Research Journal of Pharmacy and Technology

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A Comparative Study of the effect of Metformin and Metformin plus Garlic on Blood Glucose Level in patients with Type 2 Diabetes Mellitus in Iraq


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1 University of Kufa, Department of Pharmacology and Toxicology, Iraq
     

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Diabetes mellitus is an endocrine progressive disease, characterized by either lack of the peripheral tissue response to insulin or lack of it. It requires an intensive control and monitoring of blood glucose level or it would develop into serious macro- and micro- complications. Along with pharmacological treatment represented by oral hypoglycemic medications (for type2), and non-pharmacological treatment, represented by exercise and diet; natural herbal extracts such as Garlic oil also showed an additional reduce in blood glucose level in these patients. Objective: To assess the efficacy of Garlic plus Metformin and compare their effect with metformin alone in treatment of people with type 2 diabetes mellitus. Methods: we take two groups of diabetic patients treated by metformin, Garlic is administered to one group, and the other continued on metformin only. Measurements of fasting blood glucose level is taken every ten days and for three months. Results: after three months of treatment, Garlic has made a significant decrease in fasting blood glucose level (P value is less than 0.05), as compared to those who used metformin alone. Conclusion: Garlic has a beneficial effect on blood glucose level, and can be administered to diabetic patients, in the absence of contraindications.

Keywords

Metformin, Garlic, Diabetic, Neuropathy, Retinopathy.
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  • A Comparative Study of the effect of Metformin and Metformin plus Garlic on Blood Glucose Level in patients with Type 2 Diabetes Mellitus in Iraq

Abstract Views: 279  |  PDF Views: 0

Authors

Qayssar Joudah Fadheel
University of Kufa, Department of Pharmacology and Toxicology, Iraq

Abstract


Diabetes mellitus is an endocrine progressive disease, characterized by either lack of the peripheral tissue response to insulin or lack of it. It requires an intensive control and monitoring of blood glucose level or it would develop into serious macro- and micro- complications. Along with pharmacological treatment represented by oral hypoglycemic medications (for type2), and non-pharmacological treatment, represented by exercise and diet; natural herbal extracts such as Garlic oil also showed an additional reduce in blood glucose level in these patients. Objective: To assess the efficacy of Garlic plus Metformin and compare their effect with metformin alone in treatment of people with type 2 diabetes mellitus. Methods: we take two groups of diabetic patients treated by metformin, Garlic is administered to one group, and the other continued on metformin only. Measurements of fasting blood glucose level is taken every ten days and for three months. Results: after three months of treatment, Garlic has made a significant decrease in fasting blood glucose level (P value is less than 0.05), as compared to those who used metformin alone. Conclusion: Garlic has a beneficial effect on blood glucose level, and can be administered to diabetic patients, in the absence of contraindications.

Keywords


Metformin, Garlic, Diabetic, Neuropathy, Retinopathy.

References