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Evaluation of Some Physiological Parameters in Patients with Asthma


Affiliations
1 Babylon Technical Institute, Al-Furat Al-Awsat Technical University, 51015 Babylon, Iraq
2 College of Science, University of Babylon, Iraq
     

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The present study was performed to estimate some physiological parameters in patients with asthma, as well as the correlation between this disease and sex in three age groups. This work was applied on 59 asthmatic patients (23 male and 36 female) and 30 apparently healthy subjects (14 male and 16 female) as control group. The study reveals that the level of estradiol was increased significantly ( P< 0.05 ) in females compared with males, while there has been a raise in the level of estradiol of patient in the age groups (1-10), (11-20), and (31- 40) years in comparison with the with the categories (21-30) and ( > 50 ), in addition, there was higher increase in its level through the duration of the most illness than ten years, while the results of the study presented a clear difference ( P< 0.05 ) in the RBCs count of males with asthmatic compared to females. The data also displayed an obvious difference ( P< 0.05 ) in the platelets of patient males compared with healthy males, there is an increase ( P< 0.05) in the means of PCV and Hb in the age group ( > 50 ) in contrast with (1-10), (11-20) (21-30) and (31-40) groups, the results showed a significant variance in the platelets count between patients and healthy in the age group (1-10) as well as, there was a significant variance in the mean of RBCs count, PCV and Hb in the duration of illness > 10 years compared with the duration of the illness (1-5) years and (6-10) years.

Keywords

Estradiol, Asthma, Hb, PCV, RBC.
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  • Tollefsen E, Langhammer A, Romundstad P, Bjermer L, Johnsen R and Holmen TL. Female gender is associated with higher incidence and more stable respiratory symptoms during adolescence .Respir. Med, 2007; 101:896-902.

  • Cengizlier MR and Misirlioglu ED. Evaluation of risk factors in patients diagnosed with bronchial asthma. Allergol. Immunopathol .2006 (Madr); 34(1): 1-3 .

  • Zhang Z, Lai HJ, Roberg KA, Gangnon RE, Evans M D, Anderson E L and et al . Early childhood weight status in relation to asthma development in high –risk children .J. Allergy. Clin. Immunol, 2010; 126 (6): 1157 -62.

  • Vliagoftis H, Dimitriadou V, Boucher W, Rozniecki JJ, Correia I, Raam S and Theoharides T C . Estradiol augments while tamoxifen inhibits rat mast cell secretion. Int. Arch. Allergy Immunol., 1992; 98 (4): 398-409.

  • Spanos C, Mansoury M, Letourneau R, Minogiannis P, Greenwood J, Siri P, Sant GR. and Theoharides TC. Carbacholinduced bladder mast cell activation: augmentation by estradiol and implications for interstitial cystitis. Urology, 1996; 48 (5): 809-816.

  • Cocchiara R, Albeggiani G, Di Trapani G, Azzolina A, Lampiasi N, Rizzo F. and Geraci D. Modulation of rat peritoneal mast cell and human basophil histamine release by estrogens. Int. Arch. Allergy Appl. Immunol., 1990; 93 (2-3): 192–197.

  • Cocchiara R, Albeggiani G, Di Trapani G, Azzolina A, Lampiasi N, Rizzo F, Diotallevi L, Gianaroli L. and Geraci D. (1992). Estradiol enhances in vitro the histamine release induced by embryonic histamine-releasing factor (EHRF) from uterine mast cells. Hum. Reprod. , 1992; 7 (8): 1036-1041.

  • Lange P, Parner J, Prescott E, Ulrik CS and Vestbo J. Exogenous female sex steroid hormones and risk of asthma and asthma-like, symptoms: a cross sectional study of the general population. Thorax, 2001; 56:613–662.

  • Faschino Barbaro MP, De Tullio R, Cagnazzo M G, Depalo A, Carpagnano G E, Spanevello A and et al. Asthma and the menopause. Ageing Lung. 2006; 1:13–19.

  • Salam MT, Wenten M and Gilliland FD. Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women .J. Allergy Clin. Immunol. 2006; 117:1001-1007.

  • Haggerty CL, Ness RB, Kelsey S and Waterer GW. The impact of estrogen and progesterone on asthma. Ann. Allergy Asthma Immunol., 2003; 90:284- 291.

  • Piccinni M P, Giudizi M G, Biagiotti R, Beloni L, Giannarini L, Sampognaro S, Parronchi P, Manetti, R, Annunziato F and Livi C. Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J. Immunol., 1995 ; 155:128–133.

  • De Oliveira AP, Domingos HV, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho R M. and Vargaftig BB. Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol. Am. J .Physiol. Cell Physiol. 2007; 293:C1120–C1128.

  • Dacie JV and Lewis S M. Practical Hematology. 9thedn. 2001 ; 353-357.Churchillivingstone, London ,UK.

  • Hillman R S and Ault KA. Hematology in Clinical Practice. 3thedn. 2002; 46-47. McGram-Hill Company.

  • Rodak SB. Hematology Clinical Principles and Applications. 2ndedn., 2002; W.B. Saunders Company.

  • De Marco R, Locatelli F, Cerveri I, Bugiani M, Marinoni A. and Giammanco G. Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy. J. Allergy Clin. Immunol. 2002; 110 (2): 228-235.

  • Schatz M and Camargo CA Jr. The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization. Ann. Allergy Asthma Immunol., 2003 ; 91 (6): 553-558.

  • Zhao XJ, McKerr G, Dong Z, Higgins C A, Carson J, Yang ZQ. and Hannigan BM. Expression of estrogen and progesterone receptors by mast cells alone, but not lymphocytes, macrophages or other immune cells in human upper airways. Thorax. 2001; 56 (3): 205-211.

  • Narita S, Goldblum R, Watson C, Brooks EG, Estes DM, Curran EM and Midoro-Horiuti T. Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Environ. Health Perspect., 2007; 115 (1): 48-52.

  • Real FG, Svanes C, Omenaas ER, Anto JM, Plana E, Jarvis D and et al. Lung function respiratory symptoms, and the menopausal transition. J .Allergy Clin. Immunol. , 2008; l (121):72–80.

  • Macsali F, Real FG, Plana E, Sunyer J, Anto J, Dratva J, Janson C, Jarvis D, Omenaas ER, Zemp E, Wjst M, Leynaert B . and Svanes C. Early age at menarche, lung function, and adult asthma. Am. J. Respir. Crit. Care Med. 2011; 183:8–14.

  • Al-Sahab B, Hamadeh MJ, Ardern C I and Tamim H. Early Menarche Predicts Incidence of Asthma in Early Adulthood. Am. J. Epidemiol., 2011;173:S293–S293.

  • Jartti T, Saarikoski L, Jartti L, Lisinen I, Jula A, Huupponen R, Viikari J and Raitakari OT. Obesity, adipokines and asthma. Allergy, 2009; 64:770–777.

  • Jensen F, Woudwyk M, Teles A, Woidacki K, Taran F., Costa S., Malfertheiner, S.F., and Zenclussen, A. C. Estradiol and progesterone regulate the migration of mast cells from the peripherytothe uterus and induce their maturation and degranulation. PLoSONE. 2010; 5, e1 4409. doi:10.1371/journal.pone. 0014409

  • Jing H, Wang Z and Chen,Y. Effect of estradiol on mast cell number and histamine level in the mammary glands of rat. Anat.Histol. Embryol, 2011; 41, 170–176.

  • Walter J, Klein C and Wehrend A. Distribution of mast cells in vaginal, cervical and uterine tissue of non-pregnantmares: investigations on correlations with ovarian steroids. Reprod. Domest. Anim. 2011 ;47, e29–e31.

  • Freeman M R, Manlove L J, Thompson M A, Pabelick C M, Prakash Y S, and Sathish V. Estrogen Receptor Beta (erβ) Blunts Inflammation-Induced Human Airway Smooth Muscle Proliferation And Remodeling. Am J Respir Crit Care Med, 2014;189, A5318.

  • El-Desouki N I, Tabl G A and Elkhodary Y A. Biological studies on the effect of estrogen on experimentally induced asthma in mice. Toxicology and industrial health, 2013, 0748233713486959.

  • Townsend E A, Sathish V, Thompson M A, Pabelick C M, and Prakash Y S. Estrogen effects on human airway smooth muscle involve cAMP and protein kinase A. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012; 303(10), L923-L928.

  • Dimitropoulou C, White RE, Ownby DR and Catravas JD. Estrogen reduces carbachol-induced constriction of asthmatic airways by stimulating large-conductance voltage and calciumdependent potassium channels. Am J Respir Cell Mol Biol. 2005;32:239–247.

  • Matsubara S, Swasey CH, Loader JE, Dakhama A, Joetham A, Ohnishi H, Balhorn A, Miyahara N, Takeda K and Gelf EW. Estrogen determines sex differences in airway responsiveness after allergen exposure. Am J Respir Cell Mol Biol. 2008; 38:501–508.

  • Hellings PW, Vandekerckhove P, Claeys R, Billen J, Kasran, A and Ceuppens, J.L. Progesterone increases airway eosinophilia and hyper-responsiveness in a murine model of allergic asthma. Clin Exp Allergy. 2003;33:1457–1463.

  • Sullivan PJ, Jafar ZH, Harbinson PL, Restrick LJ and Costello JF, Page CP. Platelet dynamics following allergen challenge in allergic asthmatics. Repir 2000;67:514–517.

  • Ind PW, Peters AM, Malik F, Lavender JP and Dollery CT. Pulmonary platelet kinetics in asthma. Thorax 1985;40: 412–417.

  • Hemmendinger S, Pauli G, Tenabene A, Pujol JL, Bessot JC, Eber M and Cazenave JP, Platelet function: Aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man. J Allergy Clin Immunol 1989; 83:990–996.

  • Fajardo I, Svensson L, Bucht A and Pejler G. Increased levels of hypoxiasensitive proteins in allergic airway inflammation. Am J Respir Crit Care Med 2004;170(5):477–84.

  • Saito H, Yamagata T and Suzuki S. Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates. J Biol Chem 1968;243(7):1536–42.

  • Seaton A, Soutar A, Crawford V, Elton R, McNerlan S and Cherrie J. Particulate air pollution and the blood. Thorax, 1999; 54:1027-1032.

  • Bai KM, Krishnakumari MK, Ramesh HP, Shivanandappa T, and Majumder SK. Short-term toxicity study of zinc phosphide in Albino rats (Rattusnorvegicus). Indian J. exp. Biol. 1980; 18(8): 854-857.

  • Quinn CT. The acute chest syndrome of sickle cell disease. J. Pediatr., 1999; 135: 416-422.

  • Jessica HB, Eric AM, Robert CS and Michael RD. Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia. Blood, 2006 108: 2923-2927.

  • Dratva J, Schindler C, Curjuric I, Stolz D, Macsali F, Real-Gmez F, et al., . on behalf of the SAPALDIA Team. Perimenstrual increase in bronchial hyper-reactivity in premenopausal women: results from the population-based SAPALDIA 2 cohort. J. Allergy Clin. Immunol. , 2010; 125:823-9.


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  • Evaluation of Some Physiological Parameters in Patients with Asthma

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Authors

Thanaa Abdulmahdi Mokif
Babylon Technical Institute, Al-Furat Al-Awsat Technical University, 51015 Babylon, Iraq
Alaa Jawad Hassan
College of Science, University of Babylon, Iraq
Zainab Nasser Nabat
Babylon Technical Institute, Al-Furat Al-Awsat Technical University, 51015 Babylon, Iraq

Abstract


The present study was performed to estimate some physiological parameters in patients with asthma, as well as the correlation between this disease and sex in three age groups. This work was applied on 59 asthmatic patients (23 male and 36 female) and 30 apparently healthy subjects (14 male and 16 female) as control group. The study reveals that the level of estradiol was increased significantly ( P< 0.05 ) in females compared with males, while there has been a raise in the level of estradiol of patient in the age groups (1-10), (11-20), and (31- 40) years in comparison with the with the categories (21-30) and ( > 50 ), in addition, there was higher increase in its level through the duration of the most illness than ten years, while the results of the study presented a clear difference ( P< 0.05 ) in the RBCs count of males with asthmatic compared to females. The data also displayed an obvious difference ( P< 0.05 ) in the platelets of patient males compared with healthy males, there is an increase ( P< 0.05) in the means of PCV and Hb in the age group ( > 50 ) in contrast with (1-10), (11-20) (21-30) and (31-40) groups, the results showed a significant variance in the platelets count between patients and healthy in the age group (1-10) as well as, there was a significant variance in the mean of RBCs count, PCV and Hb in the duration of illness > 10 years compared with the duration of the illness (1-5) years and (6-10) years.

Keywords


Estradiol, Asthma, Hb, PCV, RBC.

References