Research Journal of Pharmacy and Technology

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Synthesis, Characterization, Antimicrobial activity and Release Study of Cinnamon loaded poly (DL-lactide-co-glycolide) Nanoparticles


Affiliations
1 Department of Chemistry, Amity Institute of Applied Sciences, Amity University, Sector 125, Noida, Uttar Pradesh-201313 (India), India
     

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Nanoscale drug delivery systems have shown their ability to encapsulate a variety of therapeutic agents. By encapsulating these molecules the solubility and stability of drug is improved. Cinnamon act as potential drug for lot of curable diseases such as Diabetes. For increasing its bioavailability as a drug, nanoencapsulation of cinnamon powder was carried out using solvent evaporation method. The effect of organic solvent and surfactant such as PVA (Polyvinyl alcohol) and Pluronic F-68 was studied. The morphology and particle size of nanoparticles was studied using Transmission Electron Microscopy (TEM) which shows nanoparticles of small size (10 nm for Cinnamon. Nanoencapsulation of Cinnamon also shows high entrapment efficiency (82.34% for Cinnamon) respectively and also improvement in inhibition of microbial growth. During microbial analysis, the minimum inhibitory concentration (MIC) of Cinnamon loaded nanoparticles against the Staphylococcus aureus and Bacillus pumilus shows the inhibition zone of 9.12 mm and 10.39mm respectively at 6000 ppm whereas in case of Saccharomyces cerevisiae and Candida albicans the nanopaticles shows inhibition zone of 7.23mm and 8.47 mm respectively at 4000ppm. Drug release study for cinnamon and corresponding nanoparticles was also done. The main objective behind the work in hand is the preparation of Cinnamon loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles for increasing the efficacy towards different ailments.

Keywords

Bioavailability, Nanoparticles, Surfactants, Drug, Cinnamon, PLGA, PVA, Pluronic-68.
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  • Synthesis, Characterization, Antimicrobial activity and Release Study of Cinnamon loaded poly (DL-lactide-co-glycolide) Nanoparticles

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Authors

Vinod Kumari
Department of Chemistry, Amity Institute of Applied Sciences, Amity University, Sector 125, Noida, Uttar Pradesh-201313 (India), India
Aditi Sangal
Department of Chemistry, Amity Institute of Applied Sciences, Amity University, Sector 125, Noida, Uttar Pradesh-201313 (India), India

Abstract


Nanoscale drug delivery systems have shown their ability to encapsulate a variety of therapeutic agents. By encapsulating these molecules the solubility and stability of drug is improved. Cinnamon act as potential drug for lot of curable diseases such as Diabetes. For increasing its bioavailability as a drug, nanoencapsulation of cinnamon powder was carried out using solvent evaporation method. The effect of organic solvent and surfactant such as PVA (Polyvinyl alcohol) and Pluronic F-68 was studied. The morphology and particle size of nanoparticles was studied using Transmission Electron Microscopy (TEM) which shows nanoparticles of small size (10 nm for Cinnamon. Nanoencapsulation of Cinnamon also shows high entrapment efficiency (82.34% for Cinnamon) respectively and also improvement in inhibition of microbial growth. During microbial analysis, the minimum inhibitory concentration (MIC) of Cinnamon loaded nanoparticles against the Staphylococcus aureus and Bacillus pumilus shows the inhibition zone of 9.12 mm and 10.39mm respectively at 6000 ppm whereas in case of Saccharomyces cerevisiae and Candida albicans the nanopaticles shows inhibition zone of 7.23mm and 8.47 mm respectively at 4000ppm. Drug release study for cinnamon and corresponding nanoparticles was also done. The main objective behind the work in hand is the preparation of Cinnamon loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles for increasing the efficacy towards different ailments.

Keywords


Bioavailability, Nanoparticles, Surfactants, Drug, Cinnamon, PLGA, PVA, Pluronic-68.

References