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Solasodine:A Perspective on their roles in Health and Disease


Affiliations
1 Kamla Nehru Institute of Management and Technology, Sultanpur, India
2 Integral University, Lucknow 226026, India
     

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Steroidal glycoalkaloids, a category of glycosidic ingradients are originated from nitrogen-containing steroids. Structurally it includes of C27 cholestane skeleton to that 1 to 5 sugar moieties are hooked up at the 3-OH region of the aglycone part. Solasodine, in most of the solanaceous plants occurs as an aglycone a region of glycoalkloids, like solasonine, solamargine etc. Solasodine is employed as a hormone precursor within the steroid drug business for the manufacturing corticosteroids, anabolic steroids, antifertility drugs etc. Isolated Solasodine from solanum plants exploits its medicinal properties such as anticonvulsant, CNS depressant, antioxidant, cytotoxic, antinociceptive, anti-inflammatory, hepatoprotective, immunomodulatory, antiatherosclerotic, antimicrobial, and antiobesity activity, etc. In acut toxicity study, LD50 of Solasodine was found to be 1500 mg/kg after intraperitoneal administration and 2000 mg/kg, after oral administration in rats. Present review has set about to bring updated information regarding to pharmacological activities of solasodine, which may be helpful to researchers to explore a new bioactive molecules for various therapeutic application.

Keywords

Solasodine, Spiroketal, Steroidal Glycoalkaloids, Pharmaco-therapeutics.
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  • Parmar S, Gangwal A, Sheth N. Solanum xanthocarpum (Yellow Berried Night Shade): A review. Der Pharmacia Lettre. 2010; 2(4):373-383.

  • Smith SW, Giesbrecht E, Thompson M, Nelson LS, Hoffman RS. Solanaceous steroidal glycoalkaloids and poisoning by Solanum torvum, the normally edible susumber berry. Toxicon. 2008; 52: 667–676.

  • Jayakumar K, Murugan K. Solanum Alkaloids and their Pharmaceutical Roles: A Review. J Anal Pharm Res. 2016; 3(6): 00075.

  • Hussain T, Gupta RK, Sweety K, et al. Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents. Asian Pac J. of Trop Biomed. 2012: 454-460.

  • Patel K, Singh RB, Patel D. K. Medicinal significance, pharmacological activities, and analytical aspects of Solasodine: A concise report of current scientific literature. Journal of Acute Disease. 2013: 92-98.

  • Muthumani P, Meera R, Sundaraganapathy, et al. Phytochemical Investigation and Determination of Crude Alkaloidal Content (Solasodine) in Dried and Fresh Fruits of Lawsonia inermis. Research J. Pharm. and Tech. 2010; 3 (3): 736-739.

  • Nigra HM, Caso OH, and Giulietti AM. Production of Solasodine by calli from different parts of Solanum eleagnifolium Cav.plants. Plant Cell Reports. 1987; 6: 135-137.

  • Putalun W, Tanaka H, & Shoyama Y. Rapid separation of Solasodine glycosides by an immune affinity column using anti-solamargine monoclonal antibody. Cytotechnology. 1999; 31: 151–156.

  • Chen Z, Miller AR. Steroidal alkaloids in Solanaceous vegetable crops. Horticultural Reviews. 2001; 25: 171–96.

  • Araújo MGF, Galeane MC, Castro AD, et al. Pharmacognostical Evaluation of Fruits of Solanum lycocarpum A. St.-Hill. (Solanaceae). Pharmaconosy Journal. 2010; 2(9): 248-253.

  • Pawar PK, Borse TP, Pinjari RZ, Maheshwari VL. A simple technique for rapid quantitative determination of Solasodine from cultured hairy ischolar_mains of Solanum surattense. J Herb Med Toxicol. 2008; 2(1): 7-10.

  • Tanaka H, Putalun W, Shoyama Y. Western blotting of steroidal alkaloid glycosides using monoclonal antibody against solamargine. J Liq Chrom and Rel Technol. 1999; 22(10): 1503-1512.

  • Fonin, VS, Shain SS, Vandyshev VV. Enzymatic hydrolysis of steroid glycosides in plant raw material for medicinal use. Prikl. Biokhim. Mikrobiol. 1996; 32: 514–518.

  • Weissenberg M. Isolation of Solasodine and other steroidal alkaloids and sapogenins by direct hydrolysis-extraction of Solanum plants or glycosides there from. Phytochemistry. 2001; 58: 501–508.

  • Eltayeb EA, Al-Ansari AS, Roddick JG. Changes in the steroidal alkaloid Solasodine during development of Solanum nigrum & Solanum incanum. Phytochemistry. 1997; 46(3):489-494.

  • Roddick JG. Solanacae. In: W.G.D’Archy (ed). Biology and systamatics. New York: Columbia University Press; 1986: P.201.

  • Hameed A, Ijaz S, Mohammad IS, Muhammad KS, Akhtar N, Khan HMS. Aglycone solanidine and Solasodine derivatives: A natural approach towards cancer. Biomedicine & Pharmacotherapy. 2017; 94: 446–457.

  • Nasrin T, Khandaker M, Akter S, Imam MZ. Antinociceptive activity of methanol extract of leaves of Solanum sisymbriifolium in heat and chemical-induced pain. J App Pharm Sci. 2017; 7 (11):142-146.

  • Koduru S, Jimoh FO, Grierson DS, Afolayan AJ. Antioxidant activity of two steroidal alkaloids extracted from Solanum aculeastrum. J Pharmacol.Toxicol. 2007; 2: 160–167.

  • Sharma T, Airao V, Panara N, Vaishnav D, Ranpariya V, Sheth N, et al. Solasodine protects rat brain against ischemia/reperfusion injury through its antioxidant activity. Eur J Pharmacol. 2014; 725: 40-46.

  • Lecanu L, Hashim AI, McCourty A, Douriez GI, Dinca I, Yao W, et al. The naturally occurring steroid Solasodine induces neurogenesis in vitro and in vivo. Neuroscience. 2011; 183: 251-264.

  • Desai AP, Kagathara VG, Joshi H, Rangani1 AT, Mungra H. Evaluation of Antiamnesic effect of Solasodine in Mice. Int J Pharm Tech Res. 2011; 3(2):732-740.

  • Periyanayagam K, Gokila S, Balasubramaniam K.G., Jagatheeswary, et al. Protective Effect of the Leaves of Solanum torvums wartz on Drosophila melanogaster against β-Amyloid Induced Alzheimer Disease. Research J. Pharm. and Tech. 2015; 8(6): 719-727.

  • Chauhan K, Sheth N, Ranpariya V, Parmar S. Anticonvulsant activity of Solasodine isolated from Solanum sisymbriifolium fruits in rodents. Pharm Biol. 2011; 49: 194-199.

  • Joseph J, Joseph L, Georg M. Antiepileptic activity of some medicinal plants of solanaceae family-a review. W.J.P.R.2016; 5(8): 353-367.

  • Pandurangan A, Khosa RL, Hemalatha S. Anti-inflammatory activity of an alkaloid from Solanum trilobatum on acute and chronic inflammation models. Natural Product Research. 2011; 25(12): 1132–1141.

  • Emmanuel S, Ignacimuthu S, Perumalsamy R, Amalraj T. Antiinflammatory activity of Solanum trilobatum. Fitoterapia. 2006; 77(7-8): 611-612.

  • Devi RK, Radha R, Jayshree N. Formulation and Evaluation of Solasodine Transdermal Patches for Anti-Inflammatory Activity. Int.JPR. 2014; 3(4): 36-42.

  • Chiu FL and Lin JK. Tomatidine inhibits iNOS and COX-2 through suppression of NF-jB & JNK pathways in LPS-stimulated mouse macrophages. FEBS Letters. 2008; 582: 2407–2412.

  • Pandurangan A, Khosa RL, Hemalatha S. Antinociceptive activity of steroid alkaloids isolated from Solanum trilobatum Linn. J Asian Nat Prod Res. 2010; 12(8): 691-695.

  • Kumar P, Sharma B, Bakshi N. Biological activity of alkaloids from Solanum dulcamara L., Natural Product Research: Formerly Natural Product Letters. 2009;23(8): 719-723.

  • Chataing B, Concepción JL, Lobatón R, Usubillaga A. Inhibition of Trypanosoma cruzi growth in vitro by Solanum alkaloids: a comparison with ketoconazole. Planta Med. 1998; 64(1): 31-36.

  • Weissenberg M, Levy A, Svoboda JA, Ishaaya I. The effect of some Solanum steroidal alkaloids and glycoalkaloids on larvae of the red flour beetle, Tribolium castaneum, and the tobacco hornworm Manduca sexta. Phytochemistry. 1998; 47(2): 203-209.

  • Chang W, Li Y, Zhang M, Zheng S, Li Y, Lou H. Solasodine-3-O-b-D-glucopyranoside kills Candida albicans by disrupting the intracellular vacuole. Food and Chemical Toxicology. 2017; 106: 139-146.

  • Kusano G, Takahashi A, Sugiyama K, Nozoe S. Antifungal properties of Solanum alkaloids. Chem Pharm Bull. 1987; 35: 4862-4867

  • Nes WD, Hanners PK, Bean GA, Patterson GW. Inhibition of growth and sitosterol-induced sexual reproduction in Phytophtora cactorum by steroidal alkaloids. Phytopathology. 1982; 72: 447–450.

  • Wang LD, Guo DA, Yuan L, He QH, et al. Antifungal effect of three natural products on the genetic substance of Saccharomyces cerevisiae GL7 and Prototheca wickerhamii. Yao Xue Xue Bao. 2000; 35(11): 860-863.

  • Dixit VP, Varma M, Mathur NT, Mathur R, Sharma S. Hypocholesterolaemic and antiatherosclerotic effects of Solasodine. (C27H42O2N) in cholesterol fed rabbits. J. Phytotheray Res. 1992; 6(5): 270-273.

  • Dixit VP and, Gupta RS. Antispermatogenic/ antiandrogenic properties of Solasodine (C27H43O2N) obtained from Solanum xanthocarpum berries on the male genital tract of dog (Canis familaris). A histopathological approach. Int J Androl. 1982; 5(3): 295–307.

  • Dixit VP. Antifertility effects of Solasodine obtained from Solanum xanthocarpum berries in male rats and dogs. Department of Zoology, University of Rajasthan, Jaipur India; 1980.

  • Dixit VP and, Gupta RS. Antispermatogenic/ antiandrogenic properties of Solasodine (C27H43O2N) obtained from Solanum xanthocarpum berries on the male rat and dogs. J Steroid Biochem. 1986; 25: 27s.

  • Dixit VP, Gupta RS, Gupta S. Antifertility plant products: testicular cell population dynamics following Solasodine administration in rhesus monkeys (Macca mulatta). Andrologia. 1989; 21: 542– 546.

  • Gupta RS, Dixit VP. Effects of short-term treatment of solasodine on cauda epididymis in dogs. Indian J Exp Biol. 2002; 40(2): 169-173.

  • Aslam RP, Gautam PV. Antifertility effects of Solasodine obtained from Solanum xanthocarpum berries in male rats and dogs. Int J Pharm Tech. 2013; 4(4): 2305-2310.

  • Reddy NM and Reddy RN. Solanum xanthocarpum Chemical Constituents and medicinal Properties: A Review; Sch. Acad. J. Pharm. 2014); 3(2): 146-149.

  • Kanwar U, Batla A, Sanyal SN, Ranga A. Glycolytic enzyme activities of human and bovine spermatozoa treated in vitro with Solasodine. J of Ethnopharmacology. 1990;28: 249-254.

  • Cui C, Wen X, Cui M, Gao J, Sun B, Lou H. Synthesis of Solasodine glycoside derivatives and evaluation of their cytotoxic effects on human cancer cells. Drug Discoveries & Therapeutics. 2012; 6(1): 9-17.

  • Jayakumar K, Murugan K. Purified Solasodine from Solanum mauritianum Scop. and its molecular mechanism of antimetastatic potential. Journal of Phytopharmacology. 2017; 6(4): 251-259.

  • Chang LC, Tsai TR, Wang JJ, Lin CN, Kuo KW. The rhamnose moiety of solamargine plays a crucial role in triggering cell death by apoptosis. Biochem Biophys Res Commun. 1998; 242(1): 21-25.

  • Lin CN, Lu CM, Cheng MK, Gan KH, Won SJ. The cytotoxic principles of Solanum incanum. J Nat Prod. 1990; 53: 513–516.

  • Cham BE. Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies. International Journal of Clinical Medicine. 2017; 8: 692-713.

  • Cham BE. Drug therapy: Solamargine and other Solasodine rhamnosyl glycosides as anticancer agents. Modern Chemotherapy. 2013; 2: 33-49.

  • Cham BE and Chase TR. Solasodine Rhamnosyl Glycosides Cause Apoptosis in Cancer Cells. Do They Also Prime the Immune System Resulting in Long Term Protection against Cancer? Planta Medica. 2012; 78: 349-353.

  • Cham BE. Solasodine Rhamnosyl glycosides specifically bind cancer cell receptors and induce apoptosis and necrosis. Treatment for skin cancer and hope for internal cancers. Res J Biol Sci. 2007; 2(4): 503-514.

  • Cham BE. Intralesion and CuradermBEC5 Topical Combination Therapies of Solasodine Rhamnosyl Glycosides Derived from the Eggplant or Devil’s Apple Result in rapid removal of large skin cancers. Methods of Treatment Compared. International Journal of Clinical Medicine. 2012; 3: 115-124.

  • Cham BE, Daunter B, Evans RA. Topical treatment of malignant and premalignant skin lesions by very low concentrations of a standard mixture (BEC) of Solasodine glycosides. Cancer Lett. 1991; 59: 183–192.

  • Cham BE. Topical Solasodine Rhamnosyl Glycosides Derived from the Eggplant Treats Large Skin Cancers: Two Case Reports. International Journal of Clinical Medicine. 2011; 2: 473-477.

  • Panjabi S, Cook LJ, Kersey P, Marks R, Cerio R. Solasodine glycoalkaloids: a novel topical therapy for basal cell carcinoma. A double-blind, randomized, placebo-controlled, parallel group, multicenter study. Int. J. of Dermatology. 2008; 47: 78–82.

  • Koduru S, Grierson DS, Venter M, Afolayan AJ. Anticancer Activity of Steroid Alkaloids Isolated from Solanum aculeastrum. Pharm Biol. 2007; 45(8): 613–618.

  • Bhattacharya S, Kohli S, Chaudhary AS. Isolation of Solasodine from the unripe fruits of Solanum xanthocarpum Schrad and Wendl. (Solanaceae) and it’s anti cancer activity against HeLa and U937 cell lines. Austrl-Asian J Can. 2013; 12(3): 199-213.

  • Zha XM, Zhang FR, Shan JQ, Zhang YH, Liu JO, Sun HB. Synthesis and evaluation of in vitro anticancer activity of novel Solasodine derivatives. Chinese Chemical Lett. 2010; 21: 1087–1090.

  • Lin CN, Chung MI, Gan KH. Novel antihepatotoxic principles of Solanum incanum. Planta Med 1988; 54: 222.

  • Malik A, Arooj M, Butt T.T., Zahid S., et al. In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents. Drug Design, Development and Therapy. 2018; 12: 1431–1443.

  • Khaserao S and Somani R. Evaluation of the anti-obesity activity of Solasodine on high fat diet-induced obesity in the rat. Int J Pharm Pharm Sci. 2017; 9(3): 23-29.

  • Patel VB, Rathodb IS, Patel JM. Brahmbhatt MR. Anti-urolithiatic and natriuretic activity of steroidal constituents of Solanum xanthocarpum. Der Pharma Chemica. 2010; 2(1):173-176.

  • Basu A, Lahiri SC. Some Pharmacological actions of Solasonine. Indian Journal of Experimental Biology. 1977; 15: 85-289.

  • Malinovaskaia VS. Cardiotonic effect of an indigenous antirheumatic agent, Solasodine. Vrach Delo. 1968; 12: 123-124.

  • Krayer O, Briggs LH. Studies on solanum alkaloids:II. The anti-accelerator cardiac action of Solasodine and some of its derivatives. J Pharmacol. 1950; 5: 17–525.

  • Da´roczy A, Herna´di F. On the ‘‘glucocorticoid-like’’ effects of Solanum alkaloids. Acta Biochim Biophys Acad Sci Hung. 1971; 6: 327–331.

  • Kaur A, Raja SS, Thakur SS, Rao BK. Insect growth regulating activity of Solasodine on Dysdercus Similis. Comp Physiol Ecol. 1988; 13: 195–197.

  • Lingampally V, Solanki VR, Raja SS. Induction of ovarian dysfunction in tribolium confusum by Solasodine. Indian J Fundamental and App Life Sci. 2012; (2): 160-163

  • Kusano G, Takahashi A, Nozoe S, Sonoda Y, Sato Y. Solanum alkaloids as inhibitors of enzymatic conversion of dihydrolanosterol into cholesterol. Chem Pharm Bull. 1987a; 35: 4321–4323.

  • Gaffield W, Keeler RF. Craniofacial malformations induced in hamsters by steroidal alkaloids. J. Nat. Toxins. 1996; 5:25–38.

  • Friedman M, Rayburn JR, Bantle JA. Structural relationships and developmental toxicity of Solanum alkaloids in the frog teratogenesis assay- Xenopus. J Agric Food Chem. 1992; 40: 1617– 1624.

  • Friedman M, Henika PR, Mackey BE. Feeding of potato, tomato, and eggplant alkaloids affects food consumption and body and liver weights in mice. J Nutr. 1996; 126:989–999.

  • Kulcsar GJ. The effect of Solasodine on the body temperature. Arzneimittel Forschung 1976; 26(1):55-57.

  • Singh OM and Singh TP. Phytochemistry of solanum xanthocarpum: an amazing traditional healer. J Sci Ind Res. 2010; 69:732-740.

  • Baehr V and Haensel R. Immunomodulating properties of 5, 20 alpha(r)-dihydroxy-6alpha, 7-alpha-epoxy-1-oxo-(5alpha)-witha-2-, 24-dienolide & Solasodine. J Planta Med. 1982; 44 (1):32-3.

  • Seifulla K, Kovalev IE, Seifulla RD. Effect of Solasodine and Cortisone on the immunological reactivity and on the function of the blood coagulation system. Farmakol Toksikol. 1967; 30(5): 609-612.


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  • Solasodine:A Perspective on their roles in Health and Disease

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Authors

R. Kumar
Kamla Nehru Institute of Management and Technology, Sultanpur, India
M. I. Khan
Integral University, Lucknow 226026, India
M. Prasad
Kamla Nehru Institute of Management and Technology, Sultanpur, India
Badruddeen
Integral University, Lucknow 226026, India

Abstract


Steroidal glycoalkaloids, a category of glycosidic ingradients are originated from nitrogen-containing steroids. Structurally it includes of C27 cholestane skeleton to that 1 to 5 sugar moieties are hooked up at the 3-OH region of the aglycone part. Solasodine, in most of the solanaceous plants occurs as an aglycone a region of glycoalkloids, like solasonine, solamargine etc. Solasodine is employed as a hormone precursor within the steroid drug business for the manufacturing corticosteroids, anabolic steroids, antifertility drugs etc. Isolated Solasodine from solanum plants exploits its medicinal properties such as anticonvulsant, CNS depressant, antioxidant, cytotoxic, antinociceptive, anti-inflammatory, hepatoprotective, immunomodulatory, antiatherosclerotic, antimicrobial, and antiobesity activity, etc. In acut toxicity study, LD50 of Solasodine was found to be 1500 mg/kg after intraperitoneal administration and 2000 mg/kg, after oral administration in rats. Present review has set about to bring updated information regarding to pharmacological activities of solasodine, which may be helpful to researchers to explore a new bioactive molecules for various therapeutic application.

Keywords


Solasodine, Spiroketal, Steroidal Glycoalkaloids, Pharmaco-therapeutics.

References