Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Evaluation of Diuretic Activity on Leaves Extract of Cardiospermum halicacabum Linn


Affiliations
1 Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, India
2 PGP College of Pharmaceutical Science and Research Institute, Namakkal, Tamilnadu, India
     

   Subscribe/Renew Journal


In this work we studied the diuretic potential of aqueous and ethanolic leaves extract of Cardiospermum halicacabum Linn in experimental Wister rats. The ethanolic extract was done by Continuous Hot Percolation method and the aqueous extract was done by Maceration method. Both aqueous and ethanolic Extract of Cardiospermum halicacabum Linn was tested to check the presence of different active constituents like alkaloids, flavonoids, glycosides, terpenoids and saponins. The aqueous and ethanolic leaves extract Cardiospermum halicacabum Linn was used for diuretic activity at the dose 200 mg/kg was compared with standard drug furosemide (10 mg/kg). Various ion concentrations like Sodium, Potassium, Chloride and urine volume was measured. Urine volume increases in aqueous extract than the ethanolic extract. Both the extract showed more urine volume when compared to control but less than that of standard drug. The significant increases in Sodium, Potassium and Chloride ion concentration in both the extract group.

Keywords

Cardiospermum halicacabum Linn, Continuous Hot Percolation, Diuretic activity, Furosemide.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Babar Vishal Bharat. Comparative Diuretic Study of Medicinal Plants in Individual and Combination Form. Int J Res Pharmaceutical and Biomedical Sciences, 2012: 3(4), 1432-1435.

  • Umesh Kumar Sharma, Uma Shankar Sharma, Abhishek Singh, Vijit Agarwal. Diuretic activity of Kigelia pinnata bark extract. Journal of Pharmacology Research, 2010: 1(2), 17-20.

  • Muthumani P, Meera R, Venkatraman S, Sundara Ganapathy, Devi P. Study of phytochemical, analgesic and antiulcer activity of extracts of aerial parts of Cardiospermum halicacabum Linn. IJPSR, 2010: 1(10), 128-137.

  • Asha V.V, Pushpangadan P. Antipyretic activity of Cardiospermum halicacabum. Indian Journal of Experimental Biology, 1999: 37, 411-414.

  • Huma Shareef, Ghazala. H. Rizwani, Shaukat Mahmood, Raheela Khursheed, Hina Zahid. Invitro antimicrobial and phytochemical analysis of Cardiospermum halicacabum L. Pak. J. Bot, 2012:44(5), 1677-1680.

  • Malaviya S, Nandakumar K, Vaghasiya J, Bhalodiya Y, Jivani N, Sheth N, Manek R, Chauhan S. Anxiolytic activity of ischolar_main extracts of Cardiospermum halicacabum in mice. The Internet Journal of Pharmacology,2009: 7(1), 57-63.

  • Venkat Rao N, Chandra Prakash K, Shantha Kumar SM. Pharmacological Investigation of Cardiospermum halicacabum Linn in different models of diarrhea. Indian Journal of Pharmacology, 2006:38(5), 346-349.

  • Rupeshkumar M, Kavitha S, Basu S.K. Antioxidant and Hepatoprotective effect of flavanone from Cardiospermum halicacabum against acetaminophen induced hepatotoxicity in rats. Journal of Pharmacy Research, 2012: 5(1), 544-547.

  • Balija Parameshappa, Venkata Rao, Md. Ali, Mounika, Srilatha. Protective effect of aqueous extract of Cardiospermum halicacabum Linn against gentamycin induced nephrotoxicity. Scholars Research Library, 2011: 3(2), 351-357.

  • Chinnadurai Veeramani, Ganesan Pushpavalli, Kodukkur Viswanathan Pugalendi. Antihyperglycemic effect of Cardiospermum halicacabum Linn. Leaf extract on STZ-induced diabetic rats. J. Appl. Biomed, 2008: 6, 19-26.

  • Al-Snafi AE. Chemical constituents and pharmacological importance of Agropyron repens–A review. Research Journal of Pharmacology and Toxicology. 2015;1(2):37-41.

  • Khandelwal KR. Practical Pharmacognosy. Techniques and Experiments, Nirali Prakashan, Pune, Edn 16, 2006: 149-153.

  • Patel R, Mahobia NK, Gendle R, Kaushik B, Singh SK. Diuretic activity of leaves of Plectranthus amboinicus (Lour) Spreng in male albino rats. Pharmacognosy research. 2010 Mar;2(2):86.

  • Sundarrajan T, Velmurugan V, Srimathi R. Phytochemical Evaluation and In Vitro Antidiabetic Activity of Ethanolic extract of Alternanthera ficodia Linn. Research Journal of Pharmacy and Technology. 2017: 1;10(9):2981-3.

  • Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and Dales Pharmacology. Churchill Livingstone, Elsevier, Edn 6, 2007: 375-377.

  • Sangita Shukla, Rashmika Patel, Rajiv Kukkar. Study of phytochemical and diuretic potential of methanol and aqueous extracts of aerial parts of Phyla nodoflora linn. International Journal of Pharmacy and Pharmaceutical Sciences, 2009: 1(1), 85-91.

  • Devi P, Meera R, Muthumani P, Ratnaji chilakalapudi, Vijayakumar Thota, Duddu. V.D. Murthy, K. Jeyasundari. Evaluation of Alcoholic and Aqueous Extracts of Nicandra Physalodes Leaves for Diuretic Activity. International Journal of Pharmaceutical & Biological Archives, 2010:1(4), 331-334.

  • Upendra Bhadoriya, Sweta Tiwari, Praveen Sharma, Sharvan Bankey, Mahendra Mourya. Diuretic activity of extract of Salvia officinalis L. Asian Journal of Pharmacy & Life Science, 2011: 1(1), 24-28.


Abstract Views: 190

PDF Views: 0




  • Evaluation of Diuretic Activity on Leaves Extract of Cardiospermum halicacabum Linn

Abstract Views: 190  |  PDF Views: 0

Authors

V. Velmurugan
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, India
T. Sundarrajan
Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, India
A. Chandran
PGP College of Pharmaceutical Science and Research Institute, Namakkal, Tamilnadu, India
G. Arunachalam
PGP College of Pharmaceutical Science and Research Institute, Namakkal, Tamilnadu, India

Abstract


In this work we studied the diuretic potential of aqueous and ethanolic leaves extract of Cardiospermum halicacabum Linn in experimental Wister rats. The ethanolic extract was done by Continuous Hot Percolation method and the aqueous extract was done by Maceration method. Both aqueous and ethanolic Extract of Cardiospermum halicacabum Linn was tested to check the presence of different active constituents like alkaloids, flavonoids, glycosides, terpenoids and saponins. The aqueous and ethanolic leaves extract Cardiospermum halicacabum Linn was used for diuretic activity at the dose 200 mg/kg was compared with standard drug furosemide (10 mg/kg). Various ion concentrations like Sodium, Potassium, Chloride and urine volume was measured. Urine volume increases in aqueous extract than the ethanolic extract. Both the extract showed more urine volume when compared to control but less than that of standard drug. The significant increases in Sodium, Potassium and Chloride ion concentration in both the extract group.

Keywords


Cardiospermum halicacabum Linn, Continuous Hot Percolation, Diuretic activity, Furosemide.

References