Research Journal of Pharmacy and Technology

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A Review on Current Applications of Bilayer Tablets


Affiliations
1 Nirmala College of Pharmacy Muvattupuzha, Ernakulam, Kerala, India
     

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Bilayer tablet technology is an improved beneficial technology to overcome the shortcomings of the single-layered tablet. The introduction of bilayer tablets into the pharmaceutical industry has enabled the development of pre-determined release profiles of active ingredients and incorporation of incompatible active ingredients into a single unit dosage form. Bilayer tablets provide one of the important design approaches where incompatible drugs, with a different indication, and same drug with different release rate can be incorporated in a single unit. Bilayer tablet is suitable for sequential release of two drugs in combination, and for sustained release tablets in which one Layer is immediately released as initial dose and the second layer is a maintenance dose. Bilayer formulations carry one drug, and deliver each of them without any pharmacokinetic or dynamic interactions, with their individual rate of delivery. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic drugs. This review discusses various applications of bilayer tablets such as controlling of delivery rate, providing synergic property and agonistic effect, administration of fixed-dose combinations etc. In sustained release tablet formulations, the commonly used functional ingredient is HPMC and in immediate release, the commonly used functional ingredients are Sodium Starch Glycollate, Crospovidone, and Croscarmellose sodium.

Keywords

Bilayer Tablet, Immediate Release, Sustained Release, Super Disintegrant, Release Pattern.
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  • Shila V. Devtalu, Ashwini E. Patil1, Manoj M. Bari1, et al; A Review on Novel Approach – Bilayer Tablet Technology. International Journal of Pharmaceutical Sciences Review and Research. 2013; 21(1):46-52.

  • Hemanth Kumar, K. Kavitha, Selvi Arun Kumar, et al; Novel approach of bilayer technology –A review. International Journal of Pharmaceutical, Chemical and Biological Sciences.2013; 3(3):887-893.

  • Shila V. Devtalu, Ashwini E. Patil1, Manoj M. Bari1, et al; A Review on novel approach –Bilayer technology. International Journal of Pharmaceutical Sciences Review and Research. 2013; 21(1): 46-52.

  • Verma Rameshwar, Devre Kishor, Gangrade Tushar, Bi-layer tablets for various drugs: A review, Scholars Academic Journal of Pharmacy. 2014; 3(3): 271-279.

  • C. Gopinath, V. Hima Bindu, M. Nischala. An overview on bilayered tablet technology. Journal of Global Trends in Pharmaceutical Sciences. 2013; 4 (2): 1077-1085.

  • Anupam Sachan N and Ankita Gupta. Formulation and Evaluation of Bilayer Tablets of Nitazoxanide. Der Pharmacia Lettre [http://scholarsresearchlibrary.com/archive.html]. 2017; 9[7]:1-9.

  • S. Jayaprakash, S. Mohamed Halith, K. Kulathuran Pillai, et al; Formulation and evaluation of bilayer tablets of amlodipine besilate and metprolol succinate. Der Pharmacia Lettre(http://scholarsresearchlibrary.com/archive.html). 2011; 3 (4): 143-154

  • Pamu. Sandhya, Faheem Unnisa Begum, Afreen. Formulation and Evaluation of Bilayer Tablets of Glimepiride and Metformin HCL. IOSR-Journal of Pharmacy and Biological Sciences.2014); 9(1) :38-45

  • Dr. Vijaya Kuchana, Ayesha Farooqui, Peddireddy, et al; Development and characterization of bilayer tablets of candesartan cilexetil. Indo American Journal of Pharmacy. 2017; 3 (6): 338-346.

  • Lokesh Kumar, M. Vijay Kumar and Gaurav Tiwari, Combinational therapy of Rosuvastatin calcium and Fenofibrate as bilayer tablet: A potential approach to control hypolipidemia. International Journal of Pharmaceutical Sciences and Research.2016; 7(1): 413-428.

  • Navesh Veer, Lal Ratnakar Singh and Lalit Kumar Tyagi. Formulation and evaluation of bilayer sustain release tablet of Allopurinol and Telmisartan for the the treatment of hyperuricemia associated with hypertension. World Journal of Pharmacy and Pharmaceutical Sciences. 2018; 7(5): 1189-1209.

  • Chinamniranjan Patra, Arethibharani Kumar, Hemant Kumarpandit, etal; Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride. Acta Pharm. 57 (2007) 479–489.

  • Metkar Vishal, Kumar Anuj, Pant Pankaj, etal; Formulation, development and evaluation of Bilayer tablets of Lornoxicam. International Journal of Drug Development & Research. 2012; 4 (2): 173-179.

  • Momin Shahanoor, Khan Shadab, Ghadage D.M., Yadav et al; Formulation and evaluation of bilayer tablet of propranolol hydrochloride. Journal of Drug Delivery &Therapeutics. 2017; 7(2):50-57.

  • Rajeev Sharma, Naresh Kalra, Rahul Gupta etal; Development and evaluation of sustained release bilayer matrix tablet of glipizide and metformin hydrochloride. International Journal of Drug Research and Technology.2014; 4 (1):01-13

  • Surendra G. Gattani, Sohan S. Khabiya, Jitendra R. Amrutkar. Formulation and Evaluation of Bilayer Tablets of Metoclopramide Hydrochloride and DiclofenacSodium.PDA Journal of pharmaceutical science and technology.2012; 66(2):151-160.

  • R. P. Swain, Shilpa Pendela and S. Panda. Formulation and evaluation of gastro bilayer floating tablets of simvastatin as immediate release layer and atenolol as sustained release layer. Indian Journal of pharmaceutical sciences. 2016; 78(4):458-468

  • Nawar M. Toma and YehiaI. Khalil. Formulation and Evaluation of Bilayer Tablets Containing Immediate Release Aspirin Layer and Floating Clopidogrel Layer. Iraqi Journal of pharmaceutical sciences.2013; 22(1): 40-49.

  • P.H. Wakde, R.H. Kasliwal and S.B. Mane. Design and fabrication of gastro retentive bilayer floating tablet of propronolol Hcl using natural. International Journal of Pharmaceutical Sciences and Research. 2013; 4(12): 123-136.

  • GV. Wadageri, SA. Raju, SB. Shirsand, et al; Development and Evaluation of Mucoadhesive Bilayer Buccal Tablets of Carvedilol. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012; 3 (2): 576-584.

  • Shiv Kumar, Lal Ratnakar Singh and Lalit Kumar Tyagi. Formulation and evaluation of bilayer floating tablet of levocetirizine and Terbutaline. World journal of pharmacy and pharmaceutical sciences.2018; 7(5): 1210-1228.

  • Soham Shukla, Vikram Pandya, Praful Bhardiaetal. Bi-layer Tablet system – An Innovative trend. Asian Journal of Pharmaceutical Research.2013; 3(4):49-56.

  • J. Ravi Kumar Reddy, Y. Indira Muzib, K. P. R. Chowdary. Development and Characterization of Novel Trans Buccoadhesive Bilayer Tablets of Tapentadol Hydrochloride. Research Journal of Pharmaceutical Dosage forms and Technology.2013; 3(2):83-89.

  • P. Purushothaman, A. Umar Faruk Sha, T. Vetrichelvan. Formulation development and Evaluation of immediate and sustained release Bilayer Tablets Containing Amitriptyline HCl and Pregabalin for the treatment of Neuropathic Pain. Research Journal of Pharmaceutical Dosage forms and Technology.2017; 7(3):127-136.

  • Svapnil Sanghavi, Misam Polara, Manish Patel. Bilayer Tablets – A Review of State of Art. Research Journal of Pharmaceutical Dosage forms and Technology.2012; 4(3):160-165.

  • Soham Shukla, Vikram Pandya, Praful Bhardia etal. Formulation and In vitro Evaluation of Immediate Release Bilayer Tablets of Telmisartan and Amlodipine Besylate. A Review of State of Art. Research Journal of Pharmaceutical Dosage forms and Technology.2013; 5(2):79-87.

  • Nishanth I., Elango K., Deattu N. Stephen P. Formulation Development and Evaluation of Bilayer Tablets of Telmisartan for Immediate Release and Metformin Hydrochloride for Sustained Release. Research Journal of Pharmaceutical Dosage forms and Technology.2013; 5(3):139-144.

  • Hamid Khan, Mushir Ali, Alka Ahuja. Formulation and In-Vitro Evaluation of In-lay Matrix Tablets Containing Telmisartan and Hydrochlorothiazide. Research Journal of Pharmaceutical Dosage forms and Technology. 2015; 7(3):193-198.

  • Hamid Khan, Javed Ali. Formulation and Evaluation of Sustained Release Matrix Tablets Containing Aceclofenac and Paracetamol. Research Journal of Pharmaceutical Dosage forms and Technology.2017; 9(2):48-52.

  • Salma Banu S.K. and Venkateswara Rao T. Design and Development of Sustained Release Bilayered Tablets of Glipizide. Research Journal of Pharmaceutical Dosage forms and Technology.2012; 4(1):24-31.

  • Prakash N Kendre, Syed N Lateef, Rahul K Godge et al. Formulation and in vitro-in vivo Evaluation of Theophyline and Salbutamol Sulphate Sustained Release Tablets. Research Journal of Pharmaceutical Dosage Forms and Technology.2009; 1(2):103-107


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  • A Review on Current Applications of Bilayer Tablets

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Authors

Dhanish Joseph
Nirmala College of Pharmacy Muvattupuzha, Ernakulam, Kerala, India
Golda Maria Thomas
Nirmala College of Pharmacy Muvattupuzha, Ernakulam, Kerala, India

Abstract


Bilayer tablet technology is an improved beneficial technology to overcome the shortcomings of the single-layered tablet. The introduction of bilayer tablets into the pharmaceutical industry has enabled the development of pre-determined release profiles of active ingredients and incorporation of incompatible active ingredients into a single unit dosage form. Bilayer tablets provide one of the important design approaches where incompatible drugs, with a different indication, and same drug with different release rate can be incorporated in a single unit. Bilayer tablet is suitable for sequential release of two drugs in combination, and for sustained release tablets in which one Layer is immediately released as initial dose and the second layer is a maintenance dose. Bilayer formulations carry one drug, and deliver each of them without any pharmacokinetic or dynamic interactions, with their individual rate of delivery. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic drugs. This review discusses various applications of bilayer tablets such as controlling of delivery rate, providing synergic property and agonistic effect, administration of fixed-dose combinations etc. In sustained release tablet formulations, the commonly used functional ingredient is HPMC and in immediate release, the commonly used functional ingredients are Sodium Starch Glycollate, Crospovidone, and Croscarmellose sodium.

Keywords


Bilayer Tablet, Immediate Release, Sustained Release, Super Disintegrant, Release Pattern.

References