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A Comparison Study of Nefopam ketamine, Tramadol ketamine and Xylazine ketamine anesthesia in Rabbit


Affiliations
1 College of Veterinary Medicine, University of Kerbala, Karbala, Iraq
2 College of Nursing, University of Misan, Misan, Iraq
     

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This study were preformed to evaluate and compare between three anesthetic regime, using injectable anesthesia (Nefopam/ketamine), (Tramadol / Ketamine) and (xylazine/ketamine) in anesthetic protocols in rabbits. Eighteen adult local breed rabbits from both sexes weighing (1.1-1.8) Kg. were divided equally into three groups they were housed indoor to accommodate the place of experiments. The following physiological parameters (heart rate, respiratory rate and rectal body temperature) were recorded before the intramuscular injection of the drugs for each group (zero time) as a self group. Group (A) were injected tramadol hydrochloride 10% 15 mg/kg B.W as premedication, after 10min. Ketamine hydrochloride 10% at a dose of 10 mg/kg, 50 mg/kg B.W., group (B) were injected Xylazine 2%10mg/kg B.W. as premedication, after 10min. the animals were injected as same in group (A). and group (C) were injected Nefopam 2% mg/kg B.W. as premedication, after 10min. the animals were injected as same in group (A) and (B). Stages of anesthesia (induction time, surgical time and recovery time) and physiologic parameters (heart rate, respiratory rate and Rectal body temperature) were evaluated. The most significant changes were reported in group (B) which useful regimen clinically for anesthetize rabbits due to long surgical time.

Keywords

Nefopam, Ketamine, Tramadol, Anaesthesia.
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  • Praag, E. V. (2003). Anesthesia of the rabbits. Part II: Intraanesthetic period, and its monitoring. Surgery in Rabbits - Anesthesia.P1-7. From Medi Rabbit.

  • Myers, D. (2005). Tramadol Seminars. Avian and Exotic pet medicine, 14: 284 – 287.

  • Trescot, A. M.; Datta, S.; Lee, M. and Hausen, H. (2008). opioid Pharmacology. Pain Physician, 11:5133 – 5153.

  • Gorono, S. and Sablotzki, A. (2004). Clinical Pharmacology of Tramadol. Clin. Pharma. Cokinet, 43: 874 – 923.

  • Hall, L.W. and Clarke, K.W. (1991). Veterinary Anesthesia 9th ed. London: Baillere Tindall, Pp: 180 –274.

  • Thurmon, J. C.; Tranquilli, W.J. and Benson, G.J. (1996). Lumb and Jones veterinary anesthesia. 3rd ed. Baltimore: 186 – 598.

  • Abd, T.A. (2002). Caudal epidural injection of Xylazine in Cattle. Al – Qadsyiah . J. Vet. Med. Sci., 2 (1): 32 – 33.

  • Al – Kattan, L.M.D. (1999). Using of alpha 2 adrenergic agonist Xylazine and Medetomedine for injection in epidural space in goats. MSC. Thesis university of Mosul –Iraq.

  • Harcourt – Brown, F. (2002). Textbook of Rabbits medicine. 1st ed. Butter Worth Heinemann. Pp:126 – 130.

  • P.V.; Tylor, P.M.; Brondani, T.J.; Luna, S.P. and Dixon, M. J. (2008). Antinoceptive effect of Tramadol and Acepromazine in cats. Journal of Feline Medicine and Surgery, 10: 24– 31.

  • Abdullahi, E. and Stephen, U. (2005): Ketamine anesthesia following premedication of rabbits with Vit C. Jor. Vet. Sci., 6(3): 239 –241.

  • Neil, S.L.; Robert, P.M. and Sausan, E.E. (1990). A comparison of Ketamine/Xylazine and Ketamine/Xylazine/Acepromazine anesthesia in the rabbits. Lab. Anim. Sci. Vol (40), 4:395– 398.

  • Castro, D.S.; Marta, F.A.S.; Andre, C.S.; Pedro, P.M.; Marcos, V.M.P. and Paul, O.S. (2009). Comparison between the analgesic effect of Morphine and Tramadol delivered epidurally in cats receiving a standardized noxious stimulation. Journal of Feline Medicine and Surgery. 4: 1 – 6.

  • SAS, (2010). SAS/STAT Users Guide for Personal Computer. Release 9.13.SAS Institute, Inc., Cary, N.C., USA.

  • Omar R A (2009). Efficiency of some analgesics mixed with general anaesthesia and their influence on bone healing in rabbits. Ph.D. Thesis- Pharma Veterinary Med coll Uni Bagh .1-191.

  • Quesenberry KE (1995). Rabbits. Section 12. In: Saunders manual of Small animal practice. Edited by: Birchard S J and Sberding RG. WB Saunders Company.Pp:1345-1348.

  • Tabaru H Ogawa H Otsuka H and Ito K (1987). Effect of xylazine on arterial blood pressure, heart rate and electrodiagram in spinal dogs. Jpn J Vet Sci. 49(2):391-394.

  • Oda S Tsuda T and Sasaki Y (1994). Adrenergic effects on pancreatic glucagons and insulin secretion in rabbits. Tohoku J Agricu Rese: 45(1-2):29-35.

  • Hedenqvist P (2008). Anaesthesia and analgesia for surgery in rabbits and rats: A comparison of the effects of different compounds. PhD thesis from the department of physiology and pharmacology, Karolinska institute, Stockholm, Sweden.P:12.

  • Kowalska D Bielanski P and Pietras M (2008). Suitability of behavioural tests for determining the ways rabbits function in the environment and their relationship with some productive traits. 9th World Rabbit Congress (Ethology and Welfare) June 10-13, Verona – Italy: 1195-1200.

  • Hawkins M G and Johnson L (2006) Diagnostic Bronchoscopy in Rabbits. Exotic. 8(9):13-17.

  • Borkowski GL Danneman PJ Russel GB and Lang CM (1990). An evaluation of three intravenous anesthetic regimens in New Zealand rabbits. Lab Anim Sci.40(3):270-276.

  • Afshar, F.S.; Baniadam, A. and Marshipour, S.P. (2005): Effect of Xylazine – Ketamine on arterial blood pressure, arterial blood PH, rectal temperature, heart and respiratory rates in goats. Bull Vet. Inst. Pul. Way, 94: 481 – 484.

  • Estrada, C.D. and Perez, F.M. (2008): Comparative study between Tramadol and Placebo in Knee surgery under local anesthesia. Anesthesiologia, 31: 179 – 183.

  • Lipman, N.S.; Marini, R.P. and Erdman, S.E. (1990): A comparison of Ketamine/Xylazine and Ketamine/Xylazine/Acepromazine anesthesia in the rabbits. Lab. Anim. Sci., 40: 395 – 398.

  • Monteiro, E.R.; Junior, A.R.; Quirilos Ascis, H.M.; Compagnol, D. and Quitaz, J.G. (2009): Comparative study on the sedative effects of morphine, methadone, butorphanol or Tramadol in combination with Acepromazine in dog. Vet. Anesth. Analg., 36: 25 –33.


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  • A Comparison Study of Nefopam ketamine, Tramadol ketamine and Xylazine ketamine anesthesia in Rabbit

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Authors

Jassim M. Khalaf Albozachri
College of Veterinary Medicine, University of Kerbala, Karbala, Iraq
Hayder M. AL-Tomah
College of Veterinary Medicine, University of Kerbala, Karbala, Iraq
Osamah N. Wali
College of Nursing, University of Misan, Misan, Iraq
Yasser J. Jameel
College of Veterinary Medicine, University of Kerbala, Karbala, Iraq

Abstract


This study were preformed to evaluate and compare between three anesthetic regime, using injectable anesthesia (Nefopam/ketamine), (Tramadol / Ketamine) and (xylazine/ketamine) in anesthetic protocols in rabbits. Eighteen adult local breed rabbits from both sexes weighing (1.1-1.8) Kg. were divided equally into three groups they were housed indoor to accommodate the place of experiments. The following physiological parameters (heart rate, respiratory rate and rectal body temperature) were recorded before the intramuscular injection of the drugs for each group (zero time) as a self group. Group (A) were injected tramadol hydrochloride 10% 15 mg/kg B.W as premedication, after 10min. Ketamine hydrochloride 10% at a dose of 10 mg/kg, 50 mg/kg B.W., group (B) were injected Xylazine 2%10mg/kg B.W. as premedication, after 10min. the animals were injected as same in group (A). and group (C) were injected Nefopam 2% mg/kg B.W. as premedication, after 10min. the animals were injected as same in group (A) and (B). Stages of anesthesia (induction time, surgical time and recovery time) and physiologic parameters (heart rate, respiratory rate and Rectal body temperature) were evaluated. The most significant changes were reported in group (B) which useful regimen clinically for anesthetize rabbits due to long surgical time.

Keywords


Nefopam, Ketamine, Tramadol, Anaesthesia.

References