Advanced drug delivery reviews 55.12 (2003): 1595-1611.

  • Pachence, James M. Collagen‐based devices for soft tissue repair. Journal of biomedical materials research 33.1 (1996): 35-40.

  • Won’t Heal, Why Some Wounds. Understanding the Benefits of Collagen-Based Wound Dressings for Chronic Wounds.

  • Moy, Lawrence S., Ken Howe, and Ronald L. Moy. Glycolic acid modulation of collagen production in human skin fibroblast cultures in vitro. Dermatologic surgery 22.5 (1996): 439-441.

  • Horch, Raymund E., and G. Björn Stark. Comparison of the effect of a collagen dressing and a polyurethane dressing on the healing of split thickness skin graft (STSG) donor sites. Scandinavian journal of plastic and reconstructive surgery and hand surgery 32.4 (1998): 407-414.

  • Burke, John F., et al. Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury. Annals of surgery 194.4 (1981): 413.

  • Naughton, Gail K., and William R. Tolbert. Tissue engineering: skin. Yearbook of Cell and Tissue Transplantation 1996–1997. Springer, Dordrecht, 1996. 265-274.

  • Iwuagwu, F. C., D. Wilson, and F. Bailie. The use of skin grafts in postburn contracture release: a 10-year review. Plastic and reconstructive surgery 103.4 (1999): 1198-1204.

  • Medalie, Daniel A., Ronald G. Tompkins, and Jeffrey R. Morgan. Evaluation of acellular human dermis as a dermal analog in a composite skin graft. ASAIO journal (American Society for Artificial Internal Organs: 1992) 42.5 (1996): M455-62.

  • Vanstraelen, P. Comparison of calcium sodium alginate (KALTOSTAT) and porcine xenograft (EZ DERM) in the healing of split-thickness skin graft donor sites. Burns 18.2 (1992): 145-148.

  • Steinmuller, David. Immunization with skin isografts taken from tolerant mice. Science 158.3797 (1967): 127-129.

  • Stojadinovic, Alexander, et al. Angiogenic response to extracorporeal shock wave treatment in murine skin isografts. Angiogenesis 11.4 (2008): 369.

  • Lee, Kwang Hoon. Tissue-engineered human living skin substitutes: development and clinical application. Yonsei Medical Journal 41.6 (2000): 774-779.

  • Monafo, William W., Carl E. Aulenbacher, and Carlos Pappalardo. Early tangential excision of the eschars of major burns. Archives of Surgery 104.4 (1972): 503-508.

  • Warden, Glenn D., Jeffrey R. Saffle, and Melva Kravitz. A two-stage technique for excision and grafting of burn wounds. The Journal of trauma 22.2 (1982): 98-103.

  • Bianco, C., et al. Silver percutaneous absorption after exposure to silver nanoparticles: a comparison study of three human skin graft samples used for clinical applications. Burns40.7 (2014): 1390-1396.

  • Rigo, Chiara, et al. Active silver nanoparticles for wound healing. International journal of molecular sciences 14.3 (2013): 4817-4840.

  • Tian, Jun, et al. Topical delivery of silver nanoparticles promotes wound healing. ChemMedChem: Chemistry Enabling Drug Discovery 2.1 (2007): 129-136.

  • Branski, Ludwik K., et al. A review of gene and stem cell therapy in cutaneous wound healing. Burns 35.2 (2009): 171-180.

  • Lataillade, J. J., et al. New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. (2007): 785-794.

  • Arwert, Esther N., Esther Hoste, and Fiona M. Watt. Epithelial stem cells, wound healing and cancer. Nature Reviews Cancer 12.3 (2012): 170.

  • Lee, Eun Young, et al. Hypoxia‐enhanced wound‐healing function of adipose‐derived stem cells: Increase in stem cell proliferation and up‐regulation of VEGF and bFGF. Wound Repair and Regeneration 17.4 (2009): 540-547.

  • Guo, S. al, and Luisa A. DiPietro. Factors affecting wound healing. Journal of dental research 89.3 (2010): 219-229.

  • Robson, Martin C. Wound infection: a failure of wound healing caused by an imbalance of bacteria. Surgical Clinics of North America 77.3 (1997): 637-650.

  • Kubo, Masato, et al. Immunogenicity of human amniotic membrane in experimental xenotransplantation. Investigative ophthalmology & visual science 42.7 (2001): 1539-1546.

  • Fan, Zengjie, et al. A novel wound dressing based on Ag/graphene polymer hydrogel: effectively kill bacteria and accelerate wound healing. Advanced Functional Materials24.25 (2014): 3933-3943.

  • Dantzer, Eric, and Fabienne M. Braye. Reconstructive surgery using an artificial dermis (Integra): results with 39 grafts. British journal of plastic surgery 54.8 (2001): 659-664.

  • Kannon, Georgia A., and Algin B. Garrett. Moist wound healing with occlusive dressings: a clinical review. Dermatologic surgery 21.7 (1995): 583-590.

  • Macri, L., and R. A. F. Clark. Tissue engineering for cutaneous wounds: selecting the proper time and space for growth factors, cells and the extracellular matrix. Skin pharmacology and physiology 22.2 (2009): 83-93.

  • Rai, Mahendra, Alka Yadav, and Aniket Gade. Silver nanoparticles as a new generation of antimicrobials. Biotechnology advances 27.1 (2009): 76-83.


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  • Skin Wound Healing:An update on the Current knowledge and Concepts

Abstract Views: 187  |  PDF Views: 0

Authors

Ridhanya
Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies, VISTAS, Pallavaram, Chennai-117, India
K. Rajakumari
Department of Bio-Engineering, School of Engineering, Vels Institute of Science, Technology and Advanced Studies, VISTAS, Pallavaram, Chennai-117, India

Abstract


Skin wound healing is a natural biological response to an injury. It is a complex process involving cellular activities. Tissue undergoes fibrotic reactions that result in the production of a scar. Tissue Engineering helps in curing major wounds. In case of chronic burns, stem cell skin is implanted. New tissue gets regenerated. Chronic wound can be healed by collagen. Bio-film acts a microbial reservoir for infection of neighboring tissue. Collagen has many great potential in medical uses. Blood borne oxygen is very much essential for healing and repairing process. Hemostasis phase, Inflammatory phase, Proliferative phase, Maturation phase are the stages of wound healing. Common wound can be cured by antiseptic ointments and dressings. Epidermis gets regenerated and grafting of skin develops over wounded area. However, these biological substitutes helps in restoring, maintaining and improved tissue functioning for healing factor.

Keywords


Bio-Film, Tissue Engineering, Collagen, Wound Healing.

References