Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Antidiabetic Activity of leaf extract from three types of Mangrove Originating from Sambera Coastal Region Indonesia


Affiliations
1 Universitas Mulawarman, Samarinda, Indonesia
2 Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Makassar, Indonesia
3 Laboratorium Pengembangan dan Penelitian Kefarmasian Farmaka Tropis, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
     

   Subscribe/Renew Journal


This study designed to determine the antidiabetic profile ethanol extracts of leaf extract from three types of mangroves; Avicennia sp., Rhizopora sp, and Sonneratia sp. Extraction process used maceration with ethanol solvent. The phytochemical assayis carried out qualitatively including assay of alkaloids, flavonoids, steroids, terpenoids, phenolic compounds, tannins, and saponins. The method used for the antidiabetic test is the method of blood glucose tolerance. The results showed that ethanol extract of three types of mangrove leaves Avicennia sp., Rhizopora sp, and Sonneratia sp. containing secondary metabolite group alkaloids, flavonoids, steroids, terpenoids, phenolic compounds, tannins, and saponins. Ethanol extract of leaves of the three types of mangroves plants has antidiabetic activity. The ethanol extract of leaves of mangrove Rhizophora sp. with a dose of 200 mg/kg BB + glucose 2 g / kg (group P-2) showed the most excellent antidiabetic activity and lowering blood glucose levels by 31.27%. This study confirmed that three types of Mangrove from Sambera Coastal Region Indonesia showed the antidiabetic profile.

Keywords

Avicennia sp., Rhizopora sp, Sonneratia sp., Glucosetolerance, antidiabetic.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Wild, S., Roglic, G., Green, A., Sicree, R., and King, H. Journal Diabetes Care. 2004; 27(5):47-5.
  • Fitrianingsih, S.P., and Purwanti, L. Hypoglycemic Effect Test of Ambon Banana White Fruit Skin Water Extract on Mice Hyperglycemic Model of Strain Swiss Webster. Prosiding Semnas PP 2012.
  • Bandaranayake, WM. Bioactivities, Bioactive Compounds and Chemical Constituents of Mangrove Plant. Wetlands Ecology and Management, 2002 ; 10: p, 421 – 452.
  • Revathi P, JeyaseelanS.T, Thirumalaikolundusubramanian P, and Prabhu N. An Overview of Antidiabetic Profile of Mangrove Plants. Int J Pharm Pharm Sci. 2014; 6 (3):p, 1-5.
  • Hubert O.D.Y, Fifanou G.V, and Brice S. Ethnobotanical Survey of Mangrove Plant Species Used as Medicine from Ouidah to Grand-Popo Districts, Southern Benin. American Journal of Ethnomedicine. 2017; 4(18), p; 1-6. ISSN 2348-9502.
  • Nancy J.M, Ephrime B.M, Mylene M.U, and Jose M.O. International Conference on Asia Agriculture and Animal. IPCBEE, 2011; vol. 13(2011) IACSIT Press, Singapore.
  • Arora K., Nagpai M., Jain U., Jat R.C., and Jain S. Mangroves: A Novel Gregarious Phyto Medicine for Diabetes. International Journal of Research and Development in Pharmacy and Life Sciences. 2014; 3(6), p; 1244 1257. ISSN (P): 2393-932X, ISSN (E): 2278-0238.
  • Edeoga, H.O., D.E. Okwu and B.O. Mbaebie. Phytochemical Constituents of Some Nigerian Medicinal Plants. African Journal of Biotechnology. 2005; 4(7), pp. 685-688.
  • Patil M.B, And Khan P.A. Primary Phytochemical Studies of Catunaregam spinosa (Thunb) Tirven For Secondary Metabolites. Int J Pharm Bio Sci. 2017; 8(2): p. 320 323.
  • Joshi N, Bhatt S, Dhyani D.R.S, Nain J. Phytochemical Screening of Secondary Metabolites of Argemone mexicana L. Flowers. Int J Curr Pharm Res. 2016; 5 (2); p. 144-147.
  • Goverdhan P., Rani M.S., Thirupathi K., Rani S., Sathesh S., Kumar B.R., and Mohan G.K. 2008. Hypoglycemic and Anti-Hyperglycemic Effect of Aristolochia Indica Normal and Alloxan-Induced Diabetic Rats. Pharmacologyonline, 2008; 1: 20–29 (2008).
  • Takahashi, Mayumi, Shinji Ikemoto, and Osamu Ezaki. Effect of the fat/carbohydrate ratio in the diet on obesity and oral glucose tolerance in C57BL/6J mice. Journal of nutritional science and vitaminology, 1999; 45.5 .583-593.
  • Suciati, A. Effectiveness of Rhizophora mucronata Leaf Extract in Inhibiting the Growth of Aeromonas salmonicida and Vibrio harveyi. e-Jurnal Rekayasa dan Teknologi Budidaya Perairan, 2012; 1.1 (2012): 1-8.
  • Nahid A. Osman and Faiza A. Abkar.Comparatif Evaluation of Some Selected Bioactive Constituen in the Leaves and Bark of Avicennia marina (Forks) Veir from Sudanese Read See Coast. Journal of Forest Product Industries. 2015; 4(1), p. 5-11.
  • Wibowo C, C. Kusmana, A. Suryani, Y. Hartati, and P. Oktadiyani. 2009.Utilization of Api-api Mangrove Trees (Avicennia sp.) as Food and Medicines.
  • Gurudeeban S. Kaliamurthi S., and Thirugnanasambandam R. Positive Regulation of Rhizophora mucronata Poir Extracts on Blood Glucose and Lipid Profile in Diabetic Rats. iMedPub Journals. 2016; 2(2). P: 1 -8. ISSN: 2472-0151.
  • Usman. Phytochemical Test and Antibacterial Test of Mangrove Roots of Rhizophora apiculata Against Escherichia coli and Staphylococcus aureus Bacteria. Jurnal Kimia dan Pendidikan Kimia (JKPK), Des. 2017; 2(3); 169-177.
  • Chaiyadej K., Wongthap H., Vadhanavikit S., and Chantrapomma K. Bioactive Constituents from The Twigs of Sonneratia alba. Walaik.J. Sci. and Tech., 2004; 1 (1), 15–22.
  • Priya, P.D., Niranjana, C.S., and Anjali S.B. Sonneratia alba. A. Vital Source of Gamma Linolenic Acid (GLA). Asian J. of Pharmaceutical and Clinical Research. 2012; 5 (1); 171–175.
  • Teja Prabhu Vand Ravishankar K. Preliminary Phytochemical Investigation and In Vitro Antimicrobial Activity of Ethanol Extract of Sonneratia Apetala Plant. Int. Res. J. Pharm. 2013; 4(6); p.84-87.
  • Kondoy S, A. Wulur, and W. Bodhi. Potential of Cinnamomum burmanii Ethanol Leaf Extracts Against Decreasing of Blood Glucose Levels from Sucrose White Rattus (Rattus Norvegicus). Pharmacon.2013; 2: 96-99.
  • Sreedhar S., and Christy P. H. Phytochemical Analysis of Rhizophora mucronata. Scrutiny International Research Journal of Agriculture, Plant Biotechnology and Bio Products (SIRJ-APBBP). 2015; 2(2). P, 39-43.

Abstract Views: 239

PDF Views: 0




  • Antidiabetic Activity of leaf extract from three types of Mangrove Originating from Sambera Coastal Region Indonesia

Abstract Views: 239  |  PDF Views: 0

Authors

Usman
Universitas Mulawarman, Samarinda, Indonesia
M. Muh. Amir
Universitas Mulawarman, Samarinda, Indonesia
Farah Erika
Universitas Mulawarman, Samarinda, Indonesia
M. Nurdin
Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Islam Makassar, Indonesia
Hadi Kuncoro
Laboratorium Pengembangan dan Penelitian Kefarmasian Farmaka Tropis, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Abstract


This study designed to determine the antidiabetic profile ethanol extracts of leaf extract from three types of mangroves; Avicennia sp., Rhizopora sp, and Sonneratia sp. Extraction process used maceration with ethanol solvent. The phytochemical assayis carried out qualitatively including assay of alkaloids, flavonoids, steroids, terpenoids, phenolic compounds, tannins, and saponins. The method used for the antidiabetic test is the method of blood glucose tolerance. The results showed that ethanol extract of three types of mangrove leaves Avicennia sp., Rhizopora sp, and Sonneratia sp. containing secondary metabolite group alkaloids, flavonoids, steroids, terpenoids, phenolic compounds, tannins, and saponins. Ethanol extract of leaves of the three types of mangroves plants has antidiabetic activity. The ethanol extract of leaves of mangrove Rhizophora sp. with a dose of 200 mg/kg BB + glucose 2 g / kg (group P-2) showed the most excellent antidiabetic activity and lowering blood glucose levels by 31.27%. This study confirmed that three types of Mangrove from Sambera Coastal Region Indonesia showed the antidiabetic profile.

Keywords


Avicennia sp., Rhizopora sp, Sonneratia sp., Glucosetolerance, antidiabetic.

References