Research Journal of Pharmacy and Technology

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Development of New Src Inhibitors


Affiliations
1 Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syrian Arab Republic
2 Doctor in Pharmaceutical Chemistry Department, Tartous University, Syrian Arab Republic
     

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Protein kinase, especially tyrosine kinase Src, is considered as an important target for cancer therapy such as lung, prostate and central nervous system cancers, as well as its involvement in tumor metastasis. The aim of this study was to find effective and selective inhibitors of Src protein kinase using molecular modeling study, a library of chemical compounds derived from purine and Theophylline cores was then docked within the active site of the Src enzyme. The link affinity and the attitudes of binding of the suggested compounds with the active site of the previously prepared Src enzyme were determined of these compounds. The study led to three effective and highly selective compounds on the Src enzyme; two compounds derived from the Purine core Pur46 and Pur49 and one compound derived from Theophylline core Theo21. The study was completed by chemical synthesis of Theo23 molecule.

Keywords

Tyrosine Kinase, Molecular Modeling, Docking, Src, Cancer.
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  • Development of New Src Inhibitors

Abstract Views: 229  |  PDF Views: 0

Authors

Samar Alnukari
Pharmaceutics and Pharmaceutical Technology Department, Faculty of Pharmacy, Tishreen University, Syrian Arab Republic
Faten Sliman
Doctor in Pharmaceutical Chemistry Department, Tartous University, Syrian Arab Republic

Abstract


Protein kinase, especially tyrosine kinase Src, is considered as an important target for cancer therapy such as lung, prostate and central nervous system cancers, as well as its involvement in tumor metastasis. The aim of this study was to find effective and selective inhibitors of Src protein kinase using molecular modeling study, a library of chemical compounds derived from purine and Theophylline cores was then docked within the active site of the Src enzyme. The link affinity and the attitudes of binding of the suggested compounds with the active site of the previously prepared Src enzyme were determined of these compounds. The study led to three effective and highly selective compounds on the Src enzyme; two compounds derived from the Purine core Pur46 and Pur49 and one compound derived from Theophylline core Theo21. The study was completed by chemical synthesis of Theo23 molecule.

Keywords


Tyrosine Kinase, Molecular Modeling, Docking, Src, Cancer.

References