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Algesia and Analgesia in Pediatric Dentistry


Affiliations
1 Department of Pedodontics and Preventive Dentistry, Saveetha Dental College and Hospital, Saveetha University, Saveetha Institute of Medical and Technical Sciences, Chennai., India
2 Department, Department of Pedodontics and Preventive Dentistry, Sathyabama Dental College and Hospital, Chennai, India
3 Department of Pedodontics and Preventive Dentistry, Meenakshi Ammal Dental College and Hospital, Chennai, India
     

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Aim: To summarize the basic and current concepts of algesia and analgesia in pediatric dental practice by a thorough systematic literature research of databases. Background: Electronic databases were used to conduct a computerized search like MEDLINE, Pub Med, Scopus and Evidence-based Medicine reviews using the terms ‘‘analgesics,’’ “drugs for pain,” “pain in children,” and “dental pain management”. Review results: Effective management of pain in children is a major priority for patients, parents, and health-care providers. Analgesics, class of drugs which helps to relieve pain, act either on peripheral nerve endings or in the central nervous system. Dental practitioners’ knowledge to prescribe the most effective drug and appropriate dose to alleviate pain is necessary. Conclusion: A pain management strategy in pediatric dentistry includes the ‘3-D’ approach that provides a systematic way of evaluating and managing the acute dental pain patient using combined non-pharmacologic and pharmacologic strategies. Clinical significance: Thorough knowledge about the drugs and its combination can result in achieving required postoperative analgesia thereby reducing adverse effects in children.

Keywords

Analgesics, Algesia, Analgesia, Medications, Dental Pain.
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  • Ofelia L. Elvir-Lazo, Paul F. White. The role of multimodal analgesia in pain management after ambulatory surgery. Curr Opin Anesthesiol. 2010, 23:697–703.

  • Natalia E. Morone, Debra K. Weiner. Pain as the 5th vital sign: Exposing the vital need for pain education. ClinTher. 2013;35:1728–1732.

  • American Academy of Pediatric Dentistry. Policy on Pediatric Pain Management. Reference Manual 2016;37:82-83.

  • S. M. Walker. Pain in children: recent advances and ongoing challenges. Br J Anaesth. 2008;101:101–10.

  • Ashley PF, Parekh S, Moles DR, Anand P, Behbehani A. Preoperative analgesics for additional pain relief in children and adolescents having dental treatment. Cochrane Database Syst Rev. 2012;9.

  • Clifford J. Woolf. Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management. Ann Intern Med. 2004;140:441-451.

  • Massieh Moayedi, Karen D. Davis. Theories of pain: from specificity to gate control. J Neurophysiol. 2013;109:5–12.

  • E.S. Troullos, R.D. Freeman, R.A. Dionne. The Scientific Basis for Analgesic Use in Dentistry. Anesth Prog. 1986;33:123–138.

  • Cliff K. S. Ong, R. A. Seymour. Pathogenesis of Postoperative Oral Surgical Pain. Anesth Prog. 2003;50:5-17.

  • Daniela Motoc, Nicoleta Clarisa Turtoi, Virgil Vasca, Elisabeta Vasca, Francisc Schneider. Physiology of pain – general mechanisms and individual differences. J. Med. Ar. 2010;13:19-23.

  • G. Allen Finley, Linda S. Franck, Ruth E. Grunau, Carl L. von Baeyer. Why Children’s Pain Matters. Pain: Clinical updates. 2005;13:1-6.

  • Alberto Loizzo, Stefano Loizzo, Anna Capasso. Neurobiology of Pain in Children: An Overview. Open Biochem J. 2009;3:18-25.

  • P. N. Praveen Rao, Edward E. Knaus. Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond. J Pharm Pharm Sci. 2008;11:81s-110s.

  • Laurence L. Brunton, John S. Lazo, Keith L. Parker. Goodman & Gilman’s The Pharmacological basics of Therapeutics. Eleventh Edition. McGraw-Hill publishing;2006.

  • Carin E. Dugowson, Priya Gnanashanmugam. Nonsteroidal Anti-Inflammatory Drugs. Phys Med RehabilClin N Am. 2006;17:347–354.

  • Igor Kissin. The Development of New Analgesics over the Past 50 Years: A Lack of Real Breakthrough Drugs. Anesth Analg. 2010;110:780-789.

  • Michael J. Brownstein. A brief history of opiates, opioid peptides, and opioid receptors. Proc Natl Acad Sci. 1993;90:5391-93.

  • K. D. Tripathi. Essentials of Medical Pharmacology. Sixth Edition. Jaypee Publishers; 2008

  • Finkel, Richard, Clark, Michelle A., Cubeddu, Luigi X. Lippincott's Illustrated Reviews: Pharmacology. Fourth Edition. Lippincott Williams & Wilkins; 2009.

  • Wikipedia. Available at: https://en.wikipedia.org/ [Accessed May 8, 2016]

  • Muhammad Amer, Valeriani R. Bead, Joan Bathon, Roger S. Blumenthal, David N. Edwards. Use of Nonsteroidal Anti-Inflammatory Drugs in Patients with Cardiovascular Disease: A Cautionary Tale. Cardiol Rev. 2010;18:204–212.

  • Drugs.com (2016). Available at: http://www.drugs.com/ [Accessed May 8, 2016]

  • Enrique Hernández- Cortez. Non-steroidal Anti-inflammatory Analgesics in Children. Anestesiaen México 2006;18: 162-164.

  • 24. Sarfaraz Ahmad, Sajid Ali, Intakhab Alam, Sarfaraz Alam, Nawazish Alam, Maksood Ali. Drug Interactions of OTC Analgesics-Aspirin: A Review. Research J. Pharm. and Tech. 8(5): May, 2015; Page 580-586.

  • CIMS India (2016). Mims.com. Available at: http://www.mims.com/india [Accessed May 8, 2016]

  • Raymond A. Dionne, Charles W. Berthold. Therapeutic Uses of Non-Steroidal Anti-Inflammatory Drugs in Dentistry. Crit Rev Oral Biol Med 2001;12:315-330.

  • Dionne RA, Campell RA, Cooper SA, Hall DL, Buckingham B: Suppression of post operative pain by preoperative administration of ibuprofen in comparison to placebo, acetaminophen and acetaminophen plus codeine. J Clin Pharmacol 1983;23:37-43.

  • Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao. Design and Evaluation of Nimesulide Lozenges for Pediatrics. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 818-820.

  • Penniston SG, Hargreaves KM (1996). Evaluation of periapical injection of ketorolac for management of endodontic pain. J Endod 22:55-59.

  • Forbes JA, Kehm CJ, Grodin CD, Beaver JW (1990). Evaluation of ketorolac, ibuprofen, acetaminophen and an acetaminophencodeine combination in postoperative oral surgery pain. Pharmacotherapy 10(Suppl 6 Pt 2):94s-105s.

  • Mark Donaldson, Jason H. Goodchild. Appropriate analgesic prescribing for the general dentist. Gen Dent. 2010;58:291-7.

  • Lokken P and Skjelbred P: Analgesic and anti-inflammatory effects of paracematol evaluated by bilateral oral surgery. Br J Clin Pharm 1980;10:253S-260S.

  • Quiding H, Oikarinen V, Sane J, Sjoblad A: Analgesic efficacy after single and repeated doses of codeine and acetaminophen. J Clin Pharm 1984;24:27-34.

  • Skjelbred P, Album B, Lokken P: Acetylsalicylic acid versus paracematol; effect on post operative course. Eur J Clin Pharm 1977;12:257-264.

  • Tinesh Dayaa Rao, M.P. Santhosh kumar M.D.S. Analgesic Efficacy of Paracetamol Vs Ketorolac after Dental Extractions. Research J. Pharm. and Tech 2018; 11(8): 3375-3379.

  • Daniel E. Becker. Pain Management: Part 1: Managing Acute and Postoperative Dental Pain. Anesth Prog. 2010;57:67-79.

  • Pharmacology of Analgesics: Clinical Considerations | Continuing Education Course | dentalcare.com Introduction | DentalCare.com (2016). Dentalcare.com. Available at: http://www.dentalcare.com/en-US/dental-education/continuing-education/ce442/ce442.aspx [Accessed May 8, 2016]

  • R A Seymour. Use of analgesics in postoperative dental pain: a review. J R Soc Med. 1984;77:949–954.

  • A Gordon Macleod, B Ashford, M Voltz, B Williams, T Cramond, L Gorta, JM Simpson. Paracetamol versus paracetamol-codeine in the treatment of post-operative dental pain: A randomized, double-blind, prospective trial. Aust Dent J. 2002;47:147-151.

  • Breivik EK, Barkvoll P, Skovlund E. Combining diclofenac with acetaminophen or acetaminophen-codeine after oral surgery: a randomized, double-blind single-dose study. Clin Pharmacol Ther 1999; 66: 625-35.

  • Matthews RW, Scully CM, Levers BG. The efficacy of diclofenac sodium with and without paracetamol in the control of post-surgical dental pain. Br Dent J. 1984;157:357-9.

  • Gazal G, Mackie IC. A comparison of paracetamol, ibuprofen or their combination for pain relief following extractions in children under general anaesthesia: a randomized controlled trial. Int J Paediatr Dent 2007;17:169–77

  • Ianiro SR, Jeansonne BG, McNeal SF, Eleazer PD. The effect of preoperative acetaminophen or a combination of acetaminophen and ibuprofen on the success of inferior alveolar nerve block for teeth with irreversible pulpitis. J Endod 2007;33:11–4

  • Menhinick KA, Gutmann JL, Regan JD, Taylor SE, Buschang PH. The efficacy of pain control following nonsurgical ischolar_main canal treatment using ibuprofen or a combination of ibuprofen and acetaminophen in a randomized, double-blind, placebo controlled study. Int Endod J 2004;37:531–41

  • Srinivas Pyati, Tong J. Gan. Perioperative Pain Management. CNS Drugs 2007;21:185-211

  • Divya James, Nabeel Nazar. Role of Anti-anxiety Drugs in Patient Cooperation during Minor Surgical Procedure. Research J. Pharm. and Tech 2018; 11(8):3389-3391.

  • Rashmi Saikhedkar, Esha Verma. Role of Medications in the Treatment of Alveolar Osteitis: A Review. Research J. Pharm. and Tech. 8(10): Oct., 2015; Page 1445-1448

  • Moore PA, Acs G, Hargreaves JA: Post extraction pain relief in children: a clinical trial of liquid analgesics. Int J Clin Pharmacol Ther Toxicol 1985;23:573-77.

  • McGaw T, Raborn W, Grace M: Analgesics in pediatric dental surgery: relative efficacy of aluminum ibuprofen suspension and acetaminophen elixir. ASDC J Dent Child 1987;54:106-9.

  • Morshed Nasir, Rawshon Ara Parveen, Nazmun Nahar Alam. Pattern of Analgesic Use in Post-Operative Pain Management in a Tertiary Level Teaching Hospital in Bangladesh. Research J. Pharm. and Tech. 2016; 9(5): 493-496.

  • Primosch RE, Antony SJ, Courts FJ: The efficacy of preoperative analgesic administration on the post-operative pain management of pediatric dental patients. Anesth Pain Control Dent 1993;2:102-6.

  • Robert E. Primosch, Donna L. Nichols, Frank J. Courts. Comparison of preoperative ibuprofen, acetaminophen and placebo administration on the parental report of post-extraction pain in children. Pediatr Dent. 1995;17(3):187-191.

  • Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi. Influence of Different Beverages on Disintegration Behavior of Pain Reliever Immediate Release Formulations. Res. J. Pharm. Dosage Form. & Tech. 9(1): Jan.-Mar. 2017; Page 29-32

  • Bernhardt MK, Southard KA, Batterson KD, Logan HL, Baker KA, Jakobsen JR. The effect of pre-emptive and/or postoperative ibuprofen therapy for orthodontic pain. Am J Orthod Dentofacial Orthop 2001;120(1):20–7.

  • Garach Bhavik kumar D., Parth D. Raiyani. Postoperative pain after spine surgery: Comparative efficacy of diclofenac and etoricoxib in combination with tramadol and paracetamol at lower doses. Research J. Pharmacology and Pharmacodynamics. 2013; 5(1): 62-69.

  • Steen Law SL, Southard KA, Law AS, Logan HL, Jakobsen JR. An evaluation of preoperative ibuprofen for treatment of pain associated with orthodontic separator placement. Am J Orthod Dentofacial Orthop 2000;118(6):629–35.

  • Baygin O, Tuzuner T, Isik B, Kusgoz A, Tanriver M. Comparison of pre-emptive ibuprofen, paracetamol, and placebo administration in reducing post-operative pain in primary tooth extraction. Int J Paediat Dent 2011;21(4):306–13.

  • American Academy of Pediatric Dentistry. Useful Medications for Oral Conditions. Reference Manual 2016;37:407-14.

  • Krishnaveni K, Shanmuga Sundaram R, Sambath Kumar R, Sumitha SK, Teena Johny, Rosmi Jose. A Study of Self Medication Practices among the People in Ernakulam District, Kerala, India. Research J. Pharm. and Tech 2018; 11(2):700-704.

  • P. Sankaravadivoo (A) Rohini, Pradeepa, Pradeep Kumar Rathinavelu, Meignana Arumugham Indhiran, Srisakthi Duraikannan. Prevalence of Self Medication Practices among Dental Undergraduates Students. Research J. Pharm. and Tech 2018; 11(4): 1496-1498.


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  • Algesia and Analgesia in Pediatric Dentistry

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Authors

R. Vignesh
Department of Pedodontics and Preventive Dentistry, Saveetha Dental College and Hospital, Saveetha University, Saveetha Institute of Medical and Technical Sciences, Chennai., India
C. Vishnu Rekha
Department, Department of Pedodontics and Preventive Dentistry, Sathyabama Dental College and Hospital, Chennai, India
Parisa Norouzi Baghkomeh
Department of Pedodontics and Preventive Dentistry, Meenakshi Ammal Dental College and Hospital, Chennai, India
Sankar Annamalai
Department of Pedodontics and Preventive Dentistry, Meenakshi Ammal Dental College and Hospital, Chennai, India
D. Ditto Sharmin
Department of Pedodontics and Preventive Dentistry, Meenakshi Ammal Dental College and Hospital, Chennai, India

Abstract


Aim: To summarize the basic and current concepts of algesia and analgesia in pediatric dental practice by a thorough systematic literature research of databases. Background: Electronic databases were used to conduct a computerized search like MEDLINE, Pub Med, Scopus and Evidence-based Medicine reviews using the terms ‘‘analgesics,’’ “drugs for pain,” “pain in children,” and “dental pain management”. Review results: Effective management of pain in children is a major priority for patients, parents, and health-care providers. Analgesics, class of drugs which helps to relieve pain, act either on peripheral nerve endings or in the central nervous system. Dental practitioners’ knowledge to prescribe the most effective drug and appropriate dose to alleviate pain is necessary. Conclusion: A pain management strategy in pediatric dentistry includes the ‘3-D’ approach that provides a systematic way of evaluating and managing the acute dental pain patient using combined non-pharmacologic and pharmacologic strategies. Clinical significance: Thorough knowledge about the drugs and its combination can result in achieving required postoperative analgesia thereby reducing adverse effects in children.

Keywords


Analgesics, Algesia, Analgesia, Medications, Dental Pain.

References