Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Role of Copper (II) Ion, in the Photochemical and Photosensitizing Properties of Zomepirac


Affiliations
1 Organic Chemistry Section, Department of Chemistry, Uttaranchal University, Dehradun 248001, India
     

   Subscribe/Renew Journal


A solution of zomepirac in methanol was irradiated with UVA light (λ=254) in Rayonet photochemical reactor. Photoproducts obtained were isolated and characterized on the basis of IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. Photochemical behavior of zomepirac was also studied in presence of copper (ii) ions. Copper at very low levels of concentration, modulates the distribution of zomepirac stable photoproducts as well as inhibits the DNA cleavage photo induced by the drug, via a highly efficient electron transfer process with the main transient species generated in the zomepirac photolysis.

Keywords

Zomepirac, Copper, Electron Transfer, Photosensitization.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ahmad W; Zaheer M R; Gupta A; Iqbal, J; Photodegradation of trimeprazine triggered by self-photogenerated singlet molecular oxygen, Journal of Saudi Chemical Society, 2016, 20, 543–546.

  • Ahmad W; Photoinduced Aromatization of Asymmetrically Substituted 1, 4-Dihydropyridine Derivative Drug Cilnidipine, 2014, 1-6.

  • Gupta A; J, Iqbal; W, Ahmad; Zaheer M R; Photoinduced electron transfer photodegradation of photosensitive diuretic drugxipamide, Journal of Taibah University for Science, 2014, 8, 64– 70.

  • Farzadkia, M; Bazrafshan, E; Esrafili, A; Kyu Yang, J; ShirzadSiboni, M; Photocatalytic degradation of Metronidazole with illuminated TiO2 nanoparticles, Journal of Environmental Health Science & Engineering, 2015, 13, 35-37.

  • Klefah A. K; Musa Leif A. Eriksson; Photodegradation Mechanism of Nonsteroidal Anti-Inflammatory Drugs Containing Thiophene Moieties: Suprofen and Tiaprofenic Acid, J. Phys. Chem. B, 2009, 113, 11306–11313.

  • chen F; yuwang P; wen K; chen C; Wu A; Photolysis of NSAIDs. II. Online LC-MS Determination of Photodegradants from Carprofen, Journal of Food and Drug Analysis, 2003, 11, 186-190.

  • Klefah A. K. Musa; Eriksson L A; Photodegradation mechanism of the common non-steroidanti-inflammatory drug diclofenac and its carbazole photoproduct. Phys. Chem. Chem. Phys., 2009, 11, 4601–4610.

  • Klefah A. K. M; Matxain J M; Eriksson L A; Mechanism of Photoinduced Decomposition of Ketoprofen; J. Med. Chem. 2007, 50, 1735-1743.

  • Wang C C, Chen F A, Chen C J, Chao S H; Wu A B; Photolysis of NSAIDs. IV. Photoproducts of Zomepirac determined by LC-ESIMS; Biomed. Chromatogr, 2004, 18: 820–825.

  • Chen C; Chen F, Chih-jui C, Kun-shan wu; Anbang w; Stabilityindicating HPLC Assay Method of Zomepirac; Journal of Food and Drug Analysis, 2003,11, 2, 87-91.

  • Sortinoi S; Scaiano J C; Laser Flash Photolysis of Tolmetin: A Photoadiabatic Decarboxylation with a Triplet Carbanion as the Key Intermediate in the Photodecomposition Photochemistry and Photobiology, 1999, 69, 167-172.

  • Chen C J I; Development of stability-indicating high performance liquid chromatographic assay methods of NSAIDs—tolmetin and zomepirac. II. Photostability of tolmetin. MasterThesis, Taipei Medical University, Taipei, Taiwan (in Chinese), 2002

  • Ezzat M; Abdel-Moety; Mohamed A; Ibrahim, Rezk M R; Photodegradation and photostability-indication of mequitazine Spectrochimica Acta Part A, 2009, 74,740–745.

  • Shah R P; Singh S; Identification and characterization of a photolytic degradation product of telmisartan using LC–MS/TOF, LC–MSn, LC–NMR and on-line H/D exchange mass studies; Journal of Pharmaceutical and Biomedical Analysis; 2010, 53, 755–761.

  • Fasani E; Tilocca F; Albini A; Photochemistry of Oxazolidinone Antibacterial Drugs, Photochemistry and Photobiology, 2009, 85: 879–885.

  • Pontiki E; Hadjipavlou-Litina D; Chaviara A T; Evaluation of antiinflammatory and antioxidant activities of Copper (II) Schiff mono-base and Copper (II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5- methyl-thiazole; Journal of Enzyme Inhibition and Medicinal Chemistry; 2008; 23; 1011–1017.

  • Balamurugan V., Shankar S; Chandramohan S., Synthesis, Characterization and Antioxidant Activity of a Novel Cu (II) Complex of Schiff Base Derived from N, N’-bis(benzoin)-1,4 Butane Diimine; International Journal of Biological Chemistry, 2014, 8, 85-90.

  • Ibrahim M M; Motaleb A E; Ramadan M; Shaban S Y; Mersal Samir G A M; Shazly A E; Juaid S A; Syntheses, characterization and antioxidant activity studies of mixed-ligand copper(II) complexes of 2,2′-bipyridine and glycine: The X-ray crystal structure of [Cu(BPy )(Gly)]ClO; Journal of Molecular Structure, 2017, 1134, 319-329.

  • Bal-Demirci T, Şahin M, Kondakçı E, Özyürek M, ulküseven B, Apak R, Synthesis and antioxidant activities of transition metal complexes based 3-hydroxysalicylaldehyde-Smethylthiosemicarbazone, Spectrochim Acta A Mol Biomol Spectrosc. 2015;5; 138:866-72.

  • Antioxidant Activities of Plumbagin and Its Cu (II) Complex Bioinorganic Chemistry and Applications Volume 2011, 898726, 5.


Abstract Views: 184

PDF Views: 0




  • Role of Copper (II) Ion, in the Photochemical and Photosensitizing Properties of Zomepirac

Abstract Views: 184  |  PDF Views: 0

Authors

Waseem Ahmad
Organic Chemistry Section, Department of Chemistry, Uttaranchal University, Dehradun 248001, India

Abstract


A solution of zomepirac in methanol was irradiated with UVA light (λ=254) in Rayonet photochemical reactor. Photoproducts obtained were isolated and characterized on the basis of IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. Photochemical behavior of zomepirac was also studied in presence of copper (ii) ions. Copper at very low levels of concentration, modulates the distribution of zomepirac stable photoproducts as well as inhibits the DNA cleavage photo induced by the drug, via a highly efficient electron transfer process with the main transient species generated in the zomepirac photolysis.

Keywords


Zomepirac, Copper, Electron Transfer, Photosensitization.

References