![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextgreen.png)
![Open Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_open_medium.gif)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltextred.png)
![Restricted Access](https://i-scholar.in/lib/pkp/templates/images/icons/fulltext_restricted_medium.gif)
Curcumin Loaded Ethosomal Vesicular Drug Delivery System for the Treatment of Melanoma Skin Cancer
Subscribe/Renew Journal
Curcumin has an excellent safety profile having various pleiotropic actions, including anti-inflammatory, antioxidant, antitumoral, anticancer, and antimicrobial activities, with the potential for neuroprotective activity but the poor oral bioavailability limits its use as oral dosage form. The purpose of this study was to formulate and evaluate the transdermal drug delivery system of Ethosomes containing curcumin, a potent anti-cancer drug. Study on various formulation excipients revealed that all the excipients shown some variation which affected the vesicle size, zeta potential, PDI and entrapment efficiency. Batch prepared with 10 % of soya lecithin, 4.5 % of ethanol and 10% of cholesterol showed maximum entrapment efficiency of 81.2±3.12.In in vitro drug permeation studies using dialysis bag, the samples withdrawn in equal time intervals shown more drug release from the dialysis bag in comparison with that of inhouse paclitaxel gel which conform that the curcumin loaded ethosomal gel is a better formulation for the further studies. In ex vivo, permeation study using pork ear skin, curcumin loaded ethosomal gel showed the greater drug deposition on the skin > 60 % in 12 hrs for the better curability for the melanoma. Whereas inhouse paclitaxel gel shown < 60 % of drug deposition in 12 h. The comparison of both ethosomal gel and inhouse paclitaxel gel reveals that ethosomal gel shown maximum release within 12 hrs in both in vitro and ex vivo studies, which can be taken for the further in vitro cell line and in vivo study.
Keywords
Curcumin, Anticancer, Ethosomes, Melanoma, PDI.
Subscription
Login to verify subscription
User
Font Size
Information
- E. Touitou, N. Dayan, L. Bergelson, B. Godin, M. Eliaz, Ethosomes — novel vesicular carriers for enhanced delivery: characterization and skin penetration properties Journal of Controlled Release 65 (2000) 403–418
- Donatella Paolino, Giuseppe Lucania, Domenico Mardente, Franco Alhaique, Massimo Fresta, Ethosomes for skin delivery of ammonium glycyrrhizinate: In vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers Journal of Controlled Release 106 (2005) 99–110
- Cavalli, R., Marengo, E., Rodriguez, L., and Gasco, M. R. (1996). Effects of some experimental factors on the production process of solid lipid nanoparticles. European journal of pharmaceutics and biopharmaceutics, 42(2), 110-115.
- Chen, Y. J., Jinetal. (2006). [Preparation of solid lipid nanoparticles loaded with Xionggui powder-supercritical carbon dioxide fluid extraction and their evaluation in vitro release]. Zhongguo Zhong yao za zhi= Zhongguozhongyaozazhi= China journal of Chinese Materia Medica, 31(5), 376-379.
- Elldem, T., Speiser, P., and Hineal, A. (1991). Optimization of spray-dried and congealed lipid microparticles and cha-racterization of their surface morphology by scanning electron microscopy. Pharm Res, 8, 47-54.
- Ducat, E.etal. (2010). The experimental design as practical approach to develop and optimize a formulation of peptide-loaded liposomes. AAPS Pharm Sci Tech, 11(2), 966-975.
- Bhattacharyya, S,P. et al. (2012). Flurbiprofen loaded solid lipid nanoparticle formulation and optimization by using response surface methodology. International Journal of Pharmacy and Pharmaceutical Sciences, 4.
- Ankita, S., Bharakada, V., Rajesh, Ks., Jha, Ll. (2013). Experimental design and optimization studies of thermoreversible hydrogel containing liposomes for the controlled delivery of 5-fluoro uracil. Pharmagene, 1, 24-32.
- Avadi, Mr. et al. (2010). Preparation and characterization of insulin nanoparticles using chitosan and Arabic gum with ionic gelation method. Nanomed-Nanotechnol, 6, 58-63.
![](https://i-scholar.in/public/site/images/abstractview.png)
Abstract Views: 212
![](https://i-scholar.in/public/site/images/pdfview.png)
PDF Views: 0