Research Journal of Pharmacy and Technology

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Role of Copper (II) Ion, in the Photochemical and Photosensitizing Properties of Zomepirac


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1 Organic Chemistry Section, Department of Chemistry, Uttaranchal University, Dehradun 248001, India
     

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A solution of zomepirac in methanol was irradiated with UVA light (λ=254) in Rayonet photochemical reactor. Photoproducts obtained were isolated and characterized on the basis of IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. Photochemical behavior of zomepirac was also studied in presence of copper (ii) ions. Copper at very low levels of concentration, modulates the distribution of zomepirac stable photoproducts as well as inhibits the DNA cleavage photo induced by the drug, via a highly efficient electron transfer process with the main transient species generated in the zomepirac photolysis.

Keywords

Zomepirac, Copper, Electron Transfer, Photosensitization.
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  • Role of Copper (II) Ion, in the Photochemical and Photosensitizing Properties of Zomepirac

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Authors

Waseem Ahmad
Organic Chemistry Section, Department of Chemistry, Uttaranchal University, Dehradun 248001, India

Abstract


A solution of zomepirac in methanol was irradiated with UVA light (λ=254) in Rayonet photochemical reactor. Photoproducts obtained were isolated and characterized on the basis of IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. Photochemical behavior of zomepirac was also studied in presence of copper (ii) ions. Copper at very low levels of concentration, modulates the distribution of zomepirac stable photoproducts as well as inhibits the DNA cleavage photo induced by the drug, via a highly efficient electron transfer process with the main transient species generated in the zomepirac photolysis.

Keywords


Zomepirac, Copper, Electron Transfer, Photosensitization.

References