Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Microbubbles-A Potential Novel Targeted Drug Delivery


Affiliations
1 University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, 509001, Telangana State, India
     

   Subscribe/Renew Journal


The natural toxic nature of chemotherapy drugs is essential for them to kill cancer cells, but it is also having the source of unfavourable side effects experienced by the patients. To reduce these side effects have to limit the healthy tissue exposure by encapsulating the drug. And the drug should be probable for rapid release inside the tumour. The microbubbles have an average size of less than that of red blood cells having 1–10 μm which are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field after reaching the specific area of interest. Micro bubbles dispersion method was introduced and investigated to develop oxygen transfer at low agitation rates and thus decreases power consumption and shear stress on the microorganisms. Microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. The micro bubbles may be targeted to specific tissue by incorporating protein ligands on the surface. This review focuses on the synthesis, characteristics of micro bubbles that give them beneficial properties and some important aspects of ultrasound parameters that are influence to enhance micro bubble mediated drug delivery.

Keywords

Microbubbles, Drug Delivery, Ultrasound, Ligands, Gene Delivery.
Subscription Login to verify subscription
User
Notifications
Font Size


  • J.E., Dayton. P.A, May. D,. Allen. J, Klibanov. A,. Ferrara. K. Optical observation of contrast agent destruction, appl. Phys. Lett 2000; 77:1056-1058

  • Marmottant.P,.Hilgenfeldt. S, :Controlled Vesicle deformation and lysis by single oscillating bubbles, Nature 2003; 423:153-156.

  • De Jong N, Bouakaz A, Frinking P. Basic acoustic properties of micro bubbles. Echocardiography. 2002; 19(3):229–240.

  • Von Bibra H, Voigt JU, Froman M, Bone D, Wranne B, Juhlin-Dannfeldt A. Interaction of micro bubbles with ultrasound. Echocardiography. 1999; 16(7 Pt 2):733–741. de Jong N, Bouakaz A, Frinking P. Basic acoustic properties of micro bubbles. Echocardiography. 2002; 19(3):229–240.

  • Von Bibra H, Voigt JU, Froman M, Bone D, Wranne B, Juhlin-Dannfeldt A. Interaction of micro bubbles with ultrasound. Echocardiography. 1999; 16(7 Pt 2):733–741.

  • Kheirolomoom A, Dayton PA, Lum AF, Little E, Paoli EE, Zheng H, et al. Acoustically active micro bubbles conjugated to liposome’s: characterization of a proposed drug delivery vehicle. J Control Release. 2007; 118 (3):275– 84.

  • Sirsi SR, Borden MA. Micro bubble compositions, properties and biomedical applications. Bubble Science, Engineering and Technology. 2009; 1(1/2):3–17.

  • Rajesh Patel; Micro bubble : An ultrasound contrast agent in molecular imaging, Pharma Times, May 2008; Vol. 40; Pg 15.

  • Deepika Maliwal; Micro bubbles Contrast Agents Using Ultrasound; Research Journal of Pharmacy and Technology; Vol. 1; issue 03; July-Sept. 2008.

  • Eniola A.O. and Hammer D.A.; In vitro characterization of leukocyte mimetic for targeting therapeutics to the endothelium using two receptors; Biomaterials; 2005; Vol.26; 7136-44.

  • Eniola A.O., Willcox P.J. and Hammer D.A.; Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligand pairs; Biophys. J.; 2003; 85; 2720-31.

  • Yiyao Liu, Hirakazu Miyoshi; Encapsulated Ultrasound micro bubbles: Therapeutic application in drug/ gene delivery; Journal of Controlled Release; Vol. 114; 2006; Pg 89.

  • Kanchan Maske, D. Shalini Rai, V. Swati Kale, B. Deepika Raut and G. Ashwini Chintales. Micro bubble and its applications. Int. J. of Pharm. and Life Sci. (IJPLS), Vol. 3, Issue 12: December: 2012, 2228-2235.

  • Nalini Kurup, Prajakta Naik, Microbubbles: a novel delivery system, JPRHC Volume 2 Issue 3, 228-234.

  • Yiyao. L, Hirakazu. M: Encapsulated Ultrasound micro bubbles: Therapeutic application in drug/ gene delivery; Journal of Controlled Release;; 2006; 114: 89

  • Bjerknes K., Sontaum P. C.; Preparation of polymeric micro bubbles: formulation studies and product characterisation. International Journal of Pharmaceutics; 1997; 158: 129.

  • Klibanov. A.V. Rychak. J.J,. Yang. W.C, Alikhani. S, Acton. S, Lindner. S.R,. Ley. K, Targeted ultrasound contrast agent for molecular imaging of inflammation in high-shear flow, Contrast Media Mol. Imaging; 2006; 1 :259–266.

  • Lentacker. I, Geers. B, Demeester. J, De Smedt. S.C, Sanders, N.N: Design and evaluation of doxorubicin-containing micro bubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved, Mol. Ther. 2010; 18: 101–108

  • Miller MW: Gene transfection and drug delivery. Ultrasound Med Biol 2000:59-62.

  • Unger EC, McCreery TP, Sweitzer RH: Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest Radiol 1998; 33:886-892.

  • Fritz TA, Unger EC, Sutherland G, Sahn D: Phase I clinical trials of MRX-115. A new ultrasound contrast agent. Invest Radiol 1997; 32:735-740.

  • Lindner JR, : Ultrasound assessment of inflammation and renal tissue injury with micro bubbles targeted to P-selectin. Song J, Christiansen J, Klibanov AL, Xu F, Ley K Circulation 2001; 104:2107-2112.

  • Weller GE, Ultrasound imaging of acute cardiac transplant rejection with micro bubbles targeted to intercellular adhesion molecule-1 Lu E, Csikari MM, Klibanov AL, Fischer D, Wagner WR, : Circulation 2003; 108:218-224.

  • Chomas JE, Dayton P, Allen J : Mechanisms of contrast agent destruction. IEEE. Trans Ultrason Ferroelectr Freq Control 2001; 48:232-248.

  • Chomas JE, Dayton P, May D, Ferrara K: Threshold of fragmentation for ultrasonic contrast agents. J Biomed Opt 2001; 6:141-150.

  • Song J, Chappell JC, Qi M, Kaul S, Price RJ: Influence of injection site, microvascular pressure and ultrasound variables on micro bubble-mediated delivery of microspheres to muscle. J Am Coll Cardiol 2002; 39:726-731.

  • LeongPoi H, Christiansen J, Heppner P, Lewis C, Klibanov A,.Kaul S, Lindner J, 2005; 111:3248-3254.

  • Klibanov A.L.; Targetted delivery of gas filled microspheres, contrast agents for ultrasound imaging : Adv. Drug Delivery Review; 1999; 37: 139-157.

  • Klibanov A.L.; Ligand carrying gas filled micro bubble : Ultrasound contrast agents for targeted molecular imaging; Bioconjug. Chem.2005; 16: 9-17

  • Lindner J.R.; Micro bubbles in medical Imaging : Current applications and future directions, Nat Rev. Drug Discovery 2004; 13:527-532.

  • McCulloch M.C., Gresser S., Moos J.; Ultrasound contrast physics : A series on contrast echocardiography; article 3; J Am Soc Echocardiogy; 13: 959-67.

  • Lewis. C.W, McConaughy. J, Rinkevich. D, Klibanov. A.L, Lindner. J.R, Development of a novel micro bubble agent for ultrasound-mediated targeted drug delivery, Circulation 110, 2004; 5: 511.

  • Marmottant. P, Hilgenfeldt. S, Controlled vesicle deformation and lysis by single oscillating bubbles, Nature 2003; 423: 153–156.

  • Jain Hitesh, Patel Parth, Fanse Suraj, Patel Prachi, Yadav Shikha, Microbubbles - A potential ultrasound tool in drug delivery, AJPCR, 2011, 4(2), 6-11.

  • Annemieke van Wamel, Klazina Kooimam; Vibrating microbubbles poking individual cells : Drug transfer into cells via sonoporation; Journal of Controlled Release; Vol.112; 2006 Pg 149.

  • Ka-Yun Ng and Terry. O. Matsunga; Ultrasound Mediated drug delivery; Wiley Publications.

  • Lindner J.R., Klibanov A.L., and Ley K.; Targetting inflammation, In : Biomedical aspects of drug targeting; 2002; 149-172.

  • Ying-Zheng Zhao Æ Cui-Tao Lu; Factors that affect the efficiency of antisenseoligodeoxyribonucleotide transfection by insonated gas-filled lipid microbubbles; J Nanopart Res (2008) 10:449–454.

  • Patil Praful, Waghulde Sandeep, Baviskar Tushar, Singh Shweta, Naik Pravin, Juvatkar Pritam, Gorde Nilesh, Kale Mohan. Microububble: Targated Drug Delivery System: A Review Int. J. Pharm. Sci. Rev. Res., 46(2), September - October 2017; Article No. 13, Pages: 66-76.

  • Sophie Hernota B. and Alexander L. Klibanova, Microbubbles in ultrasound-triggered drug and gene delivery; Advanced Drug Delivery Reviews Volume 60, Issue 10, 30 June 2008, Pages 1153-1166.

  • Nalini Kurup, Prajakta Naik, Microbubbles: a novel delivery system, JPRHC volume 2 issue 3 228-234.


Abstract Views: 180

PDF Views: 0




  • Microbubbles-A Potential Novel Targeted Drug Delivery

Abstract Views: 180  |  PDF Views: 0

Authors

G. Chinna Devi
University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, 509001, Telangana State, India
A. Eswar Kumar
University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, 509001, Telangana State, India

Abstract


The natural toxic nature of chemotherapy drugs is essential for them to kill cancer cells, but it is also having the source of unfavourable side effects experienced by the patients. To reduce these side effects have to limit the healthy tissue exposure by encapsulating the drug. And the drug should be probable for rapid release inside the tumour. The microbubbles have an average size of less than that of red blood cells having 1–10 μm which are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field after reaching the specific area of interest. Micro bubbles dispersion method was introduced and investigated to develop oxygen transfer at low agitation rates and thus decreases power consumption and shear stress on the microorganisms. Microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. The micro bubbles may be targeted to specific tissue by incorporating protein ligands on the surface. This review focuses on the synthesis, characteristics of micro bubbles that give them beneficial properties and some important aspects of ultrasound parameters that are influence to enhance micro bubble mediated drug delivery.

Keywords


Microbubbles, Drug Delivery, Ultrasound, Ligands, Gene Delivery.

References