Alcoholic Extract of Poly Herbal Powder Mixture for Anti-Obesity effect on Wistar Rats

Background: According to WHO (World Health Organization), more than 50 million pre-school children and approximately 2 billion adults are overweighed and more than half a billion are obese. Obesity is a matter of concern for population worldwide. For the treatment of obesity, the use of Ayurveda, as well as traditional forms of medication, has turned widely popular amongst the Indians. In fact, the world population is adopting many traditional medications, herbs, and formulations as a part of the lifestyle to cure obesity. Natural sources have always proved to bring long-term results as well as considered to be efficacious and safe as compared to the trending weight-loss product market. Objective: The objective of the paper is to evaluate and proclaim the effectiveness of extract of powdered poly herbs prepared in the laboratory from sources such as Ajowan fruit, Cinnamon bark, Leaves of pomegranate, Garlic buds and dried fruits of black pepper which could be potential anti-obesity source. Methods: The experiment was performed on Wistar male rats four weeks old weighing approx. 200-250g. They were administered the prepared herbal extract for evaluating the anti-obesity action. Throughout the experiment, the rats were divided into six groups with 6 rats in each group. Group I was considered as Normal Control Group hence normal pellet diet was given and no drug was administered to the rats of this group. Obesity was induced through HFD (high-fat diet) in standard and treated groups (Group II to VI). Group II was not given any medication to reduce obesity whereas a standard dose of Orlistat 5 mg/kg b. wt and was administered in Group III. Groups IV, V, VI were administered with Alcoholic Extracts containing different concentrations of Poly Herbal Powder and the anti-obesity action was recorded. The food intake, body weight, serum lipid profiles like, total TG, total serum cholesterol (TC), High-density lipoprotein (HDL), Low-density lipoprotein (LDL), Very Low-density lipoprotein VLDL, Blood glucose. Results: The average results of all groups were noted, plotted and analyzed where the results pointed out the anti-obesity activity in all groups. The standard group reported anti-obesity action whereas the treated groups with the maximum concentration was reported to be comparatively goodin anti-obesity action as compared to the standard group. Conclusions: The results concluded that the formulated herbal extract from powdered sources of dried herbs proved to be effective in the treatment of obesity. Multiple parameters were evaluated which directly pointed out that the extract is effective in relieving from the problem of obesity. The most effective treatment of the three concentrations of the prepared herbal extract was found to be Group VI HFD + Prepared Extract 200 mg/kg b. wt.