Research Journal of Pharmacy and Technology

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Effect of Ethanol Extract from Purple Eggplant Skin (Solanum melongena L) On Blood Glucose Levels and Pancreatic Β Cells Regeneration on White Rats Male Hypercholesterolemia-Diabetic


Affiliations
1 Program Studi S1 Farmasi, STIFA Pelita Mas, Palu, Indonesia
2 Laboratorium Penelitian dan Pengembangan Kefarmasian FARMAKA TROPIS, Universitas Mulawarman, Samarinda, Indonesia
     

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To observed secondary metabolite compounds in the purpleeggplant skin fruit ethanol extract, the effect and effective dose on blood glucose levels and regeneration of pancreatic β cells of white rats male Hypercholesterolemia-Diabetic. This research is a laboratory experiment with a Phytochemical assay using a specified reagent for the ethanol extract of purple eggplant skin. The effect and effective dose on blood glucose levels and regeneration of pancreatic β cells animal model using posttest randomized controlled-group design. A total of 30 rats were divided into six groups. Group I; normal control given standard feed: group II; negative control is given Na CMC 0.5%, high cholesterol feed and induced by streptozotocin 30 mg/kg BW; experimental groups were given extract of ethanol from purple eggplant skin each with dose 25, 50 and 100 mg/kg BW, high cholesterol feed, and streptozotocin 30 mg/kg BW. The data obtained were analyzed using one-way ANOVA test at 95% confidence level and continued with LSD Post Hoc test and description of histologic damage level of the pancreaswas analyzed by Kruskal-Wallis test followed by Mann-Whitney test for observed the difference between treatments. Extracts ethanol of purple eggplant skinaffect blood glucose levels and pancreatic β cell regeneration and an effective dose is a dose of 25 mg/kg body weight was the most effective extract.This research confirm that the ethanol extract from purple eggplant skin (Solanum melongena L) affect blood glucose levels and pancreatic β cell regeneration.

Keywords

Solanum Melongena L, Purple Eggplant, Diabetic, Histology, Pancreatic.
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  • Trilestari Herni.. Relationship between dietary behavior and glucose levels when in type II diabetes mellitus patients in Ambarketawang Yogyakarta. Jurnal Sains dan Kesehatan. 2016

  • International Diabetes Federation. 2015. IDF Diabetes Atlas. 7th Edition.

  • Fajans SS, Bell GI, and Polonsky KS. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. New England Journal of Medicine 2001;345(13); 971-980.

  • Tandi J, Wulandari Ayu, Asrifa. Effect of Gendola Merah Leaf Ethanol Extract (Basella alba L.) against Creatinine levels, urea and Rat Kidney tubules Histological Description White Males (Rattus norvegicus) diabetic Streptozotocin induced. Jurnal Farmasi Galenika2017; 3(2); 93 – 102.

  • Martiningsih NW, Sukarta IN, dan Yuniana PE. Phytochemical Screening and Antioxidant Activity Test of Ethanol Extracts of Purple Eggplant Fruit (Solanum melongena L.). (Jurnal Kimia) Journal Of Chemistry2014; 8(2); 145-152.

  • Gürbüz N, Uluişik S, Frary A, Frary A, Doğanlar S. Health benefits and bioactive compounds of eggplant, Food Chemistry2018; 268(1); 602-610.

  • Aer BN, Wullur AC, Citraningtyas G. The effect of purple eggplant skin ethanol extract (Solanum melongena L.) Against Blood Sugar Levels in Male White Rat Strains Wistar (Rattus norvegicus). Jurnal Ilmiah Pharmacon 2013; 2 (4); 135-141.

  • Suryani N. Endang HT. Aulanni’am. Effect of Methanolic Swieteniamahagoni Seed Extracts in Increasing Insulin Level, Decreasing TNF-α Expression and Repairing Pancreatic Tissue Damage on Diabetic Rat. Jurnal Kedokteran Brawijaya 2013;27(3); 137-145.

  • Azhari DM, Yuliet Y, and Khaerati K. Powder Oyster Mushroom Activity Test (Pleurotus ostreatus (Jacq.) P. Kumm) Against Blood Glucose Levels in Animal Models of Diabetes Hypercholesterolemia. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) 2016; 2(2); 96-102.

  • Harborne JB. Phytochemical methods: A guide to modern techniques of plant analysis. 1987.

  • Shepherd PR, and Kahn BB. Glucose transporters and insulin action—implications for insulin resistance and diabetes mellitus. New England Journal of Medicine 1999; 341(4); 248-257.

  • Tandi J, As’ad Suryani, Natzir R, Bukhari A. Test of Ethanol extract Red Gedi Leaves (Abelmoschus Manihot.(L.) Medik) in White Rat (Rattus Norvegicus)Type 2 Diabetes Mellitus. International Journal of Sciences: Basic and Applied Research (IJSBAR) 2016; 30(4); p. 84.

  • Asrifa A, Yusriadi Y, and Martina A. Effect Test of Gendola Merah Leaf Ethanol Extract (Basella alba L.) Against Tubular Histological Overview of Kidney White Male Rat (Rattus Norvegicus) Streptozotocin induced. Farmakologika-Jurnal Farmasi 2017;14(02); 165-173.

  • Tandi J, Amelia J, Ayu G, Irwan. Effect Of Ethanol Extract of Kenikir (CosmosCaudatus Kunth.) Leaves In Blood Glucose,Cholesterol And Toward Histopathology Pancreas Description In Male White Rats (RattusNorvegicus).Proceeding International Seminar and Expo on Jamu 2 2017;43-45.

  • Tandi J, Hanifah M, Yuliet, Yusriadi. Effectiveness of Red Gedi Leaf Extract on Blood Glucose, Malondialdehyde, 8-Hydroxy-Deoxiguanosine, and Insulin Diabetes Mice. J. Trop. Pharm. Chem2016; 3(4);265-266.

  • Tendean I, Kenta YS, Mulyani S. Test of Taro Leaf Ethanol Extract (Colocasia Escuenta (L.) Schott.) Against Histopathology Overview of Male White Rat Pancreas (Rattus norvegicus) Diabetes hypercholesterolemia. Farmakologika - Jurnal Farmasi 2017; 14(2); 138-148,


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  • Effect of Ethanol Extract from Purple Eggplant Skin (Solanum melongena L) On Blood Glucose Levels and Pancreatic Β Cells Regeneration on White Rats Male Hypercholesterolemia-Diabetic

Abstract Views: 278  |  PDF Views: 0

Authors

Joni Tandi
Program Studi S1 Farmasi, STIFA Pelita Mas, Palu, Indonesia
Rama Danthy
Program Studi S1 Farmasi, STIFA Pelita Mas, Palu, Indonesia
Purwaningsih
Program Studi S1 Farmasi, STIFA Pelita Mas, Palu, Indonesia
Hadi Kuncoro
Laboratorium Penelitian dan Pengembangan Kefarmasian FARMAKA TROPIS, Universitas Mulawarman, Samarinda, Indonesia

Abstract


To observed secondary metabolite compounds in the purpleeggplant skin fruit ethanol extract, the effect and effective dose on blood glucose levels and regeneration of pancreatic β cells of white rats male Hypercholesterolemia-Diabetic. This research is a laboratory experiment with a Phytochemical assay using a specified reagent for the ethanol extract of purple eggplant skin. The effect and effective dose on blood glucose levels and regeneration of pancreatic β cells animal model using posttest randomized controlled-group design. A total of 30 rats were divided into six groups. Group I; normal control given standard feed: group II; negative control is given Na CMC 0.5%, high cholesterol feed and induced by streptozotocin 30 mg/kg BW; experimental groups were given extract of ethanol from purple eggplant skin each with dose 25, 50 and 100 mg/kg BW, high cholesterol feed, and streptozotocin 30 mg/kg BW. The data obtained were analyzed using one-way ANOVA test at 95% confidence level and continued with LSD Post Hoc test and description of histologic damage level of the pancreaswas analyzed by Kruskal-Wallis test followed by Mann-Whitney test for observed the difference between treatments. Extracts ethanol of purple eggplant skinaffect blood glucose levels and pancreatic β cell regeneration and an effective dose is a dose of 25 mg/kg body weight was the most effective extract.This research confirm that the ethanol extract from purple eggplant skin (Solanum melongena L) affect blood glucose levels and pancreatic β cell regeneration.

Keywords


Solanum Melongena L, Purple Eggplant, Diabetic, Histology, Pancreatic.

References