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An Outlook for a Novel Approach:Self-Micro Emulsifying Drug Delivery System (SMEDDS)


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1 Pharmaceutical Sciences, Assam down Town University, Guwahati–781026, India
     

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Self-micro emulsifying drug delivery system (SMEDDS) has been one of the exclusive approaches to improve solubility and increase bioavailability for the poorly aqueous soluble drug. Due to microstructural features of active entity and formulation as a whole, vigorous researches are being carried to explore the significance and possibility of this drug delivery system at present. SMEDDS is an isotropic mixture of oil, surfactant, co-surfactant and water which involves encapsulation of drug into the lipid base and the formulation as a whole have unique ability to form fine o/w emulsion upon gentle agitation. The whole emulsification process requires only little entropy change which is obtained from the peristaltic motion of gut. Due to microstructural features of active entity and formulation as a whole provided by this approach, vigorous researches are being done at present time to interrelate the in vitro results obtained with in vivo responses. Considering the fact that 40% of the newly discovered drugs are lipophilic in nature, it signifies that the study in this approach will continue and more commercial formulation will be made available in near future. This review gives an overview on SMEDDS with sequential demystification thus enabling a greater understanding of their present role in medicine and drug delivery.

Keywords

Self-Emulsifying, Drug Delivery System, Novel Approach, Lipophilic Drug.
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  • Tang B, Cheng GG, Xu JC. Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms. Drug Discovery Today. 2008;13: 606–612

  • Dokania S, Joshi AK. Self-micro emulsifying drug delivery system (SMEDDS) – challenges and road ahead. Drug Delivery. 2015;22: 675-690

  • Schulman JH and Hoar TP. Transparent Water-in-oil Dispersion: the Oleopathic Hydro-Micelle. Nature. 1943;152: 102-103

  • Bardhan S, Kundu K, Chakraborty G, Saha SK, Paul BK. The Schulman Method of Cosurfactant Titration of the Oil/Water Interface (Dilution Method): A Review on a Well-Known Powerful Technique in Interfacial Science for Characterization of Water-in-Oil Microemulsions. Journal of Surfactants and Detergents. 2015; 18: 547-567

  • Patel MJ, Patel SS, Patel NM, Patel MM. A Self-micro-emulsifying Drug Delivery System (SMEDDS). International Journal of Pharmaceutical Sciences Review and Research. 2010;4: 29-35

  • Savla R, Browne J, Plassat V, Wasan KM, Wasan EK. Review and analysis of FDA approved drugs using lipid-based formulations. Drug Development and Industrial Pharmacy. 2017; 43(11):1743-1758

  • Kalepu S, Nekkanti VK. Insoluble drug delivery strategies: review of recent advances and business prospects. ActaPharmaceuticaSinica B. 2015; 5(5):442-453

  • Najjar R. Microemulsions - A Brief Introduction. Available from: URL: https://www.intechopen.com/books/microemulsions-an-introduction-to-properties-and-applications/microemulsions-a-brief-introduction

  • Deshmukh A, Kulkarni S. Solid self-micro emulsifying drug delivery system of ritonavir. Drug Development and Industrial Pharmacy. 2014; 40: 477-87

  • Zhao K, Yuan Y, Wang H, Li P, Bao Z, Li Y. Preparation and evaluation of valsartan by a novel semi-solid self-micro emulsifying delivery system using Gelucire 44/14. Drug Development and Industrial Pharmacy. 2016; 42: 1545-52

  • Tung NT, Tran CS, Pham TM, Nguyen HA, Nguyen TL, Chi SC, Nguyen DD, Bui TB. Development of solidified self-micro emulsifying drug delivery systems containing l-tetrahydropalmatine: Design of experiment approach and bioavailability comparison. International Journal of Pharmaceutics. 2018; 537: 9-21

  • Savale S, Chalikwar S. Self-Micro Emulsifying Drug Delivery System (SMEDDS): A Review. Asian Journal of Biomaterial Research. 2017; 3: 12-17

  • Jing Q, Shen Y, Ren F, Chen J, Jiang Z, Peng B, Leng Y, Dong J. HPLC determination of anetholetrithione and its application to pharmacokinetics in rabbits. Journal of Pharmaceutical and Biomedical Analysis. 2006; 42(5): 613–617

  • Singh AK, Chaurasiya A, Singh M, Upadhyay SC, Mukherjee R, Khar RK. Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): development and optimization. AAPS Pharm Sci Tech. 2008; 9(2): 628–634

  • Yang S, Gursoy RN, Lambert G, Benita S. Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors. Pharmaceutical Research. 2004; 21(2): 261–270

  • Yao J, Lu Y, Zhou JP. Preparation of nobiletin in self-microemulsifying systems and its intestinal permeability in rats. Journal of Pharmacy and Pharmaceutical Sciences. 2008; 11(3): 22–9

  • Chen Y, Li G, Wu X, Chen Z, Hang J, Qin B, Chen S, Wang R (2008). "Self-microemulsifying drug delivery system (SMEDDS) of vinpocetine: formulation development and in vivo assessment. Biological and Pharmaceutical Bulletin. 2008; 31(1): 118–25

  • Lee S, Lee J, Choi YW. Design and evaluation of prostaglandin E1 (PGE1) intraurethral liquid formulation employing self-microemulsifying drug delivery system (SMEDDS) for erectile dysfunction treatment. Biological and Pharmaceutical Bulletin. 2008; 31(4): 668–672

  • Wei L, Sun P,Nie S, Pan W. Preparation and evaluation of SEDDS and SMEDDS containing carvedilol. Drug Development and Industrial Pharmacy. 2005; 31(8): 785–794

  • Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G, Lee HB, Cho SH. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. International Journal of Pharmaceutics. 2004; 274 (1): 65–73

  • Shen H, Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. Journal of Pharmacy and Pharmacology. 2006; 58(9): 1183–1191

  • Wu W, Wang Y, Que L. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. European Journal of Pharmaceutics and Biopharmaceutics. 2006; 63(3): 288–294

  • Patel D, Sawant KK. Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery systems (SMEDDS). Drug Development and Industrial Pharmacy. 2007. 33(12): 1318–1326

  • Goddeeris C, Coacci J, Van den MG. Correlation between digestion of the lipid phase of smedds and release of the anti-HIV drug UC 781 and the anti-mycotic drug enilconazole from SMEDDS. European Journal of Pharmaceutics and Biopharmaceutics. 2007; 66(2): 173–181

  • Cirri M, Mura P, Mora PC. Liquid spray formulations of xibornol by using self-microemulsifying drug delivery systems. International Journal of Pharmaceutics. 2007; 340(1): 84-91

  • Ito Y, Kusawake T, Prasad YV, Sugioka N, Shibata N, Takada K. Preparation and evaluation of oral solid heparin using emulsifier and adsorbent for in vitro and in vivo studies. International Journal of Pharmaceutics. 2006; 317(2): 114–119

  • Yi T, Wan J,Xu H, Yang X. A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics. 2008; 70(2): 439–444

  • Kim HJ, Yoon KA, Hahn M, Park ES, Chi SC. Preparation and in vitro evaluation of self-microemulsifying drug delivery systems containing idebenone. Drug Development and Industrial Pharmacy. 2000; 26(5): 523–529

  • Holm R, Porter CJ, Edwards GA, Müllertz A, Kristensen HG, Charman WN. Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides. European Journal of Pharmaceutical Sciences. 2003; 20(1): 91–97

  • Subramanian N, Ray S, Ghosal SK, Bhadra R,Moulik SP. Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib. Biological and Pharmaceutical Bulletin. 2004; 27(12): 1993–1999.

  • Zhou XT, Wang J, Wang Y, Sun JY, Nie SF, Pan WS. Design and in vitro evaluation of self-microemulsifying drug delivery systems for piroxicam. Acta Pharmaceutica Sinica C. 2008; 43(4): 415–420.

  • Reiss H. Entropy-induced dispersion of bulk liquids. Journal of colloid and Interface Science. 1975; 53: 61-70

  • Gursoy RN, Benita S. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomedicine and Pharmacotherapy. 2004; 58: 173–182

  • Patel PK, Patel MR, Patel KR. A review on self-micro emulsifying drug delivery systems. Advance Research in Pharmaceticals and Biologicals. 2014; 4: 590-598

  • Reddy BK, Karunakar A. Biopharmaceutics Classification System: A Regulatory Approach. Dissolution Technologies, 2011;1:31-35

  • Yasir M, Asif M, Kumar A, Agarwal A. Biopharmaceutical Classification system: An Account. International Journal of Pharm Tech Research. 2010; 2: 1681-1690

  • Kohli K, Chopra S, Dhar D. Self-emulsifying drug delivery systems: An approach to enhance oral bioavailability. Drug Discovery Today. 2010; 15: 958-965

  • Shukla P, Prajapati SK, Sharma UK, Shivhare S, Akhtar A. A Review on Self-micro Emulsifying Drug Delivery System: An Approach to Enhance the Oral Bioavailability of Poorly Water Soluble Drugs. International Research Journal of Pharmacy. 2012; 3: 1-6

  • Kyatanwar A., Jadhav K., Kadam V. Self-micro emulsifying drug delivery system (SMEDDS). Journal of Pharmacy Research. 2010; 3: 75-83

  • Yang RN, Lambert GG, Benita S. Enhanced oral absorption of paclitaxel in a novel self-micro emulsifying drug delivery system. Biomedicine and Pharmacotherapy. 2004; 58: 173-182

  • Kimura M, Shizuki M, Miyoshi K, Sakai T, Hidaka H, Takamura H, Matoba T. Relationship between the molecular structures and emulsification properties of edible oils. Biotechnology Biochemistry. 1994; 58: 1258–61

  • Patil RV, Patil KK, Mahajan VR, Dhaka AS. Self-emulsifying therapeutic- a review. International Journal of Pharmaceutical and Biological Archives. 2012; 3: 481-486

  • Mittal P, Rana AC, Bala R, Seth N. Lipid-based self-micro emulsifying drug delivery System (SMEDDS) for lipophilic drugs: an acquainted review. International Research Journal of Pharmacy. 2011; 2: 75-80

  • Kalamkar P, Pawar K, Baddi H, Thawkar B, Yevale R, Kale M. A Review on Self Micro Emulsifying Drug Delivery System (SMEDDS). International Journal of Pharmacy and Pharmaceutical Research. 2016; 6: 361-373 (2016)

  • Pathak A, Jain V, Nagariya AK. Recent Advances in Self Emulsifying Drug Delivery System - A Review. Drug Invention Today. 2010; 2: 123-129

  • Deokate UA, Sindhe N, Bhingare U. Novel approaches for development and characterization of SMEDDS: Review. International Journal of Current Pharmaceutical Research. 2013; 5: 5-12

  • Basalious EB, Shawky N, Badr-Eldin SM. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine: Development and optimization. International Journal of Pharmaceutics. 2010; 391: 203-211

  • Pimple SS, Yeole SE, Chaudhari PD. Formulation and Evaluation of Self Micro Emulsifying Drug Delivery system for Poorly Water Soluble Drug Risperidone. International Journal of Pharmaceutical Sciences Review and Research. 2013; 23: 155-162

  • Laddha P, Suthar V, Bhutani S. Development and Optimization of self-micro emulsifying drug delivery of domperidone. Brazilian Journal of Pharmaceutical Science. 2014; 50: 91-100

  • Kim MS, Ha ES, Choo GH and Baek IH. Preparation and in vivo Evaluation of a Dutasteride-Loaded Solid-Supersaturatable Self-Micro Emulsifying Drug Delivery System. International Journal of Molecular Sciences. 2015; 16: 10821-10833 51. Talele SG, Gudsoorkar VR. Novel Approaches for Solidification of SMEDDS. Journal of Pharmaceutical and Bio Sciences. 2016; 4: 22-23

  • Wagh MP, Singh PK, Chaudhari BS, Khairnar DA. Solid Self-emulsifying Drug Delivery System: Preparation Techniques and Dosage Forms. International Journal of Biopharmaceutics. 2014;5: 101-108 53. Maurya SD, Arya RKK, Rajpal G, Dhakar RC. Self-micro Emulsifying Drug Delivery System (SMEDDS) - A Review on Physio-chemical and Biopharmaceutical aspects. Journal of Drug Delivery and Therapeutics. 2017; 7(3): 55-65

  • Velayutham R, Masilamani K, Sathesh SK, Vuppalapati L. Bioavailability of poorly water-soluble drugs: Self-emulsifying drug delivery systems: a novel approach. International Journal of Pharmaceutical Sciences Review and Research. 2011; 10: 72-77

  • Sharma VK, Koka A, Yadav J, Sharma AK, Keservani RK. Self-Micro Emulsifying Drug Delivery Systems: A Strategy to Improve Oral Bioavailability. Ars Pharmaceutica. 2016; 57: 97-109

  • Darsika C, Fatima Grace X, Shanmuganathan S. Self-Micro Emulsifying Drug Delivery System – A Capsulization. Journal of Pharmaceutical Sciences and Research. 2016; 8: 121-124

  • Jakki R, Syed MA, Kandadi P, Veerabrahma K. Development of a Self-micro Emulsifying Drug Delivery System of Domperidone: in vitro and in vivo characterization. Acta Pharmaceutica. 2013; 63: 241-251

  • Parmar B, Patel U, Bhimani B, Sanghavi K, Patel G, Daslaniya D. SMEDDS: A Dominant Dosage Form Which Improves Bioavailability. American Journal of Pharm Tech Research. 2012; 2: 54-72

  • Gautam P, Divyesh S. Self-Micro Emulsifying Drug Delivery System to Enhance the Solubility of the Hydrophobic Drugs. Current Trends in Biomedical Engineering and BioSciences. 2018; 13: 1-6

  • Kyatanwar AU, Jadhav KR, Kadam VJ. Self-micro Emulsifying drug delivery system (SMEDDS): Review. Journal of Pharmacy Research. 2010; 3: 75-83

  • Suryawansi MR, Kondawar MS. Formulation and Evaluation of Solid self-micro emulsifying drug delivery system of Clarithromycin. Journal of Pharmaceutical Science.2014; 5: 27-35

  • Shukla JB, Patel SJ. Formulation and Evaluation of Self Micro Emulsifying System of Candesartan Cilexetil. International Journal of Pharmaceutical Sciences. 2010; 2: 143-146

  • Bora DK, Borude P, Bhise K. Formulation and Evaluation of Self micro emulsifying drug delivery system of low solubility drug for enhanced solubility and dissolution. Asian Journal of Biomedical and Pharmaceutical Sciences. 2013; 2: 7-14

  • Cote S, Gaudel G, Peracchia MT. Self-emulsifying and self-microemulsifying formulations for the oral administration of toxoids. 2005; EP1498143A1

  • Jody Firmin Marceline Voorspoels. Self-microemulsifying drug delivery systems of a HIV protease inhibitor. 2007; US 2007/0104740 A1

  • Vandana Bharat Patravale, Imran Ahmed Khan. Process and Preparation of Self micro/nano emulsifying system and compositions thereof. 2007; 208589

  • Christina Holmberg. Self-emulsifying drug delivery system. 2010; US7815933B2

  • L. Asem, S. Jiani, Z. Qiang, W. Xueqing, F. Ming. Preparation of sorafenib self-microemulsifying drug-delivery system for oral administration or intravenous injection and use thereof. 2009; CN101584661B

  • Chang-Shan Hsu. Self-micro emulsifying oral pharmaceutical composition of a hydrophilic drug and the preparation method thereof. 2012; EP2425818A1

  • Jing Lin. Self-Microemulsifying Dosage forms of low solubility active ingredients such as co-enzyme Q10. 2012; US8252326B2

  • Igor Legan, JanezKare, PolonaJurkovic. Self-microemulsifying drug delivery system. 2013; US8592490B2

  • Igor Legan, Luka Peternal, Mateja Novak Stagoj, Miha Homer, Tanja Rozman Paterka, UrosKlancar. Self-microemulsifying drug delivery system of abiraterone or abiraterone acetate. 2014; WO2014009434A1

  • H. Yesim Karasulu, Sebnem Apaydin, Evren Gundogdu, Ilgin Yildirim Simsir, Ugur Onsel Turk, Ercument Karasulu, Candeger Yilmaz, Tugce Turgay. Self-micro/ nanoemulsifying drug carrying system for oral use of Rosuvastatin. 2015; WO2015/142307Al

  • Michael A. Zeligs, Irwin C. Jacobs. Self-emulsifying formulations of DIM related indoles. 2018; US 9918965 B2

  • Bapurao Tarate, Rahul Chavan, Arvind K. Bansal. Oral solid self-emulsifying formulations: A Patent review. Recent Patents on Drug Delivery and Formulations. 2014;8:1-18

  • Laxmikant T. Gadhe, Sameeran V. Kapadi, Baburao Bachkar, Mayur Gandhi, Swati Tatele, G. N. Chaudhari. Recent Patent review on Self-micro emulsifying drug delivery system. World Journal of Pharmaceutical Research. 2015;4(3):965-979


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  • An Outlook for a Novel Approach:Self-Micro Emulsifying Drug Delivery System (SMEDDS)

Abstract Views: 255  |  PDF Views: 0

Authors

Himal Barakoti
Pharmaceutical Sciences, Assam down Town University, Guwahati–781026, India
Ananta Choudhury
Pharmaceutical Sciences, Assam down Town University, Guwahati–781026, India
Biplab Kumar Dey
Pharmaceutical Sciences, Assam down Town University, Guwahati–781026, India

Abstract


Self-micro emulsifying drug delivery system (SMEDDS) has been one of the exclusive approaches to improve solubility and increase bioavailability for the poorly aqueous soluble drug. Due to microstructural features of active entity and formulation as a whole, vigorous researches are being carried to explore the significance and possibility of this drug delivery system at present. SMEDDS is an isotropic mixture of oil, surfactant, co-surfactant and water which involves encapsulation of drug into the lipid base and the formulation as a whole have unique ability to form fine o/w emulsion upon gentle agitation. The whole emulsification process requires only little entropy change which is obtained from the peristaltic motion of gut. Due to microstructural features of active entity and formulation as a whole provided by this approach, vigorous researches are being done at present time to interrelate the in vitro results obtained with in vivo responses. Considering the fact that 40% of the newly discovered drugs are lipophilic in nature, it signifies that the study in this approach will continue and more commercial formulation will be made available in near future. This review gives an overview on SMEDDS with sequential demystification thus enabling a greater understanding of their present role in medicine and drug delivery.

Keywords


Self-Emulsifying, Drug Delivery System, Novel Approach, Lipophilic Drug.

References