Research Journal of Pharmacy and Technology

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Microbubbles-A Potential Novel Targeted Drug Delivery


Affiliations
1 University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, 509001, Telangana State, India
     

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The natural toxic nature of chemotherapy drugs is essential for them to kill cancer cells, but it is also having the source of unfavourable side effects experienced by the patients. To reduce these side effects have to limit the healthy tissue exposure by encapsulating the drug. And the drug should be probable for rapid release inside the tumour. The microbubbles have an average size of less than that of red blood cells having 1–10 μm which are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field after reaching the specific area of interest. Micro bubbles dispersion method was introduced and investigated to develop oxygen transfer at low agitation rates and thus decreases power consumption and shear stress on the microorganisms. Microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. The micro bubbles may be targeted to specific tissue by incorporating protein ligands on the surface. This review focuses on the synthesis, characteristics of micro bubbles that give them beneficial properties and some important aspects of ultrasound parameters that are influence to enhance micro bubble mediated drug delivery.

Keywords

Microbubbles, Drug Delivery, Ultrasound, Ligands, Gene Delivery.
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  • Microbubbles-A Potential Novel Targeted Drug Delivery

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Authors

G. Chinna Devi
University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, 509001, Telangana State, India
A. Eswar Kumar
University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, 509001, Telangana State, India

Abstract


The natural toxic nature of chemotherapy drugs is essential for them to kill cancer cells, but it is also having the source of unfavourable side effects experienced by the patients. To reduce these side effects have to limit the healthy tissue exposure by encapsulating the drug. And the drug should be probable for rapid release inside the tumour. The microbubbles have an average size of less than that of red blood cells having 1–10 μm which are capable of penetrating even into the small blood capillaries and releasing drug and genes under the action of ultrasound field after reaching the specific area of interest. Micro bubbles dispersion method was introduced and investigated to develop oxygen transfer at low agitation rates and thus decreases power consumption and shear stress on the microorganisms. Microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. The micro bubbles may be targeted to specific tissue by incorporating protein ligands on the surface. This review focuses on the synthesis, characteristics of micro bubbles that give them beneficial properties and some important aspects of ultrasound parameters that are influence to enhance micro bubble mediated drug delivery.

Keywords


Microbubbles, Drug Delivery, Ultrasound, Ligands, Gene Delivery.

References