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Dose Dependent Effect of Bacopa monnieri on Stress included Neural Degeneration in CA-1 and CA-3 Hippocampus Region of rat
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Aim: To evaluate the effect of Bacopa monnieri on CA-1 and CA-2 region of rats. Materials and Methods: Healthy adult male albino rats of Wistar strain weighing approximately 200-250 g were selected for the experiment. Group 1: This group consists of 6 rats housed in the laboratory for 4 weeks and was not exposed to any stress or drug except for daily handling and weighing. Group 2: This group consists of 6 rats, where each rat was given a cold stress for about 10 minutes in ice cold water with temperature around 15- 10° C. This procedure was done for the period of 4 weeks and no other drugs were induced. Group 3: This group consists of 6 rats, where they are given a cold stress for about 10 minutes in ice cold water of temperature 15- 10°C. This procedure was done for the period of 4weeks. Later each rat was given the drug Bacopa monnieri of 40mg/ kg with the required concentration for a period of 4 weeks. Group 4: This group consists of 6 rats, where they are given a cold stress for about 10 minutes in ice cold water of temperature 15- 10°C. This procedure was done for the period of 4 weeks. Later each rat was given the drug Bacopa monnieri of 80mg/ kg with the required concentration for a period of 4 weeks. Results: The present study reveals the protective and regenerative effect of Bacopa monnieri against cold-stress induced behavioural and biochemical anomalies in Wistar strain albino rats. The integrity of CA-3 hippocampal neurons, finding that Bacopa monnieri protected against age-related structural alterations. Histomorphometric study reveals an increase in the density of neuronal cells in CA-1 region. Conclusion: In our present study, the herb Bacopa monnieri is an effective drug in repairing the after effects of stress induced hippocampus of Wistar albino rats. As stress affects most of the neurons in CA region of hippocampus, the herb Bacopa monnieri can be used for improving memory in future after adequate amount of standard analysis.
Keywords
Bacopa monnieri, Wistar Rats, Cornus ammonis, Hippocampus, Stress.
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- Ramawat KG, Mérillon JM. Bioactive molecules and medicinal plants. Berlin: Springer; 2008 Oct 16.
- Marti O, Gavalda A, Jolin T, and Armario A. Effect of regulatory exposure to chronic immobilization stress on the circadian pattern of pituitary adrenal hormones, growth hormone and thyroid stimulating hormone in the adult male rat. Psychoneuroendocrinol 1993; 18: 67-77.
- Mathew J, Gangadharan G, Kuruvilla KP, Paulose CS. Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochemical research. 2011 Jan 1; 36(1):7-16.
- Bhaskar M, Jagtap AG. Exploring the possible mechanisms of action behind the antinociceptive activity of Bacopa monnieri. International journal of Ayurveda research. 2011 Jan; 2(1):2.
- Rauf K, Subhan F, Abbas M, Badshah A, Ullah I, Ullah S. Effect of Bacopasides on acquisition and expression of morphine tolerance. Phytomedicine. 2011 Jul 15; 18(10):836-42.
- Subhan F, Abbas M, Rauf K, Arfan M, Sewell RD, Ali G. The role of opioidergic mechanism in the activity of Bacopa monnieri extract against tonic and acute phasic pain modalities. Pharmacologyonline. 2010; 3:903-14.
- Preethi J, Singh HK, Charles PD, Rajan KE. Participation of microRNA 124-CREB pathway: a parallel memory enhancing mechanism of standardised extract of Bacopa monnieri (BESEB CDRI-08). Neurochemical research. 2012 Oct 1; 37(10):2167-77.
- Ramon Y Cajal S. New Ideas on the Structure of the Nervous System in Man and Vertebrates. Translated by Neely and Larry W. Swanson.
- Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002 Aug; 27(2):279.
- Wang X, Michaelis EK. Selective neuronal vulnerability to oxidative stress in the brain. Frontiers in aging neuroscience. 2010 Mar 30; 2:12.
- Ramon Y Cajal S. New Ideas on the Structure of the Nervous System in Man and Vertebrates. Translated by Neely and Larry W. Swanson.
- Redmond Jr DE, Huang YH. II. New evidence for a locus coeruleus-norepinephrine connection with anxiety. Life Sciences. 1979 Dec 24; 25(26):2149-62.
- Kumar SS, Saraswathi P, Vijayaraghavan R. Effect of bacopa monniera on cold stress induced neurodegeneration in hippocampus of wistar rats: a histomorphometric study. Journal of clinical and diagnostic research: JCDR. 2015 Jan; 9(1):AF05.
- Bose KC, Bose NK. Observations on the actions and uses of Herpestis monniera. J Ind Med Assoc. 1931; 1:60.
- Medina JH, Novas ML, Wolfman CN, De Stein ML, De Robertis E. Benzodiazepine receptors in rat cerebral cortex and hippocampus undergo rapid and reversible changes after acute stress. Neuroscience. 1983 Jun 1; 9(2):331-5.
- Squire LR, Zola-Morgan S. The medial temporal lobe memory system. Science. 1991 Sep 20; 253(5026):1380-6.
- Chatterjee N. Chemical examination of Bacopa monnieri Wettst. Part II: The Constitution of Bacoside A. Indian J. Chemistry. 1965; 3:24-9.
- Vollala VR, Upadhya S, Nayak S. Effect of Bacopa monnieri Linn.(Brahmi) extract on learning and memory in rats: A behavioral study. Journal of Veterinary Behavior: Clinical Applications and Research. 2010 Mar 1; 5(2):69-74.
- Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002 Aug; 27(2):279.
- O’Malley A, O’Connell C, Murphy KJ, Regan CM. Transient spine density increases in the mid-molecular layer of hippocampal dentate gyrus accompany consolidation of a spatial learning task in the rodent. Neuroscience. 2000 Sep 11; 99(2):229-32.
- Van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. Functional neurogenesis in the adult hippocampus. Nature. 2002 Feb; 415(6875):1030.
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