Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Galectin-8 Gene Polymorphism among Iraqi Patients with Rheumatoid Arthritis


Affiliations
1 Department of Microbiology and Immunology, College of Medicine, University of Baghdad, Baghdad, Iraq
2 Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq
3 Children Welfare Teaching Hospital, Medical City Directorate, Iraq
     

   Subscribe/Renew Journal


Ninety (90) subjects were included in this study, Fifty (50) of them (patient group) were diagnosed as established RA patients according to the 2010 American College of Rheumatology/European League Against Rheumatism (2010 ACR/EULAR) classification criteria for Rheumatoid arthritis who were attending the rheumatology outpatient clinic of Baghdad teaching hospital, and compared with 40 apparently healthy control group. TT allele had the highest association with RA while AT allele had the weakest association with RA, whoever, all these alleles did not associated significantly with RA. The study shown that there was no significant difference in the galactin-8 gene polymorphism between RA and control.

Keywords

Rheumatoid Arthritis, Galectin-8 Gene Polymorphism.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Turesson, C., O’fallon, W.M., Crowson, C.S., Gabriel, S.E. and Matteson, E.L., 2003. Extra articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years. Annals of the rheumatic diseases, 62(8), pp.722-727.

  • Chanock, S., 2007. Technologic issues in GWAS and follow-up studies.

  • Addala, L., Kumar, C.H., Reddy, N.M., Anjaneyulu, V. and Sadanani, M.D., 2012. P5 3 Codon 72 Gene Polymorphism and Risk of Oral Squamous Cell Carcinoma i n South Indian Population: A Case-Control Study. J Cancer Sci Ther, 4, pp.188-192.

  • Jurado, J., Ybarra, J., Romeo, J.H., Garcia, M. and Zabaleta-Del-Olmo, E., 2012. Angiotensin-converting enzyme gene single polymorphism as a genetic biomarker of diabetic peripheral neuropathy: longitudinal prospective study. Journal of Diabetes and its Complications, 26(2), pp.77-82.

  • Zhernakova, A., Van Diemen, C.C. and Wijmenga, C., 2009. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nature Reviews Genetics, 10(1), p.43.

  • Mackay, I.R., 2009. Clustering and commonalities among autoimmune diseases. Journal of autoimmunity, 33(3-4), pp.170-177.

  • Firestein, G.S., 2003. Evolving concepts of rheumatoid arthritis. Nature, 423(6937), p.356.

  • Lefvert, A.K., 2005. Non-MHC genetic polymorphisms with functional importance for human myasthenia gravis. In Molecular Autoimmunity (pp. 101-113). Springer, Boston, MA.

  • Orozco, G., Rueda, B. and Martin, J., 2006. Genetic basis of rheumatoid arthritis. Biomedicine and Pharmacotherapy, 60(10), pp.656-662

  • Wellcome Trust Case Control Consortium, 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), p.661.

  • Gabius, H.J., 2006. Cell surface glycans: the why and how of their functionality as biochemical signals in lectin-mediated information transfer. Critical Reviews™ in Immunology, 26(1).

  • Rüdiger, H. and Gabius, H.J., 2009. The biochemical basis and coding capacity of the sugar code. The sugar code. Fundamentals of glycosciences, pp.3-13.

  • Gabius, H.J., André, S., Jiménez-Barbero, J., Romero, A. and Solís, D., 2011. From lectin structure to functional glycomics: principles of the sugar code. Trends in biochemical sciences, 36(6),

  • Villalobo, A., Nogales-González, A. and Gabius, H.J., 2006. A guide to signaling pathways connecting protein-glycan interaction with the emerging versatile effector functionality of mammalian lectins. Trends in Glycoscience and Glycotechnology, 18(99), pp.1-37.

  • Kaltner, H. and Gabius, H.J., 2012. A toolbox of lectins for translating the sugar code: the galectin network in phylogenesis and tumors. Histology and histopathology, 27(4), pp.397-416.

  • Al-Rawi, Z.S., Alazzawi, A.J., Alajili, F.M. and Alwakil, R., 1978. Rheumatoid arthritis in population samples in Iraq. Annals of the rheumatic diseases, 37(1), p.73.

  • Al-Ubaidi AH. Comparison between anti-RA33 antibodies, anti-citrullinated peptides with rheumatoid factor and C-reactive protein in the diagnosis of Iraqi patients with rheumatoid arthritis. ., 2012.

  • Abdul-Wahid, K.M., Al-Derzi, A.R., Al-Osami, M.H. and Al-Ani, M.M., 2013. Serum Levels of Adiponectin Before and After Administration of Anti-Tumor Necrosis Factor Agents in Iraqi Patients with Rheumatoid Arthritis. International Journal of Immunology Research, 3(2), p.50.

  • Lipsky PE. 2001 Pathology and pathogenesis of rheumatoid arthritis. In: Harrisonʼs Principles of Internal Medicine 15th Ed; 3:1928-3142

  • Goronzy, J.J. and Weyand, C.M., 2005. Rheumatoid arthritis. Immunological reviews, 204(1), pp.55-73.

  • Al-Karkhi, M.A., AL-Derzi, A.R., Zeiny, S.M.M., Jassim, N.A., Mahdi, B.M. and Al-Ani, M.M.,(2016) Correlation between Anti-infliximab and Anti-CCP Antibodies Development in Patients with Rheumatoid Arthritis Treated with Infliximab in Baghdad Teaching Hospital. IOSR Journal of Dental and Medical Sciences, 14(11), pp.95-100.

  • Pál, Z., Antal, P., Srivastava, S.K., Hullám, G., Semsei, Á.F., Gál, J., Svébis, M., Soós, G., Szalai, C., André, S. and Gordeeva, E., 2012. Non-synonymous single nucleotide polymorphisms in genes for immunoregulatory galectins: association of galectin-8 (F19Y) occurrence with autoimmune diseases in a Caucasian population. Biochimica et Biophysica Acta (BBA)-General Subjects, 1820(10), pp.1512-1518.


Abstract Views: 218

PDF Views: 0




  • Galectin-8 Gene Polymorphism among Iraqi Patients with Rheumatoid Arthritis

Abstract Views: 218  |  PDF Views: 0

Authors

Tarek. Q. Muss
Department of Microbiology and Immunology, College of Medicine, University of Baghdad, Baghdad, Iraq
M. AL-Faham
Department of Microbiology and Immunology, College of Medicine, University of Baghdad, Baghdad, Iraq
Faiq I. Gorial
Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq
Adil K. Zghair
Children Welfare Teaching Hospital, Medical City Directorate, Iraq

Abstract


Ninety (90) subjects were included in this study, Fifty (50) of them (patient group) were diagnosed as established RA patients according to the 2010 American College of Rheumatology/European League Against Rheumatism (2010 ACR/EULAR) classification criteria for Rheumatoid arthritis who were attending the rheumatology outpatient clinic of Baghdad teaching hospital, and compared with 40 apparently healthy control group. TT allele had the highest association with RA while AT allele had the weakest association with RA, whoever, all these alleles did not associated significantly with RA. The study shown that there was no significant difference in the galactin-8 gene polymorphism between RA and control.

Keywords


Rheumatoid Arthritis, Galectin-8 Gene Polymorphism.

References