Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Ocular Drug Delivery System–An Update Review


Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to JSS Academy of Higher Education and Research, Mysuru), India
     

   Subscribe/Renew Journal


Eye being a unique and complex organ the access of exogenous substances to the ocular tissues are restricted by its physiology and defense mechanism. Thus the delivery of therapeutic agents to the ocular tissues is not an easy assignment. Cornea an important component present in eye is protected by very effective protective mechanisms which provide the pharmaceutical scientists a challenge of designing a formulation and delivering it to the targeted sites in sufficient concentrations. Development of newer approaches and novel therapeutic agents continue to provide delivery system a high therapeutic efficacy. Due to the defects in the traditional treatment, and also the therapeutic drug levels in targeted site is not maintained for longer time, the search of new type of ophthalmic approaches and technologies has drawn more and more attentions. In past two decades research in ocular delivery system have been accelerated towards a novel, safe and patient compliance formulation and medical devices to surpass the barriers and maintain the therapeutic level in tissues. Recently various technologies with good efficacy and biocompatibility have also been developed to treat the ocular diseases at both the anterior and posterior portion of eye. Anterior segment approaches for ocular treatment, advances are witnessed through the modulation of conventional topical drops with permeation enhancers and it also includes the development as ointments, gels etc. Several nano-formulations are also introduced for treating the anterior portion of the eye. Furthermore for posterior delivery, research focused immensely towards the development of releasing devices and also nano-formulation. Therefore these novel approaches and devices are easy to formulate, possess negligible irritation, prolonged precorneal residence time, sustained drug release, and enhanced bioavailability. An update of research advancement in ocular drug delivery provides and helps the scientists to modulate and develop safe drug delivery strategies. This review article gives update information about various approaches for delivering the drug to ocular region.

Keywords

Eye, Ocular Drug Delivery, Barriers, Conventional Drug Delivery, Novel Dosage Form, Approaches.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ashim K. Mitra. Textbook of Ophthalmic Drug Delivery Systems. Drugs and the Pharmaceutical Sciences.2nd Edition, Revised and Expanded.

  • Ripal Gaudana, J.Jwala, Sai H. S. Boddu, Ashim K. Mitra. Recent Perspectives in Ocular Drug Delivery. Pharmaceutical Research, Vol May2009; 26:No.5.

  • K. P. Sampath Kumar, Debjit Bhowmik, Shravan Paswan, Shweta Srivastava. Recent challenges and advances in Ophthalmic drug delivery system. The Pharma Innovation.2012; Vol.No.4.

  • Patel PB, Shastri DH, Shelat PK, Shukla A K. Ophthalmic Drug Delivery System: Challenges and Approaches. Systematic Reviews in Pharmacy. 2010; Vol 1:Issue 2.

  • Upendra Kumar Sharma, Amita Verma, Sunil Kumar Prajapati, Himanshu Pandey. Ocular drug delivery: Assorted Obstructions and Contemporary progresses. International Journal of Research and Development in Pharmacy and Life sciences.2013; Vol 2:No 4, pp 464-473.

  • Vincent H. L. Lee, Joseph R.Robinson. Review: Topical Ocular drug delivery: Recent developments and future challenges.1986; Vol 2: pp 67-108.

  • Pawar Pravin, Yadav Adhikrao, Gharge Varsha. Ocular drug delivery and Novel formulation: A review. Asian journal of Pharmacy and Technology.2018; Vol 8(4).

  • Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra. Ocular drug delivery systems: An overview. World Journal of Pharmacology.2013June9; 2(2):47-64.

  • Noriyuki Kuno, Shinobu Fujii. Recent Advances in Ocular drug delivery systems. Polymers 2011; 3:193-221.

  • Foziyah Zakir, Singh Manvi, Iqbal Zeenat.Ocular drug delivery:Recent updates. International Journal of Drug Regulatory Affairs, 2016; 4(4):15-22.

  • Divya Gupta.Review on Ocular drug delivery. Pharmatutor Pharmacy Infopedia.2018.

  • Chrystete Le Bourlais, Liliane Acar, Hosein Zia, Pierre A. Sado, Thomas Needham, Roger Leverge. Ophthalmic Drug Delivery Systems-Recent Advances. January 1998; Vol 17:Issue 1:33-58p.

  • Kritika Nayak, Manju Misra.A review on recent drug delivery systems for posterior segment of eye. Biomedicine and Pharmacotherapy. Elsevier; 2018; 107:1564-82.

  • Kristiina Jarvinen, Tomi Jarvinen, Arto Urtti. Ocular absorption following topical delivery. Advanced drug delivery reviews. Elsevier.1995; 16: 3-19.

  • Saiichi Mishima, MD.Some Physiological aspects of the Precorneal Tear film. Arch Ophthalmol.1965; 73(2):233-241.

  • Ingrida Januleviciene, Lina Siaudvytyte, Ruta Barsauskaite. Opthalmic drug delivery in Glaucoma-A review. Research Gate.2012; 4(1):243-251.

  • Shravan Kumar Paswan, Pritt Verma, Mahendra Singh Yadav. Review-Advance Technique in Ocular drug delivery system. World journal of Pharmacy and Pharmaceutical sciences.2015; Vol 4:346-365.

  • Mittanamalli S Sridhar. Anatomy of cornea and ocular surface. Indian Journal of Ophthalmology.2018; 66(2):190-194.

  • Revathy V. Nair, Sreeja C. Nair, Anoop K. R. Current trends in Ocular drug systems and its applications. Research Journal of Pharmacy and Technology.2015; 8(5).

  • Kishore Cholkar, Supriya Reddy Dasari, Dhananjay Pal and Ashim K Mitra. Eye: Anatomy, Physiology and Barriers to drug delivery. Research Gate.2013; 1-36p.

  • Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra. Ocular drug delivery. American Association of Pharmaceutical Scientists Journal.2010; Vol 12:No.3.

  • Nathaniel J. Kim, Alon Harris, Alhasan Elghouche, Willy Gama, and Brent Siesky. Ocular Permeation Enhancers. Nano-Biomaterials for Ophthalmic drug delivery.177-209p.

  • Hao Chen, Yingying Jin, Lin Sun, Xi Li, Kaihui Nan, Huihua Lia. Recent development in ophthalmic drug delivery systems for therapy of both anterior and posterior segment diseases. Colloid and Interface Science Communications.Elsevier.2018; 24(March):54-61.

  • Indu Pal Kaur, R.Smitha. Penetration enhancers and ocular bioadhesives: Two new avenues for ophthalmic drug delivery. Drug delivery and Industrial pharmacy.2002; 28(4):353-369.

  • Ramaiyan Dhanapal, J.Vijaya Ratna. Ocular drug delivery system-A review. International Journal of Innovative drug discovery.2012; Vol 2:Issue 1:4-15.

  • Peter WJ Morrison and Vitaliy V Khutoryanskiy. Advances in ophthalmic drug delivery. Therapeutic Delivery.2014; 5(12):1297-1315.

  • John C. Lang. Ocular drug delivery conventional ocular formulations. Advanced drug delivery reviews.1995:16(1):39-43.

  • Akanksha Tiwari, Raj Kumar Shukla. Novel ocular drug delivery systems: An overview. Journal of Chemical and Pharmaceutical research.2010; 2(3):348-355.

  • P. Tangri, S. Khurana. Basics of Ocular drug delivery systems. International Journal of Research in Pharmaceutical and Biomedical sciences.2011; Vol 2(4).

  • K. S. Rathore, R. K. Nema, S. S. Sisodia. An overview and advancement in ocular drug delivery systems. International Journal of Pharmaceutical sciences and research.2010; Vol 1(10):11-23.

  • Yasmin Sultana, R Jain, M. Aqil and Asgar Ali. Review of Ocular drug delivery. Current drug delivery.2006; 3(2):207-217.

  • Patel Vishal, Agarwal Y.K. Current status and advanced approaches in ocular drug delivery system. Journal of Global Trends in Pharmaceutical Sciences.2011; Vol 2(2):pp 131-148.

  • Monali N. Dumore, Mahesh R. Mishra, Nitin G Dumore. Formulation of Ketoconazole ophthalmic ointment using cow ghee as a base and penetration enhancer. International research journal of Pharmacy.2016; 7(7).

  • Rathore K.S, Nema R.K. An insight into Ophthalmic drug delivery system. International Journal of Pharmaceutical sciences and Drug research; 2009:1(1):1-5.

  • Shulin Ding. Recent developments in ophthalmic drug delivery. Research focus.1998; Vol 1: No 8.

  • Anchal Tyagi, Pramod Kumar Sharma, Rishabha Malviya. Novel technology and future propects of ocular drug delivery. Journal of basic pharmacology and toxicology.2017; 1(4):1-8.

  • Koichi Baba, Yuji Tanaka, Akira Kubota, Hitoshi Kasai, Shunji Yokokura, Hachiro Nakanishi, Kohji Nishida. A method for enhancing the ocular penetration of eye drops using nanoparticles of hydrolysable dye. Journal of Controlled release.Elsevier.2011; 153:278-287.

  • Priyanka Agarwal, Di Huang, Sachin S, Thakur, Ilva D Rupenthal. Chapter 4 Nanotechnology for ocular drug delivery. Design of Nanostructures for versatile therapeutic applications. Elsevier.2018; 137-188p.

  • James N. Chang. Recent advances in ophthalmic drug delivery. Handbook of Non-Invasive Drug delivery system.Elsevier.2010.165-192p.

  • M.J, Barea, M. J. Jenkins, M. H. Gaber, R. H. Bridson. Evaluation of liposomes coated with a pH responsive polymer. International journal of pharmaceutics.Elsevier.2010; 402:89-94.

  • Yerikala Ramesh, Chandrasekhar B, Kothapalli, Jayachandra Reddy Peddappi Reddigari. A novel approaches on Ocular drug delivery system. Journal of drug delivery and therapeutics. 2017; 7(6):117-124.

  • Smita Nayak, Madhuri Jadhav, Vaidhun Bhaskar. Recent advances in Ocular drug delivery system. Research Journal of Pharmacy and Technology.2016; 9(7).

  • Vijay Shinde, P. Amsa, S. Tamizharasi, D. Karthikeyan, T. Shivakumar, Aniket Kale. Formulation and Characterization of Eudragit RS 100 Nanosuspension for ocular delivery of Indomethacin. Research Journal of Pharmacy and Technology. 2010; 3(3).

  • Karthikeyan D, Pandey V. P. Preparation and Invitro characterization of Diclonefac sodium Niosomes for ocular use. Research Journal of Pharmacy and Technology. 2009; 2(4).

  • Yumei Wu, Yuanyuan Liu, Xinyue Li, Dereje Kebebe. Research progress of in-situ gelling ophthalmic drug delivery system. Asian journal of Pharmaceutical sciences.Elsevier.2018; 000:1-15.

  • S. K. Gupta, I. L. Singhvi. Insitu gelling system and other possible innovative approach for Ocular Disease: A review. Research Journal of Pharmacy and Technology.2011; 4(6).

  • Ashwini S. Mhetre, Ajay D. Shinde. Study of Intraocular permeability enhancement of Brimonidine tartrate by formulation in its insitu thermoreversible gel. Asian journal of Pharmaceutics.2016; 10(4):S527.

  • K. H. Hsu, S. Gause, A. Chauhan. Review of ophthalmic drug delivery by Contact lenses. Journal of drug delivery Science Technology.Elsevier.2014; 24(2):123-35.

  • Prina Mehta, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany. Development and Characterisation of electrospun timolol maleate-loaded polymeric contact lens coatings containing various permeation enhancers. International Journal of Pharmaceutics.2017; 532(1), pp408-420.

  • Li Gan, Yong Gan, Chunliu Zhu, Xinxin Zhang, Jiabi Zhu. Novel microemulsion insitu electrolyte triggered gelling system for ophthalmic delivery of lipophilic cyclosporine A:Invitro and invivo results. Elsevier.2009; 365(1-2):143-9.

  • Jae Hwan Jung, Bryce Chiang, Hans E. Grossniklaus, Mark R Prausnitz. Ocular drug delivery targeted by Iontophoresis in the suprachoroidal space using Microneedle. Journal of controlled release. Elsevier. 2018; 277:14-22.

  • Kurtis Moffatt, Yujing Wang, Thakur Raghu Raj Singh, Ryan F Donnelly. Microneedles for enhanced transdermal and intraocular drug delivery. Current opinion Pharmacology.Elsevier.2017; 36:14-21.

  • Rathore K. S, Nema R.K. Review on Ocular inserts. International Journal of Pharm Tech Research.2009; Vol 1, No 2, pp 164-169.

  • Gerard Lee See, Ayano Sagesaka, Hazuki Torizuka, Hiroaki Todo, Kenji Sugibayashi. Iontophoresis aided drug delivery into the eyeball via eyelid skin. Journal of drug delivery science and Technology.Elsevier.2018; 47:380-385.

  • Prina Mehta, Rita Haj Ahmad, All Al-Kinani. Approaches in topical ocular drug delivery and developments in the use of contact lenses as drug delivery devices. Therapeutic delivery.2017; 8(7):521-541.

  • Shambhavi Shahi, Shirish Deshpande. Iontophoresis: An approach to drug delivery enhancement. International journal of pharmaceutical sciences and research; 2017.

  • C.J.F Bertens, M. Gijs, R. M. M. A. Nuijts, F.J.H.M. Van den Biggelaar. Topical drug delivery devices. A review. Experimental Eye Research.Elsevier.2018; 168:149-60.

  • Di Huang, Ying Shan Chen, Ilva D. Rupenthal. Overcoming ocular drug delivery barriers through the use of physical forces. Advanced drug delivery reviews. Elsevier.2018; 126:96-112.

  • Chhavi Gupta, Anuj Chanuhan. Ophthalmic delivery of Cyclosporine A by Punctal plugs. Journal of Controlled release.Elsevier.2011; 150:70-76.

  • Karthikeyan D, Sonkar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, Bhowmick M, Shivakumar T. Development and Characterization of Modified Ocular Inserts with improved ocular compatibility. Research Journal of Pharmacy and Technology.2008; 1(2):93-9.

  • Deepak Nautiyal, Vikram Singh, Sahadat Ali. Formulation and Evaluation of Sustained release of Ofloxacin ocular inserts. Research journal of Pharmacy and Technology.2012; 5(12).

  • Karthikeyan D, Vijaikumar S, Pandey V.P, Nandha Kumar J, Sengottuvelu S, T Shivakumar. Preparation and evaluation of ocular inserts for controlled delivery of Ciprofloxacin hydrochloride. Research journal of Pharmacy and Technology.2008; 1(1).

  • Preeti K. Suresh, Geeta Barsa, Abhishek K. Sah, Sanjay J. Daharwal. Ocular implants as drug delivery device in ophthalmic therapeutics: An overview. Research journal of Pharmacy and Technology. 2014; 7(6).

  • Karthikeyan D, Bhowmick M, Pandey VP, Sengottuvelu S, Sonkar S, Gupta N, Mohod V, Shivakumar T. Design and Evaluation of Ofloxacin Extended Release Ocular Inserts for once a day therapy. Research Journal of Pharmacy and Technology. 2008; 1(4).


Abstract Views: 197

PDF Views: 0




  • Ocular Drug Delivery System–An Update Review

Abstract Views: 197  |  PDF Views: 0

Authors

L. Mythili
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to JSS Academy of Higher Education and Research, Mysuru), India
G. N. K. Ganesh
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to JSS Academy of Higher Education and Research, Mysuru), India
C. Monisha
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to JSS Academy of Higher Education and Research, Mysuru), India
R. Kayalvizhi
Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund. (Affiliated to JSS Academy of Higher Education and Research, Mysuru), India

Abstract


Eye being a unique and complex organ the access of exogenous substances to the ocular tissues are restricted by its physiology and defense mechanism. Thus the delivery of therapeutic agents to the ocular tissues is not an easy assignment. Cornea an important component present in eye is protected by very effective protective mechanisms which provide the pharmaceutical scientists a challenge of designing a formulation and delivering it to the targeted sites in sufficient concentrations. Development of newer approaches and novel therapeutic agents continue to provide delivery system a high therapeutic efficacy. Due to the defects in the traditional treatment, and also the therapeutic drug levels in targeted site is not maintained for longer time, the search of new type of ophthalmic approaches and technologies has drawn more and more attentions. In past two decades research in ocular delivery system have been accelerated towards a novel, safe and patient compliance formulation and medical devices to surpass the barriers and maintain the therapeutic level in tissues. Recently various technologies with good efficacy and biocompatibility have also been developed to treat the ocular diseases at both the anterior and posterior portion of eye. Anterior segment approaches for ocular treatment, advances are witnessed through the modulation of conventional topical drops with permeation enhancers and it also includes the development as ointments, gels etc. Several nano-formulations are also introduced for treating the anterior portion of the eye. Furthermore for posterior delivery, research focused immensely towards the development of releasing devices and also nano-formulation. Therefore these novel approaches and devices are easy to formulate, possess negligible irritation, prolonged precorneal residence time, sustained drug release, and enhanced bioavailability. An update of research advancement in ocular drug delivery provides and helps the scientists to modulate and develop safe drug delivery strategies. This review article gives update information about various approaches for delivering the drug to ocular region.

Keywords


Eye, Ocular Drug Delivery, Barriers, Conventional Drug Delivery, Novel Dosage Form, Approaches.

References