Research Journal of Pharmacy and Technology

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Sulfisoxazole Guanidinyl Derivatives:Synthesis, Characterization and Docking Studies for potential Anti-TB agents


Affiliations
1 Department of Chemistry, Bangurnagar Arts, Science and Commerce College, Dandeli- 581325, Karnataka, India
2 Department of Chemistry, JSS College for Women, Saraswathipuram, Mysore-570 009 Karnataka, India
3 DOS in Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, Karnataka, India
     

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Guanidine’s are major functionality in natural and synthetic compound, which exhibit a variety of activities like antidiabetic, antimicrobial, antiviral, anticancer, antibiotic and anti-inflammatory etc. The wide spread of guanidine compounds in the field of pharmaceutical, makes them as one of the attractive pharmacophores. The presence of the -CN3 group in guanidine compounds makes them to have efficient affinity towards various substituents with wide range of biochemical activities. In the present study, novel Sulfisoxazole guanidinyl derivatives were synthesized and characterized by LCMS and NMR spectral studies. The synthesized compounds were screened for anti-TB and anti-oxidant activities. It was found that compounds with electron donating groups exhibited superior activity.

Keywords

Guanidines, Sulfisoxazole, Anti-TB Activity, Anti-Oxidant Activity.
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  • Sulfisoxazole Guanidinyl Derivatives:Synthesis, Characterization and Docking Studies for potential Anti-TB agents

Abstract Views: 237  |  PDF Views: 0

Authors

Mahesh Bhat
Department of Chemistry, Bangurnagar Arts, Science and Commerce College, Dandeli- 581325, Karnataka, India
N. Madhu
Department of Chemistry, JSS College for Women, Saraswathipuram, Mysore-570 009 Karnataka, India
B. K. Sagar
DOS in Chemistry, University of Mysore, Manasagangothri, Mysore-570 006, Karnataka, India
E. Vijay Sekhar
Department of Chemistry, JSS College for Women, Saraswathipuram, Mysore-570 009 Karnataka, India

Abstract


Guanidine’s are major functionality in natural and synthetic compound, which exhibit a variety of activities like antidiabetic, antimicrobial, antiviral, anticancer, antibiotic and anti-inflammatory etc. The wide spread of guanidine compounds in the field of pharmaceutical, makes them as one of the attractive pharmacophores. The presence of the -CN3 group in guanidine compounds makes them to have efficient affinity towards various substituents with wide range of biochemical activities. In the present study, novel Sulfisoxazole guanidinyl derivatives were synthesized and characterized by LCMS and NMR spectral studies. The synthesized compounds were screened for anti-TB and anti-oxidant activities. It was found that compounds with electron donating groups exhibited superior activity.

Keywords


Guanidines, Sulfisoxazole, Anti-TB Activity, Anti-Oxidant Activity.

References