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Synthesis and Characterization New Heterocyclic Compounds Derivatives from Vanillin


Affiliations
1 Department of Physiology and Pharmacology/College of Veterinary Medicine/University of Kerbala, Iraq
2 Department of Chemistry, College of Sciences/University of Kerbala, Iraq
     

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In this article, some new heterocyclic derivatives, for example pyrimidine and pyrazoles were synthesized by reaction vanillin with paracetamol utilizing KOH as a catalyst to synthase 3-(4-hydroxy-3-methoxyphenyl)-N-(4- hydroxyphenyl)acrylamide(1).The compound (1) on react with Sodium azide, hydrazine, urea, and thiourea in the existence of acetic acid or KOH and ethanol as a catalyst to give (2,3,4,5) compounds. The reaction monitors by TLC. All synthesized compounds have been distinguished by melting point, IR, 1H.NMR spectroscopy.

Keywords

Vanillin, Paracetamol, Heterocyclic.
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  • Synthesis and Characterization New Heterocyclic Compounds Derivatives from Vanillin

Abstract Views: 190  |  PDF Views: 0

Authors

Hutham Abd Ali Abd Al Hussain
Department of Physiology and Pharmacology/College of Veterinary Medicine/University of Kerbala, Iraq
Sawsan Khudhair Abbas
Department of Chemistry, College of Sciences/University of Kerbala, Iraq

Abstract


In this article, some new heterocyclic derivatives, for example pyrimidine and pyrazoles were synthesized by reaction vanillin with paracetamol utilizing KOH as a catalyst to synthase 3-(4-hydroxy-3-methoxyphenyl)-N-(4- hydroxyphenyl)acrylamide(1).The compound (1) on react with Sodium azide, hydrazine, urea, and thiourea in the existence of acetic acid or KOH and ethanol as a catalyst to give (2,3,4,5) compounds. The reaction monitors by TLC. All synthesized compounds have been distinguished by melting point, IR, 1H.NMR spectroscopy.

Keywords


Vanillin, Paracetamol, Heterocyclic.

References