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Gastroprotective Effect of Lannea coromandelica Stem Bark in Rat induced by Aspirin
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Lannea coromandelica is one of plant dispersed in Sulawesi. Inhabitants from the Southeast Sulawesi apply Lannea coromandelica Bark to relief symptom of gastritis or peptic ulcer. Phenolic compounds of Lannea coromandelica Stem bark contains antioxidant activity. The study investigated the gastroprotective effect of Lannea coromandelica stem bark. Ethanol extract of Lannea coromandelica Stem bark (LCSB) was evaluated its anti-ulcer activity using aspirin-induced rats. Normal group was given 0.05% Na CMC. Positive group was given sucralfat 360 mg / kgBW and aspirin 600mg/kg BW, group I was given extract of LCSB at dose 400 mg / kgBW and aspirin 600 mg/kgBW, group II was given extract of LCSB at dose 800 mg / kg BW and aspirin 600 mg/kgBW, and group III was given extract of LCSB at dose 1200 mg / kg BW and aspirin 600 mg/kg BW. Extract of LCSB was administered orally in various doses for three days prior to the ulcer induction. On the 4th-day rats, all rats were observed 8 hours after aspirin induction to determine ulcer index and percent inhibition. Results of this study revealed that LCSB extract significantly reduced the ulcer index and percent inhibition (p=0.00). Extract of LCSB shows gastroprotective activities.
Keywords
Bark of Javanesse wood, Lannea coromandelica, Aspirin, Gastroprotective, Rat.
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- Nie Y, Liana LK, Evacuasiany E. The Effect of Kencur's Rhizome Ethanol Extract (Kaempferia galangal L.) Against Gastric Mucosal to Swiss Webster Mice in Induce by Asetosal. Jurnal Medika Planta. 2012;2(1).
- Oviedo JA, Wolfe MM. Management of stress-related erosive syndrome. Current Therapy in Gastroenterology and Liver Disease, fifth edition. Hamilton, Ontario: BC Decker, Inc. 2005:161-6.
- Febrina T. Efek Seduhan Jahe Terhadap Tingkat Kerusakan Mukosa Gaster Mencit yang Diinduksi oleh Aspirin Ditinjau dari Gambaran Histopatologi, Skripsi, Fakultas Kedokteran Universitas Andalas: Padang. 2008.
- Prawirodiharjo E. Uji Aktivitas Antioksidan dan Uji Toksisitas Ekstrak Etanol 70% dan Ekstrak Air Kulit Batang Kayu Jawa (Lannea coromandelica), 2014, Bachelor Thesis, Program Studi Farmasi, UIN Syarif Hidayatullah: Jakarta.
- Wirastuty RY. Uji Efektifitas Gel Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea coromandelica) Pada Kelinci (Oryctolaguscuniculus) Sebagai Obatpenyembuhan Luka Bakar. Journal of Pharmaceutical Science and Herbal Technology. 2017;1(1):32-5.
- Wahid A. In Vitro Phytochemical and Biological Investigation of Plant Lannae coromandelica (Family: Anaradiceae). Thesis. 2009.. Department of Pharmacy, East West University: Bangladesh.
- Sari PS, Mun’im AB, Kusumaningtyas D. Aktivitas Gastroprotektif Kombinasi Ekstrak Kulit Batang Mimba (Azadirachta indica A. Juss) dan Rimpang Kunyit (Curcuma domestica Linn.) pada Tikus Putih yang Diinduksi Asetosal (Gastroprotective Activity of Combination of Neem. Jurnal Ilmu Kefarmasian. 2013;11(2):97-101.
- Venkata, S.S.N., Kantamredi, Nagendra L.Y., dan Satyanarayana, K.V.V.V. 2010. Preliminary Phytocemical Analysis of Some Important Indian Plant Species. International Journal of Pharma and Bio Sciences. 1 (4): 351-358.
- Rahman, M.S., Bilkis, B., Chowdhury, K.M., Rahman dan Rashid, M.A. 2008, Preliminary cytotoxicity screening of some of Bangladesh. J.Pharm. Science. 7: 47-52.
- Indraswary R. Efek Konsentrasi Ekstrak Buah Adas (Foeniculum vulgare Mill.) Topikal pada Epitelisasi Penyembuhan Luka Gingiva Labial Tikus Sprague Dawley In Vivo. Majalah Universitas Sultan Agung. 2011.
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